Familial aggregation of attention-deficit/hyperactivity disorder / Qi CHEN in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.231-239 Titre : Familial aggregation of attention-deficit/hyperactivity disorder Type de document : texte imprimé Auteurs : Qi CHEN, Auteur ; Isabell BRIKELL, Auteur ; Paul LICHTENSTEIN, Auteur ; Eva SERLACHIUS, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Sven SANDIN, Auteur ; Henrik LARSSON, Auteur Article en page(s) : p.231-239 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  diagnosis  family factor  sex differences  adulthood Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) aggregates in families. To date, the strength, pattern, and characteristics of the familial aggregation have not been thoroughly assessed in a population-based family sample. Methods In this cohort study, we identified relative pairs of twins, full and half-siblings, and full and half cousins from 1,656,943 unique individuals born in Sweden between 1985 and 2006. The relatives of index persons were followed from their third birthday to 31 December 2009 for ADHD diagnosis. Birth year adjusted hazard ratio (HR), that is, the rate of ADHD in relatives of ADHD-affected index persons compared with the rate of ADHD in relatives of unaffected index persons, was estimated in the different types of relatives using Cox proportional hazards model. Results During the follow-up, 31,865 individuals were diagnosed with ADHD (male to female ratio was 3.7). The birth year adjusted HRs were as follows: 70.45 for monozygotic twins; 8.44 for dizygotic twins; 8.27 for full siblings; 2.86 for maternal half-siblings; 2.31 for paternal half-siblings; 2.24 for full cousins; 1.47 for half cousins. Maternal half-siblings had significantly higher HR than in paternal half-siblings. The HR did not seem to be affected by index person's sex. Full siblings of index persons with ADHD diagnosis present at age 18 or older had a higher rate of ADHD (HR: 11.49) than full siblings of index persons with ADHD diagnosis only before age 18 (HR: 4.68). Conclusions Familial aggregation of ADHD increases with increasing genetic relatedness. The familial aggregation is driven by not only genetic factors but also a small amount of shared environmental factors. Persistence of ADHD into adulthood indexes stronger familial aggregation of ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Familial aggregation of attention-deficit/hyperactivity disorder [texte imprimé] / Qi CHEN, Auteur ; Isabell BRIKELL, Auteur ; Paul LICHTENSTEIN, Auteur ; Eva SERLACHIUS, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Sven SANDIN, Auteur ; Henrik LARSSON, Auteur . - p.231-239. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.231-239 Mots-clés : Attention-deficit/hyperactivity disorder  diagnosis  family factor  sex differences  adulthood Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) aggregates in families. To date, the strength, pattern, and characteristics of the familial aggregation have not been thoroughly assessed in a population-based family sample. Methods In this cohort study, we identified relative pairs of twins, full and half-siblings, and full and half cousins from 1,656,943 unique individuals born in Sweden between 1985 and 2006. The relatives of index persons were followed from their third birthday to 31 December 2009 for ADHD diagnosis. Birth year adjusted hazard ratio (HR), that is, the rate of ADHD in relatives of ADHD-affected index persons compared with the rate of ADHD in relatives of unaffected index persons, was estimated in the different types of relatives using Cox proportional hazards model. Results During the follow-up, 31,865 individuals were diagnosed with ADHD (male to female ratio was 3.7). The birth year adjusted HRs were as follows: 70.45 for monozygotic twins; 8.44 for dizygotic twins; 8.27 for full siblings; 2.86 for maternal half-siblings; 2.31 for paternal half-siblings; 2.24 for full cousins; 1.47 for half cousins. Maternal half-siblings had significantly higher HR than in paternal half-siblings. The HR did not seem to be affected by index person's sex. Full siblings of index persons with ADHD diagnosis present at age 18 or older had a higher rate of ADHD (HR: 11.49) than full siblings of index persons with ADHD diagnosis only before age 18 (HR: 4.68). Conclusions Familial aggregation of ADHD increases with increasing genetic relatedness. The familial aggregation is driven by not only genetic factors but also a small amount of shared environmental factors. Persistence of ADHD into adulthood indexes stronger familial aggregation of ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Parental incarceration and psychiatric disorders, suicidal behavior, risk-taking, and substance misuse events in offspring: A longitudinal within-individual study / Aurora JÄRVINEN in Journal of Child Psychology and Psychiatry, 67-9 (September 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-9 (September 2026) . - p.1476-1487 Titre : Parental incarceration and psychiatric disorders, suicidal behavior, risk-taking, and substance misuse events in offspring: A longitudinal within-individual study Type de document : texte imprimé Auteurs : Aurora JÄRVINEN, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Isabell BRIKELL, Auteur ; Zheng CHANG, Auteur ; Brian M. D'ONOFRIO, Auteur ; Seena FAZEL, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Antti LATVALA, Auteur Article en page(s) : p.1476-1487 Langues : Anglais (eng) Mots-clés : Parental incarceration  intergenerational relations  psychopathology  behavioral problems  register-based study  quasi-experimental study Index. décimale : PER Périodiques Résumé : Background Parental incarceration (PI) is associated with mental and behavioral problems in offspring, but causality remains unclear. We conducted a quasi-experimental within-individual study on the associations of PI with offspring psychiatric disorders, suicidal behavior, risk-taking, and substance misuse events, aiming to test the effect of PI on offspring. Methods The study included 43,011 and 5,912 individuals born in Sweden 1973?2010 and exposed to paternal or maternal incarceration, respectively, between ages 10 and 30. Using data from nationwide registers available until the end of 2020, we examined associations between PI and offspring time-varying events in a longitudinal within-individual design to control for time-invariant confounding. We further studied potential moderation effects in within-individual models by offspring sex, family living arrangements, age, and other factors. For comparison, we conducted corresponding between-individual analyses. Results Overall, no clear within-individual associations between paternal or maternal incarceration and offspring events were observed (HRs 0.99?1.08 and 0.82?1.03, respectively), but in a sensitivity analysis, the first recorded exposure to PI was associated with a slightly increased risk of some events (HRs 1.08?1.10). Regarding moderation effects, preliminary evidence suggested that child?father coresiding, paternal offending type, and exposure age slightly moderated the within-individual associations for certain outcomes. Statistically significant associations were found in all between-individual models. Conclusions The elevated rates of mental and behavioral problems among offspring exposed to PI are unlikely to be due to a direct impact of PI, but an impact may exist under certain circumstances. These findings can help in targeting support to this vulnerable group. En ligne : https://doi.org/10.1111/jcpp.70152 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Parental incarceration and psychiatric disorders, suicidal behavior, risk-taking, and substance misuse events in offspring: A longitudinal within-individual study [texte imprimé] / Aurora JÄRVINEN, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Isabell BRIKELL, Auteur ; Zheng CHANG, Auteur ; Brian M. D'ONOFRIO, Auteur ; Seena FAZEL, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Antti LATVALA, Auteur . - p.1476-1487. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-9 (September 2026) . - p.1476-1487 Mots-clés : Parental incarceration  intergenerational relations  psychopathology  behavioral problems  register-based study  quasi-experimental study Index. décimale : PER Périodiques Résumé : Background Parental incarceration (PI) is associated with mental and behavioral problems in offspring, but causality remains unclear. We conducted a quasi-experimental within-individual study on the associations of PI with offspring psychiatric disorders, suicidal behavior, risk-taking, and substance misuse events, aiming to test the effect of PI on offspring. Methods The study included 43,011 and 5,912 individuals born in Sweden 1973?2010 and exposed to paternal or maternal incarceration, respectively, between ages 10 and 30. Using data from nationwide registers available until the end of 2020, we examined associations between PI and offspring time-varying events in a longitudinal within-individual design to control for time-invariant confounding. We further studied potential moderation effects in within-individual models by offspring sex, family living arrangements, age, and other factors. For comparison, we conducted corresponding between-individual analyses. Results Overall, no clear within-individual associations between paternal or maternal incarceration and offspring events were observed (HRs 0.99?1.08 and 0.82?1.03, respectively), but in a sensitivity analysis, the first recorded exposure to PI was associated with a slightly increased risk of some events (HRs 1.08?1.10). Regarding moderation effects, preliminary evidence suggested that child?father coresiding, paternal offending type, and exposure age slightly moderated the within-individual associations for certain outcomes. Statistically significant associations were found in all between-individual models. Conclusions The elevated rates of mental and behavioral problems among offspring exposed to PI are unlikely to be due to a direct impact of PI, but an impact may exist under certain circumstances. These findings can help in targeting support to this vulnerable group. En ligne : https://doi.org/10.1111/jcpp.70152 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Sex differences in psychiatric diagnoses preceding autism diagnosis and their stability post autism diagnosis / Miriam I. MARTINI in Journal of Child Psychology and Psychiatry, 66-8 (August 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1170-1181 Titre : Sex differences in psychiatric diagnoses preceding autism diagnosis and their stability post autism diagnosis Type de document : texte imprimé Auteurs : Miriam I. MARTINI, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Agnieszka BUTWICKA, Auteur ; Ebba DU RIETZ, Auteur ; Aleksandra KANINA, Auteur ; Isabell BRIKELL, Auteur ; Zheng CHANG, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Sven BÖLTE, Auteur ; Francesca HAPPE, Auteur ; Mark J. TAYLOR, Auteur Article en page(s) : p.1170-1181 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  sex differences  psychiatric diagnoses  follow-up study Index. décimale : PER Périodiques Résumé : Background Autistic individuals often receive psychiatric diagnoses prior to their autism diagnosis. It remains unclear to what extent autistic females and males differ in their likelihood of receiving psychiatric diagnoses prior to their autism diagnosis and continue seeking care for them after an autism diagnosis. Methods In a nationwide cohort of all individuals born in Sweden 1990 2015 with a clinical autism diagnosis (N 72,331, nfemales 24,110), we used linear and logistic regression to estimate the association between sex and (a) psychiatric diagnoses before autism diagnosis, including time trends by autism diagnosis year (2010 2020), (b) autism diagnosis age in those with preceding diagnoses, (c) stability of preceding diagnoses (defined as continued care utilization indicated through diagnosis or medication in the 5 years following autism diagnosis). Results In total 54.2% of autistic females and 40.9% of autistic males received at least one preceding psychiatric diagnosis (most common: ADHD, anxiety, depression). Autistic females showed higher odds than males for most preceding psychiatric diagnoses (ORrange 1.29 [1.18, 1.41] 10.69 [8.06, 14.17]), except psychotic disorders (OR 0.91 [0.78, 1.06]) and ADHD (OR 0.69 [0.66, 0.71]). Sex differences in preceding diagnoses were persistent across different autism diagnosis years (2010 2020). For most conditions, females with a preceding diagnosis were diagnosed with autism later than males with the same condition. For both sexes, the stability of preceding diagnoses varied considerably (23.1% 88.9%) and was less than 50% for most diagnoses. Females showed a higher stability for anxiety, sleep disorders and self-harm (ORrange 1.45 [1.30, 1.62] 2.37 [1.93, 2.90]), and males for psychotic disorders (OR 0.60 [0.44, 0.81]). Conclusions Autistic females are more likely to be diagnosed with psychiatric conditions prior to an autism diagnosis and receive care for them post autism diagnosis. Our findings emphasize the variability of clinical presentation and importance of disentangling persistent support needs from overlapping diagnostic presentations, particularly in autistic females, to provide appropriate and timely care. En ligne : https://doi.org/10.1111/jcpp.14130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Sex differences in psychiatric diagnoses preceding autism diagnosis and their stability post autism diagnosis [texte imprimé] / Miriam I. MARTINI, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Agnieszka BUTWICKA, Auteur ; Ebba DU RIETZ, Auteur ; Aleksandra KANINA, Auteur ; Isabell BRIKELL, Auteur ; Zheng CHANG, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Sven BÖLTE, Auteur ; Francesca HAPPE, Auteur ; Mark J. TAYLOR, Auteur . - p.1170-1181. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1170-1181 Mots-clés : Autism spectrum disorder  sex differences  psychiatric diagnoses  follow-up study Index. décimale : PER Périodiques Résumé : Background Autistic individuals often receive psychiatric diagnoses prior to their autism diagnosis. It remains unclear to what extent autistic females and males differ in their likelihood of receiving psychiatric diagnoses prior to their autism diagnosis and continue seeking care for them after an autism diagnosis. Methods In a nationwide cohort of all individuals born in Sweden 1990 2015 with a clinical autism diagnosis (N 72,331, nfemales 24,110), we used linear and logistic regression to estimate the association between sex and (a) psychiatric diagnoses before autism diagnosis, including time trends by autism diagnosis year (2010 2020), (b) autism diagnosis age in those with preceding diagnoses, (c) stability of preceding diagnoses (defined as continued care utilization indicated through diagnosis or medication in the 5 years following autism diagnosis). Results In total 54.2% of autistic females and 40.9% of autistic males received at least one preceding psychiatric diagnosis (most common: ADHD, anxiety, depression). Autistic females showed higher odds than males for most preceding psychiatric diagnoses (ORrange 1.29 [1.18, 1.41] 10.69 [8.06, 14.17]), except psychotic disorders (OR 0.91 [0.78, 1.06]) and ADHD (OR 0.69 [0.66, 0.71]). Sex differences in preceding diagnoses were persistent across different autism diagnosis years (2010 2020). For most conditions, females with a preceding diagnosis were diagnosed with autism later than males with the same condition. For both sexes, the stability of preceding diagnoses varied considerably (23.1% 88.9%) and was less than 50% for most diagnoses. Females showed a higher stability for anxiety, sleep disorders and self-harm (ORrange 1.45 [1.30, 1.62] 2.37 [1.93, 2.90]), and males for psychotic disorders (OR 0.60 [0.44, 0.81]). Conclusions Autistic females are more likely to be diagnosed with psychiatric conditions prior to an autism diagnosis and receive care for them post autism diagnosis. Our findings emphasize the variability of clinical presentation and importance of disentangling persistent support needs from overlapping diagnostic presentations, particularly in autistic females, to provide appropriate and timely care. En ligne : https://doi.org/10.1111/jcpp.14130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

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