[article] 
inResearch in Autism Spectrum Disorders > 101 (March 2023) . - 102086

Titre :	Higher anesthetic dose requirement for sedation in children with autism spectrum disorder compared to neuro-atypical controls- a prospective observational study
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Sowmyashree Mayur KAKU, Auteur ; Sonia BANSAL, Auteur ; Umamaheswara GS RAO, Auteur ; Rose Dawn BHARATH, Auteur ; Shoba SRINATH, Auteur ; Satish Chandra GIRIMAJI, Auteur
Article en page(s) :	102086
Langues :	Anglais (eng)
Mots-clés :	Sedation  MRI  Imaging  Autism  Anesthetic
Index. décimale :	PER Périodiques
Résumé :	Introduction Children with Autism Spectrum Disorders (ASD) are known to require general anesthesia or sedation for undergoing procedures like Magnetic Resonance Imaging (MRI). The dose required for sedation may vary depending on multiple factors. The aim of this study was to compare the sedative requirements of children with ASD with those who do not have ASD for undergoing MRI. Methods Thirty-four children with ASD and 31 neuro-atypical controls (children with other neurological disorders undergoing MRI) were recruited into the study. Children were premedicated with injection midazolam 0.1 mg/kg. This was followed by dexmedetomidine 2 mcg/kg over 2 min, followed by 2 mcg/kg/hour infusion inside the MRI gantry. If the above anesthetic was insufficient to make the child immobile, a bolus dose of thiopentone 3 mg/kg was supplemented and this was compared between the two groups. The children were monitored with ECG, and oxygen saturation. Since, these children were on sedative medications, each patient was given a sedation score depending on the number of sedative medications, the child was receiving. Results Twenty one of 34 children in the ASD group required thiopentone for sedation while 5 of 31 in the control group required thiopentone supplementation (p< 0.001). The thiopentone requirement continued to be significantly different between the two groups at each level of sedation score (0, 1, 2 +) (p< 0.004). Conclusion Children with ASD required higher anesthetic dose for sedation compared to neuro-atypical controls for MRI. This study has shown that dexmedetomidine can be safely used for children with autism and additional sedatives are often required for imaging.
En ligne :	https://doi.org/10.1016/j.rasd.2022.102086
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

[article] Higher anesthetic dose requirement for sedation in children with autism spectrum disorder compared to neuro-atypical controls- a prospective observational study [Texte imprimé et/ou numérique] / Sowmyashree Mayur KAKU, Auteur ; Sonia BANSAL, Auteur ; Umamaheswara GS RAO, Auteur ; Rose Dawn BHARATH, Auteur ; Shoba SRINATH, Auteur ; Satish Chandra GIRIMAJI, Auteur . - 102086.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 101 (March 2023) . - 102086

Mots-clés :	Sedation  MRI  Imaging  Autism  Anesthetic
Index. décimale :	PER Périodiques
Résumé :	Introduction Children with Autism Spectrum Disorders (ASD) are known to require general anesthesia or sedation for undergoing procedures like Magnetic Resonance Imaging (MRI). The dose required for sedation may vary depending on multiple factors. The aim of this study was to compare the sedative requirements of children with ASD with those who do not have ASD for undergoing MRI. Methods Thirty-four children with ASD and 31 neuro-atypical controls (children with other neurological disorders undergoing MRI) were recruited into the study. Children were premedicated with injection midazolam 0.1 mg/kg. This was followed by dexmedetomidine 2 mcg/kg over 2 min, followed by 2 mcg/kg/hour infusion inside the MRI gantry. If the above anesthetic was insufficient to make the child immobile, a bolus dose of thiopentone 3 mg/kg was supplemented and this was compared between the two groups. The children were monitored with ECG, and oxygen saturation. Since, these children were on sedative medications, each patient was given a sedation score depending on the number of sedative medications, the child was receiving. Results Twenty one of 34 children in the ASD group required thiopentone for sedation while 5 of 31 in the control group required thiopentone supplementation (p< 0.001). The thiopentone requirement continued to be significantly different between the two groups at each level of sedation score (0, 1, 2 +) (p< 0.004). Conclusion Children with ASD required higher anesthetic dose for sedation compared to neuro-atypical controls for MRI. This study has shown that dexmedetomidine can be safely used for children with autism and additional sedatives are often required for imaging.
En ligne :	https://doi.org/10.1016/j.rasd.2022.102086
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492