Actigraphic investigation of circadian rhythm functioning and activity levels in children with mucopolysaccharidosis type III (Sanfilippo syndrome) / Rachel A. MUMFORD in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.31 Titre : Actigraphic investigation of circadian rhythm functioning and activity levels in children with mucopolysaccharidosis type III (Sanfilippo syndrome) Type de document : texte imprimé Auteurs : Rachel A. MUMFORD, Auteur ; Louise V. MAHON, Auteur ; Simon JONES, Auteur ; Brian W. BIGGER, Auteur ; Maria CANAL, Auteur ; Dougal Julian HARE, Auteur Article en page(s) : p.31 Langues : Anglais (eng) Mots-clés : Actigraphy  Circadian rhythms  Mucopolysaccharidosis type III  Sanfilippo  Sleep Index. décimale : PER Périodiques Résumé : BACKGROUND: Sleep disturbance is part of the behavioural phenotype of the rare genetic condition mucopolysaccharidosis (MPS) type III. A growing body of evidence suggests that underlying disturbance in circadian rhythm functioning may explain sleep problems within the MPS III population. METHODS: Actigraphic data were recorded in eight children with MPS III over 7-10 days and compared to age-matched typically developing controls. Parameters of circadian rhythmicity and activity levels across a 24-h period were analysed. RESULTS: Statistically and clinically significant differences between the two groups were noted. Analysis indicated that children with MPS III showed significantly increased fragmentation of circadian rhythm and reduced stability with external cues (zeitgebers), compared to controls. Average times of activity onset and offset were indicative of a phase delayed sleep-wake cycle for some children in the MPS III group. Children with MPS III had significantly higher activity levels during the early morning hours (midnight-6 am) compared to controls. CONCLUSIONS: Results are consistent with previous research into MPS III and suggest that there is an impairment in circadian rhythm functioning in children with this condition. Implications for clinical practice and the management of sleep difficulties are discussed. En ligne : http://dx.doi.org/10.1186/s11689-015-9126-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348 [article] Actigraphic investigation of circadian rhythm functioning and activity levels in children with mucopolysaccharidosis type III (Sanfilippo syndrome) [texte imprimé] / Rachel A. MUMFORD, Auteur ; Louise V. MAHON, Auteur ; Simon JONES, Auteur ; Brian W. BIGGER, Auteur ; Maria CANAL, Auteur ; Dougal Julian HARE, Auteur . - p.31. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.31 Mots-clés : Actigraphy  Circadian rhythms  Mucopolysaccharidosis type III  Sanfilippo  Sleep Index. décimale : PER Périodiques Résumé : BACKGROUND: Sleep disturbance is part of the behavioural phenotype of the rare genetic condition mucopolysaccharidosis (MPS) type III. A growing body of evidence suggests that underlying disturbance in circadian rhythm functioning may explain sleep problems within the MPS III population. METHODS: Actigraphic data were recorded in eight children with MPS III over 7-10 days and compared to age-matched typically developing controls. Parameters of circadian rhythmicity and activity levels across a 24-h period were analysed. RESULTS: Statistically and clinically significant differences between the two groups were noted. Analysis indicated that children with MPS III showed significantly increased fragmentation of circadian rhythm and reduced stability with external cues (zeitgebers), compared to controls. Average times of activity onset and offset were indicative of a phase delayed sleep-wake cycle for some children in the MPS III group. Children with MPS III had significantly higher activity levels during the early morning hours (midnight-6 am) compared to controls. CONCLUSIONS: Results are consistent with previous research into MPS III and suggest that there is an impairment in circadian rhythm functioning in children with this condition. Implications for clinical practice and the management of sleep difficulties are discussed. En ligne : http://dx.doi.org/10.1186/s11689-015-9126-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348

An investigation into social information processing in young people with Asperger syndrome / Andrea FLOOD in Autism, 15-5 (September 2011)  

Public ISBD [article]  inAutism > 15-5 (September 2011) . - p.601-624 Titre : An investigation into social information processing in young people with Asperger syndrome Type de document : texte imprimé Auteurs : Andrea FLOOD, Auteur ; Dougal Julian HARE, Auteur ; Paul WALLIS, Auteur Année de publication : 2011 Article en page(s) : p.601-624 Langues : Anglais (eng) Mots-clés : Asperger Syndrome  social cognition  social skills  social functioning Index. décimale : PER Périodiques Résumé : Deficits in social functioning are a core feature of autistic spectrum disorders (ASD), being linked to various cognitive and developmental factors, but there has been little attempt to draw on normative models of social cognition to understand social behaviour in ASD. The current study explored the utility of Crick and Dodge’s (1994) information processing model to studying social cognition in ASD, and examined associations between social information processing patterns, theory of mind skills and social functioning. A matched-group design compared young people with Asperger syndrome with typically developing peers, using a social information processing interview previously designed for this purpose. The Asperger syndrome group showed significantly different patterns of information processing at the intent attribution, response generation and response evaluation stages of the information processing model. Theory of mind skills were found to be significantly associated with parental ratings of peer problems in the Asperger syndrome group but not with parental ratings of pro-social behaviour, with only limited evidence of an association between social information processing and measures of theory of mind and social functioning. Overall, the study supports the use of normative social information processing approaches to understanding social functioning in ASD. En ligne : http://dx.doi.org/10.1177/1362361310387803 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=144 [article] An investigation into social information processing in young people with Asperger syndrome [texte imprimé] / Andrea FLOOD, Auteur ; Dougal Julian HARE, Auteur ; Paul WALLIS, Auteur . - 2011 . - p.601-624. Langues : Anglais (eng) in Autism > 15-5 (September 2011) . - p.601-624 Mots-clés : Asperger Syndrome  social cognition  social skills  social functioning Index. décimale : PER Périodiques Résumé : Deficits in social functioning are a core feature of autistic spectrum disorders (ASD), being linked to various cognitive and developmental factors, but there has been little attempt to draw on normative models of social cognition to understand social behaviour in ASD. The current study explored the utility of Crick and Dodge’s (1994) information processing model to studying social cognition in ASD, and examined associations between social information processing patterns, theory of mind skills and social functioning. A matched-group design compared young people with Asperger syndrome with typically developing peers, using a social information processing interview previously designed for this purpose. The Asperger syndrome group showed significantly different patterns of information processing at the intent attribution, response generation and response evaluation stages of the information processing model. Theory of mind skills were found to be significantly associated with parental ratings of peer problems in the Asperger syndrome group but not with parental ratings of pro-social behaviour, with only limited evidence of an association between social information processing and measures of theory of mind and social functioning. Overall, the study supports the use of normative social information processing approaches to understanding social functioning in ASD. En ligne : http://dx.doi.org/10.1177/1362361310387803 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=144

An Investigation of the “Jumping to Conclusions” Data-Gathering Bias and Paranoid Thoughts in Asperger Syndrome / Claire JANSCH in Journal of Autism and Developmental Disorders, 44-1 (January 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-1 (January 2014) . - p.111-119 Titre : An Investigation of the “Jumping to Conclusions” Data-Gathering Bias and Paranoid Thoughts in Asperger Syndrome Type de document : texte imprimé Auteurs : Claire JANSCH, Auteur ; Dougal Julian HARE, Auteur Article en page(s) : p.111-119 Langues : Anglais (eng) Mots-clés : Reasoning biases  Jumping to conclusions  Asperger syndrome  Anxiety  Depressions  Paranoia Index. décimale : PER Périodiques Résumé : The existence of a data-gathering bias, in the form of jumping to conclusions, and links to paranoid ideation was investigated in Asperger syndrome (AS). People with AS (N = 30) were compared to a neurotypical control group (N = 30) on the Reading the Mind in the Eyes and the Beads tasks, with self-report measures of depression, general anxiety, social anxiety, self-consciousness and paranoid ideation. The AS group performed less well than the control group on the Reading the Mind in the Eyes Task with regard to accuracy but responded more quickly and tended to make decisions on the basis of less evidence on the Beads Task with 50 % demonstrating a clear ‘jumping to conclusions bias’, whereas none of the control group showed such a bias. Depression and general anxiety were associated with paranoid ideation but not data-gathering style, which was contrary to expectation. En ligne : http://dx.doi.org/10.1007/s10803-013-1855-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220 [article] An Investigation of the “Jumping to Conclusions” Data-Gathering Bias and Paranoid Thoughts in Asperger Syndrome [texte imprimé] / Claire JANSCH, Auteur ; Dougal Julian HARE, Auteur . - p.111-119. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-1 (January 2014) . - p.111-119 Mots-clés : Reasoning biases  Jumping to conclusions  Asperger syndrome  Anxiety  Depressions  Paranoia Index. décimale : PER Périodiques Résumé : The existence of a data-gathering bias, in the form of jumping to conclusions, and links to paranoid ideation was investigated in Asperger syndrome (AS). People with AS (N = 30) were compared to a neurotypical control group (N = 30) on the Reading the Mind in the Eyes and the Beads tasks, with self-report measures of depression, general anxiety, social anxiety, self-consciousness and paranoid ideation. The AS group performed less well than the control group on the Reading the Mind in the Eyes Task with regard to accuracy but responded more quickly and tended to make decisions on the basis of less evidence on the Beads Task with 50 % demonstrating a clear ‘jumping to conclusions bias’, whereas none of the control group showed such a bias. Depression and general anxiety were associated with paranoid ideation but not data-gathering style, which was contrary to expectation. En ligne : http://dx.doi.org/10.1007/s10803-013-1855-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220

An investigation of the middle and late behavioural phenotypes of Mucopolysaccharidosis Type-III / Elaine M. CROSS in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.46 Titre : An investigation of the middle and late behavioural phenotypes of Mucopolysaccharidosis Type-III Type de document : texte imprimé Auteurs : Elaine M. CROSS, Auteur ; Sean GRANT, Auteur ; Simon JONES, Auteur ; Brian W. BIGGER, Auteur ; James E. WRAITH, Auteur ; Louise V. MAHON, Auteur ; Michelle LOMAX, Auteur ; Dougal Julian HARE, Auteur Article en page(s) : p.46 Langues : Anglais (eng) Mots-clés : Behavioural phenotype  Mps iii  Mucopolysaccharidosis  Sanfilippo syndrome Index. décimale : PER Périodiques Résumé : BACKGROUND: Mucopolysaccharidosis type-III (MPS III) is an autosomal recessive lysosomal storage disorder. It causes progressive physical and cognitive decline and has been linked to increased incidences of behavioural problems. METHODS: Data on the behaviour and adaptive skills of 20 children with MPS III and 25 children with intellectual disability (ID) (17 included in analysis) were gathered via parental report questionnaire. The frequencies of different types of behaviour displayed by children with MPS III and children with ID were compared across two age categories. RESULTS: The total frequency of challenging behaviours displayed by children aged 2-9 years with MPS III and ID was not significantly different. Behaviours associated with hyperactivity, orality, unusual body movements and inattention were seen significantly more frequently in 2-9 year olds with MPS III than in those with ID. Children aged 10-15 years with MPS III showed significantly fewer problem behaviours than a contrasting group with ID. The frequency of challenging behaviours displayed by children with MPS III and their adaptive skills was found to decrease with age. CONCLUSIONS: Behaviours relating to hyperactivity, orality, unusual body movements and inattention are part of the behavioural phenotype of the middle phase of MPS III. The late phase of MPS III is associated with low rates of problem behaviour and loss of adaptive skills. Therefore, families with a child with MPS III may benefit from a different type of clinical service when the child is aged 2-9 years, than when aged 10-15 years. En ligne : http://dx.doi.org/10.1186/1866-1955-6-46 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 [article] An investigation of the middle and late behavioural phenotypes of Mucopolysaccharidosis Type-III [texte imprimé] / Elaine M. CROSS, Auteur ; Sean GRANT, Auteur ; Simon JONES, Auteur ; Brian W. BIGGER, Auteur ; James E. WRAITH, Auteur ; Louise V. MAHON, Auteur ; Michelle LOMAX, Auteur ; Dougal Julian HARE, Auteur . - p.46. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.46 Mots-clés : Behavioural phenotype  Mps iii  Mucopolysaccharidosis  Sanfilippo syndrome Index. décimale : PER Périodiques Résumé : BACKGROUND: Mucopolysaccharidosis type-III (MPS III) is an autosomal recessive lysosomal storage disorder. It causes progressive physical and cognitive decline and has been linked to increased incidences of behavioural problems. METHODS: Data on the behaviour and adaptive skills of 20 children with MPS III and 25 children with intellectual disability (ID) (17 included in analysis) were gathered via parental report questionnaire. The frequencies of different types of behaviour displayed by children with MPS III and children with ID were compared across two age categories. RESULTS: The total frequency of challenging behaviours displayed by children aged 2-9 years with MPS III and ID was not significantly different. Behaviours associated with hyperactivity, orality, unusual body movements and inattention were seen significantly more frequently in 2-9 year olds with MPS III than in those with ID. Children aged 10-15 years with MPS III showed significantly fewer problem behaviours than a contrasting group with ID. The frequency of challenging behaviours displayed by children with MPS III and their adaptive skills was found to decrease with age. CONCLUSIONS: Behaviours relating to hyperactivity, orality, unusual body movements and inattention are part of the behavioural phenotype of the middle phase of MPS III. The late phase of MPS III is associated with low rates of problem behaviour and loss of adaptive skills. Therefore, families with a child with MPS III may benefit from a different type of clinical service when the child is aged 2-9 years, than when aged 10-15 years. En ligne : http://dx.doi.org/10.1186/1866-1955-6-46 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347

Anxiety in Asperger’s syndrome: Assessment in real time / Dougal Julian HARE in Autism, 19-5 (July 2015)  

Public ISBD [article]  inAutism > 19-5 (July 2015) . - p.542-552 Titre : Anxiety in Asperger’s syndrome: Assessment in real time Type de document : texte imprimé Auteurs : Dougal Julian HARE, Auteur ; Christopher WOOD, Auteur ; Sarah WASTELL, Auteur ; Paul SKIRROW, Auteur Article en page(s) : p.542-552 Langues : Anglais (eng) Mots-clés : anxiety  Asperger’s syndrome  cognitive processes  experience sampling methodology Index. décimale : PER Périodiques Résumé : Anxiety is a major problem for many people with Asperger’s syndrome who may have qualitatively different fears from a non-Asperger’s syndrome population. Research has relied on measures developed for non-Asperger’s syndrome populations that require reporting past experiences of anxiety, which may confound assessment in people with Asperger’s syndrome due to problems with autobiographical memory as are often reported in this group.Experience sampling methodology was used to record real-time everyday experiences in 20 adults with Asperger’s syndrome and 20 neurotypical adults. Within-subject analysis was used to explore the phenomenology of thoughts occurring in people with Asperger’s syndrome when they were anxious. Comparisons were made with the group that did not have Asperger’s syndrome. The Asperger’s syndrome group were significantly more anxious than the comparison group. Factors associated with feelings of anxiety in the Asperger’s syndrome group were high levels of self-focus, worries about everyday events and periods of rumination lasting over 10 min. People in the Asperger’s syndrome group also had a tendency to think in the image form, but this was not associated with feelings of anxiety. The results are discussed with reference to psychological models of Asperger’s syndrome, cognitive models of anxiety and implications for psychological therapy for this group. En ligne : http://dx.doi.org/10.1177/1362361314531340 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261 [article] Anxiety in Asperger’s syndrome: Assessment in real time [texte imprimé] / Dougal Julian HARE, Auteur ; Christopher WOOD, Auteur ; Sarah WASTELL, Auteur ; Paul SKIRROW, Auteur . - p.542-552. Langues : Anglais (eng) in Autism > 19-5 (July 2015) . - p.542-552 Mots-clés : anxiety  Asperger’s syndrome  cognitive processes  experience sampling methodology Index. décimale : PER Périodiques Résumé : Anxiety is a major problem for many people with Asperger’s syndrome who may have qualitatively different fears from a non-Asperger’s syndrome population. Research has relied on measures developed for non-Asperger’s syndrome populations that require reporting past experiences of anxiety, which may confound assessment in people with Asperger’s syndrome due to problems with autobiographical memory as are often reported in this group.Experience sampling methodology was used to record real-time everyday experiences in 20 adults with Asperger’s syndrome and 20 neurotypical adults. Within-subject analysis was used to explore the phenomenology of thoughts occurring in people with Asperger’s syndrome when they were anxious. Comparisons were made with the group that did not have Asperger’s syndrome. The Asperger’s syndrome group were significantly more anxious than the comparison group. Factors associated with feelings of anxiety in the Asperger’s syndrome group were high levels of self-focus, worries about everyday events and periods of rumination lasting over 10 min. People in the Asperger’s syndrome group also had a tendency to think in the image form, but this was not associated with feelings of anxiety. The results are discussed with reference to psychological models of Asperger’s syndrome, cognitive models of anxiety and implications for psychological therapy for this group. En ligne : http://dx.doi.org/10.1177/1362361314531340 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261

Anxiety in high-functioning autism: A pilot study of experience sampling using a mobile platform / Dougal Julian HARE in Autism, 20-6 (August 2016)  

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Approaching Reality: The Use of Personal Construct Assessment in Working with People with Asperger Syndrome / Dougal Julian HARE in Autism, 3-2 (June 1999)  

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Asperger Through the Looking Glass: An Exploratory Study of Self-Understanding in People with Asperger’s Syndrome / Paul JACKSON in Journal of Autism and Developmental Disorders, 42-5 (May 2012)  

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Editorial / Dougal Julian HARE in Autism, 12-6 (November 2008)  

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Editorial / Dougal Julian HARE in Autism, 13-2 (March 2009)  

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Editorial / Dougal Julian HARE in Autism, 13-3 (May 2009)  

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Editorial / Dougal Julian HARE in Autism, 14-2 (March 2010)  

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Editorial / Dougal Julian HARE in Autism, 15-4 (July 2011)  

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Editorial / Dougal Julian HARE in Autism, 11-4 (July 2007)  

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Editorial / Dougal Julian HARE in Autism, 11-2 (March 2007)  

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