Acceptability and safety of a probiotic beverage supplementation (Bio-K +) and feasibility of the proposed protocol in children with a diagnosis of autism spectrum disorder / Ghizlane GAOUGAOU in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Acceptability and safety of a probiotic beverage supplementation (Bio-K +) and feasibility of the proposed protocol in children with a diagnosis of autism spectrum disorder Type de document : texte imprimé Auteurs : Ghizlane GAOUGAOU, Auteur ; Riham ZAHRA, Auteur ; Sophia MOREL, Auteur ; Véronique BÉLANGER, Auteur ; Inga Sophia KNOTH, Auteur ; Dominique COUSINEAU, Auteur ; Baudouin Forgeot D'ARC, Auteur ; Kelly GRZYWACZ, Auteur ; Guy ROUSSEAU, Auteur ; Eric DÉZIEL, Auteur ; Roger GODBOUT, Auteur ; Sarah LIPPE, Auteur ; Mathieu MILLETTE, Auteur ; Valérie MARCIL, Auteur Langues : Anglais (eng) Mots-clés : Humans  Autism Spectrum Disorder/diet therapy/complications  Probiotics/administration & dosage/adverse effects/therapeutic use  Male  Child  Female  Child, Preschool  Feasibility Studies  Gastrointestinal Diseases  Sleep Wake Disorders  Dietary Supplements  Beverages  Patient Acceptance of Health Care  Acceptability  Autism spectrum disorders  Autistic symptoms  Children  Feasibility  Gastrointestinal symptoms  Probiotics  Safety  Sleep disorder  by the ethics review board of the CHU Sainte-Justine (#2021–3412). Informed  consent was obtained from all participants and parents involved in the study.  Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders defined by stereotyped behavior and challenges in social communication and social interaction. ASD is associated with various comorbidities, including anxiety, gastrointestinal (GI) symptoms and sleep disorders. Evidence supports an association between intestinal dysbiosis and the severity of ASD-related symptoms. Probiotic intake was suggested to restore microbial homeostasis and decrease neurobehavioral, GI and sleep symptoms in individuals diagnosed with autism. METHODS: This study aims to evaluate the acceptability and safety of a Bio-K + probiotics beverage in autistic children aged 4 to 11 years and the feasibility of the proposed research protocol to measure its impact on behaviors and comorbidities. The 30-week study consisted of daily supplementation with Bio-K + probiotics for 14 weeks. Acceptability and safety were monitored throughout the study. Feasibility was assessed by comparing recruitment and completion rates to pre-established thresholds. Preliminary impact of supplementation on behaviors (Autism Treatment Evaluation Checklist (ATEC) score), GI symptoms and sleep disorders was evaluated. RESULTS: Of the 23 children recruited (mean age 6.7 ± 2.2 years, 70% males), 65% had GI problems and 91% had sleep disorders. Probiotic supplementation was accepted by all participants and no product-related adverse event was reported. Feasibility rates exceeded pre-established thresholds for almost all study outcomes including recruitment rate, compliance, electroencephalography, actigraphy and completion of questionnaires. Preliminary data suggest an improvement in behaviors associated with autism assessed with the total ATEC score, and in GI symptoms and sleep disorders. CONCLUSION: This study demonstrates probiotic beverage acceptability and safety and protocol feasibility in autistic children. To further support our data, a double-blinded placebo-controlled study is needed to determine its efficacy. En ligne : https://dx.doi.org/10.1186/s11689-025-09617-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Acceptability and safety of a probiotic beverage supplementation (Bio-K +) and feasibility of the proposed protocol in children with a diagnosis of autism spectrum disorder [texte imprimé] / Ghizlane GAOUGAOU, Auteur ; Riham ZAHRA, Auteur ; Sophia MOREL, Auteur ; Véronique BÉLANGER, Auteur ; Inga Sophia KNOTH, Auteur ; Dominique COUSINEAU, Auteur ; Baudouin Forgeot D'ARC, Auteur ; Kelly GRZYWACZ, Auteur ; Guy ROUSSEAU, Auteur ; Eric DÉZIEL, Auteur ; Roger GODBOUT, Auteur ; Sarah LIPPE, Auteur ; Mathieu MILLETTE, Auteur ; Valérie MARCIL, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Autism Spectrum Disorder/diet therapy/complications  Probiotics/administration & dosage/adverse effects/therapeutic use  Male  Child  Female  Child, Preschool  Feasibility Studies  Gastrointestinal Diseases  Sleep Wake Disorders  Dietary Supplements  Beverages  Patient Acceptance of Health Care  Acceptability  Autism spectrum disorders  Autistic symptoms  Children  Feasibility  Gastrointestinal symptoms  Probiotics  Safety  Sleep disorder  by the ethics review board of the CHU Sainte-Justine (#2021–3412). Informed  consent was obtained from all participants and parents involved in the study.  Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders defined by stereotyped behavior and challenges in social communication and social interaction. ASD is associated with various comorbidities, including anxiety, gastrointestinal (GI) symptoms and sleep disorders. Evidence supports an association between intestinal dysbiosis and the severity of ASD-related symptoms. Probiotic intake was suggested to restore microbial homeostasis and decrease neurobehavioral, GI and sleep symptoms in individuals diagnosed with autism. METHODS: This study aims to evaluate the acceptability and safety of a Bio-K + probiotics beverage in autistic children aged 4 to 11 years and the feasibility of the proposed research protocol to measure its impact on behaviors and comorbidities. The 30-week study consisted of daily supplementation with Bio-K + probiotics for 14 weeks. Acceptability and safety were monitored throughout the study. Feasibility was assessed by comparing recruitment and completion rates to pre-established thresholds. Preliminary impact of supplementation on behaviors (Autism Treatment Evaluation Checklist (ATEC) score), GI symptoms and sleep disorders was evaluated. RESULTS: Of the 23 children recruited (mean age 6.7 ± 2.2 years, 70% males), 65% had GI problems and 91% had sleep disorders. Probiotic supplementation was accepted by all participants and no product-related adverse event was reported. Feasibility rates exceeded pre-established thresholds for almost all study outcomes including recruitment rate, compliance, electroencephalography, actigraphy and completion of questionnaires. Preliminary data suggest an improvement in behaviors associated with autism assessed with the total ATEC score, and in GI symptoms and sleep disorders. CONCLUSION: This study demonstrates probiotic beverage acceptability and safety and protocol feasibility in autistic children. To further support our data, a double-blinded placebo-controlled study is needed to determine its efficacy. En ligne : https://dx.doi.org/10.1186/s11689-025-09617-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

Dream Content Analysis in Persons with an Autism Spectrum Disorder / Anne-Marie DAOUST in Journal of Autism and Developmental Disorders, 38-4 (April 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-4 (April 2008) . - p.634-643 Titre : Dream Content Analysis in Persons with an Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Anne-Marie DAOUST, Auteur ; Laurent MOTTRON, Auteur ; Félix-Antoine LUSIGNAN, Auteur ; Claude M.J. BRAUN, Auteur ; Roger GODBOUT, Auteur Année de publication : 2008 Article en page(s) : p.634-643 Langues : Anglais (eng) Mots-clés : Autism Dream Emotions REM-sleep Questionnaire Polysomnography Index. décimale : PER Périodiques Résumé : Dream questionnaires were completed by 28 young adults with autism spectrum disorder (ASD) participants. Seventy-nine typically developed individual served as the control group. In a subset of 17 persons with ASD and 11 controls matched for verbal IQ, dream narratives were obtained following REM sleep awakenings in a sleep laboratory. Questionnaires revealed that participants with ASD, compared to controls, had fewer recollections of dreaming, fewer bad dreams and fewer emotions. In the sleep laboratory, dream content narratives following REM sleep awakenings were shorter in ASD participants than in controls. ASD participants also reported fewer settings, objects, characters, social interactions, activities, and emotions. It is concluded that these characteristics of dreaming in ASD may reflect neurocognitive dimensions specific to this condition. En ligne : http://dx.doi.org/10.1007/s10803-007-0431-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=340 [article] Dream Content Analysis in Persons with an Autism Spectrum Disorder [texte imprimé] / Anne-Marie DAOUST, Auteur ; Laurent MOTTRON, Auteur ; Félix-Antoine LUSIGNAN, Auteur ; Claude M.J. BRAUN, Auteur ; Roger GODBOUT, Auteur . - 2008 . - p.634-643. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-4 (April 2008) . - p.634-643 Mots-clés : Autism Dream Emotions REM-sleep Questionnaire Polysomnography Index. décimale : PER Périodiques Résumé : Dream questionnaires were completed by 28 young adults with autism spectrum disorder (ASD) participants. Seventy-nine typically developed individual served as the control group. In a subset of 17 persons with ASD and 11 controls matched for verbal IQ, dream narratives were obtained following REM sleep awakenings in a sleep laboratory. Questionnaires revealed that participants with ASD, compared to controls, had fewer recollections of dreaming, fewer bad dreams and fewer emotions. In the sleep laboratory, dream content narratives following REM sleep awakenings were shorter in ASD participants than in controls. ASD participants also reported fewer settings, objects, characters, social interactions, activities, and emotions. It is concluded that these characteristics of dreaming in ASD may reflect neurocognitive dimensions specific to this condition. En ligne : http://dx.doi.org/10.1007/s10803-007-0431-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=340

Enhanced connectivity between visual cortex and other regions of the brain in autism: a REM sleep EEG coherence study / Cathy LEVEILLE in Autism Research, 3-5 (October 2010)  

Public ISBD [article]  inAutism Research > 3-5 (October 2010) . - p.280-285 Titre : Enhanced connectivity between visual cortex and other regions of the brain in autism: a REM sleep EEG coherence study Type de document : texte imprimé Auteurs : Cathy LEVEILLE, Auteur ; Elise B. BARBEAU, Auteur ; Christianne BOLDUC, Auteur ; Elyse LIMOGES, Auteur ; Claude BERTHIAUME, Auteur ; Elyse CHEVRIER, Auteur ; Laurent MOTTRON, Auteur ; Roger GODBOUT, Auteur Année de publication : 2010 Article en page(s) : p.280-285 Langues : Anglais (eng) Mots-clés : autism  occipital cortex  REM sleep EEG  EEG coherence  visual perception  neural coupling Index. décimale : PER Périodiques Résumé : Functional interregional neural coupling was measured as EEG coherence during REM sleep, a state of endogenous cortical activation, in 9 adult autistic individuals (21.1±4.0 years) and 13 typically developed controls (21.5±4.3 years) monitored for two consecutive nights in a sleep laboratory. Spectral analysis was performed on 60 s of artefact-free EEG samples distributed equally throughout the first four REM sleep periods of the second night. EEG coherence was calculated for six frequency bands (delta, theta, alpha, sigma, beta, and total spectrum) using a 22-electrode montage. The magnitude of coherence function was computed for intra- and interhemispheric pairs of recording sites. Results were compared by Multivariate Analysis of Variance (MANOVA). Each time the autistic group showed a greater EEG coherence than the controls; it involved intrahemispheric communication among the left visual cortex (O1) and other regions either close to or distant from the occipital cortex. In contrast, lower coherence values involved frontal electrodes in the right hemisphere. No significant differences between groups were found for interhemispheric EEG coherence. These results show that the analysis of EEG coherence during REM sleep can disclose patterns of cortical connectivity that can be reduced or increased in adults with autism compared to typically developed individuals, depending of the cortical areas studied. Superior coherence involving visual perceptual areas in autism is consistent with an enhanced role of perception in autistic brain organization. En ligne : http://dx.doi.org/10.1002/aur.155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 [article] Enhanced connectivity between visual cortex and other regions of the brain in autism: a REM sleep EEG coherence study [texte imprimé] / Cathy LEVEILLE, Auteur ; Elise B. BARBEAU, Auteur ; Christianne BOLDUC, Auteur ; Elyse LIMOGES, Auteur ; Claude BERTHIAUME, Auteur ; Elyse CHEVRIER, Auteur ; Laurent MOTTRON, Auteur ; Roger GODBOUT, Auteur . - 2010 . - p.280-285. Langues : Anglais (eng) in Autism Research > 3-5 (October 2010) . - p.280-285 Mots-clés : autism  occipital cortex  REM sleep EEG  EEG coherence  visual perception  neural coupling Index. décimale : PER Périodiques Résumé : Functional interregional neural coupling was measured as EEG coherence during REM sleep, a state of endogenous cortical activation, in 9 adult autistic individuals (21.1±4.0 years) and 13 typically developed controls (21.5±4.3 years) monitored for two consecutive nights in a sleep laboratory. Spectral analysis was performed on 60 s of artefact-free EEG samples distributed equally throughout the first four REM sleep periods of the second night. EEG coherence was calculated for six frequency bands (delta, theta, alpha, sigma, beta, and total spectrum) using a 22-electrode montage. The magnitude of coherence function was computed for intra- and interhemispheric pairs of recording sites. Results were compared by Multivariate Analysis of Variance (MANOVA). Each time the autistic group showed a greater EEG coherence than the controls; it involved intrahemispheric communication among the left visual cortex (O1) and other regions either close to or distant from the occipital cortex. In contrast, lower coherence values involved frontal electrodes in the right hemisphere. No significant differences between groups were found for interhemispheric EEG coherence. These results show that the analysis of EEG coherence during REM sleep can disclose patterns of cortical connectivity that can be reduced or increased in adults with autism compared to typically developed individuals, depending of the cortical areas studied. Superior coherence involving visual perceptual areas in autism is consistent with an enhanced role of perception in autistic brain organization. En ligne : http://dx.doi.org/10.1002/aur.155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115

NREM sleep EEG activity and procedural memory: A comparison between young neurotypical and autistic adults without sleep complaints / Annie-Claude ROCHETTE in Autism Research, 11-4 (April 2018)  

Public ISBD [article]  inAutism Research > 11-4 (April 2018) . - p.613-623 Titre : NREM sleep EEG activity and procedural memory: A comparison between young neurotypical and autistic adults without sleep complaints Type de document : texte imprimé Auteurs : Annie-Claude ROCHETTE, Auteur ; Isabelle SOULIERES, Auteur ; Claude BERTHIAUME, Auteur ; Roger GODBOUT, Auteur Article en page(s) : p.613-623 Langues : Anglais (eng) Mots-clés : Eeg  autism  autism spectrum disorder  delta activity  learning  memory  procedural memory  sleep Index. décimale : PER Périodiques Résumé : Delta EEG activity (0.75-3.75 Hz) during non-Rapid eye movement (NREM) sleep reflects the thalamo-cortical system contribution to memory consolidation. The functional integrity of this system is thought to be compromised in the Autism spectrum disorder (ASD). This lead us to investigate the topography of NREM sleep Delta EEG activity in young adults with ASD and typically-developed individuals (TYP). The relationship between Delta EEG activity and sensory-motor procedural information was also examined using a rotary pursuit task. Two dependent variables were computed: a learning index (performance increase across trials) and a performance index (average performance for all trials). The ASD group showed less Delta EEG activity during NREM sleep over the parieto-occipital recording sites compared to the TYP group. Delta EEG activity dropped more abruptly from frontal to posterior regions in the ASD group. Both groups of participants learned the task at a similar rate but the ASD group performed less well in terms of contact time with the target. Delta EEG activity during NREM sleep, especially during stage 2, correlated positively with the learning index for electrodes located all over the cortex in the TYP group, but only in the frontal region in the ASD group. Delta EEG activity, especially during stage 2, correlated positively with the performance index, but in the ASD group only. These results reveal an atypical thalamo-cortical functioning over the parieto-occipital region in ASD. They also point toward an atypical relationship between the frontal area and the encoding of sensory-motor procedural memory in ASD. Autism Res 2018, 11: 613-623. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Slow EEG waves recorded from the scalp during sleep are thought to facilitate learning and memory during daytime. We compared these EEG waves in young autistic adults to typically-developing young adults. We found less slow EEG waves in the ASD group and the pattern of relationship with memory differed between groups. This suggests atypicalities in the way sleep mechanisms are associated with learning and performance in a sensory-motor procedural memory task in ASD individuals. En ligne : http://dx.doi.org/10.1002/aur.1933 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358 [article] NREM sleep EEG activity and procedural memory: A comparison between young neurotypical and autistic adults without sleep complaints [texte imprimé] / Annie-Claude ROCHETTE, Auteur ; Isabelle SOULIERES, Auteur ; Claude BERTHIAUME, Auteur ; Roger GODBOUT, Auteur . - p.613-623. Langues : Anglais (eng) in Autism Research > 11-4 (April 2018) . - p.613-623 Mots-clés : Eeg  autism  autism spectrum disorder  delta activity  learning  memory  procedural memory  sleep Index. décimale : PER Périodiques Résumé : Delta EEG activity (0.75-3.75 Hz) during non-Rapid eye movement (NREM) sleep reflects the thalamo-cortical system contribution to memory consolidation. The functional integrity of this system is thought to be compromised in the Autism spectrum disorder (ASD). This lead us to investigate the topography of NREM sleep Delta EEG activity in young adults with ASD and typically-developed individuals (TYP). The relationship between Delta EEG activity and sensory-motor procedural information was also examined using a rotary pursuit task. Two dependent variables were computed: a learning index (performance increase across trials) and a performance index (average performance for all trials). The ASD group showed less Delta EEG activity during NREM sleep over the parieto-occipital recording sites compared to the TYP group. Delta EEG activity dropped more abruptly from frontal to posterior regions in the ASD group. Both groups of participants learned the task at a similar rate but the ASD group performed less well in terms of contact time with the target. Delta EEG activity during NREM sleep, especially during stage 2, correlated positively with the learning index for electrodes located all over the cortex in the TYP group, but only in the frontal region in the ASD group. Delta EEG activity, especially during stage 2, correlated positively with the performance index, but in the ASD group only. These results reveal an atypical thalamo-cortical functioning over the parieto-occipital region in ASD. They also point toward an atypical relationship between the frontal area and the encoding of sensory-motor procedural memory in ASD. Autism Res 2018, 11: 613-623. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Slow EEG waves recorded from the scalp during sleep are thought to facilitate learning and memory during daytime. We compared these EEG waves in young autistic adults to typically-developing young adults. We found less slow EEG waves in the ASD group and the pattern of relationship with memory differed between groups. This suggests atypicalities in the way sleep mechanisms are associated with learning and performance in a sensory-motor procedural memory task in ASD individuals. En ligne : http://dx.doi.org/10.1002/aur.1933 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358

Poor sleep affects daytime functioning in typically developing and autistic children not complaining of sleep problems: A questionnaire-based and polysomnographic study / Andréane LAMBERT in Research in Autism Spectrum Disorders, 23 (March 2016)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 23 (March 2016) . - p.94-106 Titre : Poor sleep affects daytime functioning in typically developing and autistic children not complaining of sleep problems: A questionnaire-based and polysomnographic study Type de document : texte imprimé Auteurs : Andréane LAMBERT, Auteur ; Sophie TESSIER, Auteur ; Annie-Claude ROCHETTE, Auteur ; Peter SCHERZER, Auteur ; Laurent MOTTRON, Auteur ; Roger GODBOUT, Auteur Article en page(s) : p.94-106 Langues : Anglais (eng) Mots-clés : Autism phenotype  EEG  Insomnia  Sleep disorders Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum (AS) is a neurodevelopmental condition associated with poor sleep, which impairs daytime functioning. Most studies of sleep in autism have been based on subjective measures, notably parental reports. A few studies have used objective, laboratory polysomnography (PSG) measures, but often include confounding factors such as intellectual disability, sleep problems, other psychiatric illnesses, and medication. To address these limitations, we examined the relationship between sleep and behavior in prototypical AS of typical level of intelligence and non-autistic children not complaining of sleep problems. We examined sleep variables with The Children’ Sleep Habit Questionnaire (CSHQ) and a daily sleep agenda, both filled out by parents, and by PSG. These subjective and objective measures both revealed that sleep latency was longer in AS than in non-autistic children. Furthermore, AS children also showed less slow-wave sleep (SWS: stages 3 + 4), fewer sleep spindles and fewer K-complexes than non-autistic children. REM sleep, including eye movement density, was similar between the two groups. The proportion of light sleep, (stage 1 non-REM sleep) was negatively correlated with IQ (Wechsler and Raven matrices) in both groups of participants. A large amount of SWS predicted low levels of internalizing behavior in both groups and typical social functioning as determined by ADOS in AS children. These results indicate that autistic children not complaining of sleep problems may nonetheless be affected by poor sleep, which in turn influences their daytime functioning. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.11.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Poor sleep affects daytime functioning in typically developing and autistic children not complaining of sleep problems: A questionnaire-based and polysomnographic study [texte imprimé] / Andréane LAMBERT, Auteur ; Sophie TESSIER, Auteur ; Annie-Claude ROCHETTE, Auteur ; Peter SCHERZER, Auteur ; Laurent MOTTRON, Auteur ; Roger GODBOUT, Auteur . - p.94-106. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 23 (March 2016) . - p.94-106 Mots-clés : Autism phenotype  EEG  Insomnia  Sleep disorders Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum (AS) is a neurodevelopmental condition associated with poor sleep, which impairs daytime functioning. Most studies of sleep in autism have been based on subjective measures, notably parental reports. A few studies have used objective, laboratory polysomnography (PSG) measures, but often include confounding factors such as intellectual disability, sleep problems, other psychiatric illnesses, and medication. To address these limitations, we examined the relationship between sleep and behavior in prototypical AS of typical level of intelligence and non-autistic children not complaining of sleep problems. We examined sleep variables with The Children’ Sleep Habit Questionnaire (CSHQ) and a daily sleep agenda, both filled out by parents, and by PSG. These subjective and objective measures both revealed that sleep latency was longer in AS than in non-autistic children. Furthermore, AS children also showed less slow-wave sleep (SWS: stages 3 + 4), fewer sleep spindles and fewer K-complexes than non-autistic children. REM sleep, including eye movement density, was similar between the two groups. The proportion of light sleep, (stage 1 non-REM sleep) was negatively correlated with IQ (Wechsler and Raven matrices) in both groups of participants. A large amount of SWS predicted low levels of internalizing behavior in both groups and typical social functioning as determined by ADOS in AS children. These results indicate that autistic children not complaining of sleep problems may nonetheless be affected by poor sleep, which in turn influences their daytime functioning. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.11.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Le traitement cognitivo-comportemental des troubles de sommeil chez les enfants et les adolescents / Evelyne MARTELLO

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Le traitement cognitivo-comportemental des troubles de sommeil chez les enfants et les adolescents / Évelyne TOUCHETTE

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Troubles du sommeil / Roger GODBOUT in Bulletin Scientifique de l'arapi (Le), 21 (Printemps 2008)

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