Parent and youth dopamine D4 receptor genotypes moderate multilevel contextual effects on rural African American youth's risk behavior / Junhan CHO in Development and Psychopathology, 28-2 (May 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-2 (May 2016) . - p.433-445 Titre : Parent and youth dopamine D4 receptor genotypes moderate multilevel contextual effects on rural African American youth's risk behavior Type de document : Texte imprimé et/ou numérique Auteurs : Junhan CHO, Auteur ; Steven M. KOGAN, Auteur Article en page(s) : p.433-445 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The present investigation extends research on Gene × Environment interactions and youth risk behavior by linking multilevel contextual factors, such as community disadvantage and protective parenting practices, to both parental and youth dopamine D4 receptor (DRD4) genotypes. We expected community disadvantage to influence youth risk behavior via a series of indirect effects involving protective parenting and youth's planful future orientation when both parents’ and youth's DRD4 status was considered. Genetic moderation processes also were tested to determine whether they conformed to a diathesis–stress or a differential susceptibility model. Hypotheses were investigated with data from 361 rural African American youth and their parents assessed 3 times when youth were ages 16 to 19. Community disadvantage interacted with parental DRD4 status to predict low levels of protective parenting. Protective parenting, in turn, interacted with youth DRD4 status to forecast increases in youth's planful future orientations, a proximal influence on changes in risk behavior. The Parental DRD4 × Community Disadvantage interaction, but not youth DRD4 × Protective Parenting, conformed to a differential susceptibility model. Indirect effect analyses revealed a significant indirect path linking community disadvantage to youth risk behavior through a series of multilevel Gene × Environment interaction processes. En ligne : http://dx.doi.org/10.1017/S0954579415000565 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Parent and youth dopamine D4 receptor genotypes moderate multilevel contextual effects on rural African American youth's risk behavior [Texte imprimé et/ou numérique] / Junhan CHO, Auteur ; Steven M. KOGAN, Auteur . - p.433-445. Langues : Anglais (eng) in Development and Psychopathology > 28-2 (May 2016) . - p.433-445 Index. décimale : PER Périodiques Résumé : The present investigation extends research on Gene × Environment interactions and youth risk behavior by linking multilevel contextual factors, such as community disadvantage and protective parenting practices, to both parental and youth dopamine D4 receptor (DRD4) genotypes. We expected community disadvantage to influence youth risk behavior via a series of indirect effects involving protective parenting and youth's planful future orientation when both parents’ and youth's DRD4 status was considered. Genetic moderation processes also were tested to determine whether they conformed to a diathesis–stress or a differential susceptibility model. Hypotheses were investigated with data from 361 rural African American youth and their parents assessed 3 times when youth were ages 16 to 19. Community disadvantage interacted with parental DRD4 status to predict low levels of protective parenting. Protective parenting, in turn, interacted with youth DRD4 status to forecast increases in youth's planful future orientations, a proximal influence on changes in risk behavior. The Parental DRD4 × Community Disadvantage interaction, but not youth DRD4 × Protective Parenting, conformed to a differential susceptibility model. Indirect effect analyses revealed a significant indirect path linking community disadvantage to youth risk behavior through a series of multilevel Gene × Environment interaction processes. En ligne : http://dx.doi.org/10.1017/S0954579415000565 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

Pathways linking adverse environments to emerging adults’ substance abuse and depressive symptoms: A prospective analysis of rural African American men / Steven M. KOGAN in Development and Psychopathology, 33-4 (October 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-4 (October 2021) . - p.1496-1506 Titre : Pathways linking adverse environments to emerging adults’ substance abuse and depressive symptoms: A prospective analysis of rural African American men Type de document : Texte imprimé et/ou numérique Auteurs : Steven M. KOGAN, Auteur ; Dayoung BAE, Auteur ; Junhan CHO, Auteur ; Alicia K. SMITH, Auteur ; Shota NISHITANI, Auteur Article en page(s) : p.1496-1506 Langues : Anglais (eng) Mots-clés : African American men  depressive symptoms  emerging adulthood  social development  substance abuse Index. décimale : PER Périodiques Résumé : For African American emerging adult men, developmental challenges are evident in their escalating substance abuse and depressive symptoms; this is particularly true for men from low-resource communities. The present study tests a developmental model linking childhood adversity and contemporaneous contextual stressors to increases in emerging adults’ substance use and depressive symptoms, indirectly, via increases in defensive/hostile relational schemas and social developmental risk factors (e.g., risky peers and romantic partners, lack of involvement in school or work). We also advance exploratory hypotheses regarding DNA methylation in the oxytocin receptor gene (OXTR) as a moderator of the effects of stress on relational schemas. Hypotheses were tested with three waves of data from 505 rural African American men aged 19–25 years. Adverse childhood experiences predicted exposure to emerging adult contextual stressors. Contextual stressors forecast increases in defensive/hostile relational schemas, which increased social developmental risk factors. Social developmental risk factors proximally predicted increases in substance abuse and depressive symptoms. OXTR DNA methylation moderated the effects of contextual stressors on defensive/hostile relational schemas. Findings suggest that early exposures to stress carry forward to affect the development of social developmental risk factors in emerging adulthood, which place rural African American men at risk for increased substance abuse and depressive symptoms during the emerging adult years. En ligne : http://dx.doi.org/10.1017/S0954579420000632 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Pathways linking adverse environments to emerging adults’ substance abuse and depressive symptoms: A prospective analysis of rural African American men [Texte imprimé et/ou numérique] / Steven M. KOGAN, Auteur ; Dayoung BAE, Auteur ; Junhan CHO, Auteur ; Alicia K. SMITH, Auteur ; Shota NISHITANI, Auteur . - p.1496-1506. Langues : Anglais (eng) in Development and Psychopathology > 33-4 (October 2021) . - p.1496-1506 Mots-clés : African American men  depressive symptoms  emerging adulthood  social development  substance abuse Index. décimale : PER Périodiques Résumé : For African American emerging adult men, developmental challenges are evident in their escalating substance abuse and depressive symptoms; this is particularly true for men from low-resource communities. The present study tests a developmental model linking childhood adversity and contemporaneous contextual stressors to increases in emerging adults’ substance use and depressive symptoms, indirectly, via increases in defensive/hostile relational schemas and social developmental risk factors (e.g., risky peers and romantic partners, lack of involvement in school or work). We also advance exploratory hypotheses regarding DNA methylation in the oxytocin receptor gene (OXTR) as a moderator of the effects of stress on relational schemas. Hypotheses were tested with three waves of data from 505 rural African American men aged 19–25 years. Adverse childhood experiences predicted exposure to emerging adult contextual stressors. Contextual stressors forecast increases in defensive/hostile relational schemas, which increased social developmental risk factors. Social developmental risk factors proximally predicted increases in substance abuse and depressive symptoms. OXTR DNA methylation moderated the effects of contextual stressors on defensive/hostile relational schemas. Findings suggest that early exposures to stress carry forward to affect the development of social developmental risk factors in emerging adulthood, which place rural African American men at risk for increased substance abuse and depressive symptoms during the emerging adult years. En ligne : http://dx.doi.org/10.1017/S0954579420000632 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

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