Atypical sensory reactivity influences auditory attentional control in adults with autism spectrum disorders / Debra S. KARHSON in Autism Research, 9-10 (October 2016)  

Public ISBD [article]  inAutism Research > 9-10 (October 2016) . - p.1079-1092 Titre : Atypical sensory reactivity influences auditory attentional control in adults with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Debra S. KARHSON, Auteur ; Edward J. GOLOB, Auteur Article en page(s) : p.1079-1092 Langues : Anglais (eng) Mots-clés : P50  P1  N100  autism  attention  EEG/ERP  sensory  reactivity Index. décimale : PER Périodiques Résumé : Frequent observations of atypical sensory reactivity in people with autism spectrum disorders (ASD) suggest that the perceptual experience of those on the Spectrum is dissimilar to neurotypicals. Moreover, variable attention abilities in people with ASD, ranging from good control to periods of high distractibility, may be related to atypical sensory reactivity. This study used auditory event-related potential (ERP) measures to evaluate top-down and bottom-up attentional processes as a function of perceptual load, and examined these factors with respect to sensory reactivity. Twenty-five age and IQ-matched participants (ASD: 22.5 year, SD?=?4.1 year; Controls: 22.8 year, SD?=?5.1 year) completed the Adolescent/Adult Sensory Profile prior to performing a modified 3-stimulus (target, non-target, and distractor) auditory oddball target detection task EEG was recorded during task completion. ERP analysis assessed early sensory processing (P50, ?50 ms latency; N100, ?100 ms latency), cognitive control (N200, ?200 ms latency), and attentional processing (P3a and P3b, ?300 ms latency). Behavioral data demonstrates participants with ASD and neurotypical performed similarly on auditory target detection, but diverged on sensory profiles. Target ERP measures associated with top-down control (P3b latency) significantly increased under greater load in controls, but not in participants with ASD. Early ERP responses associated with bottom-up attention (P50 amplitude) were positively correlated to increased sensory sensitivity. Findings suggest specific neural mechanisms for increased perceptual capacity and enhanced bottom-up processing of sensory stimuli in people with autism. Results from participants with ASD are consistent with load theory and enhanced perceptual functioning. En ligne : http://dx.doi.org/10.1002/aur.1593 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Atypical sensory reactivity influences auditory attentional control in adults with autism spectrum disorders [Texte imprimé et/ou numérique] / Debra S. KARHSON, Auteur ; Edward J. GOLOB, Auteur . - p.1079-1092. Langues : Anglais (eng) in Autism Research > 9-10 (October 2016) . - p.1079-1092 Mots-clés : P50  P1  N100  autism  attention  EEG/ERP  sensory  reactivity Index. décimale : PER Périodiques Résumé : Frequent observations of atypical sensory reactivity in people with autism spectrum disorders (ASD) suggest that the perceptual experience of those on the Spectrum is dissimilar to neurotypicals. Moreover, variable attention abilities in people with ASD, ranging from good control to periods of high distractibility, may be related to atypical sensory reactivity. This study used auditory event-related potential (ERP) measures to evaluate top-down and bottom-up attentional processes as a function of perceptual load, and examined these factors with respect to sensory reactivity. Twenty-five age and IQ-matched participants (ASD: 22.5 year, SD?=?4.1 year; Controls: 22.8 year, SD?=?5.1 year) completed the Adolescent/Adult Sensory Profile prior to performing a modified 3-stimulus (target, non-target, and distractor) auditory oddball target detection task EEG was recorded during task completion. ERP analysis assessed early sensory processing (P50, ?50 ms latency; N100, ?100 ms latency), cognitive control (N200, ?200 ms latency), and attentional processing (P3a and P3b, ?300 ms latency). Behavioral data demonstrates participants with ASD and neurotypical performed similarly on auditory target detection, but diverged on sensory profiles. Target ERP measures associated with top-down control (P3b latency) significantly increased under greater load in controls, but not in participants with ASD. Early ERP responses associated with bottom-up attention (P50 amplitude) were positively correlated to increased sensory sensitivity. Findings suggest specific neural mechanisms for increased perceptual capacity and enhanced bottom-up processing of sensory stimuli in people with autism. Results from participants with ASD are consistent with load theory and enhanced perceptual functioning. En ligne : http://dx.doi.org/10.1002/aur.1593 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Plasma anandamide concentrations are lower in children with autism spectrum disorder / Debra S. KARHSON in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 18p. Titre : Plasma anandamide concentrations are lower in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Debra S. KARHSON, Auteur ; K. M. KRASINSKA, Auteur ; J. A. DALLAIRE, Auteur ; R. A. LIBOVE, Auteur ; J. M. PHILLIPS, Auteur ; A. S. CHIEN, Auteur ; J. P. GARNER, Auteur ; A. Y. HARDAN, Auteur ; Karen J. PARKER, Auteur Article en page(s) : 18p. Langues : Anglais (eng) Mots-clés : Anandamide  Autism spectrum disorder  Blood biomarker  Cannabinoid Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted, stereotyped behaviors and impairments in social communication. Although the underlying biological mechanisms of ASD remain poorly understood, recent preclinical research has implicated the endogenous cannabinoid (or endocannabinoid), anandamide, as a significant neuromodulator in rodent models of ASD. Despite this promising preclinical evidence, no clinical studies to date have tested whether endocannabinoids are dysregulated in individuals with ASD. Here, we addressed this critical gap in knowledge by optimizing liquid chromatography-tandem mass spectrometry methodology to quantitatively analyze anandamide concentrations in banked blood samples collected from a cohort of children with and without ASD (N = 112). Findings: Anandamide concentrations significantly differentiated ASD cases (N = 59) from controls (N = 53), such that children with lower anandamide concentrations were more likely to have ASD (p = 0.041). In keeping with this notion, anandamide concentrations were also significantly lower in ASD compared to control children (p = 0.034). Conclusions: These findings are the first empirical human data to translate preclinical rodent findings to confirm a link between plasma anandamide concentrations in children with ASD. Although preliminary, these data suggest that impaired anandamide signaling may be involved in the pathophysiology of ASD. En ligne : http://dx.doi.org/10.1186/s13229-018-0203-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354 [article] Plasma anandamide concentrations are lower in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Debra S. KARHSON, Auteur ; K. M. KRASINSKA, Auteur ; J. A. DALLAIRE, Auteur ; R. A. LIBOVE, Auteur ; J. M. PHILLIPS, Auteur ; A. S. CHIEN, Auteur ; J. P. GARNER, Auteur ; A. Y. HARDAN, Auteur ; Karen J. PARKER, Auteur . - 18p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 18p. Mots-clés : Anandamide  Autism spectrum disorder  Blood biomarker  Cannabinoid Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted, stereotyped behaviors and impairments in social communication. Although the underlying biological mechanisms of ASD remain poorly understood, recent preclinical research has implicated the endogenous cannabinoid (or endocannabinoid), anandamide, as a significant neuromodulator in rodent models of ASD. Despite this promising preclinical evidence, no clinical studies to date have tested whether endocannabinoids are dysregulated in individuals with ASD. Here, we addressed this critical gap in knowledge by optimizing liquid chromatography-tandem mass spectrometry methodology to quantitatively analyze anandamide concentrations in banked blood samples collected from a cohort of children with and without ASD (N = 112). Findings: Anandamide concentrations significantly differentiated ASD cases (N = 59) from controls (N = 53), such that children with lower anandamide concentrations were more likely to have ASD (p = 0.041). In keeping with this notion, anandamide concentrations were also significantly lower in ASD compared to control children (p = 0.034). Conclusions: These findings are the first empirical human data to translate preclinical rodent findings to confirm a link between plasma anandamide concentrations in children with ASD. Although preliminary, these data suggest that impaired anandamide signaling may be involved in the pathophysiology of ASD. En ligne : http://dx.doi.org/10.1186/s13229-018-0203-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354

---

1 (1 - 2 / 2)