Action prediction in 10-month-old infants at high and low familial risk for Autism Spectrum Disorder / Ricarda BRAUKMANN in Research in Autism Spectrum Disorders, 49 (May 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 49 (May 2018) . - p.34-46 Titre : Action prediction in 10-month-old infants at high and low familial risk for Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Ricarda BRAUKMANN, Auteur ; Emma K. WARD, Auteur ; Roy S. HESSELS, Auteur ; Harold BEKKERING, Auteur ; Jan K. BUITELAAR, Auteur ; Sabine HUNNIUS, Auteur Article en page(s) : p.34-46 Langues : Anglais (eng) Mots-clés : Eye tracking  Infant  Siblings  ASD  Action prediction Index. décimale : PER Périodiques Résumé : Background Several studies have reported action prediction difficulties in Autism Spectrum Disorder (ASD). Although action prediction develops in infancy, little is known about prediction abilities in infants at risk for ASD. Methods Using eye tracking, we measured action anticipations in 52 10-month-old infants at high and low familial risk for ASD. Infants were repeatedly presented with actions during which a familiar object (cup/phone) was either brought to a location usually associated with the object (cup-to-mouth/phone-to-ear; usual condition) or to an unusual location (cup-to-ear/phone-to-mouth; unusual condition). We assessed infants’ anticipations to the actual target location (i.e., the location where the object was actually brought; the mouth in cup-to-mouth/phone-to-mouth actions; the ear in cup-to-ear/phone-to-ear actions) and the alternative target location (the ear in cup-to-mouth/phone-to-mouth actions; the mouth in cup-to-ear/phone-to-ear actions). Results Anticipation frequencies were modulated by object knowledge across all infants: We found more frequent anticipations towards the alternative target location for unusual compared to usual actions. This effect was in particular present for mouth anticipations which were also overall more frequent than ear anticipations. Across usual and unusual actions, infants showed more frequent anticipations towards the actual target location, potentially representing a learning effect elicited by the repeated action presentation. Importantly, there were no differences between the low- and high-risk infants in predictive eye movements. Conclusion Whereas our results suggest that familial risk for ASD does not affect action prediction in infancy, future research needs to investigate whether differences are apparent in those high-risk infants who later receive a diagnosis. En ligne : https://doi.org/10.1016/j.rasd.2018.02.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=340 [article] Action prediction in 10-month-old infants at high and low familial risk for Autism Spectrum Disorder [texte imprimé] / Ricarda BRAUKMANN, Auteur ; Emma K. WARD, Auteur ; Roy S. HESSELS, Auteur ; Harold BEKKERING, Auteur ; Jan K. BUITELAAR, Auteur ; Sabine HUNNIUS, Auteur . - p.34-46. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 49 (May 2018) . - p.34-46 Mots-clés : Eye tracking  Infant  Siblings  ASD  Action prediction Index. décimale : PER Périodiques Résumé : Background Several studies have reported action prediction difficulties in Autism Spectrum Disorder (ASD). Although action prediction develops in infancy, little is known about prediction abilities in infants at risk for ASD. Methods Using eye tracking, we measured action anticipations in 52 10-month-old infants at high and low familial risk for ASD. Infants were repeatedly presented with actions during which a familiar object (cup/phone) was either brought to a location usually associated with the object (cup-to-mouth/phone-to-ear; usual condition) or to an unusual location (cup-to-ear/phone-to-mouth; unusual condition). We assessed infants’ anticipations to the actual target location (i.e., the location where the object was actually brought; the mouth in cup-to-mouth/phone-to-mouth actions; the ear in cup-to-ear/phone-to-ear actions) and the alternative target location (the ear in cup-to-mouth/phone-to-mouth actions; the mouth in cup-to-ear/phone-to-ear actions). Results Anticipation frequencies were modulated by object knowledge across all infants: We found more frequent anticipations towards the alternative target location for unusual compared to usual actions. This effect was in particular present for mouth anticipations which were also overall more frequent than ear anticipations. Across usual and unusual actions, infants showed more frequent anticipations towards the actual target location, potentially representing a learning effect elicited by the repeated action presentation. Importantly, there were no differences between the low- and high-risk infants in predictive eye movements. Conclusion Whereas our results suggest that familial risk for ASD does not affect action prediction in infancy, future research needs to investigate whether differences are apparent in those high-risk infants who later receive a diagnosis. En ligne : https://doi.org/10.1016/j.rasd.2018.02.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=340

Investigating the Predictive Validity of the Quantitative Checklist for Autism in Toddlers and the Autism Diagnostic Observation Schedule-2 in Children at Elevated Likelihood for Autism / Sarah SCHAUBROECK in Journal of Autism and Developmental Disorders, 56-2 (February 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-2 (February 2026) . - p.633-647 Titre : Investigating the Predictive Validity of the Quantitative Checklist for Autism in Toddlers and the Autism Diagnostic Observation Schedule-2 in Children at Elevated Likelihood for Autism Type de document : texte imprimé Auteurs : Sarah SCHAUBROECK, Auteur ; Ellen DEMURIE, Auteur ; Jannath BEGUM-ALI, Auteur ; Sven BÖLTE, Auteur ; Sofie BOTERBERG, Auteur ; Jan BUITELAAR, Auteur ; Tony CHARMAN, Auteur ; Terje FALCK-YTTER, Auteur ; Sabine HUNNIUS, Auteur ; Mark JOHNSON, Auteur ; Emily JONES, Auteur ; Greg PASCO, Auteur ; Carlijn VAN DEN BOOMEN, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur Article en page(s) : p.633-647 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study examined the recurrence rate of autism in siblings at elevated likelihood (EL) and the predictive validity of the Q-CHAT and ADOS-2 at 14 and 24 months (m) for a clinical best estimate (CBE) autism diagnosis at 3 years. 331 EL-siblings (47.9% girls) from the prospective longitudinal EuroSibs study underwent ADOS-2 assessments and caregivers completed the Q-CHAT at 14 m and 24 m. At 3 years CBE was determined using DSM-5 criteria. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were estimated. Autism recurrence rate was 25.7% [95% CI (21.1, 30.6)]. Q-CHAT sensitivity was 31.8% [95% CI (21.4, 43.6)] at 14 m and 30.6% [95% CI (20.7, 41.7)] at 24 m. Specificity was 81.2% [95% CI (75.4, 86.2)] at 14 m and 94.8% [95% CI (91.2, 97.2)] at 24 m. PPV was 35.6% [95% CI (24.2, 48.2)] at 14 m and 66.7% [95% CI (49.8, 81.1)] at 24 m. NPV was 78.5% [95% CI (72.6, 83.7)] and 79.9% [95% CI (74.7, 84.6)] respectively. ADOS-2 demonstrated a of 64.3% [95% CI (45.9, 80.2)] and 69.3% [95% CI (58.4, 79.0)] and a specificity of 71.1% [95% CI (60.3, 80.4)] and 68.7% [95% CI (62.5, 74.5)] at 14 m and 24 m respectively. PPV was 45% [95% CI (30.3, 60.4)] at 14 m and 41.9% [95% CI (33.5, 50.7)] at 24 m. NPV was 84.4% [95% CI (74.2, 91.8)] at 14 m and 87.3% [95% CI (81.9, 91.6)] at 24 m. Q-CHAT and ADOS-2 at 14 m and 24 m can aid in early differentiation between EL-siblings who need further assessment and those who do not, but neither has sufficient sensitivity and PPV for standalone CBE diagnosis prediction. En ligne : https://doi.org/10.1007/s10803-024-06585-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=580 [article] Investigating the Predictive Validity of the Quantitative Checklist for Autism in Toddlers and the Autism Diagnostic Observation Schedule-2 in Children at Elevated Likelihood for Autism [texte imprimé] / Sarah SCHAUBROECK, Auteur ; Ellen DEMURIE, Auteur ; Jannath BEGUM-ALI, Auteur ; Sven BÖLTE, Auteur ; Sofie BOTERBERG, Auteur ; Jan BUITELAAR, Auteur ; Tony CHARMAN, Auteur ; Terje FALCK-YTTER, Auteur ; Sabine HUNNIUS, Auteur ; Mark JOHNSON, Auteur ; Emily JONES, Auteur ; Greg PASCO, Auteur ; Carlijn VAN DEN BOOMEN, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur . - p.633-647. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-2 (February 2026) . - p.633-647 Index. décimale : PER Périodiques Résumé : This study examined the recurrence rate of autism in siblings at elevated likelihood (EL) and the predictive validity of the Q-CHAT and ADOS-2 at 14 and 24 months (m) for a clinical best estimate (CBE) autism diagnosis at 3 years. 331 EL-siblings (47.9% girls) from the prospective longitudinal EuroSibs study underwent ADOS-2 assessments and caregivers completed the Q-CHAT at 14 m and 24 m. At 3 years CBE was determined using DSM-5 criteria. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were estimated. Autism recurrence rate was 25.7% [95% CI (21.1, 30.6)]. Q-CHAT sensitivity was 31.8% [95% CI (21.4, 43.6)] at 14 m and 30.6% [95% CI (20.7, 41.7)] at 24 m. Specificity was 81.2% [95% CI (75.4, 86.2)] at 14 m and 94.8% [95% CI (91.2, 97.2)] at 24 m. PPV was 35.6% [95% CI (24.2, 48.2)] at 14 m and 66.7% [95% CI (49.8, 81.1)] at 24 m. NPV was 78.5% [95% CI (72.6, 83.7)] and 79.9% [95% CI (74.7, 84.6)] respectively. ADOS-2 demonstrated a of 64.3% [95% CI (45.9, 80.2)] and 69.3% [95% CI (58.4, 79.0)] and a specificity of 71.1% [95% CI (60.3, 80.4)] and 68.7% [95% CI (62.5, 74.5)] at 14 m and 24 m respectively. PPV was 45% [95% CI (30.3, 60.4)] at 14 m and 41.9% [95% CI (33.5, 50.7)] at 24 m. NPV was 84.4% [95% CI (74.2, 91.8)] at 14 m and 87.3% [95% CI (81.9, 91.6)] at 24 m. Q-CHAT and ADOS-2 at 14 m and 24 m can aid in early differentiation between EL-siblings who need further assessment and those who do not, but neither has sufficient sensitivity and PPV for standalone CBE diagnosis prediction. En ligne : https://doi.org/10.1007/s10803-024-06585-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=580

---

1 (1 - 2 / 2) Par page : 25 50 100 200