Initially intact neural responses to pain in autism are diminished during sustained pain / M. D. FAILLA in Autism, 22-6 (August 2018)  

Public ISBD [article]  inAutism > 22-6 (August 2018) . - p.669-683 Titre : Initially intact neural responses to pain in autism are diminished during sustained pain Type de document : Texte imprimé et/ou numérique Auteurs : M. D. FAILLA, Auteur ; E. J. MOANA-FILHO, Auteur ; G. K. ESSICK, Auteur ; Grace T. BARANEK, Auteur ; B. P. ROGERS, Auteur ; Carissa J. CASCIO, Auteur Article en page(s) : p.669-683 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  functional magnetic resonance imaging  pain  repetitive behaviors  self-injury  sensory Index. décimale : PER Périodiques Résumé : Pain assessments typically depend on self-report of the pain experience. Yet, in individuals with autism spectrum disorders, this can be an unreliable due to communication difficulties. Importantly, observations of behavioral hypo- and hyperresponsivity to pain suggest altered pain sensitivity in autism spectrum disorder. Neuroimaging may provide insight into mechanisms underlying pain behaviors. The neural pain signature reliably responds to painful stimulation and is modulated by other outside regions, affecting the pain experience. In this first functional magnetic resonance imaging study of pain in autism spectrum disorder, we investigated neural responses to pain in 15 adults with autism spectrum disorder relative to a typical comparison group (n = 16). We explored temporal and spatial properties of the neural pain signature and its modulators during sustained heat pain. The two groups had indistinguishable pain ratings and neural pain signature responses during acute pain; yet, we observed strikingly reduced neural pain signature response in autism spectrum disorder during sustained pain and after stimulus offset. The posterior cingulate cortex, a neural pain signature modulating region, mirrored this late signal reduction in autism spectrum disorder. Intact early responses, followed by diminished late responses to sustained pain, may reflect altered pain coping or evaluation in autism spectrum disorder. Evidence of a dichotomous neural response to initial versus protracted pain may clarify the coexistence of both hypo- and hyperresponsiveness to pain in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361317696043 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] Initially intact neural responses to pain in autism are diminished during sustained pain [Texte imprimé et/ou numérique] / M. D. FAILLA, Auteur ; E. J. MOANA-FILHO, Auteur ; G. K. ESSICK, Auteur ; Grace T. BARANEK, Auteur ; B. P. ROGERS, Auteur ; Carissa J. CASCIO, Auteur . - p.669-683. Langues : Anglais (eng) in Autism > 22-6 (August 2018) . - p.669-683 Mots-clés : autism spectrum disorder  functional magnetic resonance imaging  pain  repetitive behaviors  self-injury  sensory Index. décimale : PER Périodiques Résumé : Pain assessments typically depend on self-report of the pain experience. Yet, in individuals with autism spectrum disorders, this can be an unreliable due to communication difficulties. Importantly, observations of behavioral hypo- and hyperresponsivity to pain suggest altered pain sensitivity in autism spectrum disorder. Neuroimaging may provide insight into mechanisms underlying pain behaviors. The neural pain signature reliably responds to painful stimulation and is modulated by other outside regions, affecting the pain experience. In this first functional magnetic resonance imaging study of pain in autism spectrum disorder, we investigated neural responses to pain in 15 adults with autism spectrum disorder relative to a typical comparison group (n = 16). We explored temporal and spatial properties of the neural pain signature and its modulators during sustained heat pain. The two groups had indistinguishable pain ratings and neural pain signature responses during acute pain; yet, we observed strikingly reduced neural pain signature response in autism spectrum disorder during sustained pain and after stimulus offset. The posterior cingulate cortex, a neural pain signature modulating region, mirrored this late signal reduction in autism spectrum disorder. Intact early responses, followed by diminished late responses to sustained pain, may reflect altered pain coping or evaluation in autism spectrum disorder. Evidence of a dichotomous neural response to initial versus protracted pain may clarify the coexistence of both hypo- and hyperresponsiveness to pain in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361317696043 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

Intrainsular connectivity and somatosensory responsiveness in young children with ASD / M. D. FAILLA in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 25p. Titre : Intrainsular connectivity and somatosensory responsiveness in young children with ASD Type de document : Texte imprimé et/ou numérique Auteurs : M. D. FAILLA, Auteur ; B. R. PETERS, Auteur ; H. KARBASFOROUSHAN, Auteur ; J. H. FOSS-FEIG, Auteur ; Kimberly B. SCHAUDER, Auteur ; B. H. HEFLIN, Auteur ; Carissa J. CASCIO, Auteur Article en page(s) : 25p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: The human somatosensory system comprises dissociable paths for discriminative and affective touch, reflected in separate peripheral afferent populations and distinct cortical targets. Differences in behavioral and neural responses to affective touch may have an important developmental role in early social experiences, which are relevant for autism spectrum disorder (ASD). METHODS: Using probabilistic tractography, we compared the structural integrity of white matter pathways for discriminative and affective touch in young children with ASD and their typically developing (TD) peers. We examined two tracts: (1) a tract linking the thalamus with the primary somatosensory cortex, which carries discriminative tactile information, and (2) a tract linking the posterior insula-the cortical projection target of unmyelinated tactile afferents mediating affective touch-with the anterior insula, which integrates sensory and visceral inputs to interpret emotional salience of sensory stimuli. We investigated associations between tract integrity and performance on a standardized observational assessment measuring tactile discrimination and affective responses to touch. RESULTS: Both the thalamocortical and intrainsular tracts showed reduced integrity (higher mean diffusivity) in the ASD group compared to those in the TD group. Consistent with the previous findings, the ASD group exhibited impaired tactile discriminative ability, more tactile defensiveness, and more sensory seeking (e.g., enthusiastic play or repetitive engagement with a specific tactile stimulus). There was a significant relation between intrainsular tract integrity and tactile seeking. The direction of this relation differed between groups: higher intrainsular mean diffusivity (MD) (reflecting decreased tract integrity) was associated with increased tactile seeking in the TD group but with decreased tactile seeking in the ASD group. In the TD group, decreased tactile defensiveness was also associated with higher intrainsular MD, but there was no relation in the ASD group. Discriminative touch was not significantly associated with integrity of either tract in either group. CONCLUSIONS: These results support previous findings suggesting a central role for the insula in affective response to touch. While both discriminative and affective touch and both somatosensory tracts are affected in ASD, the restriction of brain-behavior associations to the intrainsular tract and tactile seeking suggests more complex and perhaps higher-order influence on differences in tactile defensiveness and discrimination. En ligne : http://dx.doi.org/10.1186/s13229-017-0143-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] Intrainsular connectivity and somatosensory responsiveness in young children with ASD [Texte imprimé et/ou numérique] / M. D. FAILLA, Auteur ; B. R. PETERS, Auteur ; H. KARBASFOROUSHAN, Auteur ; J. H. FOSS-FEIG, Auteur ; Kimberly B. SCHAUDER, Auteur ; B. H. HEFLIN, Auteur ; Carissa J. CASCIO, Auteur . - 25p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 25p. Index. décimale : PER Périodiques Résumé : BACKGROUND: The human somatosensory system comprises dissociable paths for discriminative and affective touch, reflected in separate peripheral afferent populations and distinct cortical targets. Differences in behavioral and neural responses to affective touch may have an important developmental role in early social experiences, which are relevant for autism spectrum disorder (ASD). METHODS: Using probabilistic tractography, we compared the structural integrity of white matter pathways for discriminative and affective touch in young children with ASD and their typically developing (TD) peers. We examined two tracts: (1) a tract linking the thalamus with the primary somatosensory cortex, which carries discriminative tactile information, and (2) a tract linking the posterior insula-the cortical projection target of unmyelinated tactile afferents mediating affective touch-with the anterior insula, which integrates sensory and visceral inputs to interpret emotional salience of sensory stimuli. We investigated associations between tract integrity and performance on a standardized observational assessment measuring tactile discrimination and affective responses to touch. RESULTS: Both the thalamocortical and intrainsular tracts showed reduced integrity (higher mean diffusivity) in the ASD group compared to those in the TD group. Consistent with the previous findings, the ASD group exhibited impaired tactile discriminative ability, more tactile defensiveness, and more sensory seeking (e.g., enthusiastic play or repetitive engagement with a specific tactile stimulus). There was a significant relation between intrainsular tract integrity and tactile seeking. The direction of this relation differed between groups: higher intrainsular mean diffusivity (MD) (reflecting decreased tract integrity) was associated with increased tactile seeking in the TD group but with decreased tactile seeking in the ASD group. In the TD group, decreased tactile defensiveness was also associated with higher intrainsular MD, but there was no relation in the ASD group. Discriminative touch was not significantly associated with integrity of either tract in either group. CONCLUSIONS: These results support previous findings suggesting a central role for the insula in affective response to touch. While both discriminative and affective touch and both somatosensory tracts are affected in ASD, the restriction of brain-behavior associations to the intrainsular tract and tactile seeking suggests more complex and perhaps higher-order influence on differences in tactile defensiveness and discrimination. En ligne : http://dx.doi.org/10.1186/s13229-017-0143-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

Psychometric Evaluation of the Short Sensory Profile in Youth with Autism Spectrum Disorder / Z. J. WILLIAMS in Journal of Autism and Developmental Disorders, 48-12 (December 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-12 (December 2018) . - p.4231-4249 Titre : Psychometric Evaluation of the Short Sensory Profile in Youth with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Z. J. WILLIAMS, Auteur ; M. D. FAILLA, Auteur ; K. O. GOTHAM, Auteur ; Tiffany G. WOYNAROSKI, Auteur ; Carissa J. CASCIO, Auteur Article en page(s) : p.4231-4249 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Factor analysis  Psychometric  Sensory  Short Sensory Profile  Validity Index. décimale : PER Périodiques Résumé : The Short Sensory Profile (SSP) is one of the most commonly used measures of sensory features in children with autism spectrum disorder (ASD), but psychometric studies in this population are limited. Using confirmatory factor analysis, we evaluated the structural validity of the SSP subscales in ASD children. Confirmatory factor models exhibited poor fit, and a follow-up exploratory factor analysis suggested a 9-factor structure that only replicated three of the seven original subscales. Secondary analyses suggest that while reliable, the SSP total score is substantially biased by individual differences on dimensions other than the general factor. Overall, our findings discourage the use of the SSP total score and most subscale scores in children with ASD. Implications for future research are discussed. En ligne : http://dx.doi.org/10.1007/s10803-018-3678-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] Psychometric Evaluation of the Short Sensory Profile in Youth with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Z. J. WILLIAMS, Auteur ; M. D. FAILLA, Auteur ; K. O. GOTHAM, Auteur ; Tiffany G. WOYNAROSKI, Auteur ; Carissa J. CASCIO, Auteur . - p.4231-4249. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-12 (December 2018) . - p.4231-4249 Mots-clés : Autism spectrum disorder  Factor analysis  Psychometric  Sensory  Short Sensory Profile  Validity Index. décimale : PER Périodiques Résumé : The Short Sensory Profile (SSP) is one of the most commonly used measures of sensory features in children with autism spectrum disorder (ASD), but psychometric studies in this population are limited. Using confirmatory factor analysis, we evaluated the structural validity of the SSP subscales in ASD children. Confirmatory factor models exhibited poor fit, and a follow-up exploratory factor analysis suggested a 9-factor structure that only replicated three of the seven original subscales. Secondary analyses suggest that while reliable, the SSP total score is substantially biased by individual differences on dimensions other than the general factor. Overall, our findings discourage the use of the SSP total score and most subscale scores in children with ASD. Implications for future research are discussed. En ligne : http://dx.doi.org/10.1007/s10803-018-3678-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

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