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Auteur Rose Dawn BHARATH |
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Higher anesthetic dose requirement for sedation in children with autism spectrum disorder compared to neuro-atypical controls- a prospective observational study / Sowmyashree Mayur KAKU in Research in Autism Spectrum Disorders, 101 (March 2023)
[article]
Titre : Higher anesthetic dose requirement for sedation in children with autism spectrum disorder compared to neuro-atypical controls- a prospective observational study Type de document : Texte imprimé et/ou numérique Auteurs : Sowmyashree Mayur KAKU, Auteur ; Sonia BANSAL, Auteur ; Umamaheswara GS RAO, Auteur ; Rose Dawn BHARATH, Auteur ; Shoba SRINATH, Auteur ; Satish Chandra GIRIMAJI, Auteur Article en page(s) : 102086 Langues : Anglais (eng) Mots-clés : Sedation MRI Imaging Autism Anesthetic Index. décimale : PER Périodiques Résumé : Introduction Children with Autism Spectrum Disorders (ASD) are known to require general anesthesia or sedation for undergoing procedures like Magnetic Resonance Imaging (MRI). The dose required for sedation may vary depending on multiple factors. The aim of this study was to compare the sedative requirements of children with ASD with those who do not have ASD for undergoing MRI. Methods Thirty-four children with ASD and 31 neuro-atypical controls (children with other neurological disorders undergoing MRI) were recruited into the study. Children were premedicated with injection midazolam 0.1 mg/kg. This was followed by dexmedetomidine 2 mcg/kg over 2 min, followed by 2 mcg/kg/hour infusion inside the MRI gantry. If the above anesthetic was insufficient to make the child immobile, a bolus dose of thiopentone 3 mg/kg was supplemented and this was compared between the two groups. The children were monitored with ECG, and oxygen saturation. Since, these children were on sedative medications, each patient was given a sedation score depending on the number of sedative medications, the child was receiving. Results Twenty one of 34 children in the ASD group required thiopentone for sedation while 5 of 31 in the control group required thiopentone supplementation (p< 0.001). The thiopentone requirement continued to be significantly different between the two groups at each level of sedation score (0, 1, 2 +) (p< 0.004). Conclusion Children with ASD required higher anesthetic dose for sedation compared to neuro-atypical controls for MRI. This study has shown that dexmedetomidine can be safely used for children with autism and additional sedatives are often required for imaging. En ligne : https://doi.org/10.1016/j.rasd.2022.102086 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492
in Research in Autism Spectrum Disorders > 101 (March 2023) . - 102086[article] Higher anesthetic dose requirement for sedation in children with autism spectrum disorder compared to neuro-atypical controls- a prospective observational study [Texte imprimé et/ou numérique] / Sowmyashree Mayur KAKU, Auteur ; Sonia BANSAL, Auteur ; Umamaheswara GS RAO, Auteur ; Rose Dawn BHARATH, Auteur ; Shoba SRINATH, Auteur ; Satish Chandra GIRIMAJI, Auteur . - 102086.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 101 (March 2023) . - 102086
Mots-clés : Sedation MRI Imaging Autism Anesthetic Index. décimale : PER Périodiques Résumé : Introduction Children with Autism Spectrum Disorders (ASD) are known to require general anesthesia or sedation for undergoing procedures like Magnetic Resonance Imaging (MRI). The dose required for sedation may vary depending on multiple factors. The aim of this study was to compare the sedative requirements of children with ASD with those who do not have ASD for undergoing MRI. Methods Thirty-four children with ASD and 31 neuro-atypical controls (children with other neurological disorders undergoing MRI) were recruited into the study. Children were premedicated with injection midazolam 0.1 mg/kg. This was followed by dexmedetomidine 2 mcg/kg over 2 min, followed by 2 mcg/kg/hour infusion inside the MRI gantry. If the above anesthetic was insufficient to make the child immobile, a bolus dose of thiopentone 3 mg/kg was supplemented and this was compared between the two groups. The children were monitored with ECG, and oxygen saturation. Since, these children were on sedative medications, each patient was given a sedation score depending on the number of sedative medications, the child was receiving. Results Twenty one of 34 children in the ASD group required thiopentone for sedation while 5 of 31 in the control group required thiopentone supplementation (p< 0.001). The thiopentone requirement continued to be significantly different between the two groups at each level of sedation score (0, 1, 2 +) (p< 0.004). Conclusion Children with ASD required higher anesthetic dose for sedation compared to neuro-atypical controls for MRI. This study has shown that dexmedetomidine can be safely used for children with autism and additional sedatives are often required for imaging. En ligne : https://doi.org/10.1016/j.rasd.2022.102086 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 Risk clustering and psychopathology from a multi-center cohort of Indian children, adolescents, and young adults / Debasish BASU in Development and Psychopathology, 35-2 (May 2023)
[article]
Titre : Risk clustering and psychopathology from a multi-center cohort of Indian children, adolescents, and young adults Type de document : Texte imprimé et/ou numérique Auteurs : Debasish BASU, Auteur ; Abhishek GHOSH, Auteur ; Chandrima NASKAR, Auteur ; Srinivas BALACHANDER, Auteur ; Gwen FERNANDES, Auteur ; Nilakshi VAIDYA, Auteur ; Kalyanaraman KUMARAN, Auteur ; Murali KRISHNA, Auteur ; Gareth J. BARKER, Auteur ; Eesha SHARMA, Auteur ; Pratima MURTHY, Auteur ; Bharath HOLLA, Auteur ; Sanjeev JAIN, Auteur ; Dimitri Papadopoulos ORFANOS, Auteur ; Kartik KALYANRAM, Auteur ; Meera PURUSHOTTAM, Auteur ; Rose Dawn BHARATH, Auteur ; Mathew VARGHESE, Auteur ; Kandavel THENNARASU, Auteur ; Amit CHAKRABARTI, Auteur ; Rajkumar Lenin SINGH, Auteur ; Roshan Lourembam SINGH, Auteur ; Subodh Bhagyalakshmi NANJAYYA, Auteur ; Chirag Kamal AHUJA, Auteur ; Kamakshi KARTIK, Auteur ; Ghattu KRISHNAVENI, Auteur ; Rebecca KURIYAN, Auteur ; Sunita Simon KURPAD, Auteur ; Sylvane DESRIVIERES, Auteur ; Udita IYENGAR, Auteur ; Yuning ZHANG, Auteur ; Matthew HICKMAN, Auteur ; Alex SPIERS, Auteur ; Mireille TOLEDANO, Auteur ; Gunter SCHUMANN, Auteur ; Vivek BENEGAL, Auteur Article en page(s) : p.800-808 Langues : Anglais (eng) Mots-clés : childhood experience India psychopathology social deprivation trauma Index. décimale : PER Périodiques Résumé : Developmental adversities early in life are associated with later psychopathology. Clustering may be a useful approach to group multiple diverse risks together and study their relation with psychopathology. To generate risk clusters of children, adolescents, and young adults, based on adverse environmental exposure and developmental characteristics, and to examine the association of risk clusters with manifest psychopathology. Participants (n = 8300) between 6 and 23 years were recruited from seven sites in India. We administered questionnaires to elicit history of previous exposure to adverse childhood environments, family history of psychiatric disorders in first-degree relatives, and a range of antenatal and postnatal adversities. We used these variables to generate risk clusters. Mini-International Neuropsychiatric Interview-5 was administered to evaluate manifest psychopathology. Two-step cluster analysis revealed two clusters designated as high-risk cluster (HRC) and low-risk cluster (LRC), comprising 4197 (50.5%) and 4103 (49.5%) participants, respectively. HRC had higher frequencies of family history of mental illness, antenatal and neonatal risk factors, developmental delays, history of migration, and exposure to adverse childhood experiences than LRC. There were significantly higher risks of any psychiatric disorder [Relative Risk (RR) = 2.0, 95% CI 1.8-2.3], externalizing (RR = 4.8, 95% CI 3.6-6.4) and internalizing disorders (RR = 2.6, 95% CI 2.2-2.9), and suicidality (2.3, 95% CI 1.8-2.8) in HRC. Social-environmental and developmental factors could classify Indian children, adolescents and young adults into homogeneous clusters at high or low risk of psychopathology. These biopsychosocial determinants of mental health may have practice, policy and research implications for people in low- and middle-income countries. En ligne : http://dx.doi.org/10.1017/S0954579422000050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504
in Development and Psychopathology > 35-2 (May 2023) . - p.800-808[article] Risk clustering and psychopathology from a multi-center cohort of Indian children, adolescents, and young adults [Texte imprimé et/ou numérique] / Debasish BASU, Auteur ; Abhishek GHOSH, Auteur ; Chandrima NASKAR, Auteur ; Srinivas BALACHANDER, Auteur ; Gwen FERNANDES, Auteur ; Nilakshi VAIDYA, Auteur ; Kalyanaraman KUMARAN, Auteur ; Murali KRISHNA, Auteur ; Gareth J. BARKER, Auteur ; Eesha SHARMA, Auteur ; Pratima MURTHY, Auteur ; Bharath HOLLA, Auteur ; Sanjeev JAIN, Auteur ; Dimitri Papadopoulos ORFANOS, Auteur ; Kartik KALYANRAM, Auteur ; Meera PURUSHOTTAM, Auteur ; Rose Dawn BHARATH, Auteur ; Mathew VARGHESE, Auteur ; Kandavel THENNARASU, Auteur ; Amit CHAKRABARTI, Auteur ; Rajkumar Lenin SINGH, Auteur ; Roshan Lourembam SINGH, Auteur ; Subodh Bhagyalakshmi NANJAYYA, Auteur ; Chirag Kamal AHUJA, Auteur ; Kamakshi KARTIK, Auteur ; Ghattu KRISHNAVENI, Auteur ; Rebecca KURIYAN, Auteur ; Sunita Simon KURPAD, Auteur ; Sylvane DESRIVIERES, Auteur ; Udita IYENGAR, Auteur ; Yuning ZHANG, Auteur ; Matthew HICKMAN, Auteur ; Alex SPIERS, Auteur ; Mireille TOLEDANO, Auteur ; Gunter SCHUMANN, Auteur ; Vivek BENEGAL, Auteur . - p.800-808.
Langues : Anglais (eng)
in Development and Psychopathology > 35-2 (May 2023) . - p.800-808
Mots-clés : childhood experience India psychopathology social deprivation trauma Index. décimale : PER Périodiques Résumé : Developmental adversities early in life are associated with later psychopathology. Clustering may be a useful approach to group multiple diverse risks together and study their relation with psychopathology. To generate risk clusters of children, adolescents, and young adults, based on adverse environmental exposure and developmental characteristics, and to examine the association of risk clusters with manifest psychopathology. Participants (n = 8300) between 6 and 23 years were recruited from seven sites in India. We administered questionnaires to elicit history of previous exposure to adverse childhood environments, family history of psychiatric disorders in first-degree relatives, and a range of antenatal and postnatal adversities. We used these variables to generate risk clusters. Mini-International Neuropsychiatric Interview-5 was administered to evaluate manifest psychopathology. Two-step cluster analysis revealed two clusters designated as high-risk cluster (HRC) and low-risk cluster (LRC), comprising 4197 (50.5%) and 4103 (49.5%) participants, respectively. HRC had higher frequencies of family history of mental illness, antenatal and neonatal risk factors, developmental delays, history of migration, and exposure to adverse childhood experiences than LRC. There were significantly higher risks of any psychiatric disorder [Relative Risk (RR) = 2.0, 95% CI 1.8-2.3], externalizing (RR = 4.8, 95% CI 3.6-6.4) and internalizing disorders (RR = 2.6, 95% CI 2.2-2.9), and suicidality (2.3, 95% CI 1.8-2.8) in HRC. Social-environmental and developmental factors could classify Indian children, adolescents and young adults into homogeneous clusters at high or low risk of psychopathology. These biopsychosocial determinants of mental health may have practice, policy and research implications for people in low- and middle-income countries. En ligne : http://dx.doi.org/10.1017/S0954579422000050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504