Executive functioning differences between adults with attention deficit hyperactivity disorder and autistic spectrum disorder in initiation, planning and strategy formation / Jessica BRAMHAM in Autism, 13-3 (May 2009)  

Public ISBD [article]  inAutism > 13-3 (May 2009) . - p.245-264 Titre : Executive functioning differences between adults with attention deficit hyperactivity disorder and autistic spectrum disorder in initiation, planning and strategy formation Type de document : texte imprimé Auteurs : Jessica BRAMHAM, Auteur ; Philip ASHERSON, Auteur ; Declan G.M. MURPHY, Auteur ; Ailsa RUSSELL, Auteur ; Fiona AMBERY, Auteur ; Robin D. MORRIS, Auteur ; Kiriakos XENITIDIS, Auteur ; Susan E. YOUNG, Auteur Année de publication : 2009 Article en page(s) : p.245-264 Langues : Anglais (eng) Mots-clés : ADHD adults ASD executive-functioning Index. décimale : PER Périodiques Résumé : Executive functioning deficits characterize the neuropsychological profiles of the childhood neurodevelopmental disorders of attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorder (ASD). This study sought to determine whether similar impairments exist in adults with ADHD (N = 53) and ASD (N = 45) in comparison with a healthy control group (N = 31), whether the two disorders can be distinguished on the basis of their executive functioning features, and whether these impairments are related to symptom severity. Both clinical groups were found to exhibit executive functioning deficits. The ADHD group had difficulty withholding a response, with relative preservation of initiation and planning abilities. In contrast, the ASD group exhibited significant impairments in initiation, planning and strategy formation. The specific executive functioning deficits were related to severity of response inhibition impairments in ADHD and stereotyped, repetitive behaviours in ASD. These findings suggest the pattern of executive functioning deficits follows a consistent trajectory into adulthood. En ligne : http://dx.doi.org/10.1177/1362361309103790 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=728 [article] Executive functioning differences between adults with attention deficit hyperactivity disorder and autistic spectrum disorder in initiation, planning and strategy formation [texte imprimé] / Jessica BRAMHAM, Auteur ; Philip ASHERSON, Auteur ; Declan G.M. MURPHY, Auteur ; Ailsa RUSSELL, Auteur ; Fiona AMBERY, Auteur ; Robin D. MORRIS, Auteur ; Kiriakos XENITIDIS, Auteur ; Susan E. YOUNG, Auteur . - 2009 . - p.245-264. Langues : Anglais (eng) in Autism > 13-3 (May 2009) . - p.245-264 Mots-clés : ADHD adults ASD executive-functioning Index. décimale : PER Périodiques Résumé : Executive functioning deficits characterize the neuropsychological profiles of the childhood neurodevelopmental disorders of attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorder (ASD). This study sought to determine whether similar impairments exist in adults with ADHD (N = 53) and ASD (N = 45) in comparison with a healthy control group (N = 31), whether the two disorders can be distinguished on the basis of their executive functioning features, and whether these impairments are related to symptom severity. Both clinical groups were found to exhibit executive functioning deficits. The ADHD group had difficulty withholding a response, with relative preservation of initiation and planning abilities. In contrast, the ASD group exhibited significant impairments in initiation, planning and strategy formation. The specific executive functioning deficits were related to severity of response inhibition impairments in ADHD and stereotyped, repetitive behaviours in ASD. These findings suggest the pattern of executive functioning deficits follows a consistent trajectory into adulthood. En ligne : http://dx.doi.org/10.1177/1362361309103790 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=728

Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; an fMRI study / Rayna AZUMA in Journal of Neurodevelopmental Disorders, 1-1 (March 2009)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 1-1 (March 2009) . - p.46-60 Titre : Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; an fMRI study Type de document : texte imprimé Auteurs : Rayna AZUMA, Auteur ; Eileen DALY, Auteur ; Linda E. CAMPBELL, Auteur ; Angela F. STEVENS, Auteur ; Quinton DEELEY, Auteur ; Vincent GIAMPIETRO, Auteur ; Michael BRAMMER, Auteur ; Beate GLASER, Auteur ; Fiona Z. AMBERY, Auteur ; Robin G. MORRIS, Auteur ; Steven C.R. WILLIAMS, Auteur ; Michael J. OWEN, Auteur ; Declan G.M. MURPHY, Auteur ; Kieran C. MURPHY, Auteur Article en page(s) : p.46-60 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : 22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with a microdeletion of chromosome 22q11. In addition to high rates of neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder, children with 22q11DS have a specific neuropsychological profile with particular deficits in visuospatial and working memory. However, the neurobiological substrate underlying these deficits is poorly understood. We investigated brain function during a visuospatial working memory (SWM) task in eight children with 22q11DS and 13 healthy controls, using fMRI. Both groups showed task-related activation in dorsolateral prefrontal cortex (DLPFC) and bilateral parietal association cortices. Controls activated parietal and occipital regions significantly more than those with 22q11DS but there was no significant between-group difference in DLPFC. In addition, while controls had a significant age-related increase in the activation of posterior brain regions and an age-related decrease in anterior regions, the 22q11DS children showed the opposite pattern. Genetically determined differences in the development of specific brain systems may underpin the cognitive deficits in 22q11DS, and may contribute to the later development of neuropsychiatric disorders. En ligne : http://dx.doi.org/10.1007/s11689-009-9008-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341 [article] Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; an fMRI study [texte imprimé] / Rayna AZUMA, Auteur ; Eileen DALY, Auteur ; Linda E. CAMPBELL, Auteur ; Angela F. STEVENS, Auteur ; Quinton DEELEY, Auteur ; Vincent GIAMPIETRO, Auteur ; Michael BRAMMER, Auteur ; Beate GLASER, Auteur ; Fiona Z. AMBERY, Auteur ; Robin G. MORRIS, Auteur ; Steven C.R. WILLIAMS, Auteur ; Michael J. OWEN, Auteur ; Declan G.M. MURPHY, Auteur ; Kieran C. MURPHY, Auteur . - p.46-60. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 1-1 (March 2009) . - p.46-60 Index. décimale : PER Périodiques Résumé : 22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with a microdeletion of chromosome 22q11. In addition to high rates of neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder, children with 22q11DS have a specific neuropsychological profile with particular deficits in visuospatial and working memory. However, the neurobiological substrate underlying these deficits is poorly understood. We investigated brain function during a visuospatial working memory (SWM) task in eight children with 22q11DS and 13 healthy controls, using fMRI. Both groups showed task-related activation in dorsolateral prefrontal cortex (DLPFC) and bilateral parietal association cortices. Controls activated parietal and occipital regions significantly more than those with 22q11DS but there was no significant between-group difference in DLPFC. In addition, while controls had a significant age-related increase in the activation of posterior brain regions and an age-related decrease in anterior regions, the 22q11DS children showed the opposite pattern. Genetically determined differences in the development of specific brain systems may underpin the cognitive deficits in 22q11DS, and may contribute to the later development of neuropsychiatric disorders. En ligne : http://dx.doi.org/10.1007/s11689-009-9008-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341

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