[article] 
inJournal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3780-3789

Titre :	Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Miranda ZUNIGA-KENNEDY, Auteur ; Micah DAVOREN, Auteur ; Lauren C. SHUFFREY, Auteur ; Ruth Ann LUNA, Auteur ; Tor SAVIDGE, Auteur ; Vinay PRASAD, Auteur ; George M. ANDERSON, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Kent C. WILLIAMS, Auteur
Article en page(s) :	p.3780-3789
Langues :	Anglais (eng)
Mots-clés :	Autism Spectrum Disorder/genetics  Autistic Disorder/genetics  Biomarkers  Child  Humans  Male  Serotonin  Autism  Hyperserotonemia  Immunity  Whole blood serotonin
Index. décimale :	PER Périodiques
Résumé :	Hyperserotonemia, or elevated levels of whole blood serotonin (WB5-HT), was the first biomarker linked to autism spectrum disorder (ASD). Despite numerous studies investigating the etiology of hyperserotonemia, results have been inconsistent. Recent findings suggest a relationship between the immune system and hyperserotonemia. The current study investigated whether intestinal 5-HT levels, 5-HT gene expression, or intestinal cell types predict WB5-HT. Participants included thirty-one males aged 3-18 who were classified into one of three groups: ASD and functional GI issues, typically developing with GI issues, and typically developing without GI issues. Samples from a lower endoscopy were analyzed to examine the pathways in predicting WB-5HT. Results demonstrated an association between T-Lymphocytes and WB5-HT.
En ligne :	http://dx.doi.org/10.1007/s10803-022-05597-w
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

[article] Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism [Texte imprimé et/ou numérique] / Miranda ZUNIGA-KENNEDY, Auteur ; Micah DAVOREN, Auteur ; Lauren C. SHUFFREY, Auteur ; Ruth Ann LUNA, Auteur ; Tor SAVIDGE, Auteur ; Vinay PRASAD, Auteur ; George M. ANDERSON, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Kent C. WILLIAMS, Auteur . - p.3780-3789.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3780-3789

Mots-clés :	Autism Spectrum Disorder/genetics  Autistic Disorder/genetics  Biomarkers  Child  Humans  Male  Serotonin  Autism  Hyperserotonemia  Immunity  Whole blood serotonin
Index. décimale :	PER Périodiques
Résumé :	Hyperserotonemia, or elevated levels of whole blood serotonin (WB5-HT), was the first biomarker linked to autism spectrum disorder (ASD). Despite numerous studies investigating the etiology of hyperserotonemia, results have been inconsistent. Recent findings suggest a relationship between the immune system and hyperserotonemia. The current study investigated whether intestinal 5-HT levels, 5-HT gene expression, or intestinal cell types predict WB5-HT. Participants included thirty-one males aged 3-18 who were classified into one of three groups: ASD and functional GI issues, typically developing with GI issues, and typically developing without GI issues. Samples from a lower endoscopy were analyzed to examine the pathways in predicting WB-5HT. Results demonstrated an association between T-Lymphocytes and WB5-HT.
En ligne :	http://dx.doi.org/10.1007/s10803-022-05597-w
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485