| [article] 
					| Titre : | Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development |  
					| Type de document : | texte imprimé |  
					| Auteurs : | E. STERGIAKOULI, Auteur ; George DAVEY SMITH, Auteur ; J. MARTIN, Auteur ; D. H. SKUSE, Auteur ; W. VIECHTBAUER, Auteur ; S. M. RING, Auteur ; A. RONALD, Auteur ; D. E. EVANS, Auteur ; S. E. FISHER, Auteur ; A. THAPAR, Auteur ; B. ST POURCAIN, Auteur |  
					| Article en page(s) : | 18p. |  
					| Langues : | Anglais (eng) |  
					| Mots-clés : | ADHD symptoms  Alspac  Clinical ADHD  Genetic overlap  Social communication |  
					| Index. décimale : | PER Périodiques |  
					| Résumé : | BACKGROUND: Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) symptoms and autism spectrum disorder (ASD) symptoms have been reported. Cross-trait genetic relationships are, however, subject to dynamic changes during development. We investigated the continuity of genetic overlap between ASD and ADHD symptoms in a general population sample during childhood and adolescence. We also studied uni- and cross-dimensional trait-disorder links with respect to genetic ADHD and ASD risk. METHODS: Social-communication difficulties (N = 5551, Social and Communication Disorders Checklist, SCDC) and combined hyperactive-impulsive/inattentive ADHD symptoms (N = 5678, Strengths and Difficulties Questionnaire, SDQ-ADHD) were repeatedly measured in a UK birth cohort (ALSPAC, age 7 to 17 years). Genome-wide summary statistics on clinical ASD (5305 cases; 5305 pseudo-controls) and ADHD (4163 cases; 12,040 controls/pseudo-controls) were available from the Psychiatric Genomics Consortium. Genetic trait variances and genetic overlap between phenotypes were estimated using genome-wide data. RESULTS: In the general population, genetic influences for SCDC and SDQ-ADHD scores were shared throughout development. Genetic correlations across traits reached a similar strength and magnitude (cross-trait rg = 1, pmin = 3 x 10(-4)) as those between repeated measures of the same trait (within-trait rg = 0.94, pmin = 7 x 10(-4)). Shared genetic influences between traits, especially during later adolescence, may implicate variants in K-RAS signalling upregulated genes (p-meta = 6.4 x 10(-4)). Uni-dimensionally, each population-based trait mapped to the expected behavioural continuum: risk-increasing alleles for clinical ADHD were persistently associated with SDQ-ADHD scores throughout development (marginal regression R(2) = 0.084%). An age-specific genetic overlap between clinical ASD and social-communication difficulties during childhood was also shown, as per previous reports. Cross-dimensionally, however, neither SCDC nor SDQ-ADHD scores were linked to genetic risk for disorder. CONCLUSIONS: In the general population, genetic aetiologies between social-communication difficulties and ADHD symptoms are shared throughout child and adolescent development and may implicate similar biological pathways that co-vary during development. Within both the ASD and the ADHD dimension, population-based traits are also linked to clinical disorder, although much larger clinical discovery samples are required to reliably detect cross-dimensional trait-disorder relationships. |  
					| En ligne : | http://dx.doi.org/10.1186/s13229-017-0131-2 |  
					| Permalink : | https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331 |  in Molecular Autism > 8  (2017) . - 18p.
 [article] Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development [texte imprimé] / E. STERGIAKOULI , Auteur ; George DAVEY SMITH , Auteur ; J. MARTIN , Auteur ; D. H. SKUSE , Auteur ; W. VIECHTBAUER , Auteur ; S. M. RING , Auteur ; A. RONALD , Auteur ; D. E. EVANS , Auteur ; S. E. FISHER , Auteur ; A. THAPAR , Auteur ; B. ST POURCAIN , Auteur . - 18p.Langues  : Anglais (eng )in Molecular Autism  > 8  (2017)  . - 18p. 
					| Mots-clés : | ADHD symptoms  Alspac  Clinical ADHD  Genetic overlap  Social communication |  
					| Index. décimale : | PER Périodiques |  
					| Résumé : | BACKGROUND: Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) symptoms and autism spectrum disorder (ASD) symptoms have been reported. Cross-trait genetic relationships are, however, subject to dynamic changes during development. We investigated the continuity of genetic overlap between ASD and ADHD symptoms in a general population sample during childhood and adolescence. We also studied uni- and cross-dimensional trait-disorder links with respect to genetic ADHD and ASD risk. METHODS: Social-communication difficulties (N = 5551, Social and Communication Disorders Checklist, SCDC) and combined hyperactive-impulsive/inattentive ADHD symptoms (N = 5678, Strengths and Difficulties Questionnaire, SDQ-ADHD) were repeatedly measured in a UK birth cohort (ALSPAC, age 7 to 17 years). Genome-wide summary statistics on clinical ASD (5305 cases; 5305 pseudo-controls) and ADHD (4163 cases; 12,040 controls/pseudo-controls) were available from the Psychiatric Genomics Consortium. Genetic trait variances and genetic overlap between phenotypes were estimated using genome-wide data. RESULTS: In the general population, genetic influences for SCDC and SDQ-ADHD scores were shared throughout development. Genetic correlations across traits reached a similar strength and magnitude (cross-trait rg = 1, pmin = 3 x 10(-4)) as those between repeated measures of the same trait (within-trait rg = 0.94, pmin = 7 x 10(-4)). Shared genetic influences between traits, especially during later adolescence, may implicate variants in K-RAS signalling upregulated genes (p-meta = 6.4 x 10(-4)). Uni-dimensionally, each population-based trait mapped to the expected behavioural continuum: risk-increasing alleles for clinical ADHD were persistently associated with SDQ-ADHD scores throughout development (marginal regression R(2) = 0.084%). An age-specific genetic overlap between clinical ASD and social-communication difficulties during childhood was also shown, as per previous reports. Cross-dimensionally, however, neither SCDC nor SDQ-ADHD scores were linked to genetic risk for disorder. CONCLUSIONS: In the general population, genetic aetiologies between social-communication difficulties and ADHD symptoms are shared throughout child and adolescent development and may implicate similar biological pathways that co-vary during development. Within both the ASD and the ADHD dimension, population-based traits are also linked to clinical disorder, although much larger clinical discovery samples are required to reliably detect cross-dimensional trait-disorder relationships. |  
					| En ligne : | http://dx.doi.org/10.1186/s13229-017-0131-2 |  
					| Permalink : | https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331 | 
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