Atypical Social Judgment and Sensitivity to Perceptual Cues in Autism Spectrum Disorders / Baudouin FORGEOT D'ARC in Journal of Autism and Developmental Disorders, 46-5 (May 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-5 (May 2016) . - p.1574-1581 Titre : Atypical Social Judgment and Sensitivity to Perceptual Cues in Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Baudouin FORGEOT D'ARC, Auteur ; Franck RAMUS, Auteur ; Aline LEFEBVRE, Auteur ; Delphine BROTTIER, Auteur ; Tiziana ZALLA, Auteur ; Sanaa MOUKAWANE, Auteur ; Frédérique AMSELLEM, Auteur ; Laurence LETELLIER, Auteur ; Hugo PEYRE, Auteur ; Marie-Christine MOUREN, Auteur ; Marion LEBOYER, Auteur ; Richard DELORME, Auteur Article en page(s) : p.1574-1581 Langues : Anglais (eng) Mots-clés : Autism  Social judgment  Face processing  Social cognition  Perception Index. décimale : PER Périodiques Résumé : Evaluation of faces is an important dimension of social relationships. A degraded sensitivity to facial perceptual cues might contribute to atypical social interactions in autism spectrum disorder (ASD). The current study investigated whether face based social judgment is atypical in ASD and if so, whether it could be related to a degraded sensitivity to facial perceptual cues. Individuals with ASD (n = 33) and IQ- and age-matched controls (n = 38) were enrolled in this study. Watching a series of photographic or synthetic faces, they had to judge them for “kindness”. In synthetic stimuli, the amount of perceptual cues available could be either large or small. We observed that social judgment was atypical in the ASD group on photographic stimuli, but, contrarily to the prediction based on the degraded sensitivity hypothesis, analyses on synthetic stimuli found a similar performance and a similar effect of the amount of perceptual cues in both groups. Further studies on perceptual differences between photographs and synthetic pictures of faces might help understand atypical social judgment in ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2208-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Atypical Social Judgment and Sensitivity to Perceptual Cues in Autism Spectrum Disorders [texte imprimé] / Baudouin FORGEOT D'ARC, Auteur ; Franck RAMUS, Auteur ; Aline LEFEBVRE, Auteur ; Delphine BROTTIER, Auteur ; Tiziana ZALLA, Auteur ; Sanaa MOUKAWANE, Auteur ; Frédérique AMSELLEM, Auteur ; Laurence LETELLIER, Auteur ; Hugo PEYRE, Auteur ; Marie-Christine MOUREN, Auteur ; Marion LEBOYER, Auteur ; Richard DELORME, Auteur . - p.1574-1581. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-5 (May 2016) . - p.1574-1581 Mots-clés : Autism  Social judgment  Face processing  Social cognition  Perception Index. décimale : PER Périodiques Résumé : Evaluation of faces is an important dimension of social relationships. A degraded sensitivity to facial perceptual cues might contribute to atypical social interactions in autism spectrum disorder (ASD). The current study investigated whether face based social judgment is atypical in ASD and if so, whether it could be related to a degraded sensitivity to facial perceptual cues. Individuals with ASD (n = 33) and IQ- and age-matched controls (n = 38) were enrolled in this study. Watching a series of photographic or synthetic faces, they had to judge them for “kindness”. In synthetic stimuli, the amount of perceptual cues available could be either large or small. We observed that social judgment was atypical in the ASD group on photographic stimuli, but, contrarily to the prediction based on the degraded sensitivity hypothesis, analyses on synthetic stimuli found a similar performance and a similar effect of the amount of perceptual cues in both groups. Further studies on perceptual differences between photographs and synthetic pictures of faces might help understand atypical social judgment in ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2208-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands / Aline LEFEBVRE in Autism Research, 14-11 (November 2021)  

Public ISBD [article]  inAutism Research > 14-11 (November 2021) . - p.2373-2382 Titre : Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands Type de document : texte imprimé Auteurs : Aline LEFEBVRE, Auteur ; Alicia COHEN, Auteur ; Anna MARUANI, Auteur ; Frédérique AMSELLEM, Auteur ; Anita BEGGIATO, Auteur ; Anouck AMESTOY, Auteur ; Myriam Ly LE-MOAL, Auteur ; Daniel UMBRICHT, Auteur ; Christopher H. CHATHAM, Auteur ; Lorraine MURTAGH, Auteur ; Manuel P. BOUVARD, Auteur ; Marion LEBOYER, Auteur ; Thomas BOURGERON, Auteur ; Richard DELORME, Auteur Article en page(s) : p.2373-2382 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications/genetics  Cognition  Humans  Obsessive-Compulsive Disorder/genetics  habits  heritability  neurodevelopment  phenotype Index. décimale : PER Périodiques Résumé : Repetitive behaviors (RB) represent a wide spectrum of symptoms ranging from sensory-motor stereotypies to complex cognitive rituals, frequently dichotomized as low- and high-order sub-groups of symptoms. Even though these subgroups are considered as phenomenologically distinct in autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD), brain imaging and genetic studies suggest that they have common mechanisms and pathways. This discrepancy may be explained by the frequent intellectual disability reported in ASD, which blurs the RB expressivity. Given the high heritability of RB, that is, the diversity of symptoms expressed in the relatives are dependent on those expressed in their probands, we hypothesize that if RB expressed in ASD or OCD are two distinct entities, then the RB expressed in relatives will also reflect these two dimensions. We thus conduct a linear discriminant analysis on RB in both the relatives of probands with ASD and OCD and subjects from the general population (n = 1023). The discriminant analysis results in a classification of 81.1% of the controls (p < 10(-4) ), but poorly differentiated the ASD and OCD relatives (≈46%). The stepwise analysis reveals that five symptoms attributed to high-order RB and two related to low-order RB (including hypersensitivity) are the most discriminant. Our results support the idea that the difference of RB patterns in the relatives is mild compared with the distribution of symptoms in controls. Our findings reinforce the evidence of a common biological pattern of RB both in ASD and OCD but with minor differences, specific to each of these two neuro-developmental disorders. LAY SUMMARY: Repetitive behaviors (RB), a key symptom in the classification of both OCD and ASD, are phenomenologically considered as distinct in the two disorders, which is in contrast with brain imaging studies describing a common neural circuit. Intellectual disability, which is frequently associated with ASD, makes RB in ASD more difficult to understand as it affects the expression of the RB symptoms. To avoid this bias, we propose to consider the familial aggregation in ASD and OCD by exploring RB in the first-degree relatives of ASD and OCD. Our results highlight the existence of RB expressed in relatives compared to the general population, with a common pattern of symptoms in relatives of both ASD and OCD but also minor differences, specific to each of these two neuro-developmental disorders. En ligne : http://dx.doi.org/10.1002/aur.2570 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands [texte imprimé] / Aline LEFEBVRE, Auteur ; Alicia COHEN, Auteur ; Anna MARUANI, Auteur ; Frédérique AMSELLEM, Auteur ; Anita BEGGIATO, Auteur ; Anouck AMESTOY, Auteur ; Myriam Ly LE-MOAL, Auteur ; Daniel UMBRICHT, Auteur ; Christopher H. CHATHAM, Auteur ; Lorraine MURTAGH, Auteur ; Manuel P. BOUVARD, Auteur ; Marion LEBOYER, Auteur ; Thomas BOURGERON, Auteur ; Richard DELORME, Auteur . - p.2373-2382. Langues : Anglais (eng) in Autism Research > 14-11 (November 2021) . - p.2373-2382 Mots-clés : Autism Spectrum Disorder/complications/genetics  Cognition  Humans  Obsessive-Compulsive Disorder/genetics  habits  heritability  neurodevelopment  phenotype Index. décimale : PER Périodiques Résumé : Repetitive behaviors (RB) represent a wide spectrum of symptoms ranging from sensory-motor stereotypies to complex cognitive rituals, frequently dichotomized as low- and high-order sub-groups of symptoms. Even though these subgroups are considered as phenomenologically distinct in autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD), brain imaging and genetic studies suggest that they have common mechanisms and pathways. This discrepancy may be explained by the frequent intellectual disability reported in ASD, which blurs the RB expressivity. Given the high heritability of RB, that is, the diversity of symptoms expressed in the relatives are dependent on those expressed in their probands, we hypothesize that if RB expressed in ASD or OCD are two distinct entities, then the RB expressed in relatives will also reflect these two dimensions. We thus conduct a linear discriminant analysis on RB in both the relatives of probands with ASD and OCD and subjects from the general population (n = 1023). The discriminant analysis results in a classification of 81.1% of the controls (p < 10(-4) ), but poorly differentiated the ASD and OCD relatives (≈46%). The stepwise analysis reveals that five symptoms attributed to high-order RB and two related to low-order RB (including hypersensitivity) are the most discriminant. Our results support the idea that the difference of RB patterns in the relatives is mild compared with the distribution of symptoms in controls. Our findings reinforce the evidence of a common biological pattern of RB both in ASD and OCD but with minor differences, specific to each of these two neuro-developmental disorders. LAY SUMMARY: Repetitive behaviors (RB), a key symptom in the classification of both OCD and ASD, are phenomenologically considered as distinct in the two disorders, which is in contrast with brain imaging studies describing a common neural circuit. Intellectual disability, which is frequently associated with ASD, makes RB in ASD more difficult to understand as it affects the expression of the RB symptoms. To avoid this bias, we propose to consider the familial aggregation in ASD and OCD by exploring RB in the first-degree relatives of ASD and OCD. Our results highlight the existence of RB expressed in relatives compared to the general population, with a common pattern of symptoms in relatives of both ASD and OCD but also minor differences, specific to each of these two neuro-developmental disorders. En ligne : http://dx.doi.org/10.1002/aur.2570 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Gaze direction detection in autism spectrum disorder / Baudouin FORGEOT D'ARC in Autism, 21-1 (January 2017)  

Public ISBD [article]  inAutism > 21-1 (January 2017) . - p.100-107 Titre : Gaze direction detection in autism spectrum disorder Type de document : texte imprimé Auteurs : Baudouin FORGEOT D'ARC, Auteur ; Richard DELORME, Auteur ; Tiziana ZALLA, Auteur ; Aline LEFEBVRE, Auteur ; Frédérique AMSELLEM, Auteur ; Sanaa MOUKAWANE, Auteur ; Laurence LETELLIER, Auteur ; Marion LEBOYER, Auteur ; Marie-Christine MOUREN, Auteur ; Franck RAMUS, Auteur Article en page(s) : p.100-107 Langues : Anglais (eng) Mots-clés : autism  face processing  gaze direction detection  perception  social cognition Index. décimale : PER Périodiques Résumé : Detecting where our partners direct their gaze is an important aspect of social interaction. An atypical gaze processing has been reported in autism. However, it remains controversial whether children and adults with autism spectrum disorder interpret indirect gaze direction with typical accuracy. This study investigated whether the detection of gaze direction toward an object is less accurate in autism spectrum disorder. Individuals with autism spectrum disorder (n = 33) and intelligence quotients–matched and age-matched controls (n = 38) were asked to watch a series of synthetic faces looking at objects, and decide which of two objects was looked at. The angle formed by the two possible targets and the face varied following an adaptive procedure, in order to determine individual thresholds. We found that gaze direction detection was less accurate in autism spectrum disorder than in control participants. Our results suggest that the precision of gaze following may be one of the altered processes underlying social interaction difficulties in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361316630880 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Gaze direction detection in autism spectrum disorder [texte imprimé] / Baudouin FORGEOT D'ARC, Auteur ; Richard DELORME, Auteur ; Tiziana ZALLA, Auteur ; Aline LEFEBVRE, Auteur ; Frédérique AMSELLEM, Auteur ; Sanaa MOUKAWANE, Auteur ; Laurence LETELLIER, Auteur ; Marion LEBOYER, Auteur ; Marie-Christine MOUREN, Auteur ; Franck RAMUS, Auteur . - p.100-107. Langues : Anglais (eng) in Autism > 21-1 (January 2017) . - p.100-107 Mots-clés : autism  face processing  gaze direction detection  perception  social cognition Index. décimale : PER Périodiques Résumé : Detecting where our partners direct their gaze is an important aspect of social interaction. An atypical gaze processing has been reported in autism. However, it remains controversial whether children and adults with autism spectrum disorder interpret indirect gaze direction with typical accuracy. This study investigated whether the detection of gaze direction toward an object is less accurate in autism spectrum disorder. Individuals with autism spectrum disorder (n = 33) and intelligence quotients–matched and age-matched controls (n = 38) were asked to watch a series of synthetic faces looking at objects, and decide which of two objects was looked at. The angle formed by the two possible targets and the face varied following an adaptive procedure, in order to determine individual thresholds. We found that gaze direction detection was less accurate in autism spectrum disorder than in control participants. Our results suggest that the precision of gaze following may be one of the altered processes underlying social interaction difficulties in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361316630880 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Global Sensory Features are Linked to Executive and Attentional Impairments in Autism Spectrum Disorders / Anna MARUANI ; Elise HUMEAU ; Pierre ELLUL ; Ariane CARTIGNY ; Aline LEFEBVRE ; Florine DELLAPIAZZA ; Richard DELORME ; Hugo PEYRE in Journal of Autism and Developmental Disorders, 55-8 (August 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-8 (August 2025) . - p.2788-2796 Titre : Global Sensory Features are Linked to Executive and Attentional Impairments in Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Anna MARUANI, Auteur ; Elise HUMEAU, Auteur ; Pierre ELLUL, Auteur ; Ariane CARTIGNY, Auteur ; Aline LEFEBVRE, Auteur ; Florine DELLAPIAZZA, Auteur ; Richard DELORME, Auteur ; Hugo PEYRE, Auteur Article en page(s) : p.2788-2796 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Sensory features, executive and attentional impairments are frequently reported in individuals with autism spectrum disorders (ASD). However, little is known about their complex relationships. In this study, we aim to examine the executive and attentional difficulties related to distinct sensory profiles. We identified sensory profiles with a Latent Profile Analysis (LPA) based on scores on the Short Sensory Profile (SSP) questionnaire in 95 children with ASD aged 6 to 17 years. Executive and attention functions were assessed using the Behavior Rating Inventory of Executive Functions (BRIEF) questionnaire and Attention-Deficit Hyperactivity Disorder Rating Scale (ADHD-RS). A three-cluster solution based on raw SSP scores identified a "high'', a "medium" and a "low'' SSP profile. We found a significant relationship between executive functions, attentional skills and the global severity of sensory features, reinforcing findings of previous studies in the literature. A two-cluster solution based on normalized SSP (i.e. equalized for the global severity) identified distinct sensory profiles, mainly discriminated by the score of underresponsive/seeks sensation. We found no significant difference between these two clusters for the BRIEF and ADHD-RS related scores. Our study suggests that the heterogeneity of sensory features in ASD may not be explained by differences in executive and attention functions. Future studies are needed to refine the link between sensory features and executive functions in autism. En ligne : https://doi.org/10.1007/s10803-024-06385-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Global Sensory Features are Linked to Executive and Attentional Impairments in Autism Spectrum Disorders [texte imprimé] / Anna MARUANI, Auteur ; Elise HUMEAU, Auteur ; Pierre ELLUL, Auteur ; Ariane CARTIGNY, Auteur ; Aline LEFEBVRE, Auteur ; Florine DELLAPIAZZA, Auteur ; Richard DELORME, Auteur ; Hugo PEYRE, Auteur . - p.2788-2796. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-8 (August 2025) . - p.2788-2796 Index. décimale : PER Périodiques Résumé : Sensory features, executive and attentional impairments are frequently reported in individuals with autism spectrum disorders (ASD). However, little is known about their complex relationships. In this study, we aim to examine the executive and attentional difficulties related to distinct sensory profiles. We identified sensory profiles with a Latent Profile Analysis (LPA) based on scores on the Short Sensory Profile (SSP) questionnaire in 95 children with ASD aged 6 to 17 years. Executive and attention functions were assessed using the Behavior Rating Inventory of Executive Functions (BRIEF) questionnaire and Attention-Deficit Hyperactivity Disorder Rating Scale (ADHD-RS). A three-cluster solution based on raw SSP scores identified a "high'', a "medium" and a "low'' SSP profile. We found a significant relationship between executive functions, attentional skills and the global severity of sensory features, reinforcing findings of previous studies in the literature. A two-cluster solution based on normalized SSP (i.e. equalized for the global severity) identified distinct sensory profiles, mainly discriminated by the score of underresponsive/seeks sensation. We found no significant difference between these two clusters for the BRIEF and ADHD-RS related scores. Our study suggests that the heterogeneity of sensory features in ASD may not be explained by differences in executive and attention functions. Future studies are needed to refine the link between sensory features and executive functions in autism. En ligne : https://doi.org/10.1007/s10803-024-06385-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Oculomotor behavior in children with autism spectrum disorders / Simona CALDANI in Autism, 24-3 (April 2020)  

Public ISBD [article]  inAutism > 24-3 (April 2020) . - p.670-679 Titre : Oculomotor behavior in children with autism spectrum disorders Type de document : texte imprimé Auteurs : Simona CALDANI, Auteur ; Sarah STEG, Auteur ; Aline LEFEBVRE, Auteur ; Paola ATZORI, Auteur ; Hugo PEYRE, Auteur ; Richard DELORME, Auteur ; Maria Pia BUCCI, Auteur Article en page(s) : p.670-679 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  children  express saccades  inhibitory mechanism  latency Index. décimale : PER Périodiques Résumé : To identify quantitative indicators of social communication dysfunctions, we explored the oculomotor performances in subjects with autism spectrum disorders. Discordant findings in the literature have been reported for oculomotor behavior in subjects with autism spectrum disorders. This study aimed to explore reflexive and voluntary saccadic performance in a group of 32 children with autism spectrum disorders (mean age: 12.1 +/- 0.5 years) compared to 32 age-, sex-, and IQ-matched typically developing children (control group). We used different types of reflexive and voluntary saccades: gap, step, overlap, and anti-saccades. Eye movements were recorded using an eye tracker (Mobile EBT((R))) and we measured latency, percentage of anticipatory and express saccades, errors of anti-saccades and gain. Children with autism spectrum disorders reported similar latency values with respect to typically developing children for reflexive and voluntary saccades; in contrast, they made more express and anticipatory saccades overall, as shown in paradigm testing (gap, step, overlap, and anti-saccades). Our findings support previous evidence of the atypicality of the cortical network, which is involved in saccade triggering and attentional processes in children with autism spectrum disorders. En ligne : http://dx.doi.org/10.1177/1362361319882861 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Oculomotor behavior in children with autism spectrum disorders [texte imprimé] / Simona CALDANI, Auteur ; Sarah STEG, Auteur ; Aline LEFEBVRE, Auteur ; Paola ATZORI, Auteur ; Hugo PEYRE, Auteur ; Richard DELORME, Auteur ; Maria Pia BUCCI, Auteur . - p.670-679. Langues : Anglais (eng) in Autism > 24-3 (April 2020) . - p.670-679 Mots-clés : autism spectrum disorder  children  express saccades  inhibitory mechanism  latency Index. décimale : PER Périodiques Résumé : To identify quantitative indicators of social communication dysfunctions, we explored the oculomotor performances in subjects with autism spectrum disorders. Discordant findings in the literature have been reported for oculomotor behavior in subjects with autism spectrum disorders. This study aimed to explore reflexive and voluntary saccadic performance in a group of 32 children with autism spectrum disorders (mean age: 12.1 +/- 0.5 years) compared to 32 age-, sex-, and IQ-matched typically developing children (control group). We used different types of reflexive and voluntary saccades: gap, step, overlap, and anti-saccades. Eye movements were recorded using an eye tracker (Mobile EBT((R))) and we measured latency, percentage of anticipatory and express saccades, errors of anti-saccades and gain. Children with autism spectrum disorders reported similar latency values with respect to typically developing children for reflexive and voluntary saccades; in contrast, they made more express and anticipatory saccades overall, as shown in paradigm testing (gap, step, overlap, and anti-saccades). Our findings support previous evidence of the atypicality of the cortical network, which is involved in saccade triggering and attentional processes in children with autism spectrum disorders. En ligne : http://dx.doi.org/10.1177/1362361319882861 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

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