Childhood Mild Traumatic Brain Injury is Reliably Associated with Anxiety but Not Other Examined Psychiatric Outcomes at Two-Year Follow-up, After Adjusting for Prior Mental Health / Grace REVILL in Journal of Child Psychology and Psychiatry, 66-12 (December 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-12 (December 2025) . - p.1849-1859 Titre : Childhood Mild Traumatic Brain Injury is Reliably Associated with Anxiety but Not Other Examined Psychiatric Outcomes at Two-Year Follow-up, After Adjusting for Prior Mental Health Type de document : texte imprimé Auteurs : Grace REVILL, Auteur ; Norman POOLE, Auteur ; Christina CARLISI, Auteur ; Anthony S. DAVID, Auteur ; Vaughan BELL, Auteur Article en page(s) : p.1849-1859 Langues : Anglais (eng) Mots-clés : Traumatic brain injury  neuropsychology  neuropsychiatry  epidemiology Index. décimale : PER Périodiques Résumé : Background Evidence that mild traumatic brain injury (mTBI) causes psychiatric problems in children has been mixed. Investigating this issue has been difficult due to the lack of representative longitudinal data that includes adequate measures of mTBI, subsequent mental health symptoms and service use. Methods We used data from the ABCD longitudinal cohort study to examine the association between mTBI and psychiatric diagnoses, symptoms and psychiatric service use in over 11,000 children. In both children reporting (i) previous mTBI at baseline and (ii) previously uninjured children reporting new cases of mTBI since baseline, we examined psychiatric outcomes and service use at 2-year follow-up. We also compared mTBI cases to a comparison group of participants with orthopaedic injury but without mTBI. Mixed-effects models were used and adjusted for demographic and social covariates, with missing data imputed using random forest multiple imputation. To account for baseline mental health, we used propensity-score matching to identify a comparison sample matched on confounding variables and baseline outcome measures. Results When examined without adjustment for baseline mental health, both lifetime mTBI at baseline and new occurrence of mTBI at 2-year follow-up were reliably associated with an increased risk of DSM-5 anxiety and behavioural disorders, a range of psychiatric symptom scores and increased service use. Controlling for baseline mental health in the mTBI group using propensity-score matching eliminated all statistically reliable associations apart from anxiety disorder diagnosis and symptoms, which remain associated at 2-year follow-up. Evidence for association with medication use was inconsistent. Conclusions Consistent evidence supporting an association between paediatric mTBI and subsequent anxiety was found; however, similar associations were not observed for other mental health outcomes. Regardless of potential causality, children with mTBI are likely to present with high levels of mental health difficulties, and this remains an important comorbidity that clinicians should be aware of. En ligne : https://doi.org/10.1111/jcpp.70013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Childhood Mild Traumatic Brain Injury is Reliably Associated with Anxiety but Not Other Examined Psychiatric Outcomes at Two-Year Follow-up, After Adjusting for Prior Mental Health [texte imprimé] / Grace REVILL, Auteur ; Norman POOLE, Auteur ; Christina CARLISI, Auteur ; Anthony S. DAVID, Auteur ; Vaughan BELL, Auteur . - p.1849-1859. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-12 (December 2025) . - p.1849-1859 Mots-clés : Traumatic brain injury  neuropsychology  neuropsychiatry  epidemiology Index. décimale : PER Périodiques Résumé : Background Evidence that mild traumatic brain injury (mTBI) causes psychiatric problems in children has been mixed. Investigating this issue has been difficult due to the lack of representative longitudinal data that includes adequate measures of mTBI, subsequent mental health symptoms and service use. Methods We used data from the ABCD longitudinal cohort study to examine the association between mTBI and psychiatric diagnoses, symptoms and psychiatric service use in over 11,000 children. In both children reporting (i) previous mTBI at baseline and (ii) previously uninjured children reporting new cases of mTBI since baseline, we examined psychiatric outcomes and service use at 2-year follow-up. We also compared mTBI cases to a comparison group of participants with orthopaedic injury but without mTBI. Mixed-effects models were used and adjusted for demographic and social covariates, with missing data imputed using random forest multiple imputation. To account for baseline mental health, we used propensity-score matching to identify a comparison sample matched on confounding variables and baseline outcome measures. Results When examined without adjustment for baseline mental health, both lifetime mTBI at baseline and new occurrence of mTBI at 2-year follow-up were reliably associated with an increased risk of DSM-5 anxiety and behavioural disorders, a range of psychiatric symptom scores and increased service use. Controlling for baseline mental health in the mTBI group using propensity-score matching eliminated all statistically reliable associations apart from anxiety disorder diagnosis and symptoms, which remain associated at 2-year follow-up. Evidence for association with medication use was inconsistent. Conclusions Consistent evidence supporting an association between paediatric mTBI and subsequent anxiety was found; however, similar associations were not observed for other mental health outcomes. Regardless of potential causality, children with mTBI are likely to present with high levels of mental health difficulties, and this remains an important comorbidity that clinicians should be aware of. En ligne : https://doi.org/10.1111/jcpp.70013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Does sex influence the diagnostic evaluation of autism spectrum disorder in adults? / C. Ellie WILSON in Autism, 20-7 (October 2016)  

Public ISBD [article]  inAutism > 20-7 (October 2016) . - p.808-819 Titre : Does sex influence the diagnostic evaluation of autism spectrum disorder in adults? Type de document : texte imprimé Auteurs : C. Ellie WILSON, Auteur ; Clodagh M. MURPHY, Auteur ; Gráinne M. MCALONAN, Auteur ; Dene ROBERTSON, Auteur ; Debbie SPAIN, Auteur ; Hannah HAYWARD, Auteur ; Emma WOODHOUSE, Auteur ; Quinton DEELEY, Auteur ; Nicola GILLAN, Auteur ; J. Chris OHLSEN, Auteur ; Janneke ZINKSTOK, Auteur ; Vladimira STOENCHEVA, Auteur ; Jessica FAULKNER, Auteur ; Hatice YILDIRAN, Auteur ; Vaughan BELL, Auteur ; Neil HAMMOND, Auteur ; Michael C. CRAIG, Auteur ; Declan G.M. MURPHY, Auteur Article en page(s) : p.808-819 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  diagnosis  females  males  sex differences Index. décimale : PER Périodiques Résumé : It is unknown whether sex influences the diagnostic evaluation of autism spectrum disorder, or whether male and female adults within the spectrum have different symptom profiles. This study reports sex differences in clinical outcomes for 1244 adults (935 males and 309 females) referred for autism spectrum disorder assessment. Significantly, more males (72%) than females (66%) were diagnosed with an autism spectrum disorder of any subtype (x2 = 4.09; p = 0.04). In high-functioning autism spectrum disorder adults (IQ > 70; N = 827), there were no significant sex differences in severity of socio-communicative domain symptoms. Males had significantly more repetitive behaviours/restricted interests than females (p = 0.001, d = 0.3). A multivariate analysis of variance indicated a significant interaction between autism spectrum disorder subtype (full-autism spectrum disorder/partial-autism spectrum disorder) and sex: in full-autism spectrum disorder, males had more severe socio-communicative symptoms than females; for partial-autism spectrum disorder, the reverse was true. There were no sex differences in prevalence of co-morbid psychopathologies. Sex influenced diagnostic evaluation in a clinical sample of adults with suspected autism spectrum disorder. The sexes may present with different manifestations of the autism spectrum disorder phenotype and differences vary by diagnostic subtype. Understanding and awareness of adult female repetitive behaviours/restricted interests warrant attention and sex-specific diagnostic assessment tools may need to be considered. En ligne : http://dx.doi.org/10.1177/1362361315611381 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293 [article] Does sex influence the diagnostic evaluation of autism spectrum disorder in adults? [texte imprimé] / C. Ellie WILSON, Auteur ; Clodagh M. MURPHY, Auteur ; Gráinne M. MCALONAN, Auteur ; Dene ROBERTSON, Auteur ; Debbie SPAIN, Auteur ; Hannah HAYWARD, Auteur ; Emma WOODHOUSE, Auteur ; Quinton DEELEY, Auteur ; Nicola GILLAN, Auteur ; J. Chris OHLSEN, Auteur ; Janneke ZINKSTOK, Auteur ; Vladimira STOENCHEVA, Auteur ; Jessica FAULKNER, Auteur ; Hatice YILDIRAN, Auteur ; Vaughan BELL, Auteur ; Neil HAMMOND, Auteur ; Michael C. CRAIG, Auteur ; Declan G.M. MURPHY, Auteur . - p.808-819. Langues : Anglais (eng) in Autism > 20-7 (October 2016) . - p.808-819 Mots-clés : autism spectrum disorder  diagnosis  females  males  sex differences Index. décimale : PER Périodiques Résumé : It is unknown whether sex influences the diagnostic evaluation of autism spectrum disorder, or whether male and female adults within the spectrum have different symptom profiles. This study reports sex differences in clinical outcomes for 1244 adults (935 males and 309 females) referred for autism spectrum disorder assessment. Significantly, more males (72%) than females (66%) were diagnosed with an autism spectrum disorder of any subtype (x2 = 4.09; p = 0.04). In high-functioning autism spectrum disorder adults (IQ > 70; N = 827), there were no significant sex differences in severity of socio-communicative domain symptoms. Males had significantly more repetitive behaviours/restricted interests than females (p = 0.001, d = 0.3). A multivariate analysis of variance indicated a significant interaction between autism spectrum disorder subtype (full-autism spectrum disorder/partial-autism spectrum disorder) and sex: in full-autism spectrum disorder, males had more severe socio-communicative symptoms than females; for partial-autism spectrum disorder, the reverse was true. There were no sex differences in prevalence of co-morbid psychopathologies. Sex influenced diagnostic evaluation in a clinical sample of adults with suspected autism spectrum disorder. The sexes may present with different manifestations of the autism spectrum disorder phenotype and differences vary by diagnostic subtype. Understanding and awareness of adult female repetitive behaviours/restricted interests warrant attention and sex-specific diagnostic assessment tools may need to be considered. En ligne : http://dx.doi.org/10.1177/1362361315611381 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293

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