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Auteur I. BERNARDINO |
Documents disponibles écrits par cet auteur (2)



Oscillatory motor patterning is impaired in neurofibromatosis type 1: a behavioural, EEG and fMRI study / G. SILVA in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)
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[article]
inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - p.11
Titre : Oscillatory motor patterning is impaired in neurofibromatosis type 1: a behavioural, EEG and fMRI study Type de document : Texte imprimé et/ou numérique Auteurs : G. SILVA, Auteur ; I. C. DUARTE, Auteur ; I. BERNARDINO, Auteur ; T. MARQUES, Auteur ; I. R. VIOLANTE, Auteur ; Miguel CASTELO-BRANCO, Auteur Article en page(s) : p.11 Langues : Anglais (eng) Mots-clés : Eeg Inhibition Motor coordination Neurofibromatosis type 1 fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Neurofibromatosis type1 (NF1) is associated with a broad range of behavioural deficits, and an imbalance between excitatory and inhibitory neurotransmission has been postulated in this disorder. Inhibition is involved in the control of frequency and stability of motor rhythms. Therefore, we aimed to explore the link between behavioural motor control, brain rhythms and brain activity, as assessed by EEG and fMRI in NF1. METHODS: We studied a cohort of 21 participants with NF1 and 20 age- and gender-matched healthy controls, with a finger-tapping task requiring pacing at distinct frequencies during EEG and fMRI scans. RESULTS: We found that task performance was significantly different between NF1 and controls, the latter showing higher tapping time precision. The time-frequency patterns at the beta sub-band (20-26 Hz) mirrored the behavioural modulations, with similar cyclic synchronization/desynchronization patterns for both groups. fMRI results showed a higher recruitment of the extrapyramidal motor system (putamen, cerebellum and red nucleus) in the control group during the fastest pacing condition. CONCLUSIONS: The present study demonstrated impaired precision in rhythmic pacing behaviour in NF1 as compared with controls. We found a decreased recruitment of the cerebellum, a structure where inhibitory interneurons are essential regulators of rhythmic synchronization, and in deep brain regions pivotally involved in motor pacing. Our findings shed light into the neural underpinnings of motor timing deficits in NF1. En ligne : http://dx.doi.org/10.1186/s11689-018-9230-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=351 [article] Oscillatory motor patterning is impaired in neurofibromatosis type 1: a behavioural, EEG and fMRI study [Texte imprimé et/ou numérique] / G. SILVA, Auteur ; I. C. DUARTE, Auteur ; I. BERNARDINO, Auteur ; T. MARQUES, Auteur ; I. R. VIOLANTE, Auteur ; Miguel CASTELO-BRANCO, Auteur . - p.11.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - p.11
Mots-clés : Eeg Inhibition Motor coordination Neurofibromatosis type 1 fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Neurofibromatosis type1 (NF1) is associated with a broad range of behavioural deficits, and an imbalance between excitatory and inhibitory neurotransmission has been postulated in this disorder. Inhibition is involved in the control of frequency and stability of motor rhythms. Therefore, we aimed to explore the link between behavioural motor control, brain rhythms and brain activity, as assessed by EEG and fMRI in NF1. METHODS: We studied a cohort of 21 participants with NF1 and 20 age- and gender-matched healthy controls, with a finger-tapping task requiring pacing at distinct frequencies during EEG and fMRI scans. RESULTS: We found that task performance was significantly different between NF1 and controls, the latter showing higher tapping time precision. The time-frequency patterns at the beta sub-band (20-26 Hz) mirrored the behavioural modulations, with similar cyclic synchronization/desynchronization patterns for both groups. fMRI results showed a higher recruitment of the extrapyramidal motor system (putamen, cerebellum and red nucleus) in the control group during the fastest pacing condition. CONCLUSIONS: The present study demonstrated impaired precision in rhythmic pacing behaviour in NF1 as compared with controls. We found a decreased recruitment of the cerebellum, a structure where inhibitory interneurons are essential regulators of rhythmic synchronization, and in deep brain regions pivotally involved in motor pacing. Our findings shed light into the neural underpinnings of motor timing deficits in NF1. En ligne : http://dx.doi.org/10.1186/s11689-018-9230-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=351 Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism / B. DIREITO in Autism, 25-6 (August 2021)
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[article]
inAutism > 25-6 (August 2021) . - p.1746-1760
Titre : Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism Type de document : Texte imprimé et/ou numérique Auteurs : B. DIREITO, Auteur ; S. MOUGA, Auteur ; A. SAYAL, Auteur ; M. SIMÕES, Auteur ; H. QUENTAL, Auteur ; I. BERNARDINO, Auteur ; R. PLAYLE, Auteur ; R. MCNAMARA, Auteur ; D. E. LINDEN, Auteur ; G. OLIVEIRA, Auteur ; Miguel CASTELO-BRANCO, Auteur Article en page(s) : p.1746-1760 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging/therapy Autistic Disorder/diagnostic imaging/therapy Brain/diagnostic imaging Humans Magnetic Resonance Imaging Neurofeedback autism spectrum disorder neurorehabilitation posterior superior temporal sulcus real-time functional magnetic resonance imaging social cognition Index. décimale : PER Périodiques Résumé : Neurofeedback is an emerging therapeutic approach in neuropsychiatric disorders. Its potential application in autism spectrum disorder remains to be tested. Here, we demonstrate the feasibility of real-time functional magnetic resonance imaging volitional neurofeedback in targeting social brain regions in autism spectrum disorder. In this clinical trial, autism spectrum disorder patients were enrolled in a program with five training sessions of neurofeedback. Participants were able to control their own brain activity in this social brain region, with positive clinical and neural effects. Larger, controlled, and blinded clinical studies will be required to confirm the benefits. En ligne : http://dx.doi.org/10.1177/13623613211002052 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism [Texte imprimé et/ou numérique] / B. DIREITO, Auteur ; S. MOUGA, Auteur ; A. SAYAL, Auteur ; M. SIMÕES, Auteur ; H. QUENTAL, Auteur ; I. BERNARDINO, Auteur ; R. PLAYLE, Auteur ; R. MCNAMARA, Auteur ; D. E. LINDEN, Auteur ; G. OLIVEIRA, Auteur ; Miguel CASTELO-BRANCO, Auteur . - p.1746-1760.
Langues : Anglais (eng)
in Autism > 25-6 (August 2021) . - p.1746-1760
Mots-clés : Autism Spectrum Disorder/diagnostic imaging/therapy Autistic Disorder/diagnostic imaging/therapy Brain/diagnostic imaging Humans Magnetic Resonance Imaging Neurofeedback autism spectrum disorder neurorehabilitation posterior superior temporal sulcus real-time functional magnetic resonance imaging social cognition Index. décimale : PER Périodiques Résumé : Neurofeedback is an emerging therapeutic approach in neuropsychiatric disorders. Its potential application in autism spectrum disorder remains to be tested. Here, we demonstrate the feasibility of real-time functional magnetic resonance imaging volitional neurofeedback in targeting social brain regions in autism spectrum disorder. In this clinical trial, autism spectrum disorder patients were enrolled in a program with five training sessions of neurofeedback. Participants were able to control their own brain activity in this social brain region, with positive clinical and neural effects. Larger, controlled, and blinded clinical studies will be required to confirm the benefits. En ligne : http://dx.doi.org/10.1177/13623613211002052 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451