Assembling a cohort for in-depth, longitudinal assessments of the biological embedding of child maltreatment: Methods, complexities, and lessons learned / Hannah M. C. SCHREIER in Development and Psychopathology, 33-2 (May 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-2 (May 2021) . - p.394-408 Titre : Assembling a cohort for in-depth, longitudinal assessments of the biological embedding of child maltreatment: Methods, complexities, and lessons learned Type de document : Texte imprimé et/ou numérique Auteurs : Hannah M. C. SCHREIER, Auteur ; Christine M. HEIM, Auteur ; Emma J. ROSE, Auteur ; Idan SHALEV, Auteur ; Chad E. SHENK, Auteur ; Jennie G. NOLL, Auteur Année de publication : 2021 Article en page(s) : p.394-408 Langues : Anglais (eng) Mots-clés : biological embedding  child maltreatment  cohort studies  longitudinal research  under-served populations Index. décimale : PER Périodiques Résumé : As championed by the work of Ed Zigler, investing in nurturing environments for all children is a chief tenet of primary prevention that will have far-reaching benefits to the health and welfare of all members of society. Children who endure child maltreatment (CM) are among society's most vulnerable. Prospective longitudinal research aimed at a comprehensive understanding of the mechanisms linking CM to subsequent adverse health consequences is needed to improve outcomes and to strengthen causal inference. This paper outlines the methods of the Child Health Study (CHS), a large, state-wide longitudinal cohort of recently maltreated and nonmaltreated youth aged 8-13 who will be assessed every 2 years. The CHS is designed to include in-depth assessments of multiple environmental, behavioral, neural, physiological, and molecular mechanisms through which CM may impact a broad spectrum of youth development, including behavioral and physical health outcomes. In addition to describing the conceptual framework and methods underlying the CHS, we provide information on valuable "lessons learned" in the hopes of supporting future research efforts facing similar challenges. The ultimate goal of this research is demonstrating how policies regarding CM impact the well-being, resilience and recovery of survivors and that they are worthy of large public investment. En ligne : http://dx.doi.org/10.1017/s0954579420001510 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444 [article] Assembling a cohort for in-depth, longitudinal assessments of the biological embedding of child maltreatment: Methods, complexities, and lessons learned [Texte imprimé et/ou numérique] / Hannah M. C. SCHREIER, Auteur ; Christine M. HEIM, Auteur ; Emma J. ROSE, Auteur ; Idan SHALEV, Auteur ; Chad E. SHENK, Auteur ; Jennie G. NOLL, Auteur . - 2021 . - p.394-408. Langues : Anglais (eng) in Development and Psychopathology > 33-2 (May 2021) . - p.394-408 Mots-clés : biological embedding  child maltreatment  cohort studies  longitudinal research  under-served populations Index. décimale : PER Périodiques Résumé : As championed by the work of Ed Zigler, investing in nurturing environments for all children is a chief tenet of primary prevention that will have far-reaching benefits to the health and welfare of all members of society. Children who endure child maltreatment (CM) are among society's most vulnerable. Prospective longitudinal research aimed at a comprehensive understanding of the mechanisms linking CM to subsequent adverse health consequences is needed to improve outcomes and to strengthen causal inference. This paper outlines the methods of the Child Health Study (CHS), a large, state-wide longitudinal cohort of recently maltreated and nonmaltreated youth aged 8-13 who will be assessed every 2 years. The CHS is designed to include in-depth assessments of multiple environmental, behavioral, neural, physiological, and molecular mechanisms through which CM may impact a broad spectrum of youth development, including behavioral and physical health outcomes. In addition to describing the conceptual framework and methods underlying the CHS, we provide information on valuable "lessons learned" in the hopes of supporting future research efforts facing similar challenges. The ultimate goal of this research is demonstrating how policies regarding CM impact the well-being, resilience and recovery of survivors and that they are worthy of large public investment. En ligne : http://dx.doi.org/10.1017/s0954579420001510 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444

Contextual adversity, telomere erosion, pubertal development, and health: Two models of accelerated aging, or one? / Jay BELSKY in Development and Psychopathology, 28-4 pt2 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt2 (November 2016) . - p.1367-1383 Titre : Contextual adversity, telomere erosion, pubertal development, and health: Two models of accelerated aging, or one? Type de document : Texte imprimé et/ou numérique Auteurs : Jay BELSKY, Auteur ; Idan SHALEV, Auteur Article en page(s) : p.1367-1383 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Two independent lines of inquiry suggest that growing up under conditions of contextual adversity (e.g., poverty and household chaos) accelerates aging and undermines long-term health. Whereas work addressing the developmental origins of health and disease highlights accelerated-aging effects of contextual adversity on telomere erosion, that informed by an evolutionary analysis of reproductive strategies highlights such effects with regard to pubertal development (in females). That both shorter telomeres early in life and earlier age of menarche are associated with poor health later in life raises the prospect, consistent with evolutionary life-history theory, that these two bodies of theory and research are tapping into the same evolutionary–developmental process whereby longer term health costs are traded off for increased probability of reproducing before dying via a process of accelerated aging. Here we make the case for such a claim, while highlighting biological processes responsible for these effects, as well as unknowns in the epigenetic equation that might instantiate these contextually regulated developmental processes. En ligne : http://dx.doi.org/10.1017/s0954579416000900 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Contextual adversity, telomere erosion, pubertal development, and health: Two models of accelerated aging, or one? [Texte imprimé et/ou numérique] / Jay BELSKY, Auteur ; Idan SHALEV, Auteur . - p.1367-1383. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1367-1383 Index. décimale : PER Périodiques Résumé : Two independent lines of inquiry suggest that growing up under conditions of contextual adversity (e.g., poverty and household chaos) accelerates aging and undermines long-term health. Whereas work addressing the developmental origins of health and disease highlights accelerated-aging effects of contextual adversity on telomere erosion, that informed by an evolutionary analysis of reproductive strategies highlights such effects with regard to pubertal development (in females). That both shorter telomeres early in life and earlier age of menarche are associated with poor health later in life raises the prospect, consistent with evolutionary life-history theory, that these two bodies of theory and research are tapping into the same evolutionary–developmental process whereby longer term health costs are traded off for increased probability of reproducing before dying via a process of accelerated aging. Here we make the case for such a claim, while highlighting biological processes responsible for these effects, as well as unknowns in the epigenetic equation that might instantiate these contextually regulated developmental processes. En ligne : http://dx.doi.org/10.1017/s0954579416000900 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Parental age at birth, telomere length, and autism spectrum disorders in the UK Biobank cohort / Qiaofeng YE in Autism Research, 17-11 (November 2024)  

Public ISBD [article]  inAutism Research > 17-11 (November 2024) . - p.2223-2231 Titre : Parental age at birth, telomere length, and autism spectrum disorders in the UK Biobank cohort Type de document : Texte imprimé et/ou numérique Auteurs : Qiaofeng YE, Auteur ; Abner T. APSLEY, Auteur ; Waylon J. HASTINGS, Auteur ; Laura ETZEL, Auteur ; Craig NEWSCHAFFER, Auteur ; Idan SHALEV, Auteur Article en page(s) : p.2223-2231 Langues : Anglais (eng) Mots-clés : adults  autism spectrum disorders  parental age at birth  telomere length  UK Biobank Index. décimale : PER Périodiques Résumé : Abstract Older parental age at birth is associated with increased risk of autism spectrum disorders (ASD) in offspring. Independently, shorter telomere length (TL) has also been shown to be associated with ASD in children. However, older paternal age at birth, with or without controlling for maternal age, has been associated with longer TL, a seemingly contradictory finding. Here, we conducted a retrospective cohort study among participants in the UK Biobank to disentangle associations between leukocyte TL and ASD status in adults, and the potential moderation by parental age on adult offspring's TL. Participants with ASD diagnosis (N?=?87) with a mean age of 46.0 (SD 4.4) years were matched to participants without ASD diagnosis (N?=?870) based on age, sex, ethnicity, education, household income, and assessment center. No statistically significant differences were seen in TL between participants with and without ASD when parental age at birth was not considered. However, there was a significant interaction between ASD diagnostic status and parental age on participants' TL, such that older paternal or maternal age at birth was more strongly associated with longer TL in participants with ASD. This study suggests that the shortened TL observed in children with ASD in previous research may partially depend on parental age at birth. Future studies tracking TL attrition before ASD diagnosis are warranted to depict temporal associations and the interacting effects of parental age at birth and ASD status on TL across the lifespan. En ligne : https://doi.org/10.1002/aur.3258 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=542 [article] Parental age at birth, telomere length, and autism spectrum disorders in the UK Biobank cohort [Texte imprimé et/ou numérique] / Qiaofeng YE, Auteur ; Abner T. APSLEY, Auteur ; Waylon J. HASTINGS, Auteur ; Laura ETZEL, Auteur ; Craig NEWSCHAFFER, Auteur ; Idan SHALEV, Auteur . - p.2223-2231. Langues : Anglais (eng) in Autism Research > 17-11 (November 2024) . - p.2223-2231 Mots-clés : adults  autism spectrum disorders  parental age at birth  telomere length  UK Biobank Index. décimale : PER Périodiques Résumé : Abstract Older parental age at birth is associated with increased risk of autism spectrum disorders (ASD) in offspring. Independently, shorter telomere length (TL) has also been shown to be associated with ASD in children. However, older paternal age at birth, with or without controlling for maternal age, has been associated with longer TL, a seemingly contradictory finding. Here, we conducted a retrospective cohort study among participants in the UK Biobank to disentangle associations between leukocyte TL and ASD status in adults, and the potential moderation by parental age on adult offspring's TL. Participants with ASD diagnosis (N?=?87) with a mean age of 46.0 (SD 4.4) years were matched to participants without ASD diagnosis (N?=?870) based on age, sex, ethnicity, education, household income, and assessment center. No statistically significant differences were seen in TL between participants with and without ASD when parental age at birth was not considered. However, there was a significant interaction between ASD diagnostic status and parental age on participants' TL, such that older paternal or maternal age at birth was more strongly associated with longer TL in participants with ASD. This study suggests that the shortened TL observed in children with ASD in previous research may partially depend on parental age at birth. Future studies tracking TL attrition before ASD diagnosis are warranted to depict temporal associations and the interacting effects of parental age at birth and ASD status on TL across the lifespan. En ligne : https://doi.org/10.1002/aur.3258 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=542

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