Brief Report: Service Use and Associated Expenditures Among Adolescents with Autism Spectrum Disorder Transitioning to Adulthood / L. L. SHEA in Journal of Autism and Developmental Disorders, 48-9 (September 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-9 (September 2018) . - p.3223-3227 Titre : Brief Report: Service Use and Associated Expenditures Among Adolescents with Autism Spectrum Disorder Transitioning to Adulthood Type de document : Texte imprimé et/ou numérique Auteurs : L. L. SHEA, Auteur ; M. XIE, Auteur ; P. TURCOTTE, Auteur ; S. MARCUS, Auteur ; R. FIELD, Auteur ; C. NEWSCHAFFER, Auteur ; D. MANDELL, Auteur Article en page(s) : p.3223-3227 Langues : Anglais (eng) Mots-clés : Autism  Intellectual disability  Medicaid  Service use  Transition Index. décimale : PER Périodiques Résumé : This study compared Medicaid service utilization and expenditures among adolescents with autism spectrum disorder (ASD) to adolescents with intellectual disability (ID) as they aged into adulthood. Medicaid Analytic eXtract (MAX) data was used to identify a national cohort. Winsorization was utilized to control for expenditure outliers. A greater proportion of adolescents with ASD utilized most services. Decreases in the use of key services, including psychiatric outpatient services, were observed for both groups. Changes in medical services, such as increases in inpatient and long term care services, among the ASD cohort suggest medical needs of adolescents with ASD change as they age. Information remains lacking on changing ASD symptom presentation during the transition to adolescence. En ligne : http://dx.doi.org/10.1007/s10803-018-3563-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Brief Report: Service Use and Associated Expenditures Among Adolescents with Autism Spectrum Disorder Transitioning to Adulthood [Texte imprimé et/ou numérique] / L. L. SHEA, Auteur ; M. XIE, Auteur ; P. TURCOTTE, Auteur ; S. MARCUS, Auteur ; R. FIELD, Auteur ; C. NEWSCHAFFER, Auteur ; D. MANDELL, Auteur . - p.3223-3227. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-9 (September 2018) . - p.3223-3227 Mots-clés : Autism  Intellectual disability  Medicaid  Service use  Transition Index. décimale : PER Périodiques Résumé : This study compared Medicaid service utilization and expenditures among adolescents with autism spectrum disorder (ASD) to adolescents with intellectual disability (ID) as they aged into adulthood. Medicaid Analytic eXtract (MAX) data was used to identify a national cohort. Winsorization was utilized to control for expenditure outliers. A greater proportion of adolescents with ASD utilized most services. Decreases in the use of key services, including psychiatric outpatient services, were observed for both groups. Changes in medical services, such as increases in inpatient and long term care services, among the ASD cohort suggest medical needs of adolescents with ASD change as they age. Information remains lacking on changing ASD symptom presentation during the transition to adolescence. En ligne : http://dx.doi.org/10.1007/s10803-018-3563-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Glutathione pathway gene variation and risk of autism spectrum disorders / K. BOWERS in Journal of Neurodevelopmental Disorders, 3-2 (June 2011)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 3-2 (June 2011) . - p.132-43 Titre : Glutathione pathway gene variation and risk of autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : K. BOWERS, Auteur ; Q. LI, Auteur ; Jan BRESSLER, Auteur ; D. AVRAMOPOULOS, Auteur ; C. NEWSCHAFFER, Auteur ; M. D. FALLIN, Auteur Article en page(s) : p.132-43 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Despite evidence that autism is highly heritable with estimates of 15 or more genes involved, few studies have directly examined associations of multiple gene interactions. Since inability to effectively combat oxidative stress has been suggested as a mechanism of autism, we examined genetic variation 42 genes (308 single-nucleotide polymorphisms (SNPs)) related to glutathione, the most important antioxidant in the brain, for both marginal association and multi-gene interaction among 318 case-parent trios from The Autism Genetic Resource Exchange. Models of multi-SNP interactions were estimated using the trio Logic Regression method. A three-SNP joint effect was observed for genotype combinations of SNPs in glutaredoxin, glutaredoxin 3 (GLRX3), and cystathione gamma lyase (CTH); OR = 3.78, 95% CI: 2.36, 6.04. Marginal associations were observed for four genes including two involved in the three-way interaction: CTH, alcohol dehydrogenase 5, gamma-glutamylcysteine synthetase, catalytic subunit and GLRX3. These results suggest that variation in genes involved in counterbalancing oxidative stress may contribute to autism, though replication is necessary. En ligne : http://dx.doi.org/10.1007/s11689-011-9077-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343 [article] Glutathione pathway gene variation and risk of autism spectrum disorders [Texte imprimé et/ou numérique] / K. BOWERS, Auteur ; Q. LI, Auteur ; Jan BRESSLER, Auteur ; D. AVRAMOPOULOS, Auteur ; C. NEWSCHAFFER, Auteur ; M. D. FALLIN, Auteur . - p.132-43. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 3-2 (June 2011) . - p.132-43 Index. décimale : PER Périodiques Résumé : Despite evidence that autism is highly heritable with estimates of 15 or more genes involved, few studies have directly examined associations of multiple gene interactions. Since inability to effectively combat oxidative stress has been suggested as a mechanism of autism, we examined genetic variation 42 genes (308 single-nucleotide polymorphisms (SNPs)) related to glutathione, the most important antioxidant in the brain, for both marginal association and multi-gene interaction among 318 case-parent trios from The Autism Genetic Resource Exchange. Models of multi-SNP interactions were estimated using the trio Logic Regression method. A three-SNP joint effect was observed for genotype combinations of SNPs in glutaredoxin, glutaredoxin 3 (GLRX3), and cystathione gamma lyase (CTH); OR = 3.78, 95% CI: 2.36, 6.04. Marginal associations were observed for four genes including two involved in the three-way interaction: CTH, alcohol dehydrogenase 5, gamma-glutamylcysteine synthetase, catalytic subunit and GLRX3. These results suggest that variation in genes involved in counterbalancing oxidative stress may contribute to autism, though replication is necessary. En ligne : http://dx.doi.org/10.1007/s11689-011-9077-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343

Infections in children with autism spectrum disorder: Study to Explore Early Development (SEED) / Katherine R. SABOURIN in Autism Research, 12-1 (January 2019)  

Public ISBD [article]  inAutism Research > 12-1 (January 2019) . - p.136-146 Titre : Infections in children with autism spectrum disorder: Study to Explore Early Development (SEED) Type de document : Texte imprimé et/ou numérique Auteurs : Katherine R. SABOURIN, Auteur ; A. REYNOLDS, Auteur ; Diana SCHENDEL, Auteur ; S. ROSENBERG, Auteur ; Lisa A. CROEN, Auteur ; J. A. PINTO-MARTIN, Auteur ; Laura A. SCHIEVE, Auteur ; C. NEWSCHAFFER, Auteur ; L. C. LEE, Auteur ; Carolyn G. DIGUISEPPI, Auteur Article en page(s) : p.136-146 Langues : Anglais (eng) Mots-clés : autism regression  autism spectrum disorder  childhood infection  developmental disabilities  temperature dysregulation Index. décimale : PER Périodiques Résumé : Immune system abnormalities have been widely reported among children with autism spectrum disorder (ASD), which may increase the risk of childhood infections. The Study to Explore Early Development (SEED) is a multisite case-control study of children aged 30-69 months, born in 2003-2006. Cases are children previously diagnosed and newly identified with ASD enrolled from education and clinical settings. Children with a previously diagnosed non-ASD developmental condition were included in the developmental delay/disorder (DD) control group. The population (POP) control group included children randomly sampled from birth certificates. Clinical illness from infection during the first 28 days ("neonatal," from medical records) and first three years of life (caregiver report) in cases was compared to DD and POP controls; and between cases with and without regression. Children with ASD had greater odds of neonatal (OR = 1.8; 95%CI: 1.1, 2.9) and early childhood infection (OR = 1.7; 95%CI: 1.5, 1.9) compared to POP children, and greater odds of neonatal infection (OR = 1.5; 95%CI: 1.1, 2.0) compared to DD children. Cases with regression had 1.6 times the odds (95%CI: 1.1, 2.3) of caregiver-reported infection during the first year of life compared to cases without regression, but neonatal infection risk and overall early childhood infection risk did not differ. Our results support the hypothesis that children with ASD are more likely to have infection early in life compared to the general population and to children with other developmental conditions. Future studies should examine the contributions of different causes, timing, frequency, and severity of infection to ASD risk. Autism Research 2019, 12: 136-146. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We looked at infections during early childhood in relation to autism spectrum disorder (ASD). We found that children with ASD were more likely to have an infection in the first 28 days of life and before age three compared to children with typical development. Children with ASD were also more likely than children with other developmental delays or disorders to have an infection in the first 28 days of life. En ligne : http://dx.doi.org/10.1002/aur.2012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 [article] Infections in children with autism spectrum disorder: Study to Explore Early Development (SEED) [Texte imprimé et/ou numérique] / Katherine R. SABOURIN, Auteur ; A. REYNOLDS, Auteur ; Diana SCHENDEL, Auteur ; S. ROSENBERG, Auteur ; Lisa A. CROEN, Auteur ; J. A. PINTO-MARTIN, Auteur ; Laura A. SCHIEVE, Auteur ; C. NEWSCHAFFER, Auteur ; L. C. LEE, Auteur ; Carolyn G. DIGUISEPPI, Auteur . - p.136-146. Langues : Anglais (eng) in Autism Research > 12-1 (January 2019) . - p.136-146 Mots-clés : autism regression  autism spectrum disorder  childhood infection  developmental disabilities  temperature dysregulation Index. décimale : PER Périodiques Résumé : Immune system abnormalities have been widely reported among children with autism spectrum disorder (ASD), which may increase the risk of childhood infections. The Study to Explore Early Development (SEED) is a multisite case-control study of children aged 30-69 months, born in 2003-2006. Cases are children previously diagnosed and newly identified with ASD enrolled from education and clinical settings. Children with a previously diagnosed non-ASD developmental condition were included in the developmental delay/disorder (DD) control group. The population (POP) control group included children randomly sampled from birth certificates. Clinical illness from infection during the first 28 days ("neonatal," from medical records) and first three years of life (caregiver report) in cases was compared to DD and POP controls; and between cases with and without regression. Children with ASD had greater odds of neonatal (OR = 1.8; 95%CI: 1.1, 2.9) and early childhood infection (OR = 1.7; 95%CI: 1.5, 1.9) compared to POP children, and greater odds of neonatal infection (OR = 1.5; 95%CI: 1.1, 2.0) compared to DD children. Cases with regression had 1.6 times the odds (95%CI: 1.1, 2.3) of caregiver-reported infection during the first year of life compared to cases without regression, but neonatal infection risk and overall early childhood infection risk did not differ. Our results support the hypothesis that children with ASD are more likely to have infection early in life compared to the general population and to children with other developmental conditions. Future studies should examine the contributions of different causes, timing, frequency, and severity of infection to ASD risk. Autism Research 2019, 12: 136-146. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We looked at infections during early childhood in relation to autism spectrum disorder (ASD). We found that children with ASD were more likely to have an infection in the first 28 days of life and before age three compared to children with typical development. Children with ASD were also more likely than children with other developmental delays or disorders to have an infection in the first 28 days of life. En ligne : http://dx.doi.org/10.1002/aur.2012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376

Maternal and Paternal Infertility Disorders and Treatments and Autism Spectrum Disorder: Findings from the Study to Explore Early Development / Laura A. SCHIEVE in Journal of Autism and Developmental Disorders, 47-12 (December 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-12 (December 2017) . - p.3994-4005 Titre : Maternal and Paternal Infertility Disorders and Treatments and Autism Spectrum Disorder: Findings from the Study to Explore Early Development Type de document : Texte imprimé et/ou numérique Auteurs : Laura A. SCHIEVE, Auteur ; C. DREWS-BOTSCH, Auteur ; S. HARRIS, Auteur ; C. NEWSCHAFFER, Auteur ; J. DANIELS, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Lisa A. CROEN, Auteur ; G. C. WINDHAM, Auteur Année de publication : 2017 Article en page(s) : p.3994-4005 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Epidemiology  Infertility  Neurodevelopmental disorders  Ovulation induction  Reproductive techniques, assisted Index. décimale : PER Périodiques Résumé : Previous studies of associations between ASD and conception using assisted reproductive technology (ART) are inconsistent and few studies have examined associations with other infertility treatments or infertility disorders. We examined associations between ASD and maternal/paternal infertility disorders and numerous maternal treatments among 1538 mother-child pairs in the Study to Explore Early Development, a population-based case-control study. ASD was associated with any female infertility diagnosis and several specific diagnoses: blocked tubes, endometriosis, uterine-factor infertility, and polycystic ovarian syndrome. Stratified analyses suggested associations were limited to/much stronger among second or later births. The findings were not explained by sociodemographic factors such as maternal age or education or multiple or preterm birth. ASD was not associated with ART or non-ART infertility treatments. En ligne : http://dx.doi.org/10.1007/s10803-017-3283-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326 [article] Maternal and Paternal Infertility Disorders and Treatments and Autism Spectrum Disorder: Findings from the Study to Explore Early Development [Texte imprimé et/ou numérique] / Laura A. SCHIEVE, Auteur ; C. DREWS-BOTSCH, Auteur ; S. HARRIS, Auteur ; C. NEWSCHAFFER, Auteur ; J. DANIELS, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Lisa A. CROEN, Auteur ; G. C. WINDHAM, Auteur . - 2017 . - p.3994-4005. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-12 (December 2017) . - p.3994-4005 Mots-clés : Autism spectrum disorder  Epidemiology  Infertility  Neurodevelopmental disorders  Ovulation induction  Reproductive techniques, assisted Index. décimale : PER Périodiques Résumé : Previous studies of associations between ASD and conception using assisted reproductive technology (ART) are inconsistent and few studies have examined associations with other infertility treatments or infertility disorders. We examined associations between ASD and maternal/paternal infertility disorders and numerous maternal treatments among 1538 mother-child pairs in the Study to Explore Early Development, a population-based case-control study. ASD was associated with any female infertility diagnosis and several specific diagnoses: blocked tubes, endometriosis, uterine-factor infertility, and polycystic ovarian syndrome. Stratified analyses suggested associations were limited to/much stronger among second or later births. The findings were not explained by sociodemographic factors such as maternal age or education or multiple or preterm birth. ASD was not associated with ART or non-ART infertility treatments. En ligne : http://dx.doi.org/10.1007/s10803-017-3283-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326

Prenatal exposure to beta2-adrenergic receptor agonists and risk of autism spectrum disorders / Lisa A. CROEN in Journal of Neurodevelopmental Disorders, 3-4 (December 2011)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 3-4 (December 2011) . - p.307-15 Titre : Prenatal exposure to beta2-adrenergic receptor agonists and risk of autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lisa A. CROEN, Auteur ; S. L. CONNORS, Auteur ; M. MATEVIA, Auteur ; Y. QIAN, Auteur ; C. NEWSCHAFFER, Auteur ; Andrew W. ZIMMERMAN, Auteur Article en page(s) : p.307-15 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study aims to investigate the association between prenatal exposure to terbutaline and other beta2 adrenergic receptor (B2AR) agonists and autism spectrum disorders (ASDs). The methodology used is a case-control study among children born from 1995 to 1999 at Kaiser Permanente Northern California hospitals. Cases (n = 291) were children with an ASD diagnosis; controls (n = 284) were children without ASDs, randomly sampled and frequency-matched to cases on sex, birth year, and delivery hospital. Exposure to B2AR agonists during 30 days prior to conception and each trimester of pregnancy was ascertained from prenatal medical records and health plan databases. The frequency of exposure to any B2AR agonist during pregnancy was similar for mothers of children with ASD and mothers of controls (18.9% vs. 14.8%, P = 0.19). Exposure to B2AR agonists other than terbutaline was not associated with an increased risk for ASDs. However, terbutaline exposure for >2 days during the third trimester was associated with more than a fourfold increased risk for ASDs independent of indication although the limited sample size resulted in an imprecise and nonsignificant effect estimate (OR(adj) = 4.4; 95% confidence interval, 0.8-24.6). This analysis does not offer evidence linking B2AR exposure in pregnancy with autism risk. However, exposure to terbutaline during the third trimester for >2 days may be associated with an increased risk of autism. Should this result be confirmed in larger samples, it would point to late pregnancy as an etiologic window of interest in autism risk factor research. En ligne : http://dx.doi.org/10.1007/s11689-011-9093-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343 [article] Prenatal exposure to beta2-adrenergic receptor agonists and risk of autism spectrum disorders [Texte imprimé et/ou numérique] / Lisa A. CROEN, Auteur ; S. L. CONNORS, Auteur ; M. MATEVIA, Auteur ; Y. QIAN, Auteur ; C. NEWSCHAFFER, Auteur ; Andrew W. ZIMMERMAN, Auteur . - p.307-15. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 3-4 (December 2011) . - p.307-15 Index. décimale : PER Périodiques Résumé : This study aims to investigate the association between prenatal exposure to terbutaline and other beta2 adrenergic receptor (B2AR) agonists and autism spectrum disorders (ASDs). The methodology used is a case-control study among children born from 1995 to 1999 at Kaiser Permanente Northern California hospitals. Cases (n = 291) were children with an ASD diagnosis; controls (n = 284) were children without ASDs, randomly sampled and frequency-matched to cases on sex, birth year, and delivery hospital. Exposure to B2AR agonists during 30 days prior to conception and each trimester of pregnancy was ascertained from prenatal medical records and health plan databases. The frequency of exposure to any B2AR agonist during pregnancy was similar for mothers of children with ASD and mothers of controls (18.9% vs. 14.8%, P = 0.19). Exposure to B2AR agonists other than terbutaline was not associated with an increased risk for ASDs. However, terbutaline exposure for >2 days during the third trimester was associated with more than a fourfold increased risk for ASDs independent of indication although the limited sample size resulted in an imprecise and nonsignificant effect estimate (OR(adj) = 4.4; 95% confidence interval, 0.8-24.6). This analysis does not offer evidence linking B2AR exposure in pregnancy with autism risk. However, exposure to terbutaline during the third trimester for >2 days may be associated with an increased risk of autism. Should this result be confirmed in larger samples, it would point to late pregnancy as an etiologic window of interest in autism risk factor research. En ligne : http://dx.doi.org/10.1007/s11689-011-9093-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343

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