Childhood maltreatment is associated with altered frontolimbic neurobiological activity during wakefulness in adulthood / Salvatore P. INSANA in Development and Psychopathology, 28-2 (May 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-2 (May 2016) . - p.551-564 Titre : Childhood maltreatment is associated with altered frontolimbic neurobiological activity during wakefulness in adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Salvatore P. INSANA, Auteur ; Layla BANIHASHEMI, Auteur ; Ryan J. HERRINGA, Auteur ; David J. KOLKO, Auteur ; Anne GERMAIN, Auteur Article en page(s) : p.551-564 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Childhood maltreatment can disturb brain development and subsequently lead to adverse socioemotional and mental health problems across the life span. The long-term association between childhood maltreatment and resting–wake brain activity during adulthood is unknown and was examined in the current study. Forty-one medically stable and medication-free military veterans (M = 29.31 ± 6.01 years, 78% male) completed a battery of clinical assessments and had [18F]-fluorodeoxyglucose positron emission tomography neuroimaging scans during quiet wakefulness. After statistically adjusting for later-life trauma and mental health problems, childhood maltreatment was negatively associated with brain activity within a priori defined regions that included the left orbital frontal cortex and left hippocampus. Childhood maltreatment was significantly associated with increased and decreased brain activity within six additional whole-brain clusters that included the frontal, parietal–temporal, cerebellar, limbic, and midbrain regions. Childhood maltreatment is associated with altered neural activity in adulthood within regions that are involved in executive functioning and cognitive control, socioemotional processes, autonomic functions, and sleep/wake regulation. This study provides support for taking a life span developmental approach to understanding the effects of early-life maltreatment on later-life neurobiology, socioemotional functioning, and mental health. En ligne : http://dx.doi.org/10.1017/S0954579415000589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Childhood maltreatment is associated with altered frontolimbic neurobiological activity during wakefulness in adulthood [Texte imprimé et/ou numérique] / Salvatore P. INSANA, Auteur ; Layla BANIHASHEMI, Auteur ; Ryan J. HERRINGA, Auteur ; David J. KOLKO, Auteur ; Anne GERMAIN, Auteur . - p.551-564. Langues : Anglais (eng) in Development and Psychopathology > 28-2 (May 2016) . - p.551-564 Index. décimale : PER Périodiques Résumé : Childhood maltreatment can disturb brain development and subsequently lead to adverse socioemotional and mental health problems across the life span. The long-term association between childhood maltreatment and resting–wake brain activity during adulthood is unknown and was examined in the current study. Forty-one medically stable and medication-free military veterans (M = 29.31 ± 6.01 years, 78% male) completed a battery of clinical assessments and had [18F]-fluorodeoxyglucose positron emission tomography neuroimaging scans during quiet wakefulness. After statistically adjusting for later-life trauma and mental health problems, childhood maltreatment was negatively associated with brain activity within a priori defined regions that included the left orbital frontal cortex and left hippocampus. Childhood maltreatment was significantly associated with increased and decreased brain activity within six additional whole-brain clusters that included the frontal, parietal–temporal, cerebellar, limbic, and midbrain regions. Childhood maltreatment is associated with altered neural activity in adulthood within regions that are involved in executive functioning and cognitive control, socioemotional processes, autonomic functions, and sleep/wake regulation. This study provides support for taking a life span developmental approach to understanding the effects of early-life maltreatment on later-life neurobiology, socioemotional functioning, and mental health. En ligne : http://dx.doi.org/10.1017/S0954579415000589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

Childhood maltreatment moderates the effect of combat exposure on cingulum structural integrity / Layla BANIHASHEMI in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1735-1747 Titre : Childhood maltreatment moderates the effect of combat exposure on cingulum structural integrity Type de document : Texte imprimé et/ou numérique Auteurs : Layla BANIHASHEMI, Auteur ; Meredith L. WALLACE, Auteur ; Lei K. SHEU, Auteur ; Michael C. LEE, Auteur ; Peter J. GIANAROS, Auteur ; Robert P. MACKENZIE, Auteur ; Salvatore P. INSANA, Auteur ; Anne GERMAIN, Auteur ; Ryan J. HERRINGA, Auteur Article en page(s) : p.1735-1747 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Limbic white matter pathways link emotion, cognition, and behavior and are potentially malleable to the influences of traumatic events throughout development. However, the impact of interactions between childhood and later life trauma on limbic white matter pathways has yet to be examined. Here, we examined whether childhood maltreatment moderated the effect of combat exposure on diffusion tensor imaging measures within a sample of military veterans (N = 28). We examined five limbic tracts of interest: two components of the cingulum (cingulum, cingulate gyrus, and cingulum hippocampus [CGH]), the uncinate fasciculus, the fornix/stria terminalis, and the anterior limb of the internal capsule. Using effect sizes, clinically meaningful moderator effects were found only within the CGH. Greater combat exposure was associated with decreased CGH fractional anisotropy (overall structural integrity) and increased CGH radial diffusivity (perpendicular water diffusivity) among individuals with more severe childhood maltreatment. Our findings provide preliminary evidence of the moderating effect of childhood maltreatment on the relationship between combat exposure and CGH structural integrity. These differences in CGH structural integrity could have maladaptive implications for emotion and memory, as well as provide a potential mechanism by which childhood maltreatment induces vulnerability to later life trauma exposure. En ligne : http://dx.doi.org/10.1017/S0954579417001365 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Childhood maltreatment moderates the effect of combat exposure on cingulum structural integrity [Texte imprimé et/ou numérique] / Layla BANIHASHEMI, Auteur ; Meredith L. WALLACE, Auteur ; Lei K. SHEU, Auteur ; Michael C. LEE, Auteur ; Peter J. GIANAROS, Auteur ; Robert P. MACKENZIE, Auteur ; Salvatore P. INSANA, Auteur ; Anne GERMAIN, Auteur ; Ryan J. HERRINGA, Auteur . - p.1735-1747. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1735-1747 Index. décimale : PER Périodiques Résumé : Limbic white matter pathways link emotion, cognition, and behavior and are potentially malleable to the influences of traumatic events throughout development. However, the impact of interactions between childhood and later life trauma on limbic white matter pathways has yet to be examined. Here, we examined whether childhood maltreatment moderated the effect of combat exposure on diffusion tensor imaging measures within a sample of military veterans (N = 28). We examined five limbic tracts of interest: two components of the cingulum (cingulum, cingulate gyrus, and cingulum hippocampus [CGH]), the uncinate fasciculus, the fornix/stria terminalis, and the anterior limb of the internal capsule. Using effect sizes, clinically meaningful moderator effects were found only within the CGH. Greater combat exposure was associated with decreased CGH fractional anisotropy (overall structural integrity) and increased CGH radial diffusivity (perpendicular water diffusivity) among individuals with more severe childhood maltreatment. Our findings provide preliminary evidence of the moderating effect of childhood maltreatment on the relationship between combat exposure and CGH structural integrity. These differences in CGH structural integrity could have maladaptive implications for emotion and memory, as well as provide a potential mechanism by which childhood maltreatment induces vulnerability to later life trauma exposure. En ligne : http://dx.doi.org/10.1017/S0954579417001365 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Determining the key childhood and adolescent risk factors for future BPD symptoms using regularized regression: comparison to depression and conduct disorder / Joseph E. BEENEY in Journal of Child Psychology and Psychiatry, 62-2 (February 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-2 (February 2021) . - p.223-231 Titre : Determining the key childhood and adolescent risk factors for future BPD symptoms using regularized regression: comparison to depression and conduct disorder Type de document : Texte imprimé et/ou numérique Auteurs : Joseph E. BEENEY, Auteur ; Erika E. FORBES, Auteur ; Alison E. HIPWELL, Auteur ; Melissa NANCE, Auteur ; Alexis MATTIA, Auteur ; Joely M. LAWLESS, Auteur ; Layla BANIHASHEMI, Auteur ; Stephanie D. STEPP, Auteur Année de publication : 2021 Article en page(s) : p.223-231 Langues : Anglais (eng) Mots-clés : Risk factors  borderline personality disorder  comorbidity  longitudinal studies  machine learning Index. décimale : PER Périodiques Résumé : OBJECTIVE: Research has yielded factors considered critical to risk for borderline personality disorder (BPD). Yet, these factors overlap and are relevant to other disorders, like depression and conduct disorder (CD). Regularized regression, a machine learning approach, was developed to allow identification of the most important variables in large datasets with correlated predictors. We aimed to identify critical predictors of BPD symptoms in late adolescence (ages 16-18) and determine the specificity of factors to BPD versus disorders with putatively similar etiology. METHOD: We used a prospective longitudinal dataset (n = 2,450) of adolescent girls assessed on a range of clinical, psychosocial, and demographic factors, highlighted by previous research on BPD. Predictors were grouped by developmental periods: late childhood (8-10) and early (11-13) and mid-adolescence (14-15), yielding 128 variables from 41 constructs. The same variables were used in models predicting depression and CD symptoms. RESULTS: The best-fitting model for BPD symptoms included 19 predictors and explained 33.2% of the variance. Five constructs - depressive and anxiety symptoms, self-control, harsh punishment, and poor social and school functioning - accounted for most of the variance explained. BPD was differentiated from CD by greater problems with mood and anxiety in BPD and differences in parenting risk factors. Whereas the biggest parenting risk for BPD was a punitive style of parenting, CD was predicted by both punitive and disengaged styles. BPD was differentiated from MDD by greater social problems and poor behavioral control in BPD. CONCLUSIONS: The best predictors of BPD symptoms in adolescence are features suggesting complex comorbidity, affective activation, and problems with self-control. Though some risk factors were non-specific (e.g., inattention), the disorders were distinguished in clinically significant ways. En ligne : http://dx.doi.org/10.1111/jcpp.13269 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440 [article] Determining the key childhood and adolescent risk factors for future BPD symptoms using regularized regression: comparison to depression and conduct disorder [Texte imprimé et/ou numérique] / Joseph E. BEENEY, Auteur ; Erika E. FORBES, Auteur ; Alison E. HIPWELL, Auteur ; Melissa NANCE, Auteur ; Alexis MATTIA, Auteur ; Joely M. LAWLESS, Auteur ; Layla BANIHASHEMI, Auteur ; Stephanie D. STEPP, Auteur . - 2021 . - p.223-231. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-2 (February 2021) . - p.223-231 Mots-clés : Risk factors  borderline personality disorder  comorbidity  longitudinal studies  machine learning Index. décimale : PER Périodiques Résumé : OBJECTIVE: Research has yielded factors considered critical to risk for borderline personality disorder (BPD). Yet, these factors overlap and are relevant to other disorders, like depression and conduct disorder (CD). Regularized regression, a machine learning approach, was developed to allow identification of the most important variables in large datasets with correlated predictors. We aimed to identify critical predictors of BPD symptoms in late adolescence (ages 16-18) and determine the specificity of factors to BPD versus disorders with putatively similar etiology. METHOD: We used a prospective longitudinal dataset (n = 2,450) of adolescent girls assessed on a range of clinical, psychosocial, and demographic factors, highlighted by previous research on BPD. Predictors were grouped by developmental periods: late childhood (8-10) and early (11-13) and mid-adolescence (14-15), yielding 128 variables from 41 constructs. The same variables were used in models predicting depression and CD symptoms. RESULTS: The best-fitting model for BPD symptoms included 19 predictors and explained 33.2% of the variance. Five constructs - depressive and anxiety symptoms, self-control, harsh punishment, and poor social and school functioning - accounted for most of the variance explained. BPD was differentiated from CD by greater problems with mood and anxiety in BPD and differences in parenting risk factors. Whereas the biggest parenting risk for BPD was a punitive style of parenting, CD was predicted by both punitive and disengaged styles. BPD was differentiated from MDD by greater social problems and poor behavioral control in BPD. CONCLUSIONS: The best predictors of BPD symptoms in adolescence are features suggesting complex comorbidity, affective activation, and problems with self-control. Though some risk factors were non-specific (e.g., inattention), the disorders were distinguished in clinically significant ways. En ligne : http://dx.doi.org/10.1111/jcpp.13269 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440

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