How to Test the Extreme Male Brain Theory of Autism in Terms of Foetal Androgens? / Rebecca C. KNICKMEYER in Journal of Autism and Developmental Disorders, 38-5 (May 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-5 (May 2008) . - p.995-996 Titre : How to Test the Extreme Male Brain Theory of Autism in Terms of Foetal Androgens? Type de document : texte imprimé Auteurs : Rebecca C. KNICKMEYER, Auteur ; Simon BARON-COHEN, Auteur ; Bonnie AUYEUNG, Auteur ; Emma ASHWIN, Auteur Année de publication : 2008 Article en page(s) : p.995-996 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-008-0553-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=418 [article] How to Test the Extreme Male Brain Theory of Autism in Terms of Foetal Androgens? [texte imprimé] / Rebecca C. KNICKMEYER, Auteur ; Simon BARON-COHEN, Auteur ; Bonnie AUYEUNG, Auteur ; Emma ASHWIN, Auteur . - 2008 . - p.995-996. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-5 (May 2008) . - p.995-996 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-008-0553-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=418

Sex-typical Play: Masculinization/Defeminization in Girls with an Autism Spectrum Condition / Rebecca C. KNICKMEYER in Journal of Autism and Developmental Disorders, 38-6 (July 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-6 (July 2008) . - p.1028-1035 Titre : Sex-typical Play: Masculinization/Defeminization in Girls with an Autism Spectrum Condition Type de document : texte imprimé Auteurs : Rebecca C. KNICKMEYER, Auteur ; Simon BARON-COHEN, Auteur ; Sally WHEELWRIGHT, Auteur Année de publication : 2008 Article en page(s) : p.1028-1035 Langues : Anglais (eng) Mots-clés : Autism Sex-differences Play Fetal-testosterone Index. décimale : PER Périodiques Résumé : We tested the hypothesis that prenatal masculinization of the brain by androgens increases risk of developing an autism spectrum condition (ASC). Sex-typical play was measured in n = 66 children diagnosed with an ASC and n = 55 typically developing age-matched controls. Consistent with the hypothesis, girls with autism did not show the female-typical play preferences, though this was only seen on non-pretence items. Boys with autism showed a preference for male play on non-pretence items, in keeping with their sex. Girls with autism engaged in more pretend play than boys with autism, suggesting that pretence is relatively more protected in females with autism. We conclude that play preference studies in ASC provide partial support for the fetal androgen theory. En ligne : http://dx.doi.org/10.1007/s10803-007-0475-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Sex-typical Play: Masculinization/Defeminization in Girls with an Autism Spectrum Condition [texte imprimé] / Rebecca C. KNICKMEYER, Auteur ; Simon BARON-COHEN, Auteur ; Sally WHEELWRIGHT, Auteur . - 2008 . - p.1028-1035. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-6 (July 2008) . - p.1028-1035 Mots-clés : Autism Sex-differences Play Fetal-testosterone Index. décimale : PER Périodiques Résumé : We tested the hypothesis that prenatal masculinization of the brain by androgens increases risk of developing an autism spectrum condition (ASC). Sex-typical play was measured in n = 66 children diagnosed with an ASC and n = 55 typically developing age-matched controls. Consistent with the hypothesis, girls with autism did not show the female-typical play preferences, though this was only seen on non-pretence items. Boys with autism showed a preference for male play on non-pretence items, in keeping with their sex. Girls with autism engaged in more pretend play than boys with autism, suggesting that pretence is relatively more protected in females with autism. We conclude that play preference studies in ASC provide partial support for the fetal androgen theory. En ligne : http://dx.doi.org/10.1007/s10803-007-0475-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

The Extreme Male Brain Theory of Autism: The Role of Fetal Androgens / Simon BARON-COHEN

Public ISBD in Autism Spectrum Disorders / David G. AMARAL Titre : The Extreme Male Brain Theory of Autism: The Role of Fetal Androgens Type de document : texte imprimé Auteurs : Simon BARON-COHEN, Auteur ; Bonnie AUYEUNG, Auteur ; Emma ASHWIN, Auteur ; Rebecca C. KNICKMEYER, Auteur ; Michael V. LOMBARDO, Auteur ; Bhismadev CHAKRABARTI, Auteur Année de publication : 2011 Importance : p.991-998 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140 in Autism Spectrum Disorders / David G. AMARAL The Extreme Male Brain Theory of Autism: The Role of Fetal Androgens [texte imprimé] / Simon BARON-COHEN, Auteur ; Bonnie AUYEUNG, Auteur ; Emma ASHWIN, Auteur ; Rebecca C. KNICKMEYER, Auteur ; Michael V. LOMBARDO, Auteur ; Bhismadev CHAKRABARTI, Auteur . - 2011 . - p.991-998. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140

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Turner syndrome and sexual differentiation of the brain: implications for understanding male-biased neurodevelopmental disorders / Rebecca Christine KNICKMEYER in Journal of Neurodevelopmental Disorders, 3-4 (December 2011)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 3-4 (December 2011) . - p.293-306 Titre : Turner syndrome and sexual differentiation of the brain: implications for understanding male-biased neurodevelopmental disorders Type de document : texte imprimé Auteurs : Rebecca Christine KNICKMEYER, Auteur ; Marsha DAVENPORT, Auteur Article en page(s) : p.293-306 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Turner syndrome (TS) is one of the most common sex chromosome abnormalities. Affected individuals often show a unique pattern of cognitive strengths and weaknesses and are at increased risk for a number of other neurodevelopmental conditions, many of which are more common in typical males than typical females (e.g., autism and attention-deficit hyperactivity disorder). This phenotype may reflect gonadal steroid deficiency, haploinsufficiency of X chromosome genes, failure to express parentally imprinted genes, and the uncovering of X chromosome mutations. Understanding the contribution of these different mechanisms to outcome has the potential to improve clinical care for individuals with TS and to better our understanding of the differential vulnerability to and expression of neurodevelopmental disorders in males and females. In this paper, we review what is currently known about cognition and brain development in individuals with TS, discuss underlying mechanisms and their relevance to understanding male-biased neurodevelopmental conditions, and suggest directions for future research. En ligne : http://dx.doi.org/10.1007/s11689-011-9089-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343 [article] Turner syndrome and sexual differentiation of the brain: implications for understanding male-biased neurodevelopmental disorders [texte imprimé] / Rebecca Christine KNICKMEYER, Auteur ; Marsha DAVENPORT, Auteur . - p.293-306. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 3-4 (December 2011) . - p.293-306 Index. décimale : PER Périodiques Résumé : Turner syndrome (TS) is one of the most common sex chromosome abnormalities. Affected individuals often show a unique pattern of cognitive strengths and weaknesses and are at increased risk for a number of other neurodevelopmental conditions, many of which are more common in typical males than typical females (e.g., autism and attention-deficit hyperactivity disorder). This phenotype may reflect gonadal steroid deficiency, haploinsufficiency of X chromosome genes, failure to express parentally imprinted genes, and the uncovering of X chromosome mutations. Understanding the contribution of these different mechanisms to outcome has the potential to improve clinical care for individuals with TS and to better our understanding of the differential vulnerability to and expression of neurodevelopmental disorders in males and females. In this paper, we review what is currently known about cognition and brain development in individuals with TS, discuss underlying mechanisms and their relevance to understanding male-biased neurodevelopmental conditions, and suggest directions for future research. En ligne : http://dx.doi.org/10.1007/s11689-011-9089-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343

Turner syndrome: language profile of young girls at 12 and 24 months of age / Debra B. REINHARTSEN in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : Turner syndrome: language profile of young girls at 12 and 24 months of age Type de document : texte imprimé Auteurs : Debra B. REINHARTSEN, Auteur ; Emil CORNEA, Auteur ; Margaret DERAMUS, Auteur ; Angelia B. WAITT, Auteur ; Rebecca Edmondson PRETZEL, Auteur ; Rebecca C. KNICKMEYER, Auteur ; Marsha L. DAVENPORT, Auteur ; John H. GILMORE, Auteur ; Stephen R. HOOPER, Auteur Langues : Anglais (eng) Mots-clés : Child, Preschool  Cognition  Female  Humans  Infant  Language Development  Language Development Disorders/epidemiology  Speech  Turner Syndrome/complications  Expressive language  Infants  Neurodevelopmental disorders  Receptive language  Social language  Symbolic language  Toddlers  Turner syndrome Index. décimale : PER Périodiques Résumé : BACKGROUND: Turner syndrome (TS) is a genetic disorder associated with complete or partial absence of an X chromosome affecting approximately 1/2000 live female births. Available evidence suggests that, in the school-age years, girls with TS often require speech and language services; however, little is known about the language development of infants and toddlers. METHOD: This study (N = 31) explored the language profiles of 12- and 24-month-old girls with TS, as well as the percentage of girls who might be "at risk" for language delays. We also followed a subset of 12-month-old girls with TS to 24 months of age to determine the stability of the 12-month findings. RESULTS: Although all mean scores were within the average range at both time points, results revealed a higher prevalence of 24-month-old girls with TS "at risk" for receptive language difficulties. In addition, expressive language skills significantly exceeded receptive language skills at both time points. We found 12-month-old girls to be "at risk" for social and symbolic difficulties based on clinical assessment; only symbolic difficulties were significant based on caregiver report. At 24 months, clinical assessment indicated greater use of speech sounds and words than normative expectations. Caregivers reported greater use of speech sounds, and also, greater use of gestures. Although some changes occurred over a 1-year time span (12 to 24 months), all mean test scores remained within the average range and the changes in the percentage of girls manifesting "at risk" status on either the PLS-4 or CSBS-DP were non-significant. CONCLUSIONS: Although within normal limits, receptive language skills were found to be significantly lower than expressive language skills at both ages. Social and symbolic communication skills also were in the average range, with both showing significant improvement from 12 to 24 months based on clinical assessment. Caregiver report found that use of gestures and production of speech sounds not only improved from 12 to 24 months, but also exceeded normative expectations. Findings suggest the presence of relatively intact speech and language abilities during the first 2 years of life, with perhaps some emergent concerns for receptive language development. Ongoing developmental surveillance will be important. En ligne : https://dx.doi.org/10.1186/s11689-021-09401-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Turner syndrome: language profile of young girls at 12 and 24 months of age [texte imprimé] / Debra B. REINHARTSEN, Auteur ; Emil CORNEA, Auteur ; Margaret DERAMUS, Auteur ; Angelia B. WAITT, Auteur ; Rebecca Edmondson PRETZEL, Auteur ; Rebecca C. KNICKMEYER, Auteur ; Marsha L. DAVENPORT, Auteur ; John H. GILMORE, Auteur ; Stephen R. HOOPER, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Child, Preschool  Cognition  Female  Humans  Infant  Language Development  Language Development Disorders/epidemiology  Speech  Turner Syndrome/complications  Expressive language  Infants  Neurodevelopmental disorders  Receptive language  Social language  Symbolic language  Toddlers  Turner syndrome Index. décimale : PER Périodiques Résumé : BACKGROUND: Turner syndrome (TS) is a genetic disorder associated with complete or partial absence of an X chromosome affecting approximately 1/2000 live female births. Available evidence suggests that, in the school-age years, girls with TS often require speech and language services; however, little is known about the language development of infants and toddlers. METHOD: This study (N = 31) explored the language profiles of 12- and 24-month-old girls with TS, as well as the percentage of girls who might be "at risk" for language delays. We also followed a subset of 12-month-old girls with TS to 24 months of age to determine the stability of the 12-month findings. RESULTS: Although all mean scores were within the average range at both time points, results revealed a higher prevalence of 24-month-old girls with TS "at risk" for receptive language difficulties. In addition, expressive language skills significantly exceeded receptive language skills at both time points. We found 12-month-old girls to be "at risk" for social and symbolic difficulties based on clinical assessment; only symbolic difficulties were significant based on caregiver report. At 24 months, clinical assessment indicated greater use of speech sounds and words than normative expectations. Caregivers reported greater use of speech sounds, and also, greater use of gestures. Although some changes occurred over a 1-year time span (12 to 24 months), all mean test scores remained within the average range and the changes in the percentage of girls manifesting "at risk" status on either the PLS-4 or CSBS-DP were non-significant. CONCLUSIONS: Although within normal limits, receptive language skills were found to be significantly lower than expressive language skills at both ages. Social and symbolic communication skills also were in the average range, with both showing significant improvement from 12 to 24 months based on clinical assessment. Caregiver report found that use of gestures and production of speech sounds not only improved from 12 to 24 months, but also exceeded normative expectations. Findings suggest the presence of relatively intact speech and language abilities during the first 2 years of life, with perhaps some emergent concerns for receptive language development. Ongoing developmental surveillance will be important. En ligne : https://dx.doi.org/10.1186/s11689-021-09401-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

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