[article]
| Titre : |
Interactive associations of eczema with glutathione S-transferase genes in relation to autism spectrum disorder and its severity in Jamaican children |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Sepideh SAROUKHANI, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jan BRESSLER, Auteur ; MinJae LEE, Auteur ; Courtney BYRD-WILLIAMS, Auteur ; Manouchehr HESSABI, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H. RAHBAR, Auteur |
| Article en page(s) : |
102183 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism spectrum disorder Eczema Glutathione S-transferase Oxidative stress Interaction Comorbidity |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Comorbidity of eczema withith autism spectrum disorder (ASD) is increasing. We investigated the associations of eczema and its possible interaction with polymorphisms in glutathione S-transferase (GST) genes in relation to ASD and ASD severity. Method Using data from 344 1:1 age- and sex-matched ASD cases and typically developing controls, we assessed additive and interactive associations of eczema with GST genes in relation to ASD by applying conditional logistic regression models, and in relation to ASD severity in ASD cases as measured by the Autism Diagnostic Observation Schedule-2nd Edition (ADOS-2) total and domain-specific comparison scores (CSs) by fitting general linear models. Results After adjusting for child?s age and history of breastfeeding, eczema had no additive association with ASD [Matched Odds ratio (MOR) and 95 % Confidence Intervals (CI): 1.04 (0.76, 1.41), P = 0.82] or ASD severity (all P > 0.20). Using a recessive genetic model, eczema was significantly associated with ASD only among children with the Val/Val genotype for the GSTP1 Ile105Val polymorphism [MOR (95 % CI) = 2.04 (1.02, 4.08), P = 0.04, P for interaction = 0.03]. In addition, among ASD cases with the GSTM1 DD genotype, those with eczema had a marginally significant higher mean ADOS-2 Social Affect CS than those without eczema (7.3 vs. 6.8, P = 0.08, P for interaction = 0.09). Conclusion Our findings suggest children with certain genotypes for GST genes may be more susceptible for comorbidity of eczema and ASD, which is consistent with the role of GST genes in both conditions. |
| En ligne : |
https://doi.org/10.1016/j.rasd.2023.102183 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 |
in Research in Autism Spectrum Disorders > 105 (July 2023) . - 102183
[article] Interactive associations of eczema with glutathione S-transferase genes in relation to autism spectrum disorder and its severity in Jamaican children [Texte imprimé et/ou numérique] / Sepideh SAROUKHANI, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jan BRESSLER, Auteur ; MinJae LEE, Auteur ; Courtney BYRD-WILLIAMS, Auteur ; Manouchehr HESSABI, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H. RAHBAR, Auteur . - 102183. Langues : Anglais ( eng) in Research in Autism Spectrum Disorders > 105 (July 2023) . - 102183
| Mots-clés : |
Autism spectrum disorder Eczema Glutathione S-transferase Oxidative stress Interaction Comorbidity |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Comorbidity of eczema withith autism spectrum disorder (ASD) is increasing. We investigated the associations of eczema and its possible interaction with polymorphisms in glutathione S-transferase (GST) genes in relation to ASD and ASD severity. Method Using data from 344 1:1 age- and sex-matched ASD cases and typically developing controls, we assessed additive and interactive associations of eczema with GST genes in relation to ASD by applying conditional logistic regression models, and in relation to ASD severity in ASD cases as measured by the Autism Diagnostic Observation Schedule-2nd Edition (ADOS-2) total and domain-specific comparison scores (CSs) by fitting general linear models. Results After adjusting for child?s age and history of breastfeeding, eczema had no additive association with ASD [Matched Odds ratio (MOR) and 95 % Confidence Intervals (CI): 1.04 (0.76, 1.41), P = 0.82] or ASD severity (all P > 0.20). Using a recessive genetic model, eczema was significantly associated with ASD only among children with the Val/Val genotype for the GSTP1 Ile105Val polymorphism [MOR (95 % CI) = 2.04 (1.02, 4.08), P = 0.04, P for interaction = 0.03]. In addition, among ASD cases with the GSTM1 DD genotype, those with eczema had a marginally significant higher mean ADOS-2 Social Affect CS than those without eczema (7.3 vs. 6.8, P = 0.08, P for interaction = 0.09). Conclusion Our findings suggest children with certain genotypes for GST genes may be more susceptible for comorbidity of eczema and ASD, which is consistent with the role of GST genes in both conditions. |
| En ligne : |
https://doi.org/10.1016/j.rasd.2023.102183 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 |
|
Interactive associations of eczema with glutathione S-transferase genes in relation to autism spectrum disorder and its severity in Jamaican children in Research in Autism Spectrum Disorders, 105 (July 2023)
