Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults / Jinni SU in Development and Psychopathology, 36-4 (October 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-4 (October 2024) . - p.1763-1775 Titre : Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults Type de document : Texte imprimé et/ou numérique Auteurs : Jinni SU, Auteur ; Sally I. Chun KUO, Auteur ; Fazil ALIEV, Auteur ; Jill A. RABINOWITZ, Auteur ; Belal JAMIL, Auteur ; Grace CHAN, Auteur ; Howard J. EDENBERG, Auteur ; Meredith FRANCIS, Auteur ; Victor HESSELBROCK, Auteur ; Chella KAMARAJAN, Auteur ; Sivan KINREICH, Auteur ; John KRAMER, Auteur ; Donbing LAI, Auteur ; Vivia MCCUTCHEON, Auteur ; Jacquelyn MEYERS, Auteur ; Ashwini PANDEY, Auteur ; Gayathri PANDEY, Auteur ; Martin H. PLAWECKI, Auteur ; Marc SCHUCKIT, Auteur ; Jay TISCHFIELD, Auteur ; Danielle M. DICK, Auteur Article en page(s) : p.1763-1775 Langues : Anglais (eng) Mots-clés : COGA  alcohol use  gene-environment interaction  polygenic scores  social support Index. décimale : PER Périodiques Résumé : Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use. En ligne : https://dx.doi.org/10.1017/S0954579423001141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults [Texte imprimé et/ou numérique] / Jinni SU, Auteur ; Sally I. Chun KUO, Auteur ; Fazil ALIEV, Auteur ; Jill A. RABINOWITZ, Auteur ; Belal JAMIL, Auteur ; Grace CHAN, Auteur ; Howard J. EDENBERG, Auteur ; Meredith FRANCIS, Auteur ; Victor HESSELBROCK, Auteur ; Chella KAMARAJAN, Auteur ; Sivan KINREICH, Auteur ; John KRAMER, Auteur ; Donbing LAI, Auteur ; Vivia MCCUTCHEON, Auteur ; Jacquelyn MEYERS, Auteur ; Ashwini PANDEY, Auteur ; Gayathri PANDEY, Auteur ; Martin H. PLAWECKI, Auteur ; Marc SCHUCKIT, Auteur ; Jay TISCHFIELD, Auteur ; Danielle M. DICK, Auteur . - p.1763-1775. Langues : Anglais (eng) in Development and Psychopathology > 36-4 (October 2024) . - p.1763-1775 Mots-clés : COGA  alcohol use  gene-environment interaction  polygenic scores  social support Index. décimale : PER Périodiques Résumé : Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use. En ligne : https://dx.doi.org/10.1017/S0954579423001141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students / Jinni SU in Development and Psychopathology, 30-5 (December 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-5 (December 2018) . - p.1749-1761 Titre : Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students Type de document : Texte imprimé et/ou numérique Auteurs : Jinni SU, Auteur ; Sally I. Chun KUO, Auteur ; Jacquelyn L. MEYERS, Auteur ; Mignonne C. GUY, Auteur ; Danielle M. DICK, Auteur Article en page(s) : p.1749-1761 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Numerous studies have demonstrated that genetic and environmental factors interact to influence alcohol problems. Yet prior research has primarily focused on samples of European descent and little is known about gene–environment interactions in relation to alcohol problems in non-European populations. In this study, we examined whether and how genetic risk for alcohol problems and peer deviance and interpersonal traumatic events independently and interactively influence trajectories of alcohol use disorder symptoms in a sample of African American students across the college years (N = 1,119; Mage = 18.44 years). Data were drawn from the Spit for Science study where participants completed multiple online surveys throughout college and provided a saliva sample for genotyping. Multilevel growth curve analyses indicated that alcohol dependence genome-wide polygenic risk scores did not predict trajectory of alcohol use disorder symptoms, while family history of alcohol problems was associated with alcohol use disorder symptoms at the start of college but not with the rate of change in symptoms over time. Peer deviance and interpersonal traumatic events were associated with more alcohol use disorder symptoms across college years. Neither alcohol dependence genome-wide polygenic risk scores nor family history of alcohol problems moderated the effects of these environmental risk factors on alcohol use disorder symptoms. Our findings indicated that peer deviance and experience of interpersonal traumatic events are salient risk factors that elevate risk for alcohol problems among African American college students. Family history of alcohol problems could be a useful indicator of genetic risk for alcohol problems. Gene identification efforts with much larger samples of African descent are needed to better characterize genetic risk for alcohol use disorders, in order to better understand gene–environment interaction processes in this understudied population. En ligne : http://dx.doi.org/10.1017/S0954579418000962 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students [Texte imprimé et/ou numérique] / Jinni SU, Auteur ; Sally I. Chun KUO, Auteur ; Jacquelyn L. MEYERS, Auteur ; Mignonne C. GUY, Auteur ; Danielle M. DICK, Auteur . - p.1749-1761. Langues : Anglais (eng) in Development and Psychopathology > 30-5 (December 2018) . - p.1749-1761 Index. décimale : PER Périodiques Résumé : Numerous studies have demonstrated that genetic and environmental factors interact to influence alcohol problems. Yet prior research has primarily focused on samples of European descent and little is known about gene–environment interactions in relation to alcohol problems in non-European populations. In this study, we examined whether and how genetic risk for alcohol problems and peer deviance and interpersonal traumatic events independently and interactively influence trajectories of alcohol use disorder symptoms in a sample of African American students across the college years (N = 1,119; Mage = 18.44 years). Data were drawn from the Spit for Science study where participants completed multiple online surveys throughout college and provided a saliva sample for genotyping. Multilevel growth curve analyses indicated that alcohol dependence genome-wide polygenic risk scores did not predict trajectory of alcohol use disorder symptoms, while family history of alcohol problems was associated with alcohol use disorder symptoms at the start of college but not with the rate of change in symptoms over time. Peer deviance and interpersonal traumatic events were associated with more alcohol use disorder symptoms across college years. Neither alcohol dependence genome-wide polygenic risk scores nor family history of alcohol problems moderated the effects of these environmental risk factors on alcohol use disorder symptoms. Our findings indicated that peer deviance and experience of interpersonal traumatic events are salient risk factors that elevate risk for alcohol problems among African American college students. Family history of alcohol problems could be a useful indicator of genetic risk for alcohol problems. Gene identification efforts with much larger samples of African descent are needed to better characterize genetic risk for alcohol use disorders, in order to better understand gene–environment interaction processes in this understudied population. En ligne : http://dx.doi.org/10.1017/S0954579418000962 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Genetic risk of AUDs and childhood impulsivity: Examining the role of parenting and family environment / Jinni SU in Development and Psychopathology, 34-5 (December 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-5 (December 2022) . - p.1827-1840 Titre : Genetic risk of AUDs and childhood impulsivity: Examining the role of parenting and family environment Type de document : Texte imprimé et/ou numérique Auteurs : Jinni SU, Auteur ; Angel TREVINO, Auteur ; Belal JAMIL, Auteur ; Fazil ALIEV, Auteur Article en page(s) : p.1827-1840 Langues : Anglais (eng) Mots-clés : alcohol  family conflict  impulsivity  parenting  polygenic score Index. décimale : PER Périodiques Résumé : This study examined the independent and interactive effects of genetic risk for alcohol use disorder (AUD), parenting behaviors, and family environment on childhood impulsivity. Data were drawn from White (n = 5,991), Black/African American (n = 1,693), and Hispanic/Latino (n = 2,118) youth who completed the baseline assessment (age 9 “10) and had genotypic data available from the Adolescent Brain Cognitive Development Study. Participants completed questionnaires and provided saliva or blood samples for genotyping. Results indicated no significant main effects of AUD genome-wide polygenic scores (AUD-PRS) on childhood impulsivity as measured by the UPPS-P scale across racial/ethnic groups. In general, parental monitoring and parental acceptance were associated with lower impulsivity; family conflict was associated with higher impulsivity. There was an interaction effect between AUD-PRS and family conflict, such that family conflict exacerbated the association between AUD-PRS and positive urgency, only among Black/African American youth. This was the only significant interaction effect detected from a total of 45 tests (five impulsivity dimensions, three subsamples, and three family factors), and thus may be a false positive and needs to be replicated. These findings highlight the important role of parenting behaviors and family conflict in relation to impulsivity among children. En ligne : http://dx.doi.org/10.1017/S095457942200092X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Genetic risk of AUDs and childhood impulsivity: Examining the role of parenting and family environment [Texte imprimé et/ou numérique] / Jinni SU, Auteur ; Angel TREVINO, Auteur ; Belal JAMIL, Auteur ; Fazil ALIEV, Auteur . - p.1827-1840. Langues : Anglais (eng) in Development and Psychopathology > 34-5 (December 2022) . - p.1827-1840 Mots-clés : alcohol  family conflict  impulsivity  parenting  polygenic score Index. décimale : PER Périodiques Résumé : This study examined the independent and interactive effects of genetic risk for alcohol use disorder (AUD), parenting behaviors, and family environment on childhood impulsivity. Data were drawn from White (n = 5,991), Black/African American (n = 1,693), and Hispanic/Latino (n = 2,118) youth who completed the baseline assessment (age 9 “10) and had genotypic data available from the Adolescent Brain Cognitive Development Study. Participants completed questionnaires and provided saliva or blood samples for genotyping. Results indicated no significant main effects of AUD genome-wide polygenic scores (AUD-PRS) on childhood impulsivity as measured by the UPPS-P scale across racial/ethnic groups. In general, parental monitoring and parental acceptance were associated with lower impulsivity; family conflict was associated with higher impulsivity. There was an interaction effect between AUD-PRS and family conflict, such that family conflict exacerbated the association between AUD-PRS and positive urgency, only among Black/African American youth. This was the only significant interaction effect detected from a total of 45 tests (five impulsivity dimensions, three subsamples, and three family factors), and thus may be a false positive and needs to be replicated. These findings highlight the important role of parenting behaviors and family conflict in relation to impulsivity among children. En ligne : http://dx.doi.org/10.1017/S095457942200092X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

Latent trajectories of alcohol use from early adolescence to young adulthood: Interaction effects between 5-HTTLPR and parenting quality and gender differences / Jinni SU in Development and Psychopathology, 31-2 (May 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-2 (May 2019) . - p.457-469 Titre : Latent trajectories of alcohol use from early adolescence to young adulthood: Interaction effects between 5-HTTLPR and parenting quality and gender differences Type de document : Texte imprimé et/ou numérique Auteurs : Jinni SU, Auteur ; Andrew J. SUPPLE, Auteur ; Esther M. LEERKES, Auteur ; Sally I. Chun KUO, Auteur Article en page(s) : p.457-469 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Using a large and nationally representative sample, we examined how adolescents’ 5-HTTLPR genotype and perceived parenting quality independently and interactively associated with trajectories of alcohol use from early adolescence to young adulthood and whether/how gender may moderate these associations. The sample for this study included 13,749 adolescents (53.3% female; 56.3% non-Hispanic White, 21.5% Black, 16.0% Hispanic, and 6.1% Asian) followed prospectively from adolescence to young adulthood. Using growth mixture modeling, we identified four distinct trajectories of alcohol use (i.e., persistent heavy alcohol use, developmentally limited alcohol use, late-onset heavy alcohol use, and non/light alcohol use). Results indicated that the short allele of 5-HTTLPR was associated with higher risk of membership in the persistent and the late-onset heavy alcohol use trajectories. Parenting quality was associated with lower likelihoods of following the persistent heavy and the developmentally limited alcohol use trajectories but was not associated with risk of membership for the late-onset heavy drinking trajectory. 5-HTTLPR interacted with parenting quality to predict membership in the persistent heavy alcohol use trajectory for males but not for females. Findings highlighted the importance of considering the heterogeneity in trajectories of alcohol use across development and gender in the study of Gene Environment interactions in alcohol use. En ligne : http://dx.doi.org/10.1017/S095457941800024X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393 [article] Latent trajectories of alcohol use from early adolescence to young adulthood: Interaction effects between 5-HTTLPR and parenting quality and gender differences [Texte imprimé et/ou numérique] / Jinni SU, Auteur ; Andrew J. SUPPLE, Auteur ; Esther M. LEERKES, Auteur ; Sally I. Chun KUO, Auteur . - p.457-469. Langues : Anglais (eng) in Development and Psychopathology > 31-2 (May 2019) . - p.457-469 Index. décimale : PER Périodiques Résumé : Using a large and nationally representative sample, we examined how adolescents’ 5-HTTLPR genotype and perceived parenting quality independently and interactively associated with trajectories of alcohol use from early adolescence to young adulthood and whether/how gender may moderate these associations. The sample for this study included 13,749 adolescents (53.3% female; 56.3% non-Hispanic White, 21.5% Black, 16.0% Hispanic, and 6.1% Asian) followed prospectively from adolescence to young adulthood. Using growth mixture modeling, we identified four distinct trajectories of alcohol use (i.e., persistent heavy alcohol use, developmentally limited alcohol use, late-onset heavy alcohol use, and non/light alcohol use). Results indicated that the short allele of 5-HTTLPR was associated with higher risk of membership in the persistent and the late-onset heavy alcohol use trajectories. Parenting quality was associated with lower likelihoods of following the persistent heavy and the developmentally limited alcohol use trajectories but was not associated with risk of membership for the late-onset heavy drinking trajectory. 5-HTTLPR interacted with parenting quality to predict membership in the persistent heavy alcohol use trajectory for males but not for females. Findings highlighted the importance of considering the heterogeneity in trajectories of alcohol use across development and gender in the study of Gene Environment interactions in alcohol use. En ligne : http://dx.doi.org/10.1017/S095457941800024X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393

Maternal physiological dysregulation while parenting poses risk for infant attachment disorganization and behavior problems / Esther M. LEERKES in Development and Psychopathology, 29-1 (February 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-1 (February 2017) . - p.245-257 Titre : Maternal physiological dysregulation while parenting poses risk for infant attachment disorganization and behavior problems Type de document : Texte imprimé et/ou numérique Auteurs : Esther M. LEERKES, Auteur ; Jinni SU, Auteur ; Susan D. CALKINS, Auteur ; Marion O'BRIEN, Auteur ; Andrew J. SUPPLE, Auteur Article en page(s) : p.245-257 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : AbstractThe extent to which indices of maternal physiological arousal (skin conductance augmentation) and regulation (vagal withdrawal) while parenting predict infant attachment disorganization and behavior problems directly or indirectly via maternal sensitivity was examined in a sample of 259 mothers and their infants. Two covariates, maternal self-reported emotional risk and Adult Attachment Interview attachment coherence were assessed prenatally. Mothers' physiological arousal and regulation were measured during parenting tasks when infants were 6 months old. Maternal sensitivity was observed during distress-eliciting tasks when infants were 6 and 14 months old, and an average sensitivity score was calculated. Attachment disorganization was observed during the Strange Situation when infants were 14 months old, and mothers reported on infants' behavior problems when infants were 27 months old. Over and above covariates, mothers' arousal and regulation while parenting interacted to predict infant attachment disorganization and behavior problems such that maternal arousal was associated with higher attachment disorganization and behavior problems when maternal regulation was low but not when maternal regulation was high. This effect was direct and not explained by maternal sensitivity. The results suggest that maternal physiological dysregulation while parenting places infants at risk for psychopathology. En ligne : http://dx.doi.org/10.1017/s0954579416000122 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Maternal physiological dysregulation while parenting poses risk for infant attachment disorganization and behavior problems [Texte imprimé et/ou numérique] / Esther M. LEERKES, Auteur ; Jinni SU, Auteur ; Susan D. CALKINS, Auteur ; Marion O'BRIEN, Auteur ; Andrew J. SUPPLE, Auteur . - p.245-257. Langues : Anglais (eng) in Development and Psychopathology > 29-1 (February 2017) . - p.245-257 Index. décimale : PER Périodiques Résumé : AbstractThe extent to which indices of maternal physiological arousal (skin conductance augmentation) and regulation (vagal withdrawal) while parenting predict infant attachment disorganization and behavior problems directly or indirectly via maternal sensitivity was examined in a sample of 259 mothers and their infants. Two covariates, maternal self-reported emotional risk and Adult Attachment Interview attachment coherence were assessed prenatally. Mothers' physiological arousal and regulation were measured during parenting tasks when infants were 6 months old. Maternal sensitivity was observed during distress-eliciting tasks when infants were 6 and 14 months old, and an average sensitivity score was calculated. Attachment disorganization was observed during the Strange Situation when infants were 14 months old, and mothers reported on infants' behavior problems when infants were 27 months old. Over and above covariates, mothers' arousal and regulation while parenting interacted to predict infant attachment disorganization and behavior problems such that maternal arousal was associated with higher attachment disorganization and behavior problems when maternal regulation was low but not when maternal regulation was high. This effect was direct and not explained by maternal sensitivity. The results suggest that maternal physiological dysregulation while parenting places infants at risk for psychopathology. En ligne : http://dx.doi.org/10.1017/s0954579416000122 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Stress and diurnal cortisol among Latino/a college students: A multi-risk model approach / Leah D. DOANE ; Jinni SU ; Kevin J. GRIMM in Development and Psychopathology, 36-2 (May 2024)  

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The role of adolescent social relationships in promoting alcohol resistance: Interrupting the intergenerational transmission of alcohol misuse / Mallory STEPHENSON in Development and Psychopathology, 34-5 (December 2022)  

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