Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder / J. GOODRICH AMANDA in Autism Research, 11-1 (January 2018)  

Public ISBD [article]  inAutism Research > 11-1 (January 2018) . - p.69-80 Titre : Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. GOODRICH AMANDA, Auteur ; Heather E. VOLK, Auteur ; Daniel J. TANCREDI, Auteur ; Rob MCCONNELL, Auteur ; W. LURMANN FRED, Auteur ; L. HANSEN ROBIN, Auteur ; Rebecca J. SCHMIDT, Auteur Article en page(s) : p.69-80 Langues : Anglais (eng) Mots-clés : autism  ASD  folic acid  air pollution  prenatal exposure  environmental exposure Index. décimale : PER Périodiques Résumé : Independent studies report that periconceptional folic acid (FA) may decrease the risk of autism spectrum disorder (ASD) while exposure to air pollution may increase ASD risk. We examined the joint effects of gestational FA and air pollution exposures in association with ASD. We studied 346 ASD cases and 260 typically developing controls from the CHARGE case?control study. Self?reported FA intake for each month of pregnancy was quantified. Estimates of exposure to near roadway air pollution (NRP) and criteria air pollutant measures were assigned based on maternal residential history. Among mothers with high FA intake (>800 ?g) in the first pregnancy month, exposure to increasing levels of all air pollutants, except ozone, during the first trimester was associated with decreased ASD risk, while increased ASD risk was observed for the same pollutant among mothers with low FA intake (?800 ?g). This difference was statistically significant for NO2 (e.g., NO2 and low FA intake: OR=1.53 (0.91, 2.56) vs NO2 and high FA intake: OR=0.74 (0.46, 1.19), P?interaction=0.04). Mothers exposed to higher levels (? median) of any air pollutant during the first trimester of pregnancy and who reported low FA intake were at a higher ASD risk compared to mothers exposed to lower levels of that air pollutant and who reported high first month FA intake. Joint effects showed significant (alpha? En ligne : https://doi.org/10.1002/aur.1885 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=333 [article] Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder [Texte imprimé et/ou numérique] / J. GOODRICH AMANDA, Auteur ; Heather E. VOLK, Auteur ; Daniel J. TANCREDI, Auteur ; Rob MCCONNELL, Auteur ; W. LURMANN FRED, Auteur ; L. HANSEN ROBIN, Auteur ; Rebecca J. SCHMIDT, Auteur . - p.69-80. Langues : Anglais (eng) in Autism Research > 11-1 (January 2018) . - p.69-80 Mots-clés : autism  ASD  folic acid  air pollution  prenatal exposure  environmental exposure Index. décimale : PER Périodiques Résumé : Independent studies report that periconceptional folic acid (FA) may decrease the risk of autism spectrum disorder (ASD) while exposure to air pollution may increase ASD risk. We examined the joint effects of gestational FA and air pollution exposures in association with ASD. We studied 346 ASD cases and 260 typically developing controls from the CHARGE case?control study. Self?reported FA intake for each month of pregnancy was quantified. Estimates of exposure to near roadway air pollution (NRP) and criteria air pollutant measures were assigned based on maternal residential history. Among mothers with high FA intake (>800 ?g) in the first pregnancy month, exposure to increasing levels of all air pollutants, except ozone, during the first trimester was associated with decreased ASD risk, while increased ASD risk was observed for the same pollutant among mothers with low FA intake (?800 ?g). This difference was statistically significant for NO2 (e.g., NO2 and low FA intake: OR=1.53 (0.91, 2.56) vs NO2 and high FA intake: OR=0.74 (0.46, 1.19), P?interaction=0.04). Mothers exposed to higher levels (? median) of any air pollutant during the first trimester of pregnancy and who reported low FA intake were at a higher ASD risk compared to mothers exposed to lower levels of that air pollutant and who reported high first month FA intake. Joint effects showed significant (alpha? En ligne : https://doi.org/10.1002/aur.1885 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=333

Maternal obesity and diabetes during pregnancy and early autism screening score at well-child visits in standard clinical practice / Sarah A. CARTER in Autism, 28-4 (April 2024)  

Public ISBD [article]  inAutism > 28-4 (April 2024) . - p.975-984 Titre : Maternal obesity and diabetes during pregnancy and early autism screening score at well-child visits in standard clinical practice Type de document : Texte imprimé et/ou numérique Auteurs : Sarah A. CARTER, Auteur ; Jane C. LIN, Auteur ; Ting CHOW, Auteur ; Mayra P. MARTINEZ, Auteur ; Jasmin M. ALVES, Auteur ; Klara R. FELDMAN, Auteur ; Chunyuan QIU, Auteur ; Kathleen A. PAGE, Auteur ; Rob MCCONNELL, Auteur ; Anny H. XIANG, Auteur Article en page(s) : p.975-984 Langues : Anglais (eng) Mots-clés : autism spectrum disorders,early screening tools,maternal diabetes,maternal obesity Index. décimale : PER Périodiques Résumé : Early intervention can reduce disability in children diagnosed with autism spectrum disorder. Screening for autism spectrum disorder in young children identifies those at increased likelihood of diagnosis who may need further support. This study assessed in utero exposure to maternal obesity and diabetes and offspring performance on the Quantitative Checklist for Autism in Toddlers, an autism spectrum disorder screening questionnaire administered between 18 and 24?months at well-child visits. This retrospective cohort study included 65,433 singletons born in a single healthcare system. Demographic data, maternal obesity, Type 1/Type 2 and gestational diabetes mellitus information, and Quantitative Checklist for Autism in Toddlers score in children 12-30?months old were extracted from electronic medical records. Negative binomial models were used to estimate incidence rate ratios of associations between maternal obesity and diabetes exposure and continuous offspring Quantitative Checklist for Autism in Toddlers scores. Maternal obesity, Type 1/Type 2 diabetes (incidence rate ratio: 1.13, 1.06-1.21) and gestational diabetes mellitus???26?weeks (incidence rate ratio: 1.10, 1.05-1.17) were associated with one-unit increases in Quantitative Checklist for Autism in Toddlers scores. Relationships with obesity and gestational diabetes mellitus???26?weeks remained after mutual adjustment and excluding children with autism spectrum disorder diagnoses. No associations were reported for gestational diabetes mellitus > 26?weeks. Maternal obesity and diabetes were associated with higher Quantitative Checklist for Autism in Toddlers scores in children 12-30?months old, suggesting these exposures in pregnancy may be associated with a range of early childhood behavior. Lay Abstract Early intervention and treatment can help reduce disability in children diagnosed with autism spectrum disorder. Screening for autism spectrum disorder in young children identifies those at increased likelihood of diagnosis who may need further support. Previous research has reported that exposure to maternal obesity and diabetes during pregnancy is associated with higher likelihood of autism spectrum disorder diagnosis in children. However, little is known about whether these maternal conditions are associated with how very young children score on autism spectrum disorder screening tools. This study examined associations between exposure to maternal obesity and diabetes during pregnancy and offspring scores on the Quantitative Checklist for Autism in Toddlers, an autism spectrum disorder screening questionnaire administered between 18-24?months at well-child visits. A higher score on the Quantitative Checklist for Autism in Toddlers suggests a higher likelihood of autism spectrum disorder; children with scores 3 or greater are referred to developmental pediatricians for evaluation. Our study found that children of mothers with obesity or diabetes during pregnancy had higher scores than children whose mothers did not have these conditions. Associations with maternal obesity and gestational diabetes diagnosed at or before 26?weeks of pregnancy were also present in children who did not have later autism spectrum disorder diagnoses, suggesting that exposure to these conditions during early pregnancy may be associated with a broad range of social and behavioral abilities. Identifying associations between maternal health conditions and early Quantitative Checklist for Autism in Toddlers screening scores could influence future screening and provision of support for children of mothers with these conditions. En ligne : https://dx.doi.org/10.1177/13623613231188876 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=525 [article] Maternal obesity and diabetes during pregnancy and early autism screening score at well-child visits in standard clinical practice [Texte imprimé et/ou numérique] / Sarah A. CARTER, Auteur ; Jane C. LIN, Auteur ; Ting CHOW, Auteur ; Mayra P. MARTINEZ, Auteur ; Jasmin M. ALVES, Auteur ; Klara R. FELDMAN, Auteur ; Chunyuan QIU, Auteur ; Kathleen A. PAGE, Auteur ; Rob MCCONNELL, Auteur ; Anny H. XIANG, Auteur . - p.975-984. Langues : Anglais (eng) in Autism > 28-4 (April 2024) . - p.975-984 Mots-clés : autism spectrum disorders,early screening tools,maternal diabetes,maternal obesity Index. décimale : PER Périodiques Résumé : Early intervention can reduce disability in children diagnosed with autism spectrum disorder. Screening for autism spectrum disorder in young children identifies those at increased likelihood of diagnosis who may need further support. This study assessed in utero exposure to maternal obesity and diabetes and offspring performance on the Quantitative Checklist for Autism in Toddlers, an autism spectrum disorder screening questionnaire administered between 18 and 24?months at well-child visits. This retrospective cohort study included 65,433 singletons born in a single healthcare system. Demographic data, maternal obesity, Type 1/Type 2 and gestational diabetes mellitus information, and Quantitative Checklist for Autism in Toddlers score in children 12-30?months old were extracted from electronic medical records. Negative binomial models were used to estimate incidence rate ratios of associations between maternal obesity and diabetes exposure and continuous offspring Quantitative Checklist for Autism in Toddlers scores. Maternal obesity, Type 1/Type 2 diabetes (incidence rate ratio: 1.13, 1.06-1.21) and gestational diabetes mellitus???26?weeks (incidence rate ratio: 1.10, 1.05-1.17) were associated with one-unit increases in Quantitative Checklist for Autism in Toddlers scores. Relationships with obesity and gestational diabetes mellitus???26?weeks remained after mutual adjustment and excluding children with autism spectrum disorder diagnoses. No associations were reported for gestational diabetes mellitus > 26?weeks. Maternal obesity and diabetes were associated with higher Quantitative Checklist for Autism in Toddlers scores in children 12-30?months old, suggesting these exposures in pregnancy may be associated with a range of early childhood behavior. Lay Abstract Early intervention and treatment can help reduce disability in children diagnosed with autism spectrum disorder. Screening for autism spectrum disorder in young children identifies those at increased likelihood of diagnosis who may need further support. Previous research has reported that exposure to maternal obesity and diabetes during pregnancy is associated with higher likelihood of autism spectrum disorder diagnosis in children. However, little is known about whether these maternal conditions are associated with how very young children score on autism spectrum disorder screening tools. This study examined associations between exposure to maternal obesity and diabetes during pregnancy and offspring scores on the Quantitative Checklist for Autism in Toddlers, an autism spectrum disorder screening questionnaire administered between 18-24?months at well-child visits. A higher score on the Quantitative Checklist for Autism in Toddlers suggests a higher likelihood of autism spectrum disorder; children with scores 3 or greater are referred to developmental pediatricians for evaluation. Our study found that children of mothers with obesity or diabetes during pregnancy had higher scores than children whose mothers did not have these conditions. Associations with maternal obesity and gestational diabetes diagnosed at or before 26?weeks of pregnancy were also present in children who did not have later autism spectrum disorder diagnoses, suggesting that exposure to these conditions during early pregnancy may be associated with a broad range of social and behavioral abilities. Identifying associations between maternal health conditions and early Quantitative Checklist for Autism in Toddlers screening scores could influence future screening and provision of support for children of mothers with these conditions. En ligne : https://dx.doi.org/10.1177/13623613231188876 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=525

Maternal obesity, diabetes, preeclampsia, and asthma during pregnancy and likelihood of autism spectrum disorder with gastrointestinal disturbances in offspring / Sarah A CARTER in Autism, 27-4 (May 2023)  

Public ISBD [article]  inAutism > 27-4 (May 2023) . - p.916-926 Titre : Maternal obesity, diabetes, preeclampsia, and asthma during pregnancy and likelihood of autism spectrum disorder with gastrointestinal disturbances in offspring Type de document : Texte imprimé et/ou numérique Auteurs : Sarah A CARTER, Auteur ; Jane C LIN, Auteur ; Ting CHOW, Auteur ; Xin YU, Auteur ; Md Mostafijur RAHMAN, Auteur ; Mayra P MARTINEZ, Auteur ; Klara FELDMAN, Auteur ; Sandrah P ECKEL, Auteur ; Jiu-Chiuan CHEN, Auteur ; Zhanghua CHEN, Auteur ; Pat LEVITT, Auteur ; Frederick W LURMANN, Auteur ; Rob MCCONNELL, Auteur ; Anny H XIANG, Auteur Article en page(s) : p.916-926 Langues : Anglais (eng) Mots-clés : ASD,autism,gastrointestinal disorders,GIDs,maternal asthma,maternal diabetes,maternal obesity,preeclampsia Index. décimale : PER Périodiques Résumé : Gastrointestinal disturbances (GIDs) are relatively common in children diagnosed with autism spectrum disorder (ASD). This study assessed associations between maternal obesity, diabetes, preeclampsia, and asthma and likelihood of ASD with GIDs. This retrospective cohort study included 308,536 mother-child pairs of singletons born between 2001 and 2014 in a single integrated health care system. Social demographics, maternal health conditions during pregnancy, and child?s ASD and/or GID diagnosis by age 5 were extracted from electronic medical records. Child?s outcome was classified as: no ASD no GIDs; no ASD with GIDs; ASD no GIDs; and ASD with GIDs. Multinomial logistic regression was used to estimate odds ratios of child?s outcomes associated with maternal exposures, adjusting for covariates. Compared to children with neither disorder, each maternal condition was associated with higher odds of no ASD with GIDs, ASD no GIDs, and ASD with GIDs. Association was greatest for likelihood of ASD with GIDs (Maternal obesity odds ratio (95% confidence interval): 1.37 (1.22-1.54); Diabetes: 1.50 (1.28-1.76); Preeclampsia: 1.63 (1.36-1.95); Asthma: 1.39 (1.17-1.67); relative to no ASD no GIDs). Associations were robust to mutual adjustment for all maternal exposures. Maternal obesity, diabetes, preeclampsia, and asthma exposure during pregnancy may increase likelihood of both GIDs and ASD with or without co-occurring GIDs in offspring. This association was greatest in children diagnosed with ASD with co-occurring GIDs.Lay abstractAutism spectrum disorder is heterogeneous and often accompanied by co-occurring conditions. Previous studies have shown that maternal health conditions during pregnancy including obesity, diabetes, preeclampsia, and asthma were associated with increased likelihood of autism. However, little has been done examining the likelihood associated with autism with co-occurring conditions. This study assessed these maternal health conditions in relationship to autism and gastrointestinal disturbances, a common co-occurring condition in children diagnosed with autism. Data included 308,536 mother-child pairs from one integrated health care system with comprehensive electronic medical records. Among the study cohort, 5,131 (1.7%) children had a diagnosis of autism by age 5. Gastrointestinal disturbances were present in 35.4% of children diagnosed with autism and 25.1% of children without autism diagnoses. Our results showed that each of the four maternal health conditions during pregnancy was associated with increased likelihood of gastrointestinal disturbances, autism without gastrointestinal disturbances, and autism with gastrointestinal disturbances. For all four maternal health conditions, the association was greatest for likelihood of autism with gastrointestinal disturbances. Given that children diagnosed with autism are more likely to have gastrointestinal disturbances and over 80% of gastrointestinal disturbances in this cohort were diagnosed prior to autism diagnosis, this study suggests that there may be common biological pathways between autism and gastrointestinal disturbances impacted by these maternal exposures. Future studies are warranted to assess associations between different exposures and autism with other co-occurring conditions to increase our understanding of autism heterogeneity. En ligne : https://doi.org/10.1177/13623613221118430 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Maternal obesity, diabetes, preeclampsia, and asthma during pregnancy and likelihood of autism spectrum disorder with gastrointestinal disturbances in offspring [Texte imprimé et/ou numérique] / Sarah A CARTER, Auteur ; Jane C LIN, Auteur ; Ting CHOW, Auteur ; Xin YU, Auteur ; Md Mostafijur RAHMAN, Auteur ; Mayra P MARTINEZ, Auteur ; Klara FELDMAN, Auteur ; Sandrah P ECKEL, Auteur ; Jiu-Chiuan CHEN, Auteur ; Zhanghua CHEN, Auteur ; Pat LEVITT, Auteur ; Frederick W LURMANN, Auteur ; Rob MCCONNELL, Auteur ; Anny H XIANG, Auteur . - p.916-926. Langues : Anglais (eng) in Autism > 27-4 (May 2023) . - p.916-926 Mots-clés : ASD,autism,gastrointestinal disorders,GIDs,maternal asthma,maternal diabetes,maternal obesity,preeclampsia Index. décimale : PER Périodiques Résumé : Gastrointestinal disturbances (GIDs) are relatively common in children diagnosed with autism spectrum disorder (ASD). This study assessed associations between maternal obesity, diabetes, preeclampsia, and asthma and likelihood of ASD with GIDs. This retrospective cohort study included 308,536 mother-child pairs of singletons born between 2001 and 2014 in a single integrated health care system. Social demographics, maternal health conditions during pregnancy, and child?s ASD and/or GID diagnosis by age 5 were extracted from electronic medical records. Child?s outcome was classified as: no ASD no GIDs; no ASD with GIDs; ASD no GIDs; and ASD with GIDs. Multinomial logistic regression was used to estimate odds ratios of child?s outcomes associated with maternal exposures, adjusting for covariates. Compared to children with neither disorder, each maternal condition was associated with higher odds of no ASD with GIDs, ASD no GIDs, and ASD with GIDs. Association was greatest for likelihood of ASD with GIDs (Maternal obesity odds ratio (95% confidence interval): 1.37 (1.22-1.54); Diabetes: 1.50 (1.28-1.76); Preeclampsia: 1.63 (1.36-1.95); Asthma: 1.39 (1.17-1.67); relative to no ASD no GIDs). Associations were robust to mutual adjustment for all maternal exposures. Maternal obesity, diabetes, preeclampsia, and asthma exposure during pregnancy may increase likelihood of both GIDs and ASD with or without co-occurring GIDs in offspring. This association was greatest in children diagnosed with ASD with co-occurring GIDs.Lay abstractAutism spectrum disorder is heterogeneous and often accompanied by co-occurring conditions. Previous studies have shown that maternal health conditions during pregnancy including obesity, diabetes, preeclampsia, and asthma were associated with increased likelihood of autism. However, little has been done examining the likelihood associated with autism with co-occurring conditions. This study assessed these maternal health conditions in relationship to autism and gastrointestinal disturbances, a common co-occurring condition in children diagnosed with autism. Data included 308,536 mother-child pairs from one integrated health care system with comprehensive electronic medical records. Among the study cohort, 5,131 (1.7%) children had a diagnosis of autism by age 5. Gastrointestinal disturbances were present in 35.4% of children diagnosed with autism and 25.1% of children without autism diagnoses. Our results showed that each of the four maternal health conditions during pregnancy was associated with increased likelihood of gastrointestinal disturbances, autism without gastrointestinal disturbances, and autism with gastrointestinal disturbances. For all four maternal health conditions, the association was greatest for likelihood of autism with gastrointestinal disturbances. Given that children diagnosed with autism are more likely to have gastrointestinal disturbances and over 80% of gastrointestinal disturbances in this cohort were diagnosed prior to autism diagnosis, this study suggests that there may be common biological pathways between autism and gastrointestinal disturbances impacted by these maternal exposures. Future studies are warranted to assess associations between different exposures and autism with other co-occurring conditions to increase our understanding of autism heterogeneity. En ligne : https://doi.org/10.1177/13623613221118430 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

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