Abnormal social reward processing in autism as indexed by pupillary responses to happy faces / Leigh SEPETA in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.17 Titre : Abnormal social reward processing in autism as indexed by pupillary responses to happy faces Type de document : texte imprimé Auteurs : Leigh SEPETA, Auteur ; Naotsugu TSUCHIYA, Auteur ; Mari S. DAVIES, Auteur ; Marian SIGMAN, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur Article en page(s) : p.17 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with Autism Spectrum Disorders (ASD) typically show impaired eye contact during social interactions. From a young age, they look less at faces than typically developing (TD) children and tend to avoid direct gaze. However, the reason for this behavior remains controversial; ASD children might avoid eye contact because they perceive the eyes as aversive or because they do not find social engagement through mutual gaze rewarding. METHODS: We monitored pupillary diameter as a measure of autonomic response in children with ASD (n = 20, mean age = 12.4) and TD controls (n = 18, mean age = 13.7) while they looked at faces displaying different emotions. Each face displayed happy, fearful, angry or neutral emotions with the gaze either directed to or averted from the subjects. RESULTS: Overall, children with ASD and TD controls showed similar pupillary responses; however, they differed significantly in their sensitivity to gaze direction for happy faces. Specifically, pupillary diameter increased among TD children when viewing happy faces with direct gaze as compared to those with averted gaze, whereas children with ASD did not show such sensitivity to gaze direction. We found no group differences in fixation that could explain the differential pupillary responses. There was no effect of gaze direction on pupil diameter for negative affect or neutral faces among either the TD or ASD group. CONCLUSIONS: We interpret the increased pupillary diameter to happy faces with direct gaze in TD children to reflect the intrinsic reward value of a smiling face looking directly at an individual. The lack of this effect in children with ASD is consistent with the hypothesis that individuals with ASD may have reduced sensitivity to the reward value of social stimuli. En ligne : http://dx.doi.org/10.1186/1866-1955-4-17 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344 [article] Abnormal social reward processing in autism as indexed by pupillary responses to happy faces [texte imprimé] / Leigh SEPETA, Auteur ; Naotsugu TSUCHIYA, Auteur ; Mari S. DAVIES, Auteur ; Marian SIGMAN, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur . - p.17. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.17 Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with Autism Spectrum Disorders (ASD) typically show impaired eye contact during social interactions. From a young age, they look less at faces than typically developing (TD) children and tend to avoid direct gaze. However, the reason for this behavior remains controversial; ASD children might avoid eye contact because they perceive the eyes as aversive or because they do not find social engagement through mutual gaze rewarding. METHODS: We monitored pupillary diameter as a measure of autonomic response in children with ASD (n = 20, mean age = 12.4) and TD controls (n = 18, mean age = 13.7) while they looked at faces displaying different emotions. Each face displayed happy, fearful, angry or neutral emotions with the gaze either directed to or averted from the subjects. RESULTS: Overall, children with ASD and TD controls showed similar pupillary responses; however, they differed significantly in their sensitivity to gaze direction for happy faces. Specifically, pupillary diameter increased among TD children when viewing happy faces with direct gaze as compared to those with averted gaze, whereas children with ASD did not show such sensitivity to gaze direction. We found no group differences in fixation that could explain the differential pupillary responses. There was no effect of gaze direction on pupil diameter for negative affect or neutral faces among either the TD or ASD group. CONCLUSIONS: We interpret the increased pupillary diameter to happy faces with direct gaze in TD children to reflect the intrinsic reward value of a smiling face looking directly at an individual. The lack of this effect in children with ASD is consistent with the hypothesis that individuals with ASD may have reduced sensitivity to the reward value of social stimuli. En ligne : http://dx.doi.org/10.1186/1866-1955-4-17 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344

Behavior and Sleep Problems in Children With a Family History of Autism / A.J. SCHWICHTENBERG in Autism Research, 6-3 (June 2013)  

Public ISBD [article]  inAutism Research > 6-3 (June 2013) . - p.169-176 Titre : Behavior and Sleep Problems in Children With a Family History of Autism Type de document : texte imprimé Auteurs : A.J. SCHWICHTENBERG, Auteur ; Gregory S. YOUNG, Auteur ; Ted HUTMAN, Auteur ; Ana-Maria IOSIF, Auteur ; Marian SIGMAN, Auteur ; Sally J. ROGERS, Auteur ; Sally OZONOFF, Auteur Année de publication : 2013 Article en page(s) : p.169-176 Langues : Anglais (eng) Mots-clés : autism  siblings  behavior problems  sleep Index. décimale : PER Périodiques Résumé : The present study explores behavioral and sleep outcomes in preschool-age siblings of children with autism spectrum disorders (ASD). This study focuses on behavior problems that are common in children with ASD, such as emotional reactivity, anxiety, inattention, aggression, and sleep problems. Infant siblings were recruited from families with at least one older child with ASD (high-risk group, n = 104) or families with no history of ASD (low-risk group, n = 76). As part of a longitudinal prospective study, children completed the Mullen Scales of Early Learning and the Autism Diagnostic Observation Schedule, and parents completed the Child Behavior Checklist (CBCL) and the Social Communication Questionnaire at 36 months of age. This study focuses on developmental concerns outside of ASD; therefore, only siblings who did not develop an ASD were included in analyses. Negative binomial regression analyses revealed that children in the high-risk group were more likely to have elevated behavior problems on the CBCL Anxious/Depressed and Aggression subscales. To explore sleep problems as a correlate of these behavior problems, a second series of models was specified. For both groups of children, sleep problems were associated with elevated behavior problems in each of the areas assessed (reactivity, anxiety, somatic complaints, withdrawal, attention, and aggression). These findings support close monitoring of children with a family history of ASD for both behavioral and sleep issues. En ligne : http://dx.doi.org/10.1002/aur.1278 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 [article] Behavior and Sleep Problems in Children With a Family History of Autism [texte imprimé] / A.J. SCHWICHTENBERG, Auteur ; Gregory S. YOUNG, Auteur ; Ted HUTMAN, Auteur ; Ana-Maria IOSIF, Auteur ; Marian SIGMAN, Auteur ; Sally J. ROGERS, Auteur ; Sally OZONOFF, Auteur . - 2013 . - p.169-176. Langues : Anglais (eng) in Autism Research > 6-3 (June 2013) . - p.169-176 Mots-clés : autism  siblings  behavior problems  sleep Index. décimale : PER Périodiques Résumé : The present study explores behavioral and sleep outcomes in preschool-age siblings of children with autism spectrum disorders (ASD). This study focuses on behavior problems that are common in children with ASD, such as emotional reactivity, anxiety, inattention, aggression, and sleep problems. Infant siblings were recruited from families with at least one older child with ASD (high-risk group, n = 104) or families with no history of ASD (low-risk group, n = 76). As part of a longitudinal prospective study, children completed the Mullen Scales of Early Learning and the Autism Diagnostic Observation Schedule, and parents completed the Child Behavior Checklist (CBCL) and the Social Communication Questionnaire at 36 months of age. This study focuses on developmental concerns outside of ASD; therefore, only siblings who did not develop an ASD were included in analyses. Negative binomial regression analyses revealed that children in the high-risk group were more likely to have elevated behavior problems on the CBCL Anxious/Depressed and Aggression subscales. To explore sleep problems as a correlate of these behavior problems, a second series of models was specified. For both groups of children, sleep problems were associated with elevated behavior problems in each of the areas assessed (reactivity, anxiety, somatic complaints, withdrawal, attention, and aggression). These findings support close monitoring of children with a family history of ASD for both behavioral and sleep issues. En ligne : http://dx.doi.org/10.1002/aur.1278 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202

Behavioral Profiles of Affected and Unaffected Siblings of Children with Autism: Contribution of Measures of Mother–Infant Interaction and Nonverbal Communication / Agata ROZGA in Journal of Autism and Developmental Disorders, 41-3 (March 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-3 (March 2011) . - p.287-301 Titre : Behavioral Profiles of Affected and Unaffected Siblings of Children with Autism: Contribution of Measures of Mother–Infant Interaction and Nonverbal Communication Type de document : texte imprimé Auteurs : Agata ROZGA, Auteur ; Ted HUTMAN, Auteur ; Gregory S. YOUNG, Auteur ; Sally J. ROGERS, Auteur ; Sally OZONOFF, Auteur ; Mirella DAPRETTO, Auteur ; Marian SIGMAN, Auteur Année de publication : 2011 Article en page(s) : p.287-301 Langues : Anglais (eng) Mots-clés : Autism  Broader autism phenotype  Early identification  Mother–infant interaction  Still face procedure  Nonverbal communication Index. décimale : PER Périodiques Résumé : We investigated whether deficits in social gaze and affect and in joint attention behaviors are evident within the first year of life among siblings of children with autism who go on to be diagnosed with autism or ASD (ASD) and siblings who are non-diagnosed (NoASD-sib) compared to low-risk controls. The ASD group did not differ from the other two groups at 6 months of age in the frequency of gaze, smiles, and vocalizations directed toward the caregiver, nor in their sensitivity to her withdrawal from interaction. However, by 12 months, infants in the ASD group exhibited lower rates of joint attention and requesting behaviors. In contrast, NoASD-sibs did not differ from comparison infants on any variables of interest at 6 and 12 months. En ligne : http://dx.doi.org/10.1007/s10803-010-1051-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 [article] Behavioral Profiles of Affected and Unaffected Siblings of Children with Autism: Contribution of Measures of Mother–Infant Interaction and Nonverbal Communication [texte imprimé] / Agata ROZGA, Auteur ; Ted HUTMAN, Auteur ; Gregory S. YOUNG, Auteur ; Sally J. ROGERS, Auteur ; Sally OZONOFF, Auteur ; Mirella DAPRETTO, Auteur ; Marian SIGMAN, Auteur . - 2011 . - p.287-301. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-3 (March 2011) . - p.287-301 Mots-clés : Autism  Broader autism phenotype  Early identification  Mother–infant interaction  Still face procedure  Nonverbal communication Index. décimale : PER Périodiques Résumé : We investigated whether deficits in social gaze and affect and in joint attention behaviors are evident within the first year of life among siblings of children with autism who go on to be diagnosed with autism or ASD (ASD) and siblings who are non-diagnosed (NoASD-sib) compared to low-risk controls. The ASD group did not differ from the other two groups at 6 months of age in the frequency of gaze, smiles, and vocalizations directed toward the caregiver, nor in their sensitivity to her withdrawal from interaction. However, by 12 months, infants in the ASD group exhibited lower rates of joint attention and requesting behaviors. In contrast, NoASD-sibs did not differ from comparison infants on any variables of interest at 6 and 12 months. En ligne : http://dx.doi.org/10.1007/s10803-010-1051-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118

Can family affectedness inform infant sibling outcomes of autism spectrum disorders? / A.J. SCHWICHTENBERG in Journal of Child Psychology and Psychiatry, 51-9 (September 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-9 (September 2010) . - p.1021-1030 Titre : Can family affectedness inform infant sibling outcomes of autism spectrum disorders? Type de document : texte imprimé Auteurs : A.J. SCHWICHTENBERG, Auteur ; Marian SIGMAN, Auteur ; Sally OZONOFF, Auteur ; Gregory S. YOUNG, Auteur ; Ted HUTMAN, Auteur Année de publication : 2010 Article en page(s) : p.1021-1030 Langues : Anglais (eng) Mots-clés : Autistic-disorder pervasive-developmental-disorder family-factors siblings structural-equation-modeling Index. décimale : PER Périodiques Résumé : Background:  Difficulties in communication and reciprocal social behavior are core features of autism spectrum disorders (ASD) and are often present, to varying degrees, in other family members. This prospective longitudinal infant sibling study examines whether social-communicative features of family members may inform which infants are at increased risk for ASD and other developmental concerns. Method:  Two hundred and seventeen families participated in this study. Infant siblings were recruited from families with at least one older child diagnosed with an ASD (n = 135) or at least one typically developing older child (n = 82). Families completed the Social Responsiveness Scale to assess social and communication features of the broader autism phenotype (BAP), sometimes called quantitative autistic traits (QAT). Family affectedness was assessed in two ways: categorically, based on number of affected older siblings (i.e., typical, simplex, multiplex risk groups) and dimensionally, by assessing varying degrees of QAT in all family members. Infant siblings were assessed at 36 months of age and completed the Autism Diagnostic Observation Schedule and the Mullen Scales of Early Learning. Results:  In structural equation models, comparisons between multiplex, simplex and typical groups revealed the highest rates of QAT in the multiplex group followed by the simplex and typical groups. Infant sibling outcomes were predicted by gender, family risk group, proband QAT, and additional sibling QAT. Conclusions:  Replicating previous cross-sectional and family history findings, the present study found elevated social and communication features of the BAP in siblings and fathers of ASD families, but not in mothers. While social and communication features of the BAP in mothers, fathers, and undiagnosed siblings did not predict infant sibling outcomes, having more than one affected older sibling did. Infant siblings from multiplex families were at significantly higher risk for ASD than infant siblings from simplex families in this sample. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02267.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108 [article] Can family affectedness inform infant sibling outcomes of autism spectrum disorders? [texte imprimé] / A.J. SCHWICHTENBERG, Auteur ; Marian SIGMAN, Auteur ; Sally OZONOFF, Auteur ; Gregory S. YOUNG, Auteur ; Ted HUTMAN, Auteur . - 2010 . - p.1021-1030. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-9 (September 2010) . - p.1021-1030 Mots-clés : Autistic-disorder pervasive-developmental-disorder family-factors siblings structural-equation-modeling Index. décimale : PER Périodiques Résumé : Background:  Difficulties in communication and reciprocal social behavior are core features of autism spectrum disorders (ASD) and are often present, to varying degrees, in other family members. This prospective longitudinal infant sibling study examines whether social-communicative features of family members may inform which infants are at increased risk for ASD and other developmental concerns. Method:  Two hundred and seventeen families participated in this study. Infant siblings were recruited from families with at least one older child diagnosed with an ASD (n = 135) or at least one typically developing older child (n = 82). Families completed the Social Responsiveness Scale to assess social and communication features of the broader autism phenotype (BAP), sometimes called quantitative autistic traits (QAT). Family affectedness was assessed in two ways: categorically, based on number of affected older siblings (i.e., typical, simplex, multiplex risk groups) and dimensionally, by assessing varying degrees of QAT in all family members. Infant siblings were assessed at 36 months of age and completed the Autism Diagnostic Observation Schedule and the Mullen Scales of Early Learning. Results:  In structural equation models, comparisons between multiplex, simplex and typical groups revealed the highest rates of QAT in the multiplex group followed by the simplex and typical groups. Infant sibling outcomes were predicted by gender, family risk group, proband QAT, and additional sibling QAT. Conclusions:  Replicating previous cross-sectional and family history findings, the present study found elevated social and communication features of the BAP in siblings and fathers of ASD families, but not in mothers. While social and communication features of the BAP in mothers, fathers, and undiagnosed siblings did not predict infant sibling outcomes, having more than one affected older sibling did. Infant siblings from multiplex families were at significantly higher risk for ASD than infant siblings from simplex families in this sample. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02267.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108

Cognitive and Verbal Abilities of 24- to 36-month-old Siblings of Children with Autism / Nurit YIRMIYA in Journal of Autism and Developmental Disorders, 37-2 (February 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-2 (February 2007) . - p.218-229 Titre : Cognitive and Verbal Abilities of 24- to 36-month-old Siblings of Children with Autism Type de document : texte imprimé Auteurs : Nurit YIRMIYA, Auteur ; Marian SIGMAN, Auteur ; Ifat GAMLIEL, Auteur ; Michal SHAKED, Auteur Année de publication : 2007 Article en page(s) : p.218-229 Langues : Anglais (eng) Mots-clés : Autistic-disorder Behavioral-genetics Verbal-abilities Cognitive-abilities Siblings Index. décimale : PER Périodiques Résumé : The cognitive and language skills of 30 siblings of children with autism (SIBS-A) and 30 siblings of typically developing children (SIBS-TD) were compared. Non-significant group differences emerged for cognition at both ages. At 24 months, significantly more SIBS-A demonstrated language scores one or two standard deviations below the mean compared to SIBS-TD. At 36 months, the groups differed significantly in receptive language, and more SIBS-A displayed receptive and expressive difficulties compared to SIBS-TD. Six SIBS-A (including one diagnosed with autism) revealed language scores more than two standard deviations below the mean at both ages, a pattern not seen in the SIBS-TD. Results are discussed in reference to language difficulties in autism spectrum disorders and the genetic liability for autism. En ligne : http://dx.doi.org/10.1007/s10803-006-0163-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=627 [article] Cognitive and Verbal Abilities of 24- to 36-month-old Siblings of Children with Autism [texte imprimé] / Nurit YIRMIYA, Auteur ; Marian SIGMAN, Auteur ; Ifat GAMLIEL, Auteur ; Michal SHAKED, Auteur . - 2007 . - p.218-229. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-2 (February 2007) . - p.218-229 Mots-clés : Autistic-disorder Behavioral-genetics Verbal-abilities Cognitive-abilities Siblings Index. décimale : PER Périodiques Résumé : The cognitive and language skills of 30 siblings of children with autism (SIBS-A) and 30 siblings of typically developing children (SIBS-TD) were compared. Non-significant group differences emerged for cognition at both ages. At 24 months, significantly more SIBS-A demonstrated language scores one or two standard deviations below the mean compared to SIBS-TD. At 36 months, the groups differed significantly in receptive language, and more SIBS-A displayed receptive and expressive difficulties compared to SIBS-TD. Six SIBS-A (including one diagnosed with autism) revealed language scores more than two standard deviations below the mean at both ages, a pattern not seen in the SIBS-TD. Results are discussed in reference to language difficulties in autism spectrum disorders and the genetic liability for autism. En ligne : http://dx.doi.org/10.1007/s10803-006-0163-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=627

Communicative Intentions and Symbols in Autism: Examining a Case of Altered Development / Lisa L. TRAVIS

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Conversational Abilities Among Children with Autism and Children with Developmental Delays / Lisa CAPPS in Autism, 2-4 (December 1998)  

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Developmental Trajectories in Siblings of Children with Autism: Cognition and Language from 4 Months to 7 Years / Ifat GAMLIEL in Journal of Autism and Developmental Disorders, 39-8 (August 2009)  

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Early Childhood Predictors of the Social Competence of Adults with Autism / Kristen GILLESPIE-LYNCH in Journal of Autism and Developmental Disorders, 42-2 (February 2012)  

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L'enfant autiste et son développement / Marian SIGMAN

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Is early joint attention associated with school-age pragmatic language? / Kristen GILLESPIE-LYNCH in Autism, 19-2 (February 2015)  

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Longitudinal change in the use of services in autism spectrum disorder: Understanding the role of child characteristics, family demographics, and parent cognitions / Michael SILLER in Autism, 18-4 (May 2014)  

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Mothers'narratives regarding their child with autism predict maternal synchronous behavior during play / Ted HUTMAN in Journal of Child Psychology and Psychiatry, 50-10 (October 2009)  

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Non-Verbal Communication Skills of Surgically Treated Children with Infantile Spasms / Rochelle CAPLAN in Developmental Medicine & Child Neurology, 34-6 (June 1992)

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Organization of brain networks governed by long-range connections index autistic traits in the general population / Pablo BARTTFELD in Journal of Neurodevelopmental Disorders, 5-1 (December 2013)  

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