[article]
| Titre : |
Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Miranda ZUNIGA-KENNEDY, Auteur ; Micah DAVOREN, Auteur ; Lauren C. SHUFFREY, Auteur ; Ruth Ann LUNA, Auteur ; Tor SAVIDGE, Auteur ; Vinay PRASAD, Auteur ; George M. ANDERSON, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Kent C. WILLIAMS, Auteur |
| Article en page(s) : |
p.3780-3789 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism Spectrum Disorder/genetics Autistic Disorder/genetics Biomarkers Child Humans Male Serotonin Autism Hyperserotonemia Immunity Whole blood serotonin |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Hyperserotonemia, or elevated levels of whole blood serotonin (WB5-HT), was the first biomarker linked to autism spectrum disorder (ASD). Despite numerous studies investigating the etiology of hyperserotonemia, results have been inconsistent. Recent findings suggest a relationship between the immune system and hyperserotonemia. The current study investigated whether intestinal 5-HT levels, 5-HT gene expression, or intestinal cell types predict WB5-HT. Participants included thirty-one males aged 3-18 who were classified into one of three groups: ASD and functional GI issues, typically developing with GI issues, and typically developing without GI issues. Samples from a lower endoscopy were analyzed to examine the pathways in predicting WB-5HT. Results demonstrated an association between T-Lymphocytes and WB5-HT. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-022-05597-w |
| Permalink : |
http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4857 |
in Journal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3780-3789
|
Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism in Journal of Autism and Developmental Disorders, 52-9 (September 2022)
