Aberrant "deep connectivity" in autism: A cortico-subcortical functional connectivity magnetic resonance imaging study / J. O. MAXIMO in Autism Research, 12-3 (March 2019)  

Public ISBD [article]  inAutism Research > 12-3 (March 2019) . - p.384-400 Titre : Aberrant "deep connectivity" in autism: A cortico-subcortical functional connectivity magnetic resonance imaging study Type de document : Texte imprimé et/ou numérique Auteurs : J. O. MAXIMO, Auteur ; R. K. KANA, Auteur Article en page(s) : p.384-400 Langues : Anglais (eng) Mots-clés : Asd  functional connectivity  subcortical  supramodal  unimodal Index. décimale : PER Périodiques Résumé : The number of studies examining functional brain networks in Autism Spectrum Disorder (ASD) has risen over the last decade and has characterized ASD as a disorder of altered brain connectivity. However, these studies have focused largely on cortical structures, and only a few studies have examined cortico-subcortical connectivity in regions like thalamus and basal ganglia in ASD. The goal of this study was to characterize the functional connectivity between cortex and subcortical regions in ASD using the Autism Brain Imaging Data Exchange (ABIDE-II). Resting-state functional magnetic resonance imaging data were used from 168 typically developing (TD) and 138 ASD participants across different sites from the ABIDE II dataset. Functional connectivity of basal ganglia and thalamus to unimodal and supramodal networks was examined in this study. Overconnectivity (ASD > TD) was found between unimodal (except for medial visual network) and subcortical regions, and underconnectivity (TD > ASD) was found between supramodal (except for default mode and dorsal attention networks) and subcortical regions; positive correlations between ASD phenotype and unimodal-subcortical connectivity were found and negative ones with supramodal-subcortical connectivity. These findings suggest that brain networks heavily involved in sensory processing had higher connectivity with subcortical regions, whereas those involved in higher-order thinking showed decreased connectivity in ASD. In addition, brain-behavior correlations indicated a relationship between ASD phenotype and connectivity. Thus, differences in cortico-subcortical connectivity may have a significant impact on basic and higher-order cognitive processes in ASD. Autism Res 2019, 12: 384-400 (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This study focused on examining the functional connectivity (synchronization of brain activity across regions) of two types of brain networks (unimodal and supramodal) with subcortical areas (thalamus and basal ganglia) in children, adolescents, and adults with autism spectrum disorder (ASD) and how this relates to ASD phenotype. ASD participants showed overconnectivity in unimodal networks and underconnectivity in supramodal networks. These findings provide new insights into cortico-subcortical connections between basic sensory and high-order cognitive processes. En ligne : http://dx.doi.org/10.1002/aur.2058 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387 [article] Aberrant "deep connectivity" in autism: A cortico-subcortical functional connectivity magnetic resonance imaging study [Texte imprimé et/ou numérique] / J. O. MAXIMO, Auteur ; R. K. KANA, Auteur . - p.384-400. Langues : Anglais (eng) in Autism Research > 12-3 (March 2019) . - p.384-400 Mots-clés : Asd  functional connectivity  subcortical  supramodal  unimodal Index. décimale : PER Périodiques Résumé : The number of studies examining functional brain networks in Autism Spectrum Disorder (ASD) has risen over the last decade and has characterized ASD as a disorder of altered brain connectivity. However, these studies have focused largely on cortical structures, and only a few studies have examined cortico-subcortical connectivity in regions like thalamus and basal ganglia in ASD. The goal of this study was to characterize the functional connectivity between cortex and subcortical regions in ASD using the Autism Brain Imaging Data Exchange (ABIDE-II). Resting-state functional magnetic resonance imaging data were used from 168 typically developing (TD) and 138 ASD participants across different sites from the ABIDE II dataset. Functional connectivity of basal ganglia and thalamus to unimodal and supramodal networks was examined in this study. Overconnectivity (ASD > TD) was found between unimodal (except for medial visual network) and subcortical regions, and underconnectivity (TD > ASD) was found between supramodal (except for default mode and dorsal attention networks) and subcortical regions; positive correlations between ASD phenotype and unimodal-subcortical connectivity were found and negative ones with supramodal-subcortical connectivity. These findings suggest that brain networks heavily involved in sensory processing had higher connectivity with subcortical regions, whereas those involved in higher-order thinking showed decreased connectivity in ASD. In addition, brain-behavior correlations indicated a relationship between ASD phenotype and connectivity. Thus, differences in cortico-subcortical connectivity may have a significant impact on basic and higher-order cognitive processes in ASD. Autism Res 2019, 12: 384-400 (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This study focused on examining the functional connectivity (synchronization of brain activity across regions) of two types of brain networks (unimodal and supramodal) with subcortical areas (thalamus and basal ganglia) in children, adolescents, and adults with autism spectrum disorder (ASD) and how this relates to ASD phenotype. ASD participants showed overconnectivity in unimodal networks and underconnectivity in supramodal networks. These findings provide new insights into cortico-subcortical connections between basic sensory and high-order cognitive processes. En ligne : http://dx.doi.org/10.1002/aur.2058 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387

Enhanced parietal cortex activation during location detection in children with autism / Thomas P. DERAMUS in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.37 Titre : Enhanced parietal cortex activation during location detection in children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Thomas P. DERAMUS, Auteur ; Briley S. BLACK, Auteur ; M. R. PENNICK, Auteur ; R. K. KANA, Auteur Article en page(s) : p.37 Langues : Anglais (eng) Mots-clés : Autism  Dorsal  Functional connectivity  Location detection  Object recognition  Ventral  Visual system  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Visuospatial processing has been found to be mediated primarily by two cortical routes, one of which is unique to recognizing objects (occipital-temporal, ventral or "what" pathway) and the other to detecting the location of objects in space (parietal-occipital, dorsal or "where" pathway). Considering previous findings of relative advantage in people with autism in visuospatial processing, this functional MRI study examined the connectivity in the dorsal and ventral pathways in high-functioning children with autism. METHODS: Seventeen high-functioning children and adolescents with autism spectrum disorders (ASD) and 19 age-and-IQ-matched typically developing (TD) participants took part in this study. A simple visual task involving object recognition and location detection was used. In the MRI scanner, participants were shown grey scale pictures of objects (e.g., toys, household items, etc.) and were asked to identify the objects presented or to specify the location of objects relative to a cross at the center of the screen. RESULTS: Children with ASD, relative to TD children, displayed significantly greater activation in the left inferior parietal lobule (especially the angular gyrus) while detecting the location of objects. However, there were no group differences in brain activity during object recognition. There were also differences in functional connectivity, with the ASD participants showing decreased connectivity of the inferior temporal area with parietal and occipital areas during location detection. CONCLUSIONS: The results of this study underscore previous findings of an increased reliance on visuospatial processing (increased parietal activation) for information processing in ASD individuals. In addition, such processing may be more local, focal, and detailed in ASD as evidenced from the weaker functional connectivity. En ligne : http://dx.doi.org/10.1186/1866-1955-6-37 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346 [article] Enhanced parietal cortex activation during location detection in children with autism [Texte imprimé et/ou numérique] / Thomas P. DERAMUS, Auteur ; Briley S. BLACK, Auteur ; M. R. PENNICK, Auteur ; R. K. KANA, Auteur . - p.37. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.37 Mots-clés : Autism  Dorsal  Functional connectivity  Location detection  Object recognition  Ventral  Visual system  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Visuospatial processing has been found to be mediated primarily by two cortical routes, one of which is unique to recognizing objects (occipital-temporal, ventral or "what" pathway) and the other to detecting the location of objects in space (parietal-occipital, dorsal or "where" pathway). Considering previous findings of relative advantage in people with autism in visuospatial processing, this functional MRI study examined the connectivity in the dorsal and ventral pathways in high-functioning children with autism. METHODS: Seventeen high-functioning children and adolescents with autism spectrum disorders (ASD) and 19 age-and-IQ-matched typically developing (TD) participants took part in this study. A simple visual task involving object recognition and location detection was used. In the MRI scanner, participants were shown grey scale pictures of objects (e.g., toys, household items, etc.) and were asked to identify the objects presented or to specify the location of objects relative to a cross at the center of the screen. RESULTS: Children with ASD, relative to TD children, displayed significantly greater activation in the left inferior parietal lobule (especially the angular gyrus) while detecting the location of objects. However, there were no group differences in brain activity during object recognition. There were also differences in functional connectivity, with the ASD participants showing decreased connectivity of the inferior temporal area with parietal and occipital areas during location detection. CONCLUSIONS: The results of this study underscore previous findings of an increased reliance on visuospatial processing (increased parietal activation) for information processing in ASD individuals. In addition, such processing may be more local, focal, and detailed in ASD as evidenced from the weaker functional connectivity. En ligne : http://dx.doi.org/10.1186/1866-1955-6-37 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346

Patterns of Cerebellar Connectivity with Intrinsic Connectivity Networks in Autism Spectrum Disorders / H. M. BEDNARZ in Journal of Autism and Developmental Disorders, 49-11 (November 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4498-4514 Titre : Patterns of Cerebellar Connectivity with Intrinsic Connectivity Networks in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : H. M. BEDNARZ, Auteur ; R. K. KANA, Auteur Article en page(s) : p.4498-4514 Langues : Anglais (eng) Mots-clés : Autism  Cerebellum  Default mode  Executive  Salience Index. décimale : PER Périodiques Résumé : There is growing evidence of altered connectivity in autism spectrum disorders (ASD) between the cerebellum and cortex. Three intrinsic connectivity networks (ICNs) are especially important to cognitive processing in ASD: the default mode network (DMN), executive control network (ECN), and salience networks (SNs). The goal of this study was to compare resting-state functional connectivity between the cerebellum and the DMN, ECN, and SN in ASD and typically developing children (n = 74, ages 7-12 years). Children with ASD showed stronger connectivity between the ventral DMN and left cerebellar lobules I-IV. No meaningful relationships were observed between ICN-cerebellar functional connectivity and ASD symptoms. These results suggest that the cerebellum contributes to altered network connectivity in ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04168-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Patterns of Cerebellar Connectivity with Intrinsic Connectivity Networks in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / H. M. BEDNARZ, Auteur ; R. K. KANA, Auteur . - p.4498-4514. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4498-4514 Mots-clés : Autism  Cerebellum  Default mode  Executive  Salience Index. décimale : PER Périodiques Résumé : There is growing evidence of altered connectivity in autism spectrum disorders (ASD) between the cerebellum and cortex. Three intrinsic connectivity networks (ICNs) are especially important to cognitive processing in ASD: the default mode network (DMN), executive control network (ECN), and salience networks (SNs). The goal of this study was to compare resting-state functional connectivity between the cerebellum and the DMN, ECN, and SN in ASD and typically developing children (n = 74, ages 7-12 years). Children with ASD showed stronger connectivity between the ventral DMN and left cerebellar lobules I-IV. No meaningful relationships were observed between ICN-cerebellar functional connectivity and ASD symptoms. These results suggest that the cerebellum contributes to altered network connectivity in ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04168-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

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