Committed to work but vulnerable: self-perceptions and mental health in NEET 18-year olds from a contemporary British cohort / Sidra GOLDMAN-MELLOR in Journal of Child Psychology and Psychiatry, 57-2 (February 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-2 (February 2016) . - p.196-203 Titre : Committed to work but vulnerable: self-perceptions and mental health in NEET 18-year olds from a contemporary British cohort Type de document : texte imprimé Auteurs : Sidra GOLDMAN-MELLOR, Auteur ; Avshalom CASPI, Auteur ; Louise ARSENEAULT, Auteur ; Nifemi AJALA, Auteur ; Antony AMBLER, Auteur ; Andrea DANESE, Auteur ; Helen L. FISHER, Auteur ; Abigail HUCKER, Auteur ; Candice L. ODGERS, Auteur ; Teresa WILLIAMS, Auteur ; Chloe WONG, Auteur ; Terrie E. MOFFITT, Auteur Article en page(s) : p.196-203 Langues : Anglais (eng) Mots-clés : Adolescence  depression  self-perceptions  employment  longitudinal studies  mental health Index. décimale : PER Périodiques Résumé : Background Labour market disengagement among youths has lasting negative economic and social consequences, yet is poorly understood. We compared four types of work-related self-perceptions, as well as vulnerability to mental health and substance abuse problems, among youths not in education, employment or training (NEET) and among their peers. Methods Participants were from the Environmental Risk (E-Risk) longitudinal study, a nationally representative UK cohort of 2,232 twins born in 1994–1995. We measured commitment to work, job-search effort, professional/technical skills, ‘soft’ skills (e.g. teamwork, decision-making, communication), optimism about getting ahead, and mental health and substance use disorders at age 18. We also examined childhood mental health. Results At age 18, 11.6% of participants were NEET. NEET participants reported themselves as committed to work and searching for jobs with greater diligence than their non-NEET peers. However, they reported fewer ‘soft’ skills (B = −0.98, p < .001) and felt less optimistic about their likelihood of getting ahead in life (B = −2.41, p < .001). NEET youths also had higher rates of concurrent mental health and substance abuse problems, but these did not explain the relationship with work-related self-perceptions. Nearly 60% of NEET (vs. 35% of non-NEET) youths had already experienced ≥1 mental health problem in childhood/adolescence. Associations of NEET status with concurrent mental health problems were independent of pre-existing mental health vulnerability. Conclusions Our findings indicate that while NEET is clearly an economic and mental health issue, it does not appear to be a motivation issue. Alongside skills, work-related self-perceptions and mental health problems may be targets for intervention and service provision among this high-risk population. En ligne : http://dx.doi.org/10.1111/jcpp.12459 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280 [article] Committed to work but vulnerable: self-perceptions and mental health in NEET 18-year olds from a contemporary British cohort [texte imprimé] / Sidra GOLDMAN-MELLOR, Auteur ; Avshalom CASPI, Auteur ; Louise ARSENEAULT, Auteur ; Nifemi AJALA, Auteur ; Antony AMBLER, Auteur ; Andrea DANESE, Auteur ; Helen L. FISHER, Auteur ; Abigail HUCKER, Auteur ; Candice L. ODGERS, Auteur ; Teresa WILLIAMS, Auteur ; Chloe WONG, Auteur ; Terrie E. MOFFITT, Auteur . - p.196-203. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-2 (February 2016) . - p.196-203 Mots-clés : Adolescence  depression  self-perceptions  employment  longitudinal studies  mental health Index. décimale : PER Périodiques Résumé : Background Labour market disengagement among youths has lasting negative economic and social consequences, yet is poorly understood. We compared four types of work-related self-perceptions, as well as vulnerability to mental health and substance abuse problems, among youths not in education, employment or training (NEET) and among their peers. Methods Participants were from the Environmental Risk (E-Risk) longitudinal study, a nationally representative UK cohort of 2,232 twins born in 1994–1995. We measured commitment to work, job-search effort, professional/technical skills, ‘soft’ skills (e.g. teamwork, decision-making, communication), optimism about getting ahead, and mental health and substance use disorders at age 18. We also examined childhood mental health. Results At age 18, 11.6% of participants were NEET. NEET participants reported themselves as committed to work and searching for jobs with greater diligence than their non-NEET peers. However, they reported fewer ‘soft’ skills (B = −0.98, p < .001) and felt less optimistic about their likelihood of getting ahead in life (B = −2.41, p < .001). NEET youths also had higher rates of concurrent mental health and substance abuse problems, but these did not explain the relationship with work-related self-perceptions. Nearly 60% of NEET (vs. 35% of non-NEET) youths had already experienced ≥1 mental health problem in childhood/adolescence. Associations of NEET status with concurrent mental health problems were independent of pre-existing mental health vulnerability. Conclusions Our findings indicate that while NEET is clearly an economic and mental health issue, it does not appear to be a motivation issue. Alongside skills, work-related self-perceptions and mental health problems may be targets for intervention and service provision among this high-risk population. En ligne : http://dx.doi.org/10.1111/jcpp.12459 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280

Integrated genetic and methylomic analyses identify shared biology between autism and autistic traits / A. MASSRALI in Molecular Autism, 10 (2019)  

Public ISBD [article]  inMolecular Autism > 10 (2019) . - 31 p. Titre : Integrated genetic and methylomic analyses identify shared biology between autism and autistic traits Type de document : texte imprimé Auteurs : A. MASSRALI, Auteur ; H. BRUNEL, Auteur ; E. HANNON, Auteur ; Chloe WONG, Auteur ; Simon BARON-COHEN, Auteur ; V. WARRIER, Auteur Article en page(s) : 31 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Previous studies have identified differences in DNA methylation in autistic individuals compared to neurotypical individuals. Yet, it is unclear if this extends to autistic traits-subclinical manifestation of autism features in the general population. Here, we investigate the association between DNA methylation at birth (cord blood), and scores on the Social and Communication Disorders Checklist (SCDC), a measure of autistic traits, in 701 8-year-olds, by conducting a methylome-wide association study (MWAS). We did not identify significant CpGs associated with SCDC. The most significant CpG site was cg14379490, on chromosome 9 (MWAS beta = - 1.78 +/- 0.35, p value = 5.34 x 10 (-7) ). Using methylation data for autism in peripheral tissues, we did not identify a significant concordance in effect direction of CpGs with p value < 10(-4) in the SCDC MWAS (binomial sign test, p value > 0.5). In contrast, using methylation data for autism from post-mortem brain tissues, we identify a significant concordance in effect direction of CpGs with a p value < 10(-4) in the SCDC MWAS (binomial sign test, p value = 0.004). Supporting this, we observe an enrichment for genes that are dysregulated in the post-mortem autism brain (one-sided Wilcoxon rank-sum test, p value = 6.22 x 10(-5)). Finally, integrating genome-wide association study (GWAS) data for autism (n = 46,350) with mQTL maps from cord-blood (n = 771), we demonstrate that mQTLs of CpGs associated with SCDC scores at p value thresholds of 0.01 and 0.005 are significantly shifted toward lower p values in the GWAS for autism (p < 5 x 10(-3)). We provide additional support for this using a GWAS of SCDC, and demonstrate a lack of enrichment in a GWAS of Alzheimer's disease. Our results highlight the shared cross-tissue methylation architecture of autism and autistic traits, and demonstrate that mQTLs associated with differences in DNA methylation associated with childhood autistic traits are enriched for common genetic variants associated with autism and autistic traits. En ligne : https://dx.doi.org/10.1186/s13229-019-0279-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Integrated genetic and methylomic analyses identify shared biology between autism and autistic traits [texte imprimé] / A. MASSRALI, Auteur ; H. BRUNEL, Auteur ; E. HANNON, Auteur ; Chloe WONG, Auteur ; Simon BARON-COHEN, Auteur ; V. WARRIER, Auteur . - 31 p. Langues : Anglais (eng) in Molecular Autism > 10 (2019) . - 31 p. Index. décimale : PER Périodiques Résumé : Previous studies have identified differences in DNA methylation in autistic individuals compared to neurotypical individuals. Yet, it is unclear if this extends to autistic traits-subclinical manifestation of autism features in the general population. Here, we investigate the association between DNA methylation at birth (cord blood), and scores on the Social and Communication Disorders Checklist (SCDC), a measure of autistic traits, in 701 8-year-olds, by conducting a methylome-wide association study (MWAS). We did not identify significant CpGs associated with SCDC. The most significant CpG site was cg14379490, on chromosome 9 (MWAS beta = - 1.78 +/- 0.35, p value = 5.34 x 10 (-7) ). Using methylation data for autism in peripheral tissues, we did not identify a significant concordance in effect direction of CpGs with p value < 10(-4) in the SCDC MWAS (binomial sign test, p value > 0.5). In contrast, using methylation data for autism from post-mortem brain tissues, we identify a significant concordance in effect direction of CpGs with a p value < 10(-4) in the SCDC MWAS (binomial sign test, p value = 0.004). Supporting this, we observe an enrichment for genes that are dysregulated in the post-mortem autism brain (one-sided Wilcoxon rank-sum test, p value = 6.22 x 10(-5)). Finally, integrating genome-wide association study (GWAS) data for autism (n = 46,350) with mQTL maps from cord-blood (n = 771), we demonstrate that mQTLs of CpGs associated with SCDC scores at p value thresholds of 0.01 and 0.005 are significantly shifted toward lower p values in the GWAS for autism (p < 5 x 10(-3)). We provide additional support for this using a GWAS of SCDC, and demonstrate a lack of enrichment in a GWAS of Alzheimer's disease. Our results highlight the shared cross-tissue methylation architecture of autism and autistic traits, and demonstrate that mQTLs associated with differences in DNA methylation associated with childhood autistic traits are enriched for common genetic variants associated with autism and autistic traits. En ligne : https://dx.doi.org/10.1186/s13229-019-0279-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

---

1 (1 - 2 / 2) Par page : 25 50 100 200