Life stress, the dopamine receptor gene, and emerging adult drug use trajectories: A longitudinal, multilevel, mediated moderation analysis / Gene H. BRODY in Development and Psychopathology, 24-3 (August 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-3 (August 2012) . - p.941-51 Titre : Life stress, the dopamine receptor gene, and emerging adult drug use trajectories: A longitudinal, multilevel, mediated moderation analysis Type de document : Texte imprimé et/ou numérique Auteurs : Gene H. BRODY, Auteur ; Yi-Fu CHEN, Auteur ; Tianyi YU, Auteur ; Steven R. H. BEACH, Auteur ; Steven M. KOGAN, Auteur ; Ronald L. SIMONS, Auteur ; Michael WINDLE, Auteur ; Robert A. PHILIBERT, Auteur Année de publication : 2012 Article en page(s) : p.941-51 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study was designed to examine the prospective relations of life stress and genetic status with increases in drug use. African Americans (N = 399) in rural Georgia (Wave 1 mean age = 17 years) provided three waves of data across 27.5 months and a saliva sample from which the dopamine receptor D4 (DRD4) gene was genotyped. Multilevel growth curve modeling analysis indicated that emerging adults manifested the highest escalations in drug use when they reported high life stress and carried an allele of DRD4 with 7 or more repeats (7 + R allele). In addition, emerging adults who reported high life stress and carried the 7 + R allele evinced the largest increases in two proximal risk factors for drug use: affiliations with drug-using companions and drug use vulnerability cognitions. Furthermore, when the Gene × Environment interaction effects on the increases in affiliations with drug-using companions and vulnerability cognitions were entered into the model forecasting drug use, the Life Stress × DRD4 Status interaction on drug use became nonsignificant in the presence of the risk mechanisms. This finding provides an example of “second generation” Gene × Environment interaction research in which the interaction's effects on proximal risk mechanisms account for its effects on outcomes. En ligne : http://dx.doi.org/10.1017/S0954579412000466 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Life stress, the dopamine receptor gene, and emerging adult drug use trajectories: A longitudinal, multilevel, mediated moderation analysis [Texte imprimé et/ou numérique] / Gene H. BRODY, Auteur ; Yi-Fu CHEN, Auteur ; Tianyi YU, Auteur ; Steven R. H. BEACH, Auteur ; Steven M. KOGAN, Auteur ; Ronald L. SIMONS, Auteur ; Michael WINDLE, Auteur ; Robert A. PHILIBERT, Auteur . - 2012 . - p.941-51. Langues : Anglais (eng) in Development and Psychopathology > 24-3 (August 2012) . - p.941-51 Index. décimale : PER Périodiques Résumé : This study was designed to examine the prospective relations of life stress and genetic status with increases in drug use. African Americans (N = 399) in rural Georgia (Wave 1 mean age = 17 years) provided three waves of data across 27.5 months and a saliva sample from which the dopamine receptor D4 (DRD4) gene was genotyped. Multilevel growth curve modeling analysis indicated that emerging adults manifested the highest escalations in drug use when they reported high life stress and carried an allele of DRD4 with 7 or more repeats (7 + R allele). In addition, emerging adults who reported high life stress and carried the 7 + R allele evinced the largest increases in two proximal risk factors for drug use: affiliations with drug-using companions and drug use vulnerability cognitions. Furthermore, when the Gene × Environment interaction effects on the increases in affiliations with drug-using companions and vulnerability cognitions were entered into the model forecasting drug use, the Life Stress × DRD4 Status interaction on drug use became nonsignificant in the presence of the risk mechanisms. This finding provides an example of “second generation” Gene × Environment interaction research in which the interaction's effects on proximal risk mechanisms account for its effects on outcomes. En ligne : http://dx.doi.org/10.1017/S0954579412000466 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

A model-based cluster analysis approach to adolescent problem behaviors and young adult outcomes / Eun YOUNG MUN in Development and Psychopathology, 20-1 (Winter 2008)  

Public ISBD [article]  inDevelopment and Psychopathology > 20-1 (Winter 2008) . - p.291-318 Titre : A model-based cluster analysis approach to adolescent problem behaviors and young adult outcomes Type de document : Texte imprimé et/ou numérique Auteurs : Eun YOUNG MUN, Auteur ; Michael WINDLE, Auteur ; Lisa M. SCHAINKER, Auteur Année de publication : 2008 Article en page(s) : p.291-318 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Data from a community-based sample of 1,126 10th- and 11th-grade adolescents were analyzed using a model-based cluster analysis approach to empirically identify heterogeneous adolescent subpopulations from the person-oriented and pattern-oriented perspectives. The model-based cluster analysis is a new clustering procedure to investigate population heterogeneity utilizing finite mixture multivariate normal densities and accordingly to classify subpopulations using more rigorous statistical procedures for the comparison of alternative models. Four cluster groups were identified and labeled multiproblem high-risk, smoking high-risk, normative, and low-risk groups. The multiproblem high risk exhibited a constellation of high levels of problem behaviors, including delinquent and sexual behaviors, multiple illicit substance use, and depressive symptoms at age 16. They had risky temperamental attributes and lower academic functioning and educational expectations at age 15.5 and, subsequently, at age 24 completed fewer years of education, and reported lower levels of physical health and higher levels of continued involvement in substance use and abuse. The smoking high-risk group was also found to be at risk for poorer functioning in young adulthood, compared to the low-risk group. The normative and the low risk groups were, by and large, similar in their adolescent and young adult functioning. The continuity and comorbidity path from middle adolescence to young adulthood may be aided and abetted by chronic as well as episodic substance use by adolescents. En ligne : http://dx.doi.org/10.1017/s095457940800014x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=333 [article] A model-based cluster analysis approach to adolescent problem behaviors and young adult outcomes [Texte imprimé et/ou numérique] / Eun YOUNG MUN, Auteur ; Michael WINDLE, Auteur ; Lisa M. SCHAINKER, Auteur . - 2008 . - p.291-318. Langues : Anglais (eng) in Development and Psychopathology > 20-1 (Winter 2008) . - p.291-318 Index. décimale : PER Périodiques Résumé : Data from a community-based sample of 1,126 10th- and 11th-grade adolescents were analyzed using a model-based cluster analysis approach to empirically identify heterogeneous adolescent subpopulations from the person-oriented and pattern-oriented perspectives. The model-based cluster analysis is a new clustering procedure to investigate population heterogeneity utilizing finite mixture multivariate normal densities and accordingly to classify subpopulations using more rigorous statistical procedures for the comparison of alternative models. Four cluster groups were identified and labeled multiproblem high-risk, smoking high-risk, normative, and low-risk groups. The multiproblem high risk exhibited a constellation of high levels of problem behaviors, including delinquent and sexual behaviors, multiple illicit substance use, and depressive symptoms at age 16. They had risky temperamental attributes and lower academic functioning and educational expectations at age 15.5 and, subsequently, at age 24 completed fewer years of education, and reported lower levels of physical health and higher levels of continued involvement in substance use and abuse. The smoking high-risk group was also found to be at risk for poorer functioning in young adulthood, compared to the low-risk group. The normative and the low risk groups were, by and large, similar in their adolescent and young adult functioning. The continuity and comorbidity path from middle adolescence to young adulthood may be aided and abetted by chronic as well as episodic substance use by adolescents. En ligne : http://dx.doi.org/10.1017/s095457940800014x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=333

Neighborhood × Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children / Michael WINDLE in Development and Psychopathology, 28-2 (May 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-2 (May 2016) . - p.415-431 Titre : Neighborhood × Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children Type de document : Texte imprimé et/ou numérique Auteurs : Michael WINDLE, Auteur ; Steven M. KOGAN, Auteur ; Sunbok LEE, Auteur ; Yi-Fu CHEN, Auteur ; Karlo Mankit LEI, Auteur ; Gene H. BRODY, Auteur ; Steven R. H. BEACH, Auteur ; Tianyi YU, Auteur Article en page(s) : p.415-431 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study investigated the influences of neighborhood factors (residential stability and neighborhood disadvantage) and variants of the serotonin transporter linked polymorphic region (5-HTTLPR) genotype on the development of substance use among African American children aged 10–24 years. To accomplish this, a harmonized data set of five longitudinal studies was created via pooling overlapping age cohorts to establish a database with 2,689 children and 12,474 data points to span ages 10–24 years. A description of steps used in the development of the harmonized data set is provided, including how issues such as the measurement equivalence of constructs were addressed. A sequence of multilevel models was specified to evaluate Gene × Environment effects on growth of substance use across time. Findings indicated that residential instability was associated with higher levels and a steeper gradient of growth in substance use across time. The inclusion of the 5-HTTLPR genotype provided greater precision to the relationships in that higher residential instability, in conjunction with the risk variant of 5-HTTLPR (i.e., the short allele), was associated with the highest level and steepest gradient of growth in substance use across ages 10–24 years. The findings demonstrated how the creation of a harmonized data set increased statistical power to test Gene × Environment interactions for an under studied sample. En ligne : http://dx.doi.org/10.1017/S095457941500053X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Neighborhood × Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children [Texte imprimé et/ou numérique] / Michael WINDLE, Auteur ; Steven M. KOGAN, Auteur ; Sunbok LEE, Auteur ; Yi-Fu CHEN, Auteur ; Karlo Mankit LEI, Auteur ; Gene H. BRODY, Auteur ; Steven R. H. BEACH, Auteur ; Tianyi YU, Auteur . - p.415-431. Langues : Anglais (eng) in Development and Psychopathology > 28-2 (May 2016) . - p.415-431 Index. décimale : PER Périodiques Résumé : This study investigated the influences of neighborhood factors (residential stability and neighborhood disadvantage) and variants of the serotonin transporter linked polymorphic region (5-HTTLPR) genotype on the development of substance use among African American children aged 10–24 years. To accomplish this, a harmonized data set of five longitudinal studies was created via pooling overlapping age cohorts to establish a database with 2,689 children and 12,474 data points to span ages 10–24 years. A description of steps used in the development of the harmonized data set is provided, including how issues such as the measurement equivalence of constructs were addressed. A sequence of multilevel models was specified to evaluate Gene × Environment effects on growth of substance use across time. Findings indicated that residential instability was associated with higher levels and a steeper gradient of growth in substance use across time. The inclusion of the 5-HTTLPR genotype provided greater precision to the relationships in that higher residential instability, in conjunction with the risk variant of 5-HTTLPR (i.e., the short allele), was associated with the highest level and steepest gradient of growth in substance use across ages 10–24 years. The findings demonstrated how the creation of a harmonized data set increased statistical power to test Gene × Environment interactions for an under studied sample. En ligne : http://dx.doi.org/10.1017/S095457941500053X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

Prospective effects of violence exposure across multiple contexts on early adolescents’ internalizing and externalizing problems / Sylvie MRUG in Journal of Child Psychology and Psychiatry, 51-8 (August 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-8 (August 2010) . - p.953-961 Titre : Prospective effects of violence exposure across multiple contexts on early adolescents’ internalizing and externalizing problems Type de document : Texte imprimé et/ou numérique Auteurs : Sylvie MRUG, Auteur ; Michael WINDLE, Auteur Année de publication : 2010 Article en page(s) : p.953-961 Langues : Anglais (eng) Mots-clés : Violence exposure  adolescence  internalizing problems  externalizing problems Index. décimale : PER Périodiques Résumé : Background:  Violence exposure within each setting of community, school, or home has been linked with internalizing and externalizing problems. Although many children experience violence in multiple contexts, the effects of such cross-contextual exposure have not been studied. This study addresses this gap by examining independent and interactive effects of witnessing violence and victimization in the community, home, and school on subsequent internalizing and externalizing problems in early adolescence. Methods:  A community sample of 603 boys and girls (78% African American, 20% Caucasian) participated in a longitudinal study of youth violence. During two assessments 16 months apart, adolescents reported on witnessing violence and victimization in the community, school, and home, and their internalizing and externalizing problems. Results:  Multiple regressions tested the independent and interactive effects of witnessing violence or victimization across contexts on subsequent adjustment, after controlling for initial levels of internalizing and externalizing problems and demographic covariates. Witnessing violence at school predicted anxiety and depression; witnessing at home was related to anxiety and aggression; and witnessing community violence predicted delinquency. Victimization at home was related to subsequent anxiety, depression, and aggression; victimization at school predicted anxiety; and victimization in the community was not independently related to any outcomes. Finally, witnessing violence at home was associated with more anxiety, delinquency, and aggression only if adolescents reported no exposure to community violence. Conclusions:  Violence exposure at home and school had the strongest independent effects on internalizing and externalizing outcomes. Witnessing community violence attenuated the effects of witnessing home violence on anxiety and externalizing problems, perhaps due to desensitization or different norms or expectations regarding violence. However, no comparable attenuation effects were observed for victimization across contexts. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02222.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108 [article] Prospective effects of violence exposure across multiple contexts on early adolescents’ internalizing and externalizing problems [Texte imprimé et/ou numérique] / Sylvie MRUG, Auteur ; Michael WINDLE, Auteur . - 2010 . - p.953-961. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-8 (August 2010) . - p.953-961 Mots-clés : Violence exposure  adolescence  internalizing problems  externalizing problems Index. décimale : PER Périodiques Résumé : Background:  Violence exposure within each setting of community, school, or home has been linked with internalizing and externalizing problems. Although many children experience violence in multiple contexts, the effects of such cross-contextual exposure have not been studied. This study addresses this gap by examining independent and interactive effects of witnessing violence and victimization in the community, home, and school on subsequent internalizing and externalizing problems in early adolescence. Methods:  A community sample of 603 boys and girls (78% African American, 20% Caucasian) participated in a longitudinal study of youth violence. During two assessments 16 months apart, adolescents reported on witnessing violence and victimization in the community, school, and home, and their internalizing and externalizing problems. Results:  Multiple regressions tested the independent and interactive effects of witnessing violence or victimization across contexts on subsequent adjustment, after controlling for initial levels of internalizing and externalizing problems and demographic covariates. Witnessing violence at school predicted anxiety and depression; witnessing at home was related to anxiety and aggression; and witnessing community violence predicted delinquency. Victimization at home was related to subsequent anxiety, depression, and aggression; victimization at school predicted anxiety; and victimization in the community was not independently related to any outcomes. Finally, witnessing violence at home was associated with more anxiety, delinquency, and aggression only if adolescents reported no exposure to community violence. Conclusions:  Violence exposure at home and school had the strongest independent effects on internalizing and externalizing outcomes. Witnessing community violence attenuated the effects of witnessing home violence on anxiety and externalizing problems, perhaps due to desensitization or different norms or expectations regarding violence. However, no comparable attenuation effects were observed for victimization across contexts. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02222.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108

Social Cognitive and Emotional Mediators Link Violence Exposure and Parental Nurturance to Adolescent Aggression / Wei SU in Journal of Clinical Child & Adolescent Psychology, 39-6 (November-December 2010)  

Public ISBD [article]  inJournal of Clinical Child & Adolescent Psychology > 39-6 (November-December 2010) . - p.814-824 Titre : Social Cognitive and Emotional Mediators Link Violence Exposure and Parental Nurturance to Adolescent Aggression Type de document : Texte imprimé et/ou numérique Auteurs : Wei SU, Auteur ; Sylvie MRUG, Auteur ; Michael WINDLE, Auteur Année de publication : 2010 Article en page(s) : p.814-824 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study examined aggressive fantasies, violence-approving attitudes, and empathy as mediators of the effects of violence exposure and parental nurturance on aggression. A total of 603 early adolescents (M age = 11.8 years; SD = 0.8) participated in a two-wave study, reporting on violence exposure and parental nurturance at Wave 1 and the three mediators and aggression at Wave 2. Violence-approving attitudes mediated the effects of both violence exposure and low parental nurturance on aggression. Aggressive fantasies also mediated the effects of violence exposure and empathy mediated the effects of parental nurturance. The mediation pathways through which parental nurturance were linked to aggression differed across levels of violence exposure. In the context of high violence exposure, parental nurturance was related to lower aggression through higher social emotional empathy, but under low violence exposure, the effect was mediated by greater disapproval of violence. En ligne : http://dx.doi.org/10.1080/15374416.2010.517163 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=113 [article] Social Cognitive and Emotional Mediators Link Violence Exposure and Parental Nurturance to Adolescent Aggression [Texte imprimé et/ou numérique] / Wei SU, Auteur ; Sylvie MRUG, Auteur ; Michael WINDLE, Auteur . - 2010 . - p.814-824. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 39-6 (November-December 2010) . - p.814-824 Index. décimale : PER Périodiques Résumé : This study examined aggressive fantasies, violence-approving attitudes, and empathy as mediators of the effects of violence exposure and parental nurturance on aggression. A total of 603 early adolescents (M age = 11.8 years; SD = 0.8) participated in a two-wave study, reporting on violence exposure and parental nurturance at Wave 1 and the three mediators and aggression at Wave 2. Violence-approving attitudes mediated the effects of both violence exposure and low parental nurturance on aggression. Aggressive fantasies also mediated the effects of violence exposure and empathy mediated the effects of parental nurturance. The mediation pathways through which parental nurturance were linked to aggression differed across levels of violence exposure. In the context of high violence exposure, parental nurturance was related to lower aggression through higher social emotional empathy, but under low violence exposure, the effect was mediated by greater disapproval of violence. En ligne : http://dx.doi.org/10.1080/15374416.2010.517163 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=113

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