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2-4 - August 2009 [Texte imprimé et/ou numérique] . - 2009.
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Code-barres | Cote | Support | Localisation | Section | Disponibilité |
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PER0000410 | PER ARI | Périodique | Centre d'Information et de Documentation du CRA Rhône-Alpes | PER - Périodiques | Exclu du prêt |
Dépouillements


Autism spectrum disorders in relation to parental occupation in technical fields / Gayle C. WINDHAM in Autism Research, 2-4 (August 2009)
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[article]
Titre : Autism spectrum disorders in relation to parental occupation in technical fields Type de document : Texte imprimé et/ou numérique Auteurs : Gayle C. WINDHAM, Auteur ; Judith K. GRETHER, Auteur ; Karen FESSEL, Auteur Année de publication : 2009 Article en page(s) : p.183-191 Langues : Anglais (eng) Mots-clés : autism parental-occupation broader-autism-phenotype risk-factors Index. décimale : PER Périodiques Résumé : A previous study reported that fathers of children with autism spectrum disorders (ASD) were more likely to work as engineers, requiring systemizing skills, and suggesting a distinct phenotype, but alternatively this may have been related to selection biases. We conducted a population-based study to explore whether fathers, or mothers, of children with ASD are over-represented in fields requiring highly technical skills. Subjects included 284 children with ASD and 659 gender-matched controls, born in 1994 in the San Francisco Bay Area. Parental occupation and industry were abstracted verbatim from birth certificates. Engineering, computer programming, and science were examined as highly technical occupations. To limit bias by parental socio-economic status, we selected a referent group of occupations that seemed professionally similar but of a less technical nature. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by logistic regression, adjusting for parental age, education, and child race. Mothers of cases were somewhat more likely to work in hi-tech occupations (6.7%) than mothers of controls (4.0%, P=0.07), but little difference was observed among fathers, nor for engineering separately. Compared to parents in other white collar occupations, the adjusted OR for highly technical occupations among mothers was 2.5 (95% CI: 1.2-5.3) and among fathers was 1.3 (95% CI: 0.79-2.1), with no evidence of a joint effect observed. Our results regarding maternal occupation in technical fields being associated with ASD in offspring suggest further study to distinguish parental occupation as a phenotypic marker of genetic loading vs. other social or exposure factors. En ligne : http://dx.doi.org/10.1002/aur.84 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=937
in Autism Research > 2-4 (August 2009) . - p.183-191[article] Autism spectrum disorders in relation to parental occupation in technical fields [Texte imprimé et/ou numérique] / Gayle C. WINDHAM, Auteur ; Judith K. GRETHER, Auteur ; Karen FESSEL, Auteur . - 2009 . - p.183-191.
Langues : Anglais (eng)
in Autism Research > 2-4 (August 2009) . - p.183-191
Mots-clés : autism parental-occupation broader-autism-phenotype risk-factors Index. décimale : PER Périodiques Résumé : A previous study reported that fathers of children with autism spectrum disorders (ASD) were more likely to work as engineers, requiring systemizing skills, and suggesting a distinct phenotype, but alternatively this may have been related to selection biases. We conducted a population-based study to explore whether fathers, or mothers, of children with ASD are over-represented in fields requiring highly technical skills. Subjects included 284 children with ASD and 659 gender-matched controls, born in 1994 in the San Francisco Bay Area. Parental occupation and industry were abstracted verbatim from birth certificates. Engineering, computer programming, and science were examined as highly technical occupations. To limit bias by parental socio-economic status, we selected a referent group of occupations that seemed professionally similar but of a less technical nature. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by logistic regression, adjusting for parental age, education, and child race. Mothers of cases were somewhat more likely to work in hi-tech occupations (6.7%) than mothers of controls (4.0%, P=0.07), but little difference was observed among fathers, nor for engineering separately. Compared to parents in other white collar occupations, the adjusted OR for highly technical occupations among mothers was 2.5 (95% CI: 1.2-5.3) and among fathers was 1.3 (95% CI: 0.79-2.1), with no evidence of a joint effect observed. Our results regarding maternal occupation in technical fields being associated with ASD in offspring suggest further study to distinguish parental occupation as a phenotypic marker of genetic loading vs. other social or exposure factors. En ligne : http://dx.doi.org/10.1002/aur.84 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=937 Involuntary interpretation of social cues is compromised in autism spectrum disorders / Tjeerd JELLEMA in Autism Research, 2-4 (August 2009)
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[article]
Titre : Involuntary interpretation of social cues is compromised in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Tjeerd JELLEMA, Auteur ; Herman VAN ENGELAND, Auteur ; Chantal KEMNER, Auteur ; Sophie VAN RIJN, Auteur ; Jeannette LORTEIJE, Auteur ; Mascha VAN T'WOUT, Auteur ; Edward DE HAAN, Auteur Année de publication : 2009 Article en page(s) : p.192-204 Langues : Anglais (eng) Mots-clés : social-cognition visual-illusion involuntary-processing social-attention implied-motion Index. décimale : PER Périodiques Résumé : A new social distance judgment task was used to measure quantitatively the extent to which social cues are immediately and involuntary interpreted by typically developing (TD) individuals and by individuals with autism spectrum disorders (ASD). The task thus tapped into the ability to involuntary pick up the meaning of social cues. The cues tested were social attention and implied biological motion. Task performance of the ASD and TD groups was similarly affected by a perceptual low-level illusion induced by physical characteristics of the stimuli. In contrast, a high-level illusion induced by the implications of the social cues affected only the TD individuals; the ASD individuals remained unaffected (causing them to perform superior to TD controls). The results indicate that despite intact perceptual processing, the immediate involuntary interpretation of social cues can be compromised. We propose that this type of social cue understanding is a distinct process that should be differentiated from reflective social cue understanding and is specifically compromised in ASD. We discuss evidence for an underpinning neural substrate. En ligne : http://dx.doi.org/10.1002/aur.83 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=937
in Autism Research > 2-4 (August 2009) . - p.192-204[article] Involuntary interpretation of social cues is compromised in autism spectrum disorders [Texte imprimé et/ou numérique] / Tjeerd JELLEMA, Auteur ; Herman VAN ENGELAND, Auteur ; Chantal KEMNER, Auteur ; Sophie VAN RIJN, Auteur ; Jeannette LORTEIJE, Auteur ; Mascha VAN T'WOUT, Auteur ; Edward DE HAAN, Auteur . - 2009 . - p.192-204.
Langues : Anglais (eng)
in Autism Research > 2-4 (August 2009) . - p.192-204
Mots-clés : social-cognition visual-illusion involuntary-processing social-attention implied-motion Index. décimale : PER Périodiques Résumé : A new social distance judgment task was used to measure quantitatively the extent to which social cues are immediately and involuntary interpreted by typically developing (TD) individuals and by individuals with autism spectrum disorders (ASD). The task thus tapped into the ability to involuntary pick up the meaning of social cues. The cues tested were social attention and implied biological motion. Task performance of the ASD and TD groups was similarly affected by a perceptual low-level illusion induced by physical characteristics of the stimuli. In contrast, a high-level illusion induced by the implications of the social cues affected only the TD individuals; the ASD individuals remained unaffected (causing them to perform superior to TD controls). The results indicate that despite intact perceptual processing, the immediate involuntary interpretation of social cues can be compromised. We propose that this type of social cue understanding is a distinct process that should be differentiated from reflective social cue understanding and is specifically compromised in ASD. We discuss evidence for an underpinning neural substrate. En ligne : http://dx.doi.org/10.1002/aur.83 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=937 Decreased GABA A receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism / Adrian L. OBLAK in Autism Research, 2-4 (August 2009)
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[article]
Titre : Decreased GABA A receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism Type de document : Texte imprimé et/ou numérique Auteurs : Adrian L. OBLAK, Auteur ; Terrell T. GIBBS, Auteur ; Gene J. BLATT, Auteur Année de publication : 2009 Article en page(s) : p.205-219 Langues : Anglais (eng) Mots-clés : autistic anterior-cingulate-cortex GABA post-mortem ligand-binding Index. décimale : PER Périodiques Résumé : The anterior cingulate cortex (ACC; BA 24) via its extensive limbic and high order association cortical connectivity to prefrontal cortex is a key part of an important circuitry participating in executive function, affect, and socio-emotional behavior. Multiple lines of evidence, including genetic and imaging studies, suggest that the ACC and gamma-amino-butyric acid (GABA) system may be affected in autism. The benzodiazepine binding site on the GABAA receptor complex is an important target for pharmacotherapy and has important clinical implications. The present multiple-concentration ligand-binding study utilized 3H-muscimol and 3H-flunitrazepam to determine the number (Bmax), binding affinity (Kd), and distribution of GABAA receptors and benzodiazepine binding sites, respectively, in the ACC in adult autistic and control cases. Compared to controls, the autistic group had significant decreases in the mean density of GABAA receptors in the supragranular (46.8%) and infragranular (20.2%) layers of the ACC and in the density of benzodiazepine binding sites in the supragranular (28.9%) and infragranular (16.4%) lamina. In addition, a trend for a decrease in for the density of benzodiazepine sites was found in the infragranular layers (17.1%) in the autism group. These findings suggest that in the autistic group this downregulation of both benzodiazepine sites and GABAA receptors in the ACC may be the result of increased GABA innervation and/or release disturbing the delicate excitation/inhibition balance of principal neurons as well as their output to key limbic cortical targets. Such disturbances likely underlie the core alterations in socio-emotional behaviors in autism. En ligne : http://dx.doi.org/10.1002/aur.88 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=937
in Autism Research > 2-4 (August 2009) . - p.205-219[article] Decreased GABA A receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism [Texte imprimé et/ou numérique] / Adrian L. OBLAK, Auteur ; Terrell T. GIBBS, Auteur ; Gene J. BLATT, Auteur . - 2009 . - p.205-219.
Langues : Anglais (eng)
in Autism Research > 2-4 (August 2009) . - p.205-219
Mots-clés : autistic anterior-cingulate-cortex GABA post-mortem ligand-binding Index. décimale : PER Périodiques Résumé : The anterior cingulate cortex (ACC; BA 24) via its extensive limbic and high order association cortical connectivity to prefrontal cortex is a key part of an important circuitry participating in executive function, affect, and socio-emotional behavior. Multiple lines of evidence, including genetic and imaging studies, suggest that the ACC and gamma-amino-butyric acid (GABA) system may be affected in autism. The benzodiazepine binding site on the GABAA receptor complex is an important target for pharmacotherapy and has important clinical implications. The present multiple-concentration ligand-binding study utilized 3H-muscimol and 3H-flunitrazepam to determine the number (Bmax), binding affinity (Kd), and distribution of GABAA receptors and benzodiazepine binding sites, respectively, in the ACC in adult autistic and control cases. Compared to controls, the autistic group had significant decreases in the mean density of GABAA receptors in the supragranular (46.8%) and infragranular (20.2%) layers of the ACC and in the density of benzodiazepine binding sites in the supragranular (28.9%) and infragranular (16.4%) lamina. In addition, a trend for a decrease in for the density of benzodiazepine sites was found in the infragranular layers (17.1%) in the autism group. These findings suggest that in the autistic group this downregulation of both benzodiazepine sites and GABAA receptors in the ACC may be the result of increased GABA innervation and/or release disturbing the delicate excitation/inhibition balance of principal neurons as well as their output to key limbic cortical targets. Such disturbances likely underlie the core alterations in socio-emotional behaviors in autism. En ligne : http://dx.doi.org/10.1002/aur.88 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=937 Shared and idiosyncratic cortical activation patterns in autism revealed under continuous real-life viewing conditions / Uri HASSON in Autism Research, 2-4 (August 2009)
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[article]
Titre : Shared and idiosyncratic cortical activation patterns in autism revealed under continuous real-life viewing conditions Type de document : Texte imprimé et/ou numérique Auteurs : Uri HASSON, Auteur ; Nancy J. MINSHEW, Auteur ; Marlene BEHRMANN, Auteur ; Galia AVIDAN, Auteur ; Hagar GELBARD, Auteur ; Ignacio VALLINES, Auteur ; Michal HAREL, Auteur Année de publication : 2009 Article en page(s) : p.220-231 Langues : Anglais (eng) Mots-clés : autism inter-subject-correlation functional-magnetic-resonance-imaging-(fMRI) hyperconnectivity Index. décimale : PER Périodiques Résumé : Although widespread alterations in cortical structure have been documented in individuals with autism, the functional implications of these alterations remain to be determined. Here, we adopted a novel inter-subject correlation (inter-SC) and intra-subject correlation (intra-SC) technique to quantify the reliability of the spatio-temporal responses of functional MR activity in adults with autism during free-viewing of a popular audio-visual movie. Whereas these complex stimuli evoke highly reliable shared response time courses in typical individuals, cortical activity was more variable across individuals with autism (low inter-SC). Interestingly, when we measured the responses within an autistic individual across repeated presentations of the movie, we observed a unique, idiosyncratic response time course that was reliably replicated within each individual (high intra-SC). Encouragingly, after filtering out the idiosyncratic responses from each individual time course, we were able to uncover a more typical response profile, which resembles the shared responses seen in the typical subjects. These findings indicate that, under conditions approximating real-life situations, the neural activity of individuals with autism is characterized by individualistic responses that, although reliable within an autistic individual, are both highly variable across autistic individuals and different from the responses observed within the typical subjects. These idiosyncratic responses may underlie the atypical behaviors observed in autism. At the same time, we are encouraged by the presence of the more typical activation pattern lurking beneath these idiosyncratic fluctuations. Taken together, these findings may pave the way to future research aimed at characterizing the idiosyncratic response profiles, which, in turn, might contribute to a better understanding of the heterogeneity of the autism spectrum and its diagnosis. En ligne : http://dx.doi.org/10.1002/aur.89 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=937
in Autism Research > 2-4 (August 2009) . - p.220-231[article] Shared and idiosyncratic cortical activation patterns in autism revealed under continuous real-life viewing conditions [Texte imprimé et/ou numérique] / Uri HASSON, Auteur ; Nancy J. MINSHEW, Auteur ; Marlene BEHRMANN, Auteur ; Galia AVIDAN, Auteur ; Hagar GELBARD, Auteur ; Ignacio VALLINES, Auteur ; Michal HAREL, Auteur . - 2009 . - p.220-231.
Langues : Anglais (eng)
in Autism Research > 2-4 (August 2009) . - p.220-231
Mots-clés : autism inter-subject-correlation functional-magnetic-resonance-imaging-(fMRI) hyperconnectivity Index. décimale : PER Périodiques Résumé : Although widespread alterations in cortical structure have been documented in individuals with autism, the functional implications of these alterations remain to be determined. Here, we adopted a novel inter-subject correlation (inter-SC) and intra-subject correlation (intra-SC) technique to quantify the reliability of the spatio-temporal responses of functional MR activity in adults with autism during free-viewing of a popular audio-visual movie. Whereas these complex stimuli evoke highly reliable shared response time courses in typical individuals, cortical activity was more variable across individuals with autism (low inter-SC). Interestingly, when we measured the responses within an autistic individual across repeated presentations of the movie, we observed a unique, idiosyncratic response time course that was reliably replicated within each individual (high intra-SC). Encouragingly, after filtering out the idiosyncratic responses from each individual time course, we were able to uncover a more typical response profile, which resembles the shared responses seen in the typical subjects. These findings indicate that, under conditions approximating real-life situations, the neural activity of individuals with autism is characterized by individualistic responses that, although reliable within an autistic individual, are both highly variable across autistic individuals and different from the responses observed within the typical subjects. These idiosyncratic responses may underlie the atypical behaviors observed in autism. At the same time, we are encouraged by the presence of the more typical activation pattern lurking beneath these idiosyncratic fluctuations. Taken together, these findings may pave the way to future research aimed at characterizing the idiosyncratic response profiles, which, in turn, might contribute to a better understanding of the heterogeneity of the autism spectrum and its diagnosis. En ligne : http://dx.doi.org/10.1002/aur.89 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=937 Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder / Pamela B. JACKSON in Autism Research, 2-4 (August 2009)
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[article]
Titre : Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder Type de document : Texte imprimé et/ou numérique Auteurs : Pamela B. JACKSON, Auteur ; Luigi BOCCUTO, Auteur ; Cindy SKINNER, Auteur ; Julianne S. COLLINS, Auteur ; Giovanni NERI, Auteur ; Fiorella GURRIERI, Auteur ; Charles E. SCHWARTZ, Auteur Année de publication : 2009 Article en page(s) : p.232-236 Langues : Anglais (eng) Mots-clés : autism autistic-disorder MET PDD PDD-NOS Index. décimale : PER Périodiques Résumé : Previous studies in three independent cohorts have shown that the rs1858830 C allele variant in the promoter region of the MET gene on chromosome 7q31 is associated with autism. Another study has found correlations between other alterations in the MET gene and autism in two unrelated cohorts. This study screened two cohorts, an Autistic Disorder cohort from South Carolina and a Pervasive Developmental Disorder (PDD) cohort from Italy, for the presence of the C allele variant in rs1858830. A significant increase in the C allele variant frequency was found in the South Carolina Autistic Disorder patients as compared to South Carolina Controls (2=5.8, df=1, P=0.02). In the South Carolina cohort, a significant association with Autistic Disorder was found when comparing the CC and CG genotypes to the GG genotype (odds ratio (OR)=1.64; 95% confidence interval (CI)=1.12-2.40; 2=6.5, df=1, P=0.01) in cases and controls. In the Italian cohort, no significant association with PDD was found when comparing the CC or CG genotype to the GG genotype (OR=1.20; 95% CI=0.56-2.56; 2=0.2, df=1, P=0.64). This study is the third independent study to find the rs1858830 C variant in the MET gene promoter to be associated with autism. En ligne : http://dx.doi.org/10.1002/aur.87 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938
in Autism Research > 2-4 (August 2009) . - p.232-236[article] Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder [Texte imprimé et/ou numérique] / Pamela B. JACKSON, Auteur ; Luigi BOCCUTO, Auteur ; Cindy SKINNER, Auteur ; Julianne S. COLLINS, Auteur ; Giovanni NERI, Auteur ; Fiorella GURRIERI, Auteur ; Charles E. SCHWARTZ, Auteur . - 2009 . - p.232-236.
Langues : Anglais (eng)
in Autism Research > 2-4 (August 2009) . - p.232-236
Mots-clés : autism autistic-disorder MET PDD PDD-NOS Index. décimale : PER Périodiques Résumé : Previous studies in three independent cohorts have shown that the rs1858830 C allele variant in the promoter region of the MET gene on chromosome 7q31 is associated with autism. Another study has found correlations between other alterations in the MET gene and autism in two unrelated cohorts. This study screened two cohorts, an Autistic Disorder cohort from South Carolina and a Pervasive Developmental Disorder (PDD) cohort from Italy, for the presence of the C allele variant in rs1858830. A significant increase in the C allele variant frequency was found in the South Carolina Autistic Disorder patients as compared to South Carolina Controls (2=5.8, df=1, P=0.02). In the South Carolina cohort, a significant association with Autistic Disorder was found when comparing the CC and CG genotypes to the GG genotype (odds ratio (OR)=1.64; 95% confidence interval (CI)=1.12-2.40; 2=6.5, df=1, P=0.01) in cases and controls. In the Italian cohort, no significant association with PDD was found when comparing the CC or CG genotype to the GG genotype (OR=1.20; 95% CI=0.56-2.56; 2=0.2, df=1, P=0.64). This study is the third independent study to find the rs1858830 C variant in the MET gene promoter to be associated with autism. En ligne : http://dx.doi.org/10.1002/aur.87 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938
[article]
Titre : Erratum Type de document : Texte imprimé et/ou numérique Année de publication : 2009 Article en page(s) : p.237 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.92 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938
in Autism Research > 2-4 (August 2009) . - p.237[article] Erratum [Texte imprimé et/ou numérique] . - 2009 . - p.237.
Langues : Anglais (eng)
in Autism Research > 2-4 (August 2009) . - p.237
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.92 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938 Citalopram efficacy study; interstitial 15q11-q13 duplication mouse / Edwin H. Jr COOK in Autism Research, 2-4 (August 2009)
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[article]
Titre : Citalopram efficacy study; interstitial 15q11-q13 duplication mouse Type de document : Texte imprimé et/ou numérique Auteurs : Edwin H. Jr COOK, Auteur Année de publication : 2009 Article en page(s) : p.238-240 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.94 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938
in Autism Research > 2-4 (August 2009) . - p.238-240[article] Citalopram efficacy study; interstitial 15q11-q13 duplication mouse [Texte imprimé et/ou numérique] / Edwin H. Jr COOK, Auteur . - 2009 . - p.238-240.
Langues : Anglais (eng)
in Autism Research > 2-4 (August 2009) . - p.238-240
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.94 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938
[article]
Titre : Lay abstracts Type de document : Texte imprimé et/ou numérique Année de publication : 2009 Article en page(s) : p.241-243 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.90 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938
in Autism Research > 2-4 (August 2009) . - p.241-243[article] Lay abstracts [Texte imprimé et/ou numérique] . - 2009 . - p.241-243.
Langues : Anglais (eng)
in Autism Research > 2-4 (August 2009) . - p.241-243
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.90 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938
[article]
Titre : International Society for Autism Research News Type de document : Texte imprimé et/ou numérique Année de publication : 2009 Article en page(s) : p.244 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.91 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938
in Autism Research > 2-4 (August 2009) . - p.244[article] International Society for Autism Research News [Texte imprimé et/ou numérique] . - 2009 . - p.244.
Langues : Anglais (eng)
in Autism Research > 2-4 (August 2009) . - p.244
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.91 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938