Awareness and risk factors of autism spectrum disorder in an Egyptian population / Nagwa ABDEL MEGUID in Research in Autism Spectrum Disorders, 84 (June 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 84 (June 2021) . - 101781 Titre : Awareness and risk factors of autism spectrum disorder in an Egyptian population Type de document : texte imprimé Auteurs : Nagwa ABDEL MEGUID, Auteur ; Neveen H. NASHAAT, Auteur ; Amal ELSAEID, Auteur ; Massimiliano PEANA, Auteur ; Ahmed ELNAHRY, Auteur ; Geir BJØRKLUND, Auteur Article en page(s) : 101781 Langues : Anglais (eng) Mots-clés : Autism  Awareness  Referral situations  Risk factors Index. décimale : PER Périodiques Résumé : Background The aim of the present study was to determine the type and percentage of referral situations, risk factors, associated syndromes, and parental awareness of autism spectrum disorder (ASD) children who visited the Medical Research Centre of Excellence, National Research Centre in Cairo, specialized in ASD diagnosis and management. Methods The study included 530 children who were diagnosed with ASD. For those, full medical history, clinical examination, severity evaluation, and testing the language and cognitive development were performed. The process of diagnosis and assessment of parents’ awareness and knowledge about ASD was investigated using questionnaires. Results The clinic was mainly visited by self-referral. About half of the participants (51.4 %) had previously visited other doctors (1–5 physicians) who were mostly pediatricians. The parents’ awareness was mostly limited to the term “autism”, but not the nature of ASD. Caesarean section was the most common risk factor (57.4 %), followed by jaundice (30.1 %). The most common presenting symptoms were language (81.5 %) and social (60.4 %) deficits. ASD severity was found to be high in association with attention deficit hyperactivity disorder (ADHD) and electroencephalogram (EEG) changes (p = 0.001). Conclusion The risk factors and associated syndromes in the Egyptian population studied were similar to those reported in previous studies performed in other populations, but their percentage was different. Perinatal problems were the most common risk factors, which may relate to the influence of gene-environmental interaction on the factors which could play a role in developing ASD or increasing its severity. The process of ASD diagnosis was commonly delayed among the participants. Increasing awareness and knowledge among health care professionals and parents is urgently needed to facilitate early diagnosis and intervention services, which will lead to improvement of the developmental outcomes for ASD children. The associated syndromes could be the driving force to seek medical advice and could influence the ASD severity. En ligne : https://doi.org/10.1016/j.rasd.2021.101781 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=446 [article] Awareness and risk factors of autism spectrum disorder in an Egyptian population [texte imprimé] / Nagwa ABDEL MEGUID, Auteur ; Neveen H. NASHAAT, Auteur ; Amal ELSAEID, Auteur ; Massimiliano PEANA, Auteur ; Ahmed ELNAHRY, Auteur ; Geir BJØRKLUND, Auteur . - 101781. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 84 (June 2021) . - 101781 Mots-clés : Autism  Awareness  Referral situations  Risk factors Index. décimale : PER Périodiques Résumé : Background The aim of the present study was to determine the type and percentage of referral situations, risk factors, associated syndromes, and parental awareness of autism spectrum disorder (ASD) children who visited the Medical Research Centre of Excellence, National Research Centre in Cairo, specialized in ASD diagnosis and management. Methods The study included 530 children who were diagnosed with ASD. For those, full medical history, clinical examination, severity evaluation, and testing the language and cognitive development were performed. The process of diagnosis and assessment of parents’ awareness and knowledge about ASD was investigated using questionnaires. Results The clinic was mainly visited by self-referral. About half of the participants (51.4 %) had previously visited other doctors (1–5 physicians) who were mostly pediatricians. The parents’ awareness was mostly limited to the term “autism”, but not the nature of ASD. Caesarean section was the most common risk factor (57.4 %), followed by jaundice (30.1 %). The most common presenting symptoms were language (81.5 %) and social (60.4 %) deficits. ASD severity was found to be high in association with attention deficit hyperactivity disorder (ADHD) and electroencephalogram (EEG) changes (p = 0.001). Conclusion The risk factors and associated syndromes in the Egyptian population studied were similar to those reported in previous studies performed in other populations, but their percentage was different. Perinatal problems were the most common risk factors, which may relate to the influence of gene-environmental interaction on the factors which could play a role in developing ASD or increasing its severity. The process of ASD diagnosis was commonly delayed among the participants. Increasing awareness and knowledge among health care professionals and parents is urgently needed to facilitate early diagnosis and intervention services, which will lead to improvement of the developmental outcomes for ASD children. The associated syndromes could be the driving force to seek medical advice and could influence the ASD severity. En ligne : https://doi.org/10.1016/j.rasd.2021.101781 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=446

Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder / Khaled SAAD in Journal of Child Psychology and Psychiatry, 59-1 (January 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-1 (January 2018) . - p.20-29 Titre : Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder Type de document : texte imprimé Auteurs : Khaled SAAD, Auteur ; Ahmed A. ABDEL-RAHMAN, Auteur ; Yasser M. ELSEROGY, Auteur ; Abdulrahman A. AL-ATRAM, Auteur ; Amira A. EL-HOUFEY, Auteur ; Hisham A.K. OTHMAN, Auteur ; Geir BJØRKLUND, Auteur ; Feiyong JIA, Auteur ; Mauricio A. URBINA, Auteur ; Mohamed Gamil M. ABO-ELELA, Auteur ; Faisal-Alkhateeb AHMAD, Auteur ; Khaled A. ABD EL-BASEER, Auteur ; Ahmed E. AHMED, Auteur ; Ahmad M. ABDEL-SALAM, Auteur Article en page(s) : p.20-29 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  vitamin D  children  clinical trial Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a frequent developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and nonverbal communication, and stereotyped patterns of interests and activities. It has been previously reported that there is vitamin D deficiency in autistic children; however, there is a lack of randomized controlled trials of vitamin D supplementation in ASD children. Methods This study is a double-blinded, randomized clinical trial (RCT) that was conducted on 109 children with ASD (85 boys and 24 girls; aged 3–10 years). The aim of this study was to assess the effects of vitamin D supplementation on the core symptoms of autism in children. ASD patients were randomized to receive vitamin D3 or placebo for 4 months. The serum levels of 25-hydroxycholecalciferol (25 (OH)D) were measured at the beginning and at the end of the study. The autism severity and social maturity of the children were assessed by the Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and the Autism Treatment Evaluation Checklist (ATEC). Trial registration number: UMIN-CTR Study Design: trial number: UMIN000020281. Results Supplementation of vitamin D was well tolerated by the ASD children. The daily doses used in the therapy group was 300 IU vitamin D3/kg/day, not to exceed 5,000 IU/day. The autism symptoms of the children improved significantly, following 4-month vitamin D3 supplementation, but not in the placebo group. This study demonstrates the efficacy and tolerability of high doses of vitamin D3 in children with ASD. Conclusions This study is the first double-blinded RCT proving the efficacy of vitamin D3 in ASD patients. Depending on the parameters measured in the study, oral vitamin D supplementation may safely improve signs and symptoms of ASD and could be recommended for children with ASD. At this stage, this study is a single RCT with a small number of patients, and a great deal of additional wide-scale studies are needed to critically validate the efficacy of vitamin D in ASD. En ligne : http://dx.doi.org/10.1111/jcpp.12652 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327 [article] Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder [texte imprimé] / Khaled SAAD, Auteur ; Ahmed A. ABDEL-RAHMAN, Auteur ; Yasser M. ELSEROGY, Auteur ; Abdulrahman A. AL-ATRAM, Auteur ; Amira A. EL-HOUFEY, Auteur ; Hisham A.K. OTHMAN, Auteur ; Geir BJØRKLUND, Auteur ; Feiyong JIA, Auteur ; Mauricio A. URBINA, Auteur ; Mohamed Gamil M. ABO-ELELA, Auteur ; Faisal-Alkhateeb AHMAD, Auteur ; Khaled A. ABD EL-BASEER, Auteur ; Ahmed E. AHMED, Auteur ; Ahmad M. ABDEL-SALAM, Auteur . - p.20-29. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-1 (January 2018) . - p.20-29 Mots-clés : Autism spectrum disorder  vitamin D  children  clinical trial Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a frequent developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and nonverbal communication, and stereotyped patterns of interests and activities. It has been previously reported that there is vitamin D deficiency in autistic children; however, there is a lack of randomized controlled trials of vitamin D supplementation in ASD children. Methods This study is a double-blinded, randomized clinical trial (RCT) that was conducted on 109 children with ASD (85 boys and 24 girls; aged 3–10 years). The aim of this study was to assess the effects of vitamin D supplementation on the core symptoms of autism in children. ASD patients were randomized to receive vitamin D3 or placebo for 4 months. The serum levels of 25-hydroxycholecalciferol (25 (OH)D) were measured at the beginning and at the end of the study. The autism severity and social maturity of the children were assessed by the Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and the Autism Treatment Evaluation Checklist (ATEC). Trial registration number: UMIN-CTR Study Design: trial number: UMIN000020281. Results Supplementation of vitamin D was well tolerated by the ASD children. The daily doses used in the therapy group was 300 IU vitamin D3/kg/day, not to exceed 5,000 IU/day. The autism symptoms of the children improved significantly, following 4-month vitamin D3 supplementation, but not in the placebo group. This study demonstrates the efficacy and tolerability of high doses of vitamin D3 in children with ASD. Conclusions This study is the first double-blinded RCT proving the efficacy of vitamin D3 in ASD patients. Depending on the parameters measured in the study, oral vitamin D supplementation may safely improve signs and symptoms of ASD and could be recommended for children with ASD. At this stage, this study is a single RCT with a small number of patients, and a great deal of additional wide-scale studies are needed to critically validate the efficacy of vitamin D in ASD. En ligne : http://dx.doi.org/10.1111/jcpp.12652 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327

Retraction: Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder / Khaled SAAD in Journal of Child Psychology and Psychiatry, 60-6 (June 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-6 (June 2019) . - p.711 Titre : Retraction: Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder Type de document : texte imprimé Auteurs : Khaled SAAD, Auteur ; Ahmed A. ABDEL-RAHMAN, Auteur ; Y. ELSEROGY, Auteur ; Abdulrahman A. AL-ATRAM, Auteur ; Amira EL-HOUFEY, Auteur ; H. OTHMAN, Auteur ; Geir BJØRKLUND, Auteur ; Feiyong JIA, Auteur ; Mauricio A. URBINA, Auteur ; Mohamed Gamil M. ABO-ELELA, Auteur ; Farah AHMAD, Auteur ; Khaled A. ABD EL-BASEER, Auteur ; Ahmed E. AHMED, Auteur ; Ahmad M. ABDEL-SALAM, Auteur Article en page(s) : p.711 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The above article, published in print in the Jan 2018 issue of the Journal of Child Psychology & Psychiatry and online in Wiley Online Library (wileyonlinelibrary.com), has been retracted by the JCPP Editor-in-Chief, Edmund Sonuga-Barke, and John Wiley & Sons. Following a series of communications from readers highlighting concerns about the paper (now published on the journal website), the journal editors requested that the authors send them the raw data from the trial. In response the authors informed the editors that; (i) the electronic data base had been lost following a computer outage and (ii) that they could send only 95 out of 120 hard-copy participant data sheets as one site had closed and was no longer contactable. The substantial data loss in and of itself posed a serious difficulty in verifying the correctness of the data presented in the paper. The JCPP then analysed the data from the 95 cases itself. A number of significant discrepancies emerged between the re-analysis and the findings reported in the paper both in terms of means and standard deviations of key outcome variables across the trial. These involved very substantial differences that we judged to be extremely unlikely to have arisen due to variations in composition of the original and re-analysed samples. We also discovered previously unidentified/reported problems with missing data and recording irregularities regarding changes in treatment regimen and subject identifiers. As a result of these issues the Editors no longer have confidence in the findings reported in the original paper. Based on all these matters combined and following published guidance from the Committee on Publishing Ethics (COPE) and Wiley's Best Practice Guidelines on Publishing Ethics, we have decided that the only course of action available to us is to retract the paper. En ligne : http://dx.doi.org/10.1111/jcpp.13076 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Retraction: Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder [texte imprimé] / Khaled SAAD, Auteur ; Ahmed A. ABDEL-RAHMAN, Auteur ; Y. ELSEROGY, Auteur ; Abdulrahman A. AL-ATRAM, Auteur ; Amira EL-HOUFEY, Auteur ; H. OTHMAN, Auteur ; Geir BJØRKLUND, Auteur ; Feiyong JIA, Auteur ; Mauricio A. URBINA, Auteur ; Mohamed Gamil M. ABO-ELELA, Auteur ; Farah AHMAD, Auteur ; Khaled A. ABD EL-BASEER, Auteur ; Ahmed E. AHMED, Auteur ; Ahmad M. ABDEL-SALAM, Auteur . - p.711. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-6 (June 2019) . - p.711 Index. décimale : PER Périodiques Résumé : The above article, published in print in the Jan 2018 issue of the Journal of Child Psychology & Psychiatry and online in Wiley Online Library (wileyonlinelibrary.com), has been retracted by the JCPP Editor-in-Chief, Edmund Sonuga-Barke, and John Wiley & Sons. Following a series of communications from readers highlighting concerns about the paper (now published on the journal website), the journal editors requested that the authors send them the raw data from the trial. In response the authors informed the editors that; (i) the electronic data base had been lost following a computer outage and (ii) that they could send only 95 out of 120 hard-copy participant data sheets as one site had closed and was no longer contactable. The substantial data loss in and of itself posed a serious difficulty in verifying the correctness of the data presented in the paper. The JCPP then analysed the data from the 95 cases itself. A number of significant discrepancies emerged between the re-analysis and the findings reported in the paper both in terms of means and standard deviations of key outcome variables across the trial. These involved very substantial differences that we judged to be extremely unlikely to have arisen due to variations in composition of the original and re-analysed samples. We also discovered previously unidentified/reported problems with missing data and recording irregularities regarding changes in treatment regimen and subject identifiers. As a result of these issues the Editors no longer have confidence in the findings reported in the original paper. Based on all these matters combined and following published guidance from the Committee on Publishing Ethics (COPE) and Wiley's Best Practice Guidelines on Publishing Ethics, we have decided that the only course of action available to us is to retract the paper. En ligne : http://dx.doi.org/10.1111/jcpp.13076 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

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