Autistic Traits and Abnormal Sensory Experiences in Adults / Jamie HORDER in Journal of Autism and Developmental Disorders, 44-6 (June 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1461-1469 Titre : Autistic Traits and Abnormal Sensory Experiences in Adults Type de document : Texte imprimé et/ou numérique Auteurs : Jamie HORDER, Auteur ; C. Ellie WILSON, Auteur ; M. Andreina MENDEZ, Auteur ; Declan G. M. MURPHY, Auteur Article en page(s) : p.1461-1469 Langues : Anglais (eng) Mots-clés : Adults  Anxiety  Autism  Comorbidities  Sensory Index. décimale : PER Périodiques Résumé : Sensory processing abnormalities are common in autism spectrum disorders (ASD), and now form part of the Diagnostic and Statistical Manual 5th Edition (DSM-5) diagnostic criteria, but it is unclear whether they characterize the ‘broader phenotype’ of the disorder. We recruited adults (n = 772) with and without an ASD and administered the Autism Quotient (AQ) along with the Adult/Adolescent Sensory Profile (AASP), the Cardiff Anomalous Perceptions Scale (CAPS), and the Glasgow Sensory Questionnaire (GSQ), all questionnaire measures of abnormal sensory responsivity. Autism traits were significantly correlated with scores on all three sensory scales (AQ/GSQ r = 0.478; AQ/AASP r = 0.344; AQ/CAPS r = 0.333; all p 0.001). This relationship was linear across the whole range of AQ scores and was true both in those with, and without, an ASD diagnosis. It survived correction for anxiety trait scores, and other potential confounds such as mental illness and migraine. En ligne : http://dx.doi.org/10.1007/s10803-013-2012-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 [article] Autistic Traits and Abnormal Sensory Experiences in Adults [Texte imprimé et/ou numérique] / Jamie HORDER, Auteur ; C. Ellie WILSON, Auteur ; M. Andreina MENDEZ, Auteur ; Declan G. M. MURPHY, Auteur . - p.1461-1469. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1461-1469 Mots-clés : Adults  Anxiety  Autism  Comorbidities  Sensory Index. décimale : PER Périodiques Résumé : Sensory processing abnormalities are common in autism spectrum disorders (ASD), and now form part of the Diagnostic and Statistical Manual 5th Edition (DSM-5) diagnostic criteria, but it is unclear whether they characterize the ‘broader phenotype’ of the disorder. We recruited adults (n = 772) with and without an ASD and administered the Autism Quotient (AQ) along with the Adult/Adolescent Sensory Profile (AASP), the Cardiff Anomalous Perceptions Scale (CAPS), and the Glasgow Sensory Questionnaire (GSQ), all questionnaire measures of abnormal sensory responsivity. Autism traits were significantly correlated with scores on all three sensory scales (AQ/GSQ r = 0.478; AQ/AASP r = 0.344; AQ/CAPS r = 0.333; all p 0.001). This relationship was linear across the whole range of AQ scores and was true both in those with, and without, an ASD diagnosis. It survived correction for anxiety trait scores, and other potential confounds such as mental illness and migraine. En ligne : http://dx.doi.org/10.1007/s10803-013-2012-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233

Comparison of ICD-10R, DSM-IV-TR and DSM-5 in an Adult Autism Spectrum Disorder Diagnostic Clinic / C. Ellie WILSON in Journal of Autism and Developmental Disorders, 43-11 (November 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2515-2525 Titre : Comparison of ICD-10R, DSM-IV-TR and DSM-5 in an Adult Autism Spectrum Disorder Diagnostic Clinic Type de document : Texte imprimé et/ou numérique Auteurs : C. Ellie WILSON, Auteur ; Nicola GILLAN, Auteur ; Deborah SPAIN, Auteur ; Dene ROBERTSON, Auteur ; Gedeon ROBERTS, Auteur ; Clodagh M. MURPHY, Auteur ; Stefanos MALTEZOS, Auteur ; Janneke ZINKSTOK, Auteur ; Katie JOHNSTON, Auteur ; Christina DARDANI, Auteur ; Chris OHLSEN, Auteur ; Quinton DEELEY, Auteur ; Michael C. CRAIG, Auteur ; Maria A. MENDEZ, Auteur ; Francesca HAPPE, Auteur ; Declan G. M. MURPHY, Auteur Article en page(s) : p.2515-2525 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Diagnosis  Prevalence  DSM-5 Index. décimale : PER Périodiques Résumé : An Autism Spectrum Disorder (ASD) diagnosis is often used to access services. We investigated whether ASD diagnostic outcome varied when DSM-5 was used compared to ICD-10R and DSM-IV-TR in a clinical sample of 150 intellectually able adults. Of those diagnosed with an ASD using ICD-10R, 56 % met DSM-5 ASD criteria. A further 19 % met DSM-5 (draft) criteria for Social Communication Disorder. Of those diagnosed with Autistic Disorder/Asperger Syndrome on DSM-IV-TR, 78 % met DSM-5 ASD criteria. Sensitivity of DSM-5 was significantly increased by reducing the number of criteria required for a DSM-5 diagnosis, or by rating ‘uncertain’ criteria as ‘present’, without sacrificing specificity. Reduced rates of ASD diagnosis may mean some ASD individuals will be unable to access clinical services. En ligne : http://dx.doi.org/10.1007/s10803-013-1799-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217 [article] Comparison of ICD-10R, DSM-IV-TR and DSM-5 in an Adult Autism Spectrum Disorder Diagnostic Clinic [Texte imprimé et/ou numérique] / C. Ellie WILSON, Auteur ; Nicola GILLAN, Auteur ; Deborah SPAIN, Auteur ; Dene ROBERTSON, Auteur ; Gedeon ROBERTS, Auteur ; Clodagh M. MURPHY, Auteur ; Stefanos MALTEZOS, Auteur ; Janneke ZINKSTOK, Auteur ; Katie JOHNSTON, Auteur ; Christina DARDANI, Auteur ; Chris OHLSEN, Auteur ; Quinton DEELEY, Auteur ; Michael C. CRAIG, Auteur ; Maria A. MENDEZ, Auteur ; Francesca HAPPE, Auteur ; Declan G. M. MURPHY, Auteur . - p.2515-2525. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2515-2525 Mots-clés : Autism Spectrum Disorder  Diagnosis  Prevalence  DSM-5 Index. décimale : PER Périodiques Résumé : An Autism Spectrum Disorder (ASD) diagnosis is often used to access services. We investigated whether ASD diagnostic outcome varied when DSM-5 was used compared to ICD-10R and DSM-IV-TR in a clinical sample of 150 intellectually able adults. Of those diagnosed with an ASD using ICD-10R, 56 % met DSM-5 ASD criteria. A further 19 % met DSM-5 (draft) criteria for Social Communication Disorder. Of those diagnosed with Autistic Disorder/Asperger Syndrome on DSM-IV-TR, 78 % met DSM-5 ASD criteria. Sensitivity of DSM-5 was significantly increased by reducing the number of criteria required for a DSM-5 diagnosis, or by rating ‘uncertain’ criteria as ‘present’, without sacrificing specificity. Reduced rates of ASD diagnosis may mean some ASD individuals will be unable to access clinical services. En ligne : http://dx.doi.org/10.1007/s10803-013-1799-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217

Cortical and subcortical glutathione levels in adults with autism spectrum disorder / Alice M. S. DURIEUX in Autism Research, 9-4 (April 2016)  

Public ISBD [article]  inAutism Research > 9-4 (April 2016) . - p.429-435 Titre : Cortical and subcortical glutathione levels in adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Alice M. S. DURIEUX, Auteur ; Jamie HORDER, Auteur ; M. Andreina MENDEZ, Auteur ; Alice EGERTON, Auteur ; Steven C. R. WILLIAMS, Auteur ; C. Ellie WILSON, Auteur ; Debbie SPAIN, Auteur ; Clodagh M. MURPHY, Auteur ; Dene ROBERTSON, Auteur ; Gareth J. BARKER, Auteur ; Declan G. MURPHY, Auteur ; Gráinne M. MCALONAN, Auteur Article en page(s) : p.429-435 Langues : Anglais (eng) Mots-clés : autism  magnetic resonance spectroscopy  glutathione  oxidative stress  redox Index. décimale : PER Périodiques Résumé : Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men. Autism Res 2016, 9: 429–435. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. En ligne : http://dx.doi.org/10.1002/aur.1522 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287 [article] Cortical and subcortical glutathione levels in adults with autism spectrum disorder [Texte imprimé et/ou numérique] / Alice M. S. DURIEUX, Auteur ; Jamie HORDER, Auteur ; M. Andreina MENDEZ, Auteur ; Alice EGERTON, Auteur ; Steven C. R. WILLIAMS, Auteur ; C. Ellie WILSON, Auteur ; Debbie SPAIN, Auteur ; Clodagh M. MURPHY, Auteur ; Dene ROBERTSON, Auteur ; Gareth J. BARKER, Auteur ; Declan G. MURPHY, Auteur ; Gráinne M. MCALONAN, Auteur . - p.429-435. Langues : Anglais (eng) in Autism Research > 9-4 (April 2016) . - p.429-435 Mots-clés : autism  magnetic resonance spectroscopy  glutathione  oxidative stress  redox Index. décimale : PER Périodiques Résumé : Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men. Autism Res 2016, 9: 429–435. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. En ligne : http://dx.doi.org/10.1002/aur.1522 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287

Development of a gaze contingent method for auditory threshold evaluation in non-verbal ASD children / Brian SULLIVAN in Research in Autism Spectrum Disorders, 62 (June 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 62 (June 2019) . - p.85-98 Titre : Development of a gaze contingent method for auditory threshold evaluation in non-verbal ASD children Type de document : Texte imprimé et/ou numérique Auteurs : Brian SULLIVAN, Auteur ; C. Ellie WILSON, Auteur ; David SALDANA, Auteur Article en page(s) : p.85-98 Langues : Anglais (eng) Mots-clés : Children  Audition  Non-verbal  Eye tracking  Gaze contingent  Perceptual threshold Index. décimale : PER Périodiques Résumé : Background Minimally verbal children with autistic spectrum disorder (ASD) make up an estimated third of the ASD population (Downs et al., 2005), but have been understudied due to difficulties in running experiments with such participants. We sought to develop an instrument to evaluate auditory perception, with the goal of testing both typically developing (TD) and ASD children, including minimally verbal ASD. Audio difference thresholds are typically measured by an audiologist using visual reinforcement audiometry (VRA) techniques, but this requires a trained clinician. Alternatively, mismatch negativity (MMN) via an electroencephalogram can provide an objective threshold measure and the participant can passively attend to stimuli. However, EEG equipment is expensive, and the procedure can be uncomfortable and difficult with anxious or touch sensitive participants. Method We developed a testing software for estimating auditory thresholds in children using a gaze contingent ‘game’. Our open source software uses an eye tracker, Matlab and child-oriented stimuli to automate aspects of VRA. Initial results suggest that audio thresholds can be obtained using our affordable non-invasive system, operated with minimal training, but refinement is necessary. Results Our method can obtain thresholds for most typical children, but data collection in young ASD children proved more challenging, yielding poor results, and will require further development to make the game more accessible. While promising, these results need to be corroborated with an alternate measure of difference threshold. Conclusion We document our efforts to design an effective interactive game to assess auditory perception using gaze-contingent eye-tracking methods; and provide case level insights on the testing individual participants and the heterogeneous ability and performance levels within ASD. We discuss the challenges experienced in testing and eye tracking both typical and ASD children to inform clinical and research groups to advance this promising line of research. En ligne : https://doi.org/10.1016/j.rasd.2019.02.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 [article] Development of a gaze contingent method for auditory threshold evaluation in non-verbal ASD children [Texte imprimé et/ou numérique] / Brian SULLIVAN, Auteur ; C. Ellie WILSON, Auteur ; David SALDANA, Auteur . - p.85-98. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 62 (June 2019) . - p.85-98 Mots-clés : Children  Audition  Non-verbal  Eye tracking  Gaze contingent  Perceptual threshold Index. décimale : PER Périodiques Résumé : Background Minimally verbal children with autistic spectrum disorder (ASD) make up an estimated third of the ASD population (Downs et al., 2005), but have been understudied due to difficulties in running experiments with such participants. We sought to develop an instrument to evaluate auditory perception, with the goal of testing both typically developing (TD) and ASD children, including minimally verbal ASD. Audio difference thresholds are typically measured by an audiologist using visual reinforcement audiometry (VRA) techniques, but this requires a trained clinician. Alternatively, mismatch negativity (MMN) via an electroencephalogram can provide an objective threshold measure and the participant can passively attend to stimuli. However, EEG equipment is expensive, and the procedure can be uncomfortable and difficult with anxious or touch sensitive participants. Method We developed a testing software for estimating auditory thresholds in children using a gaze contingent ‘game’. Our open source software uses an eye tracker, Matlab and child-oriented stimuli to automate aspects of VRA. Initial results suggest that audio thresholds can be obtained using our affordable non-invasive system, operated with minimal training, but refinement is necessary. Results Our method can obtain thresholds for most typical children, but data collection in young ASD children proved more challenging, yielding poor results, and will require further development to make the game more accessible. While promising, these results need to be corroborated with an alternate measure of difference threshold. Conclusion We document our efforts to design an effective interactive game to assess auditory perception using gaze-contingent eye-tracking methods; and provide case level insights on the testing individual participants and the heterogeneous ability and performance levels within ASD. We discuss the challenges experienced in testing and eye tracking both typical and ASD children to inform clinical and research groups to advance this promising line of research. En ligne : https://doi.org/10.1016/j.rasd.2019.02.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389

Does sex influence the diagnostic evaluation of autism spectrum disorder in adults? / C. Ellie WILSON in Autism, 20-7 (October 2016)  

Public ISBD [article]  inAutism > 20-7 (October 2016) . - p.808-819 Titre : Does sex influence the diagnostic evaluation of autism spectrum disorder in adults? Type de document : Texte imprimé et/ou numérique Auteurs : C. Ellie WILSON, Auteur ; Clodagh M. MURPHY, Auteur ; Grainne MCALONAN, Auteur ; Dene M ROBERTSON, Auteur ; Debbie SPAIN, Auteur ; Hannah HAYWARD, Auteur ; Emma WOODHOUSE, Auteur ; Quinton DEELEY, Auteur ; Nicola GILLAN, Auteur ; J Chris OHLSEN, Auteur ; Janneke ZINKSTOK, Auteur ; Vladimira STOENCHEVA, Auteur ; Jessica FAULKNER, Auteur ; Hatice YILDIRAN, Auteur ; Vaughan BELL, Auteur ; Neil HAMMOND, Auteur ; Michael C. CRAIG, Auteur ; Declan GM MURPHY, Auteur Article en page(s) : p.808-819 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  diagnosis  females  males  sex differences Index. décimale : PER Périodiques Résumé : It is unknown whether sex influences the diagnostic evaluation of autism spectrum disorder, or whether male and female adults within the spectrum have different symptom profiles. This study reports sex differences in clinical outcomes for 1244 adults (935 males and 309 females) referred for autism spectrum disorder assessment. Significantly, more males (72%) than females (66%) were diagnosed with an autism spectrum disorder of any subtype (x2?=?4.09; p?=?0.04). In high-functioning autism spectrum disorder adults (IQ?>?70; N?=?827), there were no significant sex differences in severity of socio-communicative domain symptoms. Males had significantly more repetitive behaviours/restricted interests than females (p?=?0.001, d?=?0.3). A multivariate analysis of variance indicated a significant interaction between autism spectrum disorder subtype (full-autism spectrum disorder/partial-autism spectrum disorder) and sex: in full-autism spectrum disorder, males had more severe socio-communicative symptoms than females; for partial-autism spectrum disorder, the reverse was true. There were no sex differences in prevalence of co-morbid psychopathologies. Sex influenced diagnostic evaluation in a clinical sample of adults with suspected autism spectrum disorder. The sexes may present with different manifestations of the autism spectrum disorder phenotype and differences vary by diagnostic subtype. Understanding and awareness of adult female repetitive behaviours/restricted interests warrant attention and sex-specific diagnostic assessment tools may need to be considered. En ligne : http://dx.doi.org/10.1177/1362361315611381 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293 [article] Does sex influence the diagnostic evaluation of autism spectrum disorder in adults? [Texte imprimé et/ou numérique] / C. Ellie WILSON, Auteur ; Clodagh M. MURPHY, Auteur ; Grainne MCALONAN, Auteur ; Dene M ROBERTSON, Auteur ; Debbie SPAIN, Auteur ; Hannah HAYWARD, Auteur ; Emma WOODHOUSE, Auteur ; Quinton DEELEY, Auteur ; Nicola GILLAN, Auteur ; J Chris OHLSEN, Auteur ; Janneke ZINKSTOK, Auteur ; Vladimira STOENCHEVA, Auteur ; Jessica FAULKNER, Auteur ; Hatice YILDIRAN, Auteur ; Vaughan BELL, Auteur ; Neil HAMMOND, Auteur ; Michael C. CRAIG, Auteur ; Declan GM MURPHY, Auteur . - p.808-819. Langues : Anglais (eng) in Autism > 20-7 (October 2016) . - p.808-819 Mots-clés : autism spectrum disorder  diagnosis  females  males  sex differences Index. décimale : PER Périodiques Résumé : It is unknown whether sex influences the diagnostic evaluation of autism spectrum disorder, or whether male and female adults within the spectrum have different symptom profiles. This study reports sex differences in clinical outcomes for 1244 adults (935 males and 309 females) referred for autism spectrum disorder assessment. Significantly, more males (72%) than females (66%) were diagnosed with an autism spectrum disorder of any subtype (x2?=?4.09; p?=?0.04). In high-functioning autism spectrum disorder adults (IQ?>?70; N?=?827), there were no significant sex differences in severity of socio-communicative domain symptoms. Males had significantly more repetitive behaviours/restricted interests than females (p?=?0.001, d?=?0.3). A multivariate analysis of variance indicated a significant interaction between autism spectrum disorder subtype (full-autism spectrum disorder/partial-autism spectrum disorder) and sex: in full-autism spectrum disorder, males had more severe socio-communicative symptoms than females; for partial-autism spectrum disorder, the reverse was true. There were no sex differences in prevalence of co-morbid psychopathologies. Sex influenced diagnostic evaluation in a clinical sample of adults with suspected autism spectrum disorder. The sexes may present with different manifestations of the autism spectrum disorder phenotype and differences vary by diagnostic subtype. Understanding and awareness of adult female repetitive behaviours/restricted interests warrant attention and sex-specific diagnostic assessment tools may need to be considered. En ligne : http://dx.doi.org/10.1177/1362361315611381 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293

Enhancing the Validity of a Quality of Life Measure for Autistic People / H. MCCONACHIE in Journal of Autism and Developmental Disorders, 48-5 (May 2018)  

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Impaired P1 Habituation and Mismatch Negativity in Children with Autism Spectrum Disorder / Francisco J. RUIZ-MARTINEZ in Journal of Autism and Developmental Disorders, 50-2 (February 2020)  

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No evidence of atypical attentional disengagement in autism: A study across the spectrum / C. Ellie WILSON in Autism, 23-3 (April 2019)  

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Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us? / Tim CADMAN in Autism Research, 8-5 (October 2015)  

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The Neuropsychology of Male Adults With High-Functioning Autism or Asperger Syndrome / C. Ellie WILSON in Autism Research, 7-5 (October 2014)  

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