Differences in age-dependent neural correlates of semantic processing between youths with autism spectrum disorder and typically developing youths / Pin-Jane CHEN in Autism Research, 9-12 (December 2016)  

Public ISBD [article]  inAutism Research > 9-12 (December 2016) . - p.1263-1273 Titre : Differences in age-dependent neural correlates of semantic processing between youths with autism spectrum disorder and typically developing youths Type de document : texte imprimé Auteurs : Pin-Jane CHEN, Auteur ; Susan Shur-Fen GAU, Auteur ; Shu-Hui LEE, Auteur ; Tai-Li CHOU, Auteur Article en page(s) : p.1263-1273 Langues : Anglais (eng) Mots-clés : autism spectrum disorders (ASD)  fMRI  semantic processing  age-dependent Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) have aberrant neural activity during semantic judgments. We aimed to examine age-dependent neural correlates of semantic processing in boys with ASD as compared to typically developing boys (TD). We used functional MRI to investigate 37 boys with ASD (mean age = 13.3 years, standard deviation = 2.4) and 35 age-, sex-, Intelligence quotient (IQ)- and handedness-matched TD boys (mean age = 13.3 years, standard deviation = 2.7) from age 8 to 18 years. Participants had to indicate whether pairs of Chinese characters presented visually were related in meaning. Group (ASD, TD) × Age (Old, Young) ANOVA was used to examine the difference of age-related changes. Direct comparisons between the adolescent group and the child group were also performed. The behavioral results showed that the ASD group had lower accuracy in the related condition relative to the TD group. The neuroimaging results showed greater activation in the cuneus and less activation in the left inferior frontal gyrus in boys with ASD than TD boys. Children with ASD produced greater activation in the cuneus than TD children. Adolescents with ASD showed reduced left IFG activation as compared to TD adolescents. Our findings suggest that TD boys may engage more in higher-level processing of retrieving or selecting semantic features while boys with ASD may rely more on lower-level visual processing during semantic judgments. The findings imply different functional organizations of the semantic system between the two groups. En ligne : http://dx.doi.org/10.1002/aur.1616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Differences in age-dependent neural correlates of semantic processing between youths with autism spectrum disorder and typically developing youths [texte imprimé] / Pin-Jane CHEN, Auteur ; Susan Shur-Fen GAU, Auteur ; Shu-Hui LEE, Auteur ; Tai-Li CHOU, Auteur . - p.1263-1273. Langues : Anglais (eng) in Autism Research > 9-12 (December 2016) . - p.1263-1273 Mots-clés : autism spectrum disorders (ASD)  fMRI  semantic processing  age-dependent Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) have aberrant neural activity during semantic judgments. We aimed to examine age-dependent neural correlates of semantic processing in boys with ASD as compared to typically developing boys (TD). We used functional MRI to investigate 37 boys with ASD (mean age = 13.3 years, standard deviation = 2.4) and 35 age-, sex-, Intelligence quotient (IQ)- and handedness-matched TD boys (mean age = 13.3 years, standard deviation = 2.7) from age 8 to 18 years. Participants had to indicate whether pairs of Chinese characters presented visually were related in meaning. Group (ASD, TD) × Age (Old, Young) ANOVA was used to examine the difference of age-related changes. Direct comparisons between the adolescent group and the child group were also performed. The behavioral results showed that the ASD group had lower accuracy in the related condition relative to the TD group. The neuroimaging results showed greater activation in the cuneus and less activation in the left inferior frontal gyrus in boys with ASD than TD boys. Children with ASD produced greater activation in the cuneus than TD children. Adolescents with ASD showed reduced left IFG activation as compared to TD adolescents. Our findings suggest that TD boys may engage more in higher-level processing of retrieving or selecting semantic features while boys with ASD may rely more on lower-level visual processing during semantic judgments. The findings imply different functional organizations of the semantic system between the two groups. En ligne : http://dx.doi.org/10.1002/aur.1616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Neural Endophenotypes of Semantic Processing and Social Functioning in Autism Spectrum Disorder / Shu-Hui LEE in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70320 Titre : Neural Endophenotypes of Semantic Processing and Social Functioning in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Shu-Hui LEE, Auteur ; Chuan-Ching LIAO, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur Article en page(s) : p. e70320 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  endophenotype  fMRI  semantic  social Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is highly heritable; however, the neural architecture underlying semantic processing and social functioning, and the extent to which it reflects familial liability, remains insufficiently understood. Unaffected siblings (SIB), who share substantial genetic liability with individuals with ASD, offer a critical framework for identifying intermediate neural phenotypes. We examined 36 individuals with ASD, 36 SIB, and 37 typically developing (TD) controls, matched for age, IQ, and handedness. Functional magnetic resonance imaging (fMRI) during a semantic judgment task was used to compare neural activation across groups and to assess whether associations with social functioning, measured by the Social Responsiveness Scale (SRS), reflected familial risk or dimensional continuity across the autism spectrum. Group comparisons revealed a graded endophenotypic pattern in inferior frontal gyrus (IFG) activation, with reduced activation in ASD and intermediate responses in SIB. The middle temporal gyrus (MTG) showed a similar but weaker gradient, with SIB not differing significantly from TD. Both ASD and SIB also demonstrated heightened cuneus activation, consistent with a heritable compensatory shift toward perceptual processing. Importantly, reduced MTG activation, along with a weaker marginal pattern in the IFG, was associated with higher SRS scores in both the familial and full samples, suggesting an association between semantic activation and social functioning. These findings clarify how familial liability and dimensional variation jointly shape the neural organization of semantic processing and social functioning in ASD. En ligne : https://doi.org/10.1002/aur.70320 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Neural Endophenotypes of Semantic Processing and Social Functioning in Autism Spectrum Disorder [texte imprimé] / Shu-Hui LEE, Auteur ; Chuan-Ching LIAO, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur . - p. e70320. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70320 Mots-clés : autism spectrum disorder  endophenotype  fMRI  semantic  social Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is highly heritable; however, the neural architecture underlying semantic processing and social functioning, and the extent to which it reflects familial liability, remains insufficiently understood. Unaffected siblings (SIB), who share substantial genetic liability with individuals with ASD, offer a critical framework for identifying intermediate neural phenotypes. We examined 36 individuals with ASD, 36 SIB, and 37 typically developing (TD) controls, matched for age, IQ, and handedness. Functional magnetic resonance imaging (fMRI) during a semantic judgment task was used to compare neural activation across groups and to assess whether associations with social functioning, measured by the Social Responsiveness Scale (SRS), reflected familial risk or dimensional continuity across the autism spectrum. Group comparisons revealed a graded endophenotypic pattern in inferior frontal gyrus (IFG) activation, with reduced activation in ASD and intermediate responses in SIB. The middle temporal gyrus (MTG) showed a similar but weaker gradient, with SIB not differing significantly from TD. Both ASD and SIB also demonstrated heightened cuneus activation, consistent with a heritable compensatory shift toward perceptual processing. Importantly, reduced MTG activation, along with a weaker marginal pattern in the IFG, was associated with higher SRS scores in both the familial and full samples, suggesting an association between semantic activation and social functioning. These findings clarify how familial liability and dimensional variation jointly shape the neural organization of semantic processing and social functioning in ASD. En ligne : https://doi.org/10.1002/aur.70320 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

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