Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders / Khaled SAAD in Journal of Autism and Developmental Disorders, 47-9 (September 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-9 (September 2017) . - p.2671-2678 Titre : Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Khaled SAAD, Auteur ; Asmaa M. ZAHRAN, Auteur ; Khalid I. ELSAYH, Auteur ; Ahmed A. ABDEL-RAHMAN, Auteur ; Abdulrahman A. AL-ATRAM, Auteur ; Almontaser HUSSEIN, Auteur ; Yasmin G. EL-GENDY, Auteur Article en page(s) : p.2671-2678 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Dendritic cells  Innate immunity  Children Index. décimale : PER Périodiques Résumé : The aim of our study was to evaluate the frequencies of myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) in children with ASD. Subjects were 32 children with ASD and 30 healthy children as controls. The numbers of mDCs and pDCs and the expression of CD86 and CD80 on the entire DCs were detected by flow cytometry. ASD children had significantly higher percentages of mDCs and pDCs when compared to controls. We found significant inverse relationships between serum 25-hydroxyvitamin D levels and the frequencies of mDCs and pDCs in autistic children. Our data suggested that DCs could play a role in the clinical course of ASD. The relationship of DCs to immune disorders in ASD remains to be determined. En ligne : https://doi.org/10.1007/s10803-017-3190-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=315 [article] Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Khaled SAAD, Auteur ; Asmaa M. ZAHRAN, Auteur ; Khalid I. ELSAYH, Auteur ; Ahmed A. ABDEL-RAHMAN, Auteur ; Abdulrahman A. AL-ATRAM, Auteur ; Almontaser HUSSEIN, Auteur ; Yasmin G. EL-GENDY, Auteur . - p.2671-2678. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-9 (September 2017) . - p.2671-2678 Mots-clés : Autism spectrum disorders  Dendritic cells  Innate immunity  Children Index. décimale : PER Périodiques Résumé : The aim of our study was to evaluate the frequencies of myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) in children with ASD. Subjects were 32 children with ASD and 30 healthy children as controls. The numbers of mDCs and pDCs and the expression of CD86 and CD80 on the entire DCs were detected by flow cytometry. ASD children had significantly higher percentages of mDCs and pDCs when compared to controls. We found significant inverse relationships between serum 25-hydroxyvitamin D levels and the frequencies of mDCs and pDCs in autistic children. Our data suggested that DCs could play a role in the clinical course of ASD. The relationship of DCs to immune disorders in ASD remains to be determined. En ligne : https://doi.org/10.1007/s10803-017-3190-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=315

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