Classifying Autism Spectrum Disorders by ADI-R: Subtypes or Severity Gradient? / Hannah CHOLEMKERY in Journal of Autism and Developmental Disorders, 46-7 (July 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-7 (July 2016) . - p.2327-2339 Titre : Classifying Autism Spectrum Disorders by ADI-R: Subtypes or Severity Gradient? Type de document : texte imprimé Auteurs : Hannah CHOLEMKERY, Auteur ; Juliane MEDDA, Auteur ; Thomas LEMPP, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : p.2327-2339 Langues : Anglais (eng) Mots-clés : Autism Diagnostic Interview-revised  Psychometric assessment  Diagnosis  Autism spectrum disorder  Cluster analysis  DSM-5 Index. décimale : PER Périodiques Résumé : To reduce phenotypic heterogeneity of Autism spectrum disorders (ASD) and add to the current diagnostic discussion this study aimed at identifying clinically meaningful ASD subgroups. Cluster analyses were used to describe empirically derived groups based on the Autism Diagnostic Interview-revised (ADI-R) in a large sample of n = 463 individuals with ASD aged 3–21. Three clusters were observed. Most severely affected individuals regarding all core symptoms were allocated to cluster 2. Cluster 3 comprised moderate symptom severity of social communication impairments (SCI) and less stereotyped repetitive behavior (RRB). Minor SCI and relatively more RRB characterized cluster 1. This study offers support for both, a symptom profile, and a gradient model of ASD within the spectrum due to the sample included. En ligne : http://dx.doi.org/10.1007/s10803-016-2760-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 [article] Classifying Autism Spectrum Disorders by ADI-R: Subtypes or Severity Gradient? [texte imprimé] / Hannah CHOLEMKERY, Auteur ; Juliane MEDDA, Auteur ; Thomas LEMPP, Auteur ; Christine M. FREITAG, Auteur . - p.2327-2339. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-7 (July 2016) . - p.2327-2339 Mots-clés : Autism Diagnostic Interview-revised  Psychometric assessment  Diagnosis  Autism spectrum disorder  Cluster analysis  DSM-5 Index. décimale : PER Périodiques Résumé : To reduce phenotypic heterogeneity of Autism spectrum disorders (ASD) and add to the current diagnostic discussion this study aimed at identifying clinically meaningful ASD subgroups. Cluster analyses were used to describe empirically derived groups based on the Autism Diagnostic Interview-revised (ADI-R) in a large sample of n = 463 individuals with ASD aged 3–21. Three clusters were observed. Most severely affected individuals regarding all core symptoms were allocated to cluster 2. Cluster 3 comprised moderate symptom severity of social communication impairments (SCI) and less stereotyped repetitive behavior (RRB). Minor SCI and relatively more RRB characterized cluster 1. This study offers support for both, a symptom profile, and a gradient model of ASD within the spectrum due to the sample included. En ligne : http://dx.doi.org/10.1007/s10803-016-2760-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290

Sensitivity and Specificity of the ADOS-2 Algorithm in a Large German Sample / Juliane E. MEDDA in Journal of Autism and Developmental Disorders, 49-2 (February 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-2 (February 2019) . - p.750-761 Titre : Sensitivity and Specificity of the ADOS-2 Algorithm in a Large German Sample Type de document : texte imprimé Auteurs : Juliane E. MEDDA, Auteur ; Hannah CHOLEMKERY, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : p.750-761 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Child psychiatric disorder  Diagnostic validity  Psychometric assessment Index. décimale : PER Périodiques Résumé : The aim of the present study was to establish diagnostic validity of the new algorithm of the Autism Diagnostic Observation Scale, the ADOS-2, to differentiate between ASD and other clinically relevant psychiatric and developmental disorders in a large German sample. Validity of ADOS and ADOS-2 diagnostic algorithms was established in 826 individuals (n = 455 autism, n = 216 autism spectrum, n = 155 non-ASD patients) by receiver operating curves. Confidence intervals overlapped largely for ADOS and ADOS-2 algorithms, confirming diagnostic validity of both algorithms. Adding information of the Social Communication Questionnaire and the Social Responsiveness Scale resulted in slightly improved classification rates for autism in Module 4. We thus replicated previous findings of the diagnostic validity of the ADOS-2 algorithms. En ligne : http://dx.doi.org/10.1007/s10803-018-3750-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382 [article] Sensitivity and Specificity of the ADOS-2 Algorithm in a Large German Sample [texte imprimé] / Juliane E. MEDDA, Auteur ; Hannah CHOLEMKERY, Auteur ; Christine M. FREITAG, Auteur . - p.750-761. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-2 (February 2019) . - p.750-761 Mots-clés : Autism spectrum disorder  Child psychiatric disorder  Diagnostic validity  Psychometric assessment Index. décimale : PER Périodiques Résumé : The aim of the present study was to establish diagnostic validity of the new algorithm of the Autism Diagnostic Observation Scale, the ADOS-2, to differentiate between ASD and other clinically relevant psychiatric and developmental disorders in a large German sample. Validity of ADOS and ADOS-2 diagnostic algorithms was established in 826 individuals (n = 455 autism, n = 216 autism spectrum, n = 155 non-ASD patients) by receiver operating curves. Confidence intervals overlapped largely for ADOS and ADOS-2 algorithms, confirming diagnostic validity of both algorithms. Adding information of the Social Communication Questionnaire and the Social Responsiveness Scale resulted in slightly improved classification rates for autism in Module 4. We thus replicated previous findings of the diagnostic validity of the ADOS-2 algorithms. En ligne : http://dx.doi.org/10.1007/s10803-018-3750-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382

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