Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia / Laura VAN KEY ; Pat BROSSEAU ; Shaun M. EACK ; David I. LEITMAN ; Dean F. SALISBURY ; Marlene BEHRMANN in Journal of Autism and Developmental Disorders, 53-12 (December 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-12 (December 2023) . - p.4856-4871 Titre : Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia Type de document : Texte imprimé et/ou numérique Auteurs : Laura VAN KEY, Auteur ; Pat BROSSEAU, Auteur ; Shaun M. EACK, Auteur ; David I. LEITMAN, Auteur ; Dean F. SALISBURY, Auteur ; Marlene BEHRMANN, Auteur Article en page(s) : p.4856-4871 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Sensory abnormalities are characteristic of autism and schizophrenia. In autism, greater trial-to-trial variability (TTV) in sensory neural responses suggest that the system is more unstable. However, these findings have only been identified in the amplitude and not in the timing of neural responses, and have not been fully explored in schizophrenia. TTV in event-related potential amplitudes and inter-trial coherence (ITC) were assessed in the auditory mismatch negativity (MMN) in autism, schizophrenia, and controls. MMN was largest in autism and smallest in schizophrenia, and TTV was greater in autism and schizophrenia compared to controls. There were no differences in ITC. Greater TTV appears to be characteristic of both autism and schizophrenia, implicating several neural mechanisms that could underlie sensory instability. En ligne : https://doi.org/10.1007/s10803-022-05771-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515 [article] Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia [Texte imprimé et/ou numérique] / Laura VAN KEY, Auteur ; Pat BROSSEAU, Auteur ; Shaun M. EACK, Auteur ; David I. LEITMAN, Auteur ; Dean F. SALISBURY, Auteur ; Marlene BEHRMANN, Auteur . - p.4856-4871. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-12 (December 2023) . - p.4856-4871 Index. décimale : PER Périodiques Résumé : Sensory abnormalities are characteristic of autism and schizophrenia. In autism, greater trial-to-trial variability (TTV) in sensory neural responses suggest that the system is more unstable. However, these findings have only been identified in the amplitude and not in the timing of neural responses, and have not been fully explored in schizophrenia. TTV in event-related potential amplitudes and inter-trial coherence (ITC) were assessed in the auditory mismatch negativity (MMN) in autism, schizophrenia, and controls. MMN was largest in autism and smallest in schizophrenia, and TTV was greater in autism and schizophrenia compared to controls. There were no differences in ITC. Greater TTV appears to be characteristic of both autism and schizophrenia, implicating several neural mechanisms that could underlie sensory instability. En ligne : https://doi.org/10.1007/s10803-022-05771-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515

Atypical development of face and greeble recognition in autism / K. Suzanne SCHERF in Journal of Child Psychology and Psychiatry, 49-8 (August 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-8 (August 2008) . - p.838 - 847 Titre : Atypical development of face and greeble recognition in autism Type de document : Texte imprimé et/ou numérique Auteurs : K. Suzanne SCHERF, Auteur ; Nancy J. MINSHEW, Auteur ; Beatriz LUNA, Auteur ; Marlene BEHRMANN, Auteur Année de publication : 2008 Article en page(s) : p.838 - 847 Langues : Anglais (eng) Mots-clés : Autism visual-processing configural-processing face-recognition greebles perceptual-development expertise adolescence child-development cognition Index. décimale : PER Périodiques Résumé : Background: Impaired face processing is a widely documented deficit in autism. Although the origin of this deficit is unclear, several groups have suggested that a lack of perceptual expertise is contributory. We investigated whether individuals with autism develop expertise in visuoperceptual processing of faces and whether any deficiency in such processing is specific to faces, or extends to other objects, too. Method: Participants performed perceptual discrimination tasks, including a face inversion task and a classification-level task, which requires especially fine-grained discriminations, on three classes of stimuli: socially-laden faces, perceptually homogenous novel objects, greebles, and perceptually heterogeneous common objects. Results: We found that children with autism develop typical levels of expertise for recognition of common objects. However, they evince poorer recognition for perceptually homogenous objects, including faces and, most especially, greebles. Conclusions: Documenting the atypical recognition abilities for greebles in children with autism has provided an important insight into the potential origin of the relatively poor face recognition skills. Our findings suggest that, throughout development, individuals with autism have a generalized deficit in visuoperceptual processing that may interfere with their ability to undertake configural processing, and that this, in turn, adversely impacts their recognition of within-class perceptually homogenous objects. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01903.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=542 [article] Atypical development of face and greeble recognition in autism [Texte imprimé et/ou numérique] / K. Suzanne SCHERF, Auteur ; Nancy J. MINSHEW, Auteur ; Beatriz LUNA, Auteur ; Marlene BEHRMANN, Auteur . - 2008 . - p.838 - 847. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-8 (August 2008) . - p.838 - 847 Mots-clés : Autism visual-processing configural-processing face-recognition greebles perceptual-development expertise adolescence child-development cognition Index. décimale : PER Périodiques Résumé : Background: Impaired face processing is a widely documented deficit in autism. Although the origin of this deficit is unclear, several groups have suggested that a lack of perceptual expertise is contributory. We investigated whether individuals with autism develop expertise in visuoperceptual processing of faces and whether any deficiency in such processing is specific to faces, or extends to other objects, too. Method: Participants performed perceptual discrimination tasks, including a face inversion task and a classification-level task, which requires especially fine-grained discriminations, on three classes of stimuli: socially-laden faces, perceptually homogenous novel objects, greebles, and perceptually heterogeneous common objects. Results: We found that children with autism develop typical levels of expertise for recognition of common objects. However, they evince poorer recognition for perceptually homogenous objects, including faces and, most especially, greebles. Conclusions: Documenting the atypical recognition abilities for greebles in children with autism has provided an important insight into the potential origin of the relatively poor face recognition skills. Our findings suggest that, throughout development, individuals with autism have a generalized deficit in visuoperceptual processing that may interfere with their ability to undertake configural processing, and that this, in turn, adversely impacts their recognition of within-class perceptually homogenous objects. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01903.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=542

Autism as a Developmental Neurobiological Disorder: New Insights from Functional Neuroimaging / Nancy J. MINSHEW

Public ISBD in Autism Spectrum Disorders / David G. AMARAL Titre : Autism as a Developmental Neurobiological Disorder: New Insights from Functional Neuroimaging Type de document : Texte imprimé et/ou numérique Auteurs : Nancy J. MINSHEW, Auteur ; K. Suzanne SCHERF, Auteur ; Marlene BEHRMANN, Auteur ; Kathryn L. HUMPHREYS, Auteur Année de publication : 2011 Importance : p.632-650 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 in Autism Spectrum Disorders / David G. AMARAL Autism as a Developmental Neurobiological Disorder: New Insights from Functional Neuroimaging [Texte imprimé et/ou numérique] / Nancy J. MINSHEW, Auteur ; K. Suzanne SCHERF, Auteur ; Marlene BEHRMANN, Auteur ; Kathryn L. HUMPHREYS, Auteur . - 2011 . - p.632-650. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139

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Cortical patterns of category-selective activation for faces, places and objects in adults with autism / Kate HUMPHREYS in Autism Research, 1-1 (February 2008)  

Public ISBD [article]  inAutism Research > 1-1 (February 2008) . - p.52-63 Titre : Cortical patterns of category-selective activation for faces, places and objects in adults with autism Type de document : Texte imprimé et/ou numérique Auteurs : Kate HUMPHREYS, Auteur ; Nancy J. MINSHEW, Auteur ; Marlene BEHRMANN, Auteur ; Uri HASSON, Auteur ; Galia AVIDAN, Auteur Année de publication : 2008 Article en page(s) : p.52-63 Langues : Anglais (eng) Mots-clés : high-functioning-autism fMRI object-perception occipito-temporal-cortex visual-system Index. décimale : PER Périodiques Résumé : Autism is associated with widespread atypicalities in perception, cognition and social behavior. A crucial question concerns how these atypicalities are reflected in the underlying brain activation. One way to examine possible perturbations of cortical organization in autism is to analyze the activation of category-selective ventral visual cortex, already clearly delineated in typical populations. We mapped out the neural correlates of face, place and common object processing, using functional magnetic resonance imaging (fMRI), in a group of high-functioning adults with autism and a typical comparison group, under both controlled and more naturalistic, viewing conditions. There were no consistent group differences in place-related regions. Although there were no significant differences in the extent of the object-related regions, there was more variability for these regions in the autism group. The most marked group differences were in face-selective cortex, with individuals with autism evincing reduced activation, not only in fusiform face area but also in superior temporal sulcus and occipital face area. Ventral visual cortex appears to be organized differently in high-functioning adults with autism, at least for face-selective regions, although subtle differences may also exist for other categories. We propose that cascading developmental effects of low-level differences in neuronal connectivity result in a much more pronounced effect on later developing cortical systems, such as that for face-processing, than earlier maturing systems (those for objects and places). En ligne : http://dx.doi.org/10.1002/aur.1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=929 [article] Cortical patterns of category-selective activation for faces, places and objects in adults with autism [Texte imprimé et/ou numérique] / Kate HUMPHREYS, Auteur ; Nancy J. MINSHEW, Auteur ; Marlene BEHRMANN, Auteur ; Uri HASSON, Auteur ; Galia AVIDAN, Auteur . - 2008 . - p.52-63. Langues : Anglais (eng) in Autism Research > 1-1 (February 2008) . - p.52-63 Mots-clés : high-functioning-autism fMRI object-perception occipito-temporal-cortex visual-system Index. décimale : PER Périodiques Résumé : Autism is associated with widespread atypicalities in perception, cognition and social behavior. A crucial question concerns how these atypicalities are reflected in the underlying brain activation. One way to examine possible perturbations of cortical organization in autism is to analyze the activation of category-selective ventral visual cortex, already clearly delineated in typical populations. We mapped out the neural correlates of face, place and common object processing, using functional magnetic resonance imaging (fMRI), in a group of high-functioning adults with autism and a typical comparison group, under both controlled and more naturalistic, viewing conditions. There were no consistent group differences in place-related regions. Although there were no significant differences in the extent of the object-related regions, there was more variability for these regions in the autism group. The most marked group differences were in face-selective cortex, with individuals with autism evincing reduced activation, not only in fusiform face area but also in superior temporal sulcus and occipital face area. Ventral visual cortex appears to be organized differently in high-functioning adults with autism, at least for face-selective regions, although subtle differences may also exist for other categories. We propose that cascading developmental effects of low-level differences in neuronal connectivity result in a much more pronounced effect on later developing cortical systems, such as that for face-processing, than earlier maturing systems (those for objects and places). En ligne : http://dx.doi.org/10.1002/aur.1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=929

Cortical Variability in the Sensory-Evoked Response in Autism / Sarah M. HAIGH in Journal of Autism and Developmental Disorders, 45-5 (May 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-5 (May 2015) . - p.1176-1190 Titre : Cortical Variability in the Sensory-Evoked Response in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Sarah M. HAIGH, Auteur ; David J. HEEGER, Auteur ; Ilan DINSTEIN, Auteur ; Nancy MINSHEW, Auteur ; Marlene BEHRMANN, Auteur Article en page(s) : p.1176-1190 Langues : Anglais (eng) Mots-clés : Autism  fMRI  Sensory-evoked  Variability Index. décimale : PER Périodiques Résumé : Previous findings have shown that individuals with autism spectrum disorder (ASD) evince greater intra-individual variability (IIV) in their sensory-evoked fMRI responses compared to typical control participants. We explore the robustness of this finding with a new sample of high-functioning adults with autism. Participants were presented with visual, somatosensory and auditory stimuli in the scanner whilst they completed a one-back task. While ASD and control participants were statistically indistinguishable with respect to behavioral responses, the new ASD group exhibited greater IIV relative to controls. We also show that the IIV was equivalent across hemispheres and remained stable over the duration of the experiment. This suggests that greater cortical IIV may be a replicable characteristic of sensory systems in autism. En ligne : http://dx.doi.org/10.1007/s10803-014-2276-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 [article] Cortical Variability in the Sensory-Evoked Response in Autism [Texte imprimé et/ou numérique] / Sarah M. HAIGH, Auteur ; David J. HEEGER, Auteur ; Ilan DINSTEIN, Auteur ; Nancy MINSHEW, Auteur ; Marlene BEHRMANN, Auteur . - p.1176-1190. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-5 (May 2015) . - p.1176-1190 Mots-clés : Autism  fMRI  Sensory-evoked  Variability Index. décimale : PER Périodiques Résumé : Previous findings have shown that individuals with autism spectrum disorder (ASD) evince greater intra-individual variability (IIV) in their sensory-evoked fMRI responses compared to typical control participants. We explore the robustness of this finding with a new sample of high-functioning adults with autism. Participants were presented with visual, somatosensory and auditory stimuli in the scanner whilst they completed a one-back task. While ASD and control participants were statistically indistinguishable with respect to behavioral responses, the new ASD group exhibited greater IIV relative to controls. We also show that the IIV was equivalent across hemispheres and remained stable over the duration of the experiment. This suggests that greater cortical IIV may be a replicable characteristic of sensory systems in autism. En ligne : http://dx.doi.org/10.1007/s10803-014-2276-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259

Endogenous Spatial Attention: Evidence for Intact Functioning in Adults With Autism / Michael A. GRUBB in Autism Research, 6-2 (April 2013)  

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Missing the big picture: impaired development of global shape processing in autism / K. Suzanne SCHERF in Autism Research, 1-2 (April 2008)  

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Over-Responsiveness and Greater Variability in Roughness Perception in Autism / Sarah M. HAIGH in Autism Research, 9-3 (March 2016)  

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Practice Makes Improvement: How Adults with Autism Out-Perform Others in a Naturalistic Visual Search Task / Cleotilde GONZALEZ in Journal of Autism and Developmental Disorders, 43-10 (October 2013)  

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Sensory Processing in Autism / Marlene BEHRMANN in Key Issues in Mental Health, 180 (2015)

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Shared and idiosyncratic cortical activation patterns in autism revealed under continuous real-life viewing conditions / Uri HASSON in Autism Research, 2-4 (August 2009)  

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Trial-to-Trial Variability in Electrodermal Activity to Odor in Autism / Sarah M. HAIGH in Autism Research, 13-12 (December 2020)  

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