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Comorbidity / Adrian ANGOLD in Journal of Child Psychology and Psychiatry, 40-1 (January 1999)
[article]
Titre : Comorbidity Type de document : Texte imprimé et/ou numérique Auteurs : Adrian ANGOLD, Auteur ; E. Jane COSTELLO, Auteur ; Alaattin ERKANLI, Auteur Année de publication : 1999 Article en page(s) : p.57-87 Langues : Anglais (eng) Mots-clés : Diagnosis comorbidity child adolescent nosology Index. décimale : PER Périodiques Résumé : We review recent research on the prevalence, causes, and effects of diagnostic comorbidity among the most common groups of child and adolescent psychiatric disorders; anxiety disorders, depressive disorders, attention deficit hyperactivity disorders, oppositional defiant and conduct disorders, and substance abuse. A meta-analysis of representative general population studies provides estimates of the strength of associations between pairs of disorders with narrower confidence intervals than have previously been available. Current evidence convincingly eliminates methodological factors as a major cause of comorbidity. We review the implications of comorbidity for understanding the development of psychopathology and for nosology. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=124
in Journal of Child Psychology and Psychiatry > 40-1 (January 1999) . - p.57-87[article] Comorbidity [Texte imprimé et/ou numérique] / Adrian ANGOLD, Auteur ; E. Jane COSTELLO, Auteur ; Alaattin ERKANLI, Auteur . - 1999 . - p.57-87.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 40-1 (January 1999) . - p.57-87
Mots-clés : Diagnosis comorbidity child adolescent nosology Index. décimale : PER Périodiques Résumé : We review recent research on the prevalence, causes, and effects of diagnostic comorbidity among the most common groups of child and adolescent psychiatric disorders; anxiety disorders, depressive disorders, attention deficit hyperactivity disorders, oppositional defiant and conduct disorders, and substance abuse. A meta-analysis of representative general population studies provides estimates of the strength of associations between pairs of disorders with narrower confidence intervals than have previously been available. Current evidence convincingly eliminates methodological factors as a major cause of comorbidity. We review the implications of comorbidity for understanding the development of psychopathology and for nosology. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=124 Comorbidity in autism spectrum disorder: A literature review / Arlene MANNION in Research in Autism Spectrum Disorders, 7-12 (December 2013)
[article]
Titre : Comorbidity in autism spectrum disorder: A literature review Type de document : Texte imprimé et/ou numérique Auteurs : Arlene MANNION, Auteur ; Geraldine LEADER, Auteur Article en page(s) : p.1595-1616 Langues : Anglais (eng) Mots-clés : Comorbidity Autism spectrum disorder Attention deficit/hyperactivity disorder (AD/HD) Epilepsy Sleep problems Gastrointestinal symptoms Index. décimale : PER Périodiques Résumé : Abstract Comorbidity is defined as the co-occurrence of two or more disorders in the same person (Matson amp; Nebel-Schwalm, 2007). The current study provides a review of the literature on comorbidity, in relation to comorbid psychiatric and medical disorders in babies and infants, children, adults and across the lifespan. We also examine comorbid conditions such as attention deficit/hyperactivity disorder (AD/HD), epilepsy, gastrointestinal symptoms, sleep problems, feeding problems and toileting problems in individuals with autism spectrum disorder. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.09.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219
in Research in Autism Spectrum Disorders > 7-12 (December 2013) . - p.1595-1616[article] Comorbidity in autism spectrum disorder: A literature review [Texte imprimé et/ou numérique] / Arlene MANNION, Auteur ; Geraldine LEADER, Auteur . - p.1595-1616.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 7-12 (December 2013) . - p.1595-1616
Mots-clés : Comorbidity Autism spectrum disorder Attention deficit/hyperactivity disorder (AD/HD) Epilepsy Sleep problems Gastrointestinal symptoms Index. décimale : PER Périodiques Résumé : Abstract Comorbidity is defined as the co-occurrence of two or more disorders in the same person (Matson amp; Nebel-Schwalm, 2007). The current study provides a review of the literature on comorbidity, in relation to comorbid psychiatric and medical disorders in babies and infants, children, adults and across the lifespan. We also examine comorbid conditions such as attention deficit/hyperactivity disorder (AD/HD), epilepsy, gastrointestinal symptoms, sleep problems, feeding problems and toileting problems in individuals with autism spectrum disorder. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.09.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 Comorbidity of allergic and autoimmune diseases in patients with autism spectrum disorder: A nationwide population-based study / Mu-Hong CHEN in Research in Autism Spectrum Disorders, 7-2 (February 2013)
[article]
Titre : Comorbidity of allergic and autoimmune diseases in patients with autism spectrum disorder: A nationwide population-based study Type de document : Texte imprimé et/ou numérique Auteurs : Mu-Hong CHEN, Auteur ; Tung-Ping SU, Auteur ; Ying-Sheue CHEN, Auteur ; Ju-Wei HSU, Auteur ; Kai-Lin HUANG, Auteur ; Wen-Han CHANG, Auteur ; Tzeng-Ji CHEN, Auteur ; Ya-Mei BAI, Auteur Année de publication : 2013 Article en page(s) : p.205-212 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Allergic diseases Autoimmune diseases Comorbidity Index. décimale : PER Périodiques Résumé : Previous clinical and genetic studies have suggested autism spectrum disorders (ASDs) is associated with immunological abnormalities involving cytokines, immunoglobulins, inflammation, and cellular immunity, but epidemiological reports are still limited. Patients with ASDs were identified in the National Health Insurance Database from 1996 to 2010, and compared with age and gender-matched controls (1:4) in an investigation of the association between ASDs and allergic/autoimmune diseases. A total of 1596 patients with ASDs were identified, and were found to have a significantly higher prevalence of allergic and autoimmune diseases than the control group. Patients with ASDs had increased risks of asthma (OR = 1.74, 95%CI = 1.51'1.99), allergic rhinitis (OR = 1.70, 95%CI = 1.51'1.91), atopic dermatitis (OR = 1.52, 95%CI = 1.30'1.78), urticaria (OR = 1.38, 95%CI = 1.12'1.69) and type 1 diabetes (OR = 4.00, 95%CI = 1.00'16.00), and a trend toward increasing comorbidity with Crohn's disease (OR = 1.46, 95%CI = 0.90'2.35). Our results support the association between ASDs and allergic diseases, and autoimmune comorbidities (type 1 diabetes and Crohn's disease). Further basic study is required to elucidate the possible underlying mechanisms and roles of allergy immunity and autoimmunity in the etiology of ASDs. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.08.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186
in Research in Autism Spectrum Disorders > 7-2 (February 2013) . - p.205-212[article] Comorbidity of allergic and autoimmune diseases in patients with autism spectrum disorder: A nationwide population-based study [Texte imprimé et/ou numérique] / Mu-Hong CHEN, Auteur ; Tung-Ping SU, Auteur ; Ying-Sheue CHEN, Auteur ; Ju-Wei HSU, Auteur ; Kai-Lin HUANG, Auteur ; Wen-Han CHANG, Auteur ; Tzeng-Ji CHEN, Auteur ; Ya-Mei BAI, Auteur . - 2013 . - p.205-212.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 7-2 (February 2013) . - p.205-212
Mots-clés : Autism spectrum disorder Allergic diseases Autoimmune diseases Comorbidity Index. décimale : PER Périodiques Résumé : Previous clinical and genetic studies have suggested autism spectrum disorders (ASDs) is associated with immunological abnormalities involving cytokines, immunoglobulins, inflammation, and cellular immunity, but epidemiological reports are still limited. Patients with ASDs were identified in the National Health Insurance Database from 1996 to 2010, and compared with age and gender-matched controls (1:4) in an investigation of the association between ASDs and allergic/autoimmune diseases. A total of 1596 patients with ASDs were identified, and were found to have a significantly higher prevalence of allergic and autoimmune diseases than the control group. Patients with ASDs had increased risks of asthma (OR = 1.74, 95%CI = 1.51'1.99), allergic rhinitis (OR = 1.70, 95%CI = 1.51'1.91), atopic dermatitis (OR = 1.52, 95%CI = 1.30'1.78), urticaria (OR = 1.38, 95%CI = 1.12'1.69) and type 1 diabetes (OR = 4.00, 95%CI = 1.00'16.00), and a trend toward increasing comorbidity with Crohn's disease (OR = 1.46, 95%CI = 0.90'2.35). Our results support the association between ASDs and allergic diseases, and autoimmune comorbidities (type 1 diabetes and Crohn's disease). Further basic study is required to elucidate the possible underlying mechanisms and roles of allergy immunity and autoimmunity in the etiology of ASDs. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.08.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186 Combining multivariate genomic approaches to elucidate the comorbidity between autism spectrum disorder and attention deficit hyperactivity disorder / H. PEYRE in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)
[article]
Titre : Combining multivariate genomic approaches to elucidate the comorbidity between autism spectrum disorder and attention deficit hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : H. PEYRE, Auteur ; T. SCHOELER, Auteur ; C. LIU, Auteur ; C. M. WILLIAMS, Auteur ; N. HOERTEL, Auteur ; A. HAVDAHL, Auteur ; J. B. PINGAULT, Auteur Article en page(s) : p.1285-1296 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/epidemiology/genetics Autism Spectrum Disorder/epidemiology/genetics Comorbidity Genome-Wide Association Study Genomics Humans Paired Box Transcription Factors/genetics Polymorphism, Single Nucleotide Repressor Proteins/genetics Autism spectrum disorder Gwas Snp attention deficit hyperactivity disorder colocalization common genetic variants comorbidity genomic structural equation modelling Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are two highly heritable neurodevelopmental disorders. Several lines of evidence point towards the presence of shared genetic factors underlying ASD and ADHD. We conducted genomic analyses of common risk variants (i.e. single nucleotide polymorphisms, SNPs) shared by ASD and ADHD, and those specific to each disorder. METHODS: With the summary data from two GWAS, one on ASD (N = 46,350) and another on ADHD (N = 55,374) individuals, we used genomic structural equation modelling and colocalization analysis to identify SNPs shared by ASD and ADHD and SNPs specific to each disorder. Functional genomic analyses were then conducted on shared and specific common genetic variants. Finally, we performed a bidirectional Mendelian randomization analysis to test whether the shared genetic risk between ASD and ADHD was interpretable in terms of reciprocal relationships between ASD and ADHD. RESULTS: We found that 37.5% of the SNPs associated with ASD (at p < 1e-6) colocalized with ADHD SNPs and that 19.6% of the SNPs associated with ADHD colocalized with ASD SNPs. We identified genes mapped to SNPs that are specific to ASD or ADHD and that are shared by ASD and ADHD, including two novel genes INSM1 and PAX1. Our bidirectional Mendelian randomization analyses indicated that the risk of ASD was associated with an increased risk of ADHD and vice versa. CONCLUSIONS: Using multivariate genomic analyses, the present study uncovers shared and specific genetic variants associated with ASD and ADHD. Further functional investigation of genes mapped to those shared variants may help identify pathophysiological pathways and new targets for treatment. En ligne : http://dx.doi.org/10.1111/jcpp.13479 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456
in Journal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1285-1296[article] Combining multivariate genomic approaches to elucidate the comorbidity between autism spectrum disorder and attention deficit hyperactivity disorder [Texte imprimé et/ou numérique] / H. PEYRE, Auteur ; T. SCHOELER, Auteur ; C. LIU, Auteur ; C. M. WILLIAMS, Auteur ; N. HOERTEL, Auteur ; A. HAVDAHL, Auteur ; J. B. PINGAULT, Auteur . - p.1285-1296.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1285-1296
Mots-clés : Attention Deficit Disorder with Hyperactivity/epidemiology/genetics Autism Spectrum Disorder/epidemiology/genetics Comorbidity Genome-Wide Association Study Genomics Humans Paired Box Transcription Factors/genetics Polymorphism, Single Nucleotide Repressor Proteins/genetics Autism spectrum disorder Gwas Snp attention deficit hyperactivity disorder colocalization common genetic variants comorbidity genomic structural equation modelling Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are two highly heritable neurodevelopmental disorders. Several lines of evidence point towards the presence of shared genetic factors underlying ASD and ADHD. We conducted genomic analyses of common risk variants (i.e. single nucleotide polymorphisms, SNPs) shared by ASD and ADHD, and those specific to each disorder. METHODS: With the summary data from two GWAS, one on ASD (N = 46,350) and another on ADHD (N = 55,374) individuals, we used genomic structural equation modelling and colocalization analysis to identify SNPs shared by ASD and ADHD and SNPs specific to each disorder. Functional genomic analyses were then conducted on shared and specific common genetic variants. Finally, we performed a bidirectional Mendelian randomization analysis to test whether the shared genetic risk between ASD and ADHD was interpretable in terms of reciprocal relationships between ASD and ADHD. RESULTS: We found that 37.5% of the SNPs associated with ASD (at p < 1e-6) colocalized with ADHD SNPs and that 19.6% of the SNPs associated with ADHD colocalized with ASD SNPs. We identified genes mapped to SNPs that are specific to ASD or ADHD and that are shared by ASD and ADHD, including two novel genes INSM1 and PAX1. Our bidirectional Mendelian randomization analyses indicated that the risk of ASD was associated with an increased risk of ADHD and vice versa. CONCLUSIONS: Using multivariate genomic analyses, the present study uncovers shared and specific genetic variants associated with ASD and ADHD. Further functional investigation of genes mapped to those shared variants may help identify pathophysiological pathways and new targets for treatment. En ligne : http://dx.doi.org/10.1111/jcpp.13479 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 Academic and psychosocial characteristics of incoming college freshmen with autism spectrum disorder: The role of comorbidity and gender / A. STURM in Autism Research, 12-6 (June 2019)
[article]
Titre : Academic and psychosocial characteristics of incoming college freshmen with autism spectrum disorder: The role of comorbidity and gender Type de document : Texte imprimé et/ou numérique Auteurs : A. STURM, Auteur ; Connie KASARI, Auteur Année de publication : 2019 Article en page(s) : p.931-940 Langues : Anglais (eng) Mots-clés : autism spectrum disorder comorbidity gender postsecondary education Index. décimale : PER Périodiques Résumé : There is a pressing need to better characterize the college-bound population of individuals with autism spectrum disorder (ASD), as prior studies have included small samples, consisting of individuals who are either recruited due to diagnosis or are treatment seeking. As postsecondary institutions look to respond to the growing need for support services for individuals with ASD, insights derived from large, population-based samples is a necessity. The current study included a sample of over 2000 incoming postsecondary students who self-identified with ASD as a part of surveys distributed by institutions nationally. The impact of heterogeneity (gender, comorbid attention-deficit/hyperactivity disorder [ADHD], and/or learning disability) on demographic characteristics, and psychosocial (psychological health, interpersonal self-confidence) and academic (self-regulated learning, intellectual self-confidence) domains critical for success in postsecondary education were compared to a matched sample of students with ADHD or no diagnoses. College-bound students with ASD broadly endorsed similar rates of ADHD, LD, and psychological disorder comorbidity to clinic-referred samples, and were more similar than different from their typically developing peers. A comorbid diagnosis of ADHD was associated with greater academic disengagement. Females with ASD and those with any comorbid disorder were more likely to self-report poorer psychological health. Findings revealed that self-reported levels of functioning in critical domains differed by self-reported comorbid disorders and gender. Findings have implications for targeted support service recommendations based on unique sources of heterogeneity (e.g., gender, presenting comorbid disorders) and are detailed in the current study. Autism Res 2019, 12: 931-940. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: College-bound students with ASD feel academically competent; however feel less confident with their peers. Students with ASD and another diagnosis (e.g., ADHD, learning disability) and girls with ASD may be particularly at risk of experiencing poorer psychological health while enrolled in postsecondary education. Using this information, postsecondary institutions can provide more targeted support services to students with ASD enrolled in postsecondary education. En ligne : https://dx.doi.org/10.1002/aur.2099 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400
in Autism Research > 12-6 (June 2019) . - p.931-940[article] Academic and psychosocial characteristics of incoming college freshmen with autism spectrum disorder: The role of comorbidity and gender [Texte imprimé et/ou numérique] / A. STURM, Auteur ; Connie KASARI, Auteur . - 2019 . - p.931-940.
Langues : Anglais (eng)
in Autism Research > 12-6 (June 2019) . - p.931-940
Mots-clés : autism spectrum disorder comorbidity gender postsecondary education Index. décimale : PER Périodiques Résumé : There is a pressing need to better characterize the college-bound population of individuals with autism spectrum disorder (ASD), as prior studies have included small samples, consisting of individuals who are either recruited due to diagnosis or are treatment seeking. As postsecondary institutions look to respond to the growing need for support services for individuals with ASD, insights derived from large, population-based samples is a necessity. The current study included a sample of over 2000 incoming postsecondary students who self-identified with ASD as a part of surveys distributed by institutions nationally. The impact of heterogeneity (gender, comorbid attention-deficit/hyperactivity disorder [ADHD], and/or learning disability) on demographic characteristics, and psychosocial (psychological health, interpersonal self-confidence) and academic (self-regulated learning, intellectual self-confidence) domains critical for success in postsecondary education were compared to a matched sample of students with ADHD or no diagnoses. College-bound students with ASD broadly endorsed similar rates of ADHD, LD, and psychological disorder comorbidity to clinic-referred samples, and were more similar than different from their typically developing peers. A comorbid diagnosis of ADHD was associated with greater academic disengagement. Females with ASD and those with any comorbid disorder were more likely to self-report poorer psychological health. Findings revealed that self-reported levels of functioning in critical domains differed by self-reported comorbid disorders and gender. Findings have implications for targeted support service recommendations based on unique sources of heterogeneity (e.g., gender, presenting comorbid disorders) and are detailed in the current study. Autism Res 2019, 12: 931-940. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: College-bound students with ASD feel academically competent; however feel less confident with their peers. Students with ASD and another diagnosis (e.g., ADHD, learning disability) and girls with ASD may be particularly at risk of experiencing poorer psychological health while enrolled in postsecondary education. Using this information, postsecondary institutions can provide more targeted support services to students with ASD enrolled in postsecondary education. En ligne : https://dx.doi.org/10.1002/aur.2099 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 Atypical Processing of Gaze Cues and Faces Explains Comorbidity between Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD) / Madeleine J. GROOM in Journal of Autism and Developmental Disorders, 47-5 (May 2017)
PermalinkBrief Report: Macrocephaly Phenotype and Psychiatric Comorbidity in a Clinical Sample of Mexican Children and Adolescents with Autism Spectrum Disorders / Lilia ALBORES-GALLO in Journal of Autism and Developmental Disorders, 47-9 (September 2017)
PermalinkA Causal and Mediation Analysis of the Comorbidity Between Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) / Elena SOKOLOVA in Journal of Autism and Developmental Disorders, 47-6 (June 2017)
PermalinkCharacterizing psychiatric comorbidity in children with autism spectrum disorder receiving publicly funded mental health services / Lauren BROOKMAN-FRAZEE in Autism, 22-8 (November 2018)
PermalinkDepressive comorbidity in preschool anxiety disorder / Kai VON KLITZING in Journal of Child Psychology and Psychiatry, 55-10 (October 2014)
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