Diagnosing ASD in Adults Without ID: Accuracy of the ADOS-2 and the ADI-R / L. FUSAR-POLI in Journal of Autism and Developmental Disorders, 47-11 (November 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3370-3379 Titre : Diagnosing ASD in Adults Without ID: Accuracy of the ADOS-2 and the ADI-R Type de document : Texte imprimé et/ou numérique Auteurs : L. FUSAR-POLI, Auteur ; Natascia BRONDINO, Auteur ; M. ROCCHETTI, Auteur ; Cristina PANISI, Auteur ; U. PROVENZANI, Auteur ; S. DAMIANI, Auteur ; Pierluigi POLITI, Auteur Article en page(s) : p.3370-3379 Langues : Anglais (eng) Mots-clés : Adi-r  Ados  Adult  Autism  Dsm-5  Diagnosis Index. décimale : PER Périodiques Résumé : Diagnosing autism spectrum disorder (ASD) in adulthood often represents a challenge in clinical practice. The aim of the present study was to evaluate the sensitivity and specificity of the ADOS and ADI-R in diagnosing ASD in adults. 113 subjects with an IQ of 70 or above were assessed through an extensive clinical evaluation. The ADOS-2 Module 4 and the ADI-R were separately administered by staff members blind to clinical judgment. Our results cautiously confirm the accuracy of ADOS-2 Module 4, while suggest that ADI-R might not be reliable in adults without intellectual disability. Clinicians' training and experience remains of primary importance while assessing adults who could potentially belong to the autism spectrum. En ligne : http://dx.doi.org/10.1007/s10803-017-3258-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] Diagnosing ASD in Adults Without ID: Accuracy of the ADOS-2 and the ADI-R [Texte imprimé et/ou numérique] / L. FUSAR-POLI, Auteur ; Natascia BRONDINO, Auteur ; M. ROCCHETTI, Auteur ; Cristina PANISI, Auteur ; U. PROVENZANI, Auteur ; S. DAMIANI, Auteur ; Pierluigi POLITI, Auteur . - p.3370-3379. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3370-3379 Mots-clés : Adi-r  Ados  Adult  Autism  Dsm-5  Diagnosis Index. décimale : PER Périodiques Résumé : Diagnosing autism spectrum disorder (ASD) in adulthood often represents a challenge in clinical practice. The aim of the present study was to evaluate the sensitivity and specificity of the ADOS and ADI-R in diagnosing ASD in adults. 113 subjects with an IQ of 70 or above were assessed through an extensive clinical evaluation. The ADOS-2 Module 4 and the ADI-R were separately administered by staff members blind to clinical judgment. Our results cautiously confirm the accuracy of ADOS-2 Module 4, while suggest that ADI-R might not be reliable in adults without intellectual disability. Clinicians' training and experience remains of primary importance while assessing adults who could potentially belong to the autism spectrum. En ligne : http://dx.doi.org/10.1007/s10803-017-3258-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Pharmacological Modulation of GABA Function in Autism Spectrum Disorders: A Systematic Review of Human Studies / Natascia BRONDINO in Journal of Autism and Developmental Disorders, 46-3 (March 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.825-839 Titre : Pharmacological Modulation of GABA Function in Autism Spectrum Disorders: A Systematic Review of Human Studies Type de document : Texte imprimé et/ou numérique Auteurs : Natascia BRONDINO, Auteur ; Laura FUSAR-POLI, Auteur ; Cristina PANISI, Auteur ; Stefano DAMIANI, Auteur ; Francesco BARALE, Auteur ; Pierluigi POLITI, Auteur Article en page(s) : p.825-839 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  GABA  Clinical trials  Systematic review Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are an emerging health problem worldwide, but little is known about their pathogenesis. It has been hypothesized that autism may result from an imbalance between excitatory glutamatergic and inhibitory GABAergic pathways. Commonly used medications such as valproate, acamprosate, and arbaclofen may act on the GABAergic system and be a potential treatment for people with ASD. The present systematic review aimed at evaluating the state-of-the-art of clinical trials of GABA modulators in autism. To date there is insufficient evidence to suggest the use of these drugs in autistic subjects, even if data are promising. Of note, short-term use of all the reviewed medications appears to be safe. Future well designed trials are needed to elucidate these preliminary findings. En ligne : http://dx.doi.org/10.1007/s10803-015-2619-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281 [article] Pharmacological Modulation of GABA Function in Autism Spectrum Disorders: A Systematic Review of Human Studies [Texte imprimé et/ou numérique] / Natascia BRONDINO, Auteur ; Laura FUSAR-POLI, Auteur ; Cristina PANISI, Auteur ; Stefano DAMIANI, Auteur ; Francesco BARALE, Auteur ; Pierluigi POLITI, Auteur . - p.825-839. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.825-839 Mots-clés : Autism spectrum disorder  GABA  Clinical trials  Systematic review Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are an emerging health problem worldwide, but little is known about their pathogenesis. It has been hypothesized that autism may result from an imbalance between excitatory glutamatergic and inhibitory GABAergic pathways. Commonly used medications such as valproate, acamprosate, and arbaclofen may act on the GABAergic system and be a potential treatment for people with ASD. The present systematic review aimed at evaluating the state-of-the-art of clinical trials of GABA modulators in autism. To date there is insufficient evidence to suggest the use of these drugs in autistic subjects, even if data are promising. Of note, short-term use of all the reviewed medications appears to be safe. Future well designed trials are needed to elucidate these preliminary findings. En ligne : http://dx.doi.org/10.1007/s10803-015-2619-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281

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