Autism Spectrum Disorder Symptoms in Infants with Fragile X Syndrome: A Prospective Case Series / Abigail L. HOGAN in Journal of Autism and Developmental Disorders, 47-6 (June 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1628-1644 Titre : Autism Spectrum Disorder Symptoms in Infants with Fragile X Syndrome: A Prospective Case Series Type de document : texte imprimé Auteurs : Abigail L. HOGAN, Auteur ; Kelly E. CARAVELLA, Auteur ; Jordan EZELL, Auteur ; Lisa RAGUE, Auteur ; Kimberly HILLS, Auteur ; Jane E. ROBERTS, Auteur Article en page(s) : p.1628-1644 Langues : Anglais (eng) Mots-clés : Fragile X syndrome  Autism spectrum disorder  Infants  Case studies Index. décimale : PER Périodiques Résumé : No studies to date have prospectively examined early autism spectrum disorder (ASD) markers in infants with fragile X syndrome (FXS), who are at elevated risk for ASD. This paper describes the developmental profiles of eight infants with FXS from 9 to 24 months of age. Four meet diagnostic criteria for ASD at 24 months of age, and four do not. Trends in these case studies suggest that early social-communicative deficits differentiate infants with and without later ASD diagnoses in ways that are similar to later-born siblings of children with ASD. Repetitive behaviors and cognitive and adaptive impairments are present in all FXS infants throughout development, suggesting that these deficits reflect the general FXS phenotype and not ASD in FXS specifically. En ligne : http://dx.doi.org/10.1007/s10803-017-3081-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] Autism Spectrum Disorder Symptoms in Infants with Fragile X Syndrome: A Prospective Case Series [texte imprimé] / Abigail L. HOGAN, Auteur ; Kelly E. CARAVELLA, Auteur ; Jordan EZELL, Auteur ; Lisa RAGUE, Auteur ; Kimberly HILLS, Auteur ; Jane E. ROBERTS, Auteur . - p.1628-1644. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1628-1644 Mots-clés : Fragile X syndrome  Autism spectrum disorder  Infants  Case studies Index. décimale : PER Périodiques Résumé : No studies to date have prospectively examined early autism spectrum disorder (ASD) markers in infants with fragile X syndrome (FXS), who are at elevated risk for ASD. This paper describes the developmental profiles of eight infants with FXS from 9 to 24 months of age. Four meet diagnostic criteria for ASD at 24 months of age, and four do not. Trends in these case studies suggest that early social-communicative deficits differentiate infants with and without later ASD diagnoses in ways that are similar to later-born siblings of children with ASD. Repetitive behaviors and cognitive and adaptive impairments are present in all FXS infants throughout development, suggesting that these deficits reflect the general FXS phenotype and not ASD in FXS specifically. En ligne : http://dx.doi.org/10.1007/s10803-017-3081-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

Brief Report: Prevalence and Predictors of DSM-Specific and Distinct Anxiety in Cognitively Impaired Autistic Preschool Children / Connor M. KERNS ; Kimberly HILLS ; Abigail L. HOGAN-BROWN ; Sara MATHERLY ; Jane E. ROBERTS in Journal of Autism and Developmental Disorders, 55-5 (May 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-5 (May 2025) . - p.1923-1931 Titre : Brief Report: Prevalence and Predictors of DSM-Specific and Distinct Anxiety in Cognitively Impaired Autistic Preschool Children Type de document : texte imprimé Auteurs : Connor M. KERNS, Auteur ; Kimberly HILLS, Auteur ; Abigail L. HOGAN-BROWN, Auteur ; Sara MATHERLY, Auteur ; Jane E. ROBERTS, Auteur Article en page(s) : p.1923-1931 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autistic individuals are twice as likely to meet criteria for anxiety than neurotypical children; yet we lack understanding of early presentations of anxiety in young autistic children, especially those with cognitive impairment. This study is the first to utilize an autism-specific anxiety diagnostic interview with 28 preschool cognitively impaired, autistic children and 18 neurotypical, age-matched controls. Results indicate that 64% of autistic children met criteria for DSM-specified or "other specified," herein referred to as "distinct," anxiety disorders; 32% met criteria for multiple anxiety disorders, with phobias occurring most often. Results indicate that anxiety is highly prevalent in cognitively-impaired, autistic preschool children, highlighting the need for developmentally-tailored assessment and treatment in early childhood. En ligne : https://doi.org/10.1007/s10803-023-05978-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Brief Report: Prevalence and Predictors of DSM-Specific and Distinct Anxiety in Cognitively Impaired Autistic Preschool Children [texte imprimé] / Connor M. KERNS, Auteur ; Kimberly HILLS, Auteur ; Abigail L. HOGAN-BROWN, Auteur ; Sara MATHERLY, Auteur ; Jane E. ROBERTS, Auteur . - p.1923-1931. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-5 (May 2025) . - p.1923-1931 Index. décimale : PER Périodiques Résumé : Autistic individuals are twice as likely to meet criteria for anxiety than neurotypical children; yet we lack understanding of early presentations of anxiety in young autistic children, especially those with cognitive impairment. This study is the first to utilize an autism-specific anxiety diagnostic interview with 28 preschool cognitively impaired, autistic children and 18 neurotypical, age-matched controls. Results indicate that 64% of autistic children met criteria for DSM-specified or "other specified," herein referred to as "distinct," anxiety disorders; 32% met criteria for multiple anxiety disorders, with phobias occurring most often. Results indicate that anxiety is highly prevalent in cognitively-impaired, autistic preschool children, highlighting the need for developmentally-tailored assessment and treatment in early childhood. En ligne : https://doi.org/10.1007/s10803-023-05978-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Developmental associations between motor and communication outcomes in Fragile X syndrome: Variation in the context of co-occurring autism / Kimberly HILLS ; Kayla SMITH ; Samuel MCQUILLIN ; Jane E. ROBERTS in Autism, 28-9 (September 2024)  

Public ISBD [article]  inAutism > 28-9 (September 2024) . - p.2191-2203 Titre : Developmental associations between motor and communication outcomes in Fragile X syndrome: Variation in the context of co-occurring autism Type de document : texte imprimé Auteurs : Kimberly HILLS, Auteur ; Kayla SMITH, Auteur ; Samuel MCQUILLIN, Auteur ; Jane E. ROBERTS, Auteur Article en page(s) : p.2191-2203 Langues : (en) Mots-clés : autism spectrum disorder  communication  development  Fragile X syndrome  motor development Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS), the leading heritable cause of intellectual disability, has a co-occurrence rate of autism spectrum disorder (ASD) estimated at ~60%. The onset and rates of motor development in FXS are slower relative to neurotypical development, and even more so in the context of co-occurring FXS+ASD. Extant evidence suggests these differences are likely to affect communication, yet this developmental process or how it varies in the context of co-occurring ASD remains unknown in FXS. We aimed to delineate developmental associations between early motor abilities and their rate of development from 9 to 60 months of age on communication outcomes in 51 children with FXS, 28 of whom had co-occurring ASD. We also aimed to identify variation in these developmental associations in the context of co-occurring ASD. Results captured within-syndrome variability in these developmental associations as a function of co-occurring ASD. Fine motor proved to be a robust predictor of receptive communication regardless of co-occurring ASD, but we identified differences between FXS with and without ASD in the association between aspects of motor development and expressive outcomes. Findings provide evidence for differential developmental processes in the context of co-occurring ASD with implications for timely developmental intervention. Lay abstract Fragile X syndrome (FXS), the leading heritable cause of intellectual disability, has a co-occurrence rate of autism spectrum disorder (ASD) estimated at ~60%. Children with FXS experience delayed achievement and slower development of key motor abilities, which happens to an even greater extent for children with both FXS and ASD. A multitude of studies have demonstrated that motor abilities are foundational skills related to later communication outcomes in neurotypical development, as well as in the context of ASD. However, these associations remain unexamined in FXS, or FXS+ASD. In this study, we aimed to determine the associations between early motor skills and their rate of development on communication outcomes in FXS. Furthermore, we investigated whether these associations varied in the context of co-occurring FXS+ASD. Results revealed within-FXS variation in the context of co-occurring ASD between some aspects of motor development and communication outcomes, yet within-FXS consistency between others. Findings provide evidence for variability in developmental processes and outcomes in FXS in the context of co-occurring ASD and offer implications for intervention. En ligne : https://dx.doi.org/10.1177/13623613231225498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Developmental associations between motor and communication outcomes in Fragile X syndrome: Variation in the context of co-occurring autism [texte imprimé] / Kimberly HILLS, Auteur ; Kayla SMITH, Auteur ; Samuel MCQUILLIN, Auteur ; Jane E. ROBERTS, Auteur . - p.2191-2203. Langues : (en) in Autism > 28-9 (September 2024) . - p.2191-2203 Mots-clés : autism spectrum disorder  communication  development  Fragile X syndrome  motor development Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS), the leading heritable cause of intellectual disability, has a co-occurrence rate of autism spectrum disorder (ASD) estimated at ~60%. The onset and rates of motor development in FXS are slower relative to neurotypical development, and even more so in the context of co-occurring FXS+ASD. Extant evidence suggests these differences are likely to affect communication, yet this developmental process or how it varies in the context of co-occurring ASD remains unknown in FXS. We aimed to delineate developmental associations between early motor abilities and their rate of development from 9 to 60 months of age on communication outcomes in 51 children with FXS, 28 of whom had co-occurring ASD. We also aimed to identify variation in these developmental associations in the context of co-occurring ASD. Results captured within-syndrome variability in these developmental associations as a function of co-occurring ASD. Fine motor proved to be a robust predictor of receptive communication regardless of co-occurring ASD, but we identified differences between FXS with and without ASD in the association between aspects of motor development and expressive outcomes. Findings provide evidence for differential developmental processes in the context of co-occurring ASD with implications for timely developmental intervention. Lay abstract Fragile X syndrome (FXS), the leading heritable cause of intellectual disability, has a co-occurrence rate of autism spectrum disorder (ASD) estimated at ~60%. Children with FXS experience delayed achievement and slower development of key motor abilities, which happens to an even greater extent for children with both FXS and ASD. A multitude of studies have demonstrated that motor abilities are foundational skills related to later communication outcomes in neurotypical development, as well as in the context of ASD. However, these associations remain unexamined in FXS, or FXS+ASD. In this study, we aimed to determine the associations between early motor skills and their rate of development on communication outcomes in FXS. Furthermore, we investigated whether these associations varied in the context of co-occurring FXS+ASD. Results revealed within-FXS variation in the context of co-occurring ASD between some aspects of motor development and communication outcomes, yet within-FXS consistency between others. Findings provide evidence for variability in developmental processes and outcomes in FXS in the context of co-occurring ASD and offer implications for intervention. En ligne : https://dx.doi.org/10.1177/13623613231225498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Emergence and rate of autism in fragile X syndrome across the first years of life / Jane E. ROBERTS in Development and Psychopathology, 32-4 (October 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-4 (October 2020) . - p.1335-1352 Titre : Emergence and rate of autism in fragile X syndrome across the first years of life Type de document : texte imprimé Auteurs : Jane E. ROBERTS, Auteur ; Jessica BRADSHAW, Auteur ; Elizabeth A. WILL, Auteur ; Abigail L. HOGAN, Auteur ; Samuel MCQUILLIN, Auteur ; Kimberly HILLS, Auteur Article en page(s) : p.1335-1352 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  developmental trajectory  early identification  fragile X syndrome  infants Index. décimale : PER Périodiques Résumé : Prospective longitudinal studies of idiopathic autism spectrum disorder (ASD) have provided insights into early symptoms and predictors of ASD during infancy, well before ASD can be diagnosed at age 2-3 years. However, research on the emergence of ASD in disorders with a known genetic etiology, contextualized in a developmental framework, is currently lacking. Using a biobehavioral multimethod approach, we (a) determined the rate of ASD in N = 51 preschoolers with fragile X syndrome (FXS) using a clinical best estimate (CBE) procedure with differential diagnoses of comorbid psychiatric disorders and (b) investigated trajectories of ASD symptoms and physiological arousal across infancy as predictors of ASD in preschoolers with FXS. ASD was not diagnosed if intellectual ability or psychiatric disorders better accounted for the symptoms. Our results determined that 60.7% of preschoolers with FXS met the Diagnostic and Statistical Manual of Mental Disorders (fifth edition) (DSM-5) criteria for ASD using the CBE procedure. In addition, 92% of these preschoolers presented with developmental delay and 45.4% also met criteria for psychiatric disorders, either anxiety, ADHD, or both. ASD diagnoses in preschoolers with FXS were predicted by elevated scores on traditional ASD screeners in addition to elevated autonomic arousal and avoidant eye contact from infancy. En ligne : http://dx.doi.org/10.1017/s0954579420000942 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Emergence and rate of autism in fragile X syndrome across the first years of life [texte imprimé] / Jane E. ROBERTS, Auteur ; Jessica BRADSHAW, Auteur ; Elizabeth A. WILL, Auteur ; Abigail L. HOGAN, Auteur ; Samuel MCQUILLIN, Auteur ; Kimberly HILLS, Auteur . - p.1335-1352. Langues : Anglais (eng) in Development and Psychopathology > 32-4 (October 2020) . - p.1335-1352 Mots-clés : autism spectrum disorder  developmental trajectory  early identification  fragile X syndrome  infants Index. décimale : PER Périodiques Résumé : Prospective longitudinal studies of idiopathic autism spectrum disorder (ASD) have provided insights into early symptoms and predictors of ASD during infancy, well before ASD can be diagnosed at age 2-3 years. However, research on the emergence of ASD in disorders with a known genetic etiology, contextualized in a developmental framework, is currently lacking. Using a biobehavioral multimethod approach, we (a) determined the rate of ASD in N = 51 preschoolers with fragile X syndrome (FXS) using a clinical best estimate (CBE) procedure with differential diagnoses of comorbid psychiatric disorders and (b) investigated trajectories of ASD symptoms and physiological arousal across infancy as predictors of ASD in preschoolers with FXS. ASD was not diagnosed if intellectual ability or psychiatric disorders better accounted for the symptoms. Our results determined that 60.7% of preschoolers with FXS met the Diagnostic and Statistical Manual of Mental Disorders (fifth edition) (DSM-5) criteria for ASD using the CBE procedure. In addition, 92% of these preschoolers presented with developmental delay and 45.4% also met criteria for psychiatric disorders, either anxiety, ADHD, or both. ASD diagnoses in preschoolers with FXS were predicted by elevated scores on traditional ASD screeners in addition to elevated autonomic arousal and avoidant eye contact from infancy. En ligne : http://dx.doi.org/10.1017/s0954579420000942 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

Life Satisfaction in Adolescents with Autism Spectrum Disorder / Kathleen Blackburn FRANKE in Journal of Autism and Developmental Disorders, 49-3 (March 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.1205-1218 Titre : Life Satisfaction in Adolescents with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Kathleen Blackburn FRANKE, Auteur ; Kimberly HILLS, Auteur ; E. Scott HUEBNER, Auteur ; Kate FLORY, Auteur Article en page(s) : p.1205-1218 Langues : Anglais (eng) Mots-clés : Adolescence  Autism spectrum disorder  High-functioning autism spectrum disorder  Life satisfaction  Positive psychology  Psychosocial assets Index. décimale : PER Périodiques Résumé : We provided evidence regarding the reliability and validity of measures of assets and life satisfaction (LS) for adolescents with autism spectrum disorder (ASD). We identified levels of LS within this population, compared these levels to those of typically developing adolescents, and described the relation between assets and LS. Forty-six adolescents with ASD and their caregivers completed questionnaires assessing LS and assets. Preliminary support was provided for the internal consistency reliability and validity of these measures in adolescents with ASD. Youth with ASD reported moderate to high levels of LS; these were lower than those of typically developing peers. Age moderated the relation between self-reported LS and some assets. Implications were discussed within the context of Schalock's (J Disabil Policy Stud 14:204-215, 2004) emerging disability paradigm. En ligne : http://dx.doi.org/10.1007/s10803-018-3822-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Life Satisfaction in Adolescents with Autism Spectrum Disorder [texte imprimé] / Kathleen Blackburn FRANKE, Auteur ; Kimberly HILLS, Auteur ; E. Scott HUEBNER, Auteur ; Kate FLORY, Auteur . - p.1205-1218. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.1205-1218 Mots-clés : Adolescence  Autism spectrum disorder  High-functioning autism spectrum disorder  Life satisfaction  Positive psychology  Psychosocial assets Index. décimale : PER Périodiques Résumé : We provided evidence regarding the reliability and validity of measures of assets and life satisfaction (LS) for adolescents with autism spectrum disorder (ASD). We identified levels of LS within this population, compared these levels to those of typically developing adolescents, and described the relation between assets and LS. Forty-six adolescents with ASD and their caregivers completed questionnaires assessing LS and assets. Preliminary support was provided for the internal consistency reliability and validity of these measures in adolescents with ASD. Youth with ASD reported moderate to high levels of LS; these were lower than those of typically developing peers. Age moderated the relation between self-reported LS and some assets. Implications were discussed within the context of Schalock's (J Disabil Policy Stud 14:204-215, 2004) emerging disability paradigm. En ligne : http://dx.doi.org/10.1007/s10803-018-3822-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

Prevalence and Predictors of Anxiety Disorders in Adolescent and Adult Males with Autism Spectrum Disorder and Fragile X Syndrome / Jordan EZELL in Journal of Autism and Developmental Disorders, 49-3 (March 2019)  

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