Anterior EEG Asymmetry and the Modifier Model of Autism / Courtney BURNETTE in Journal of Autism and Developmental Disorders, 41-8 (August 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-8 (August 2011) . - p.1113-1124 Titre : Anterior EEG Asymmetry and the Modifier Model of Autism Type de document : Texte imprimé et/ou numérique Auteurs : Courtney BURNETTE, Auteur ; Heather A. HENDERSON, Auteur ; Anne Pradella INGE, Auteur ; Nicole E. ZAHKA, Auteur ; Caley B. SCHWARTZ, Auteur ; Peter C. MUNDY, Auteur Année de publication : 2011 Article en page(s) : p.1113-1124 Langues : Anglais (eng) Mots-clés : EEG asymmetry  Social motivation  Individual differences Index. décimale : PER Périodiques Résumé : Individual differences in the expression of autism complicate research on the nature and treatment of this disorder. In the Modifier Model of Autism (Mundy et al. 2007), we proposed that individual differences in autism may result not only from syndrome specific causal processes, but also from variability in generic, non-syndrome specific modifier processes that affect the social and emotional development of all people. One study supporting this model found that measures of resting anterior EEG asymmetry, a measure reflecting complex brain processes associated with generic individual differences in approach and avoidance motivation, may help explain differences in the expression of autism in children without intellectual disabilities (Sutton et al. 2005). In the current study, we partially replicated the observation that children with autism who exhibited a pattern of left frontal EEG asymmetry tended to display milder levels of social symptoms, although in the current sample this pattern applied only to HFA children with relatively lower verbal IQs. New observations indicated that left frontal EEG asymmetry was also associated with retrospective parent reports of significantly later age of onset of symptoms, but also higher levels of self-reported outward expressions of anger as well as symptoms of obsessive compulsive disorder in school-age higher functioning children with ASD. Therefore, the results of this study provide a new and fully independent set of observations, which indicate that individual differences in anterior EEG asymmetry may significantly moderate the expression and developmental course of autism. This observation may have clinical implications for identifying meaningful diagnostic sub-groups among children with autism. En ligne : http://dx.doi.org/10.1007/s10803-010-1138-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Anterior EEG Asymmetry and the Modifier Model of Autism [Texte imprimé et/ou numérique] / Courtney BURNETTE, Auteur ; Heather A. HENDERSON, Auteur ; Anne Pradella INGE, Auteur ; Nicole E. ZAHKA, Auteur ; Caley B. SCHWARTZ, Auteur ; Peter C. MUNDY, Auteur . - 2011 . - p.1113-1124. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-8 (August 2011) . - p.1113-1124 Mots-clés : EEG asymmetry  Social motivation  Individual differences Index. décimale : PER Périodiques Résumé : Individual differences in the expression of autism complicate research on the nature and treatment of this disorder. In the Modifier Model of Autism (Mundy et al. 2007), we proposed that individual differences in autism may result not only from syndrome specific causal processes, but also from variability in generic, non-syndrome specific modifier processes that affect the social and emotional development of all people. One study supporting this model found that measures of resting anterior EEG asymmetry, a measure reflecting complex brain processes associated with generic individual differences in approach and avoidance motivation, may help explain differences in the expression of autism in children without intellectual disabilities (Sutton et al. 2005). In the current study, we partially replicated the observation that children with autism who exhibited a pattern of left frontal EEG asymmetry tended to display milder levels of social symptoms, although in the current sample this pattern applied only to HFA children with relatively lower verbal IQs. New observations indicated that left frontal EEG asymmetry was also associated with retrospective parent reports of significantly later age of onset of symptoms, but also higher levels of self-reported outward expressions of anger as well as symptoms of obsessive compulsive disorder in school-age higher functioning children with ASD. Therefore, the results of this study provide a new and fully independent set of observations, which indicate that individual differences in anterior EEG asymmetry may significantly moderate the expression and developmental course of autism. This observation may have clinical implications for identifying meaningful diagnostic sub-groups among children with autism. En ligne : http://dx.doi.org/10.1007/s10803-010-1138-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

ASD concordance of twins across DSM-IV-TR and DSM-5 diagnostic criteria / Elizabeth P. MCKERNAN in Research in Autism Spectrum Disorders, 41-42 (September 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 41-42 (September 2017) . - p.51-56 Titre : ASD concordance of twins across DSM-IV-TR and DSM-5 diagnostic criteria Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth P. MCKERNAN, Auteur ; Natalie RUSSO, Auteur ; Courtney BURNETTE, Auteur ; Wendy R. KATES, Auteur Article en page(s) : p.51-56 Langues : Anglais (eng) Mots-clés : Concordance  Monozygotic twins  DSM-5 Index. décimale : PER Périodiques Résumé : Previous research has supported a high degree of concordance for ASD among monozygotic twins, but no studies have examined concordance rates using DSM-5 diagnostic criteria for ASD. This pilot study examines monozygotic concordance for ASD from the perspective of both DSM-IV-TR and DSM-5 diagnostic criteria. Method Items of the Autism Diagnostic Interview–Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS) were matched to diagnostic criteria (Huerta et al., 2012). Diagnoses were assigned to 14 pairs of monozygotic twins, among whom at least one twin had an autism diagnosis, using DSM-IV-TR and DSM-5 criteria. McNemar tests were performed to determine whether there was a significant difference in sample pairwise concordance rates between the two diagnostic systems. Results Using strict criteria, which required items endorsed from both the ADI-R and the ADOS, eight of the fourteen twin pairs were concordant using DSM-IV-TR criteria compared to five pairs using DSM-5 criteria, yielding pairwise concordance rates of 57.14% and 35.71%, respectively. The use of either the ADI-R or the ADOS (relaxed criteria) resulted in pairwise concordance rates of 85.71% for DSM-IV-TR criteria and 78.57% for DSM-5 criteria. Pairwise concordance rates were not different across DSM-IV-TR and DSM-5 diagnostic criteria using these two methods, but were significantly greater with the use of relaxed as compared to strict criteria for DSM-5. Conclusions In this pilot study, monozygotic pairwise concordance rates were higher for DSM-5 when using information from either the ADI-R or the ADOS, as opposed to both measures. En ligne : https://doi.org/10.1016/j.rasd.2017.08.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=321 [article] ASD concordance of twins across DSM-IV-TR and DSM-5 diagnostic criteria [Texte imprimé et/ou numérique] / Elizabeth P. MCKERNAN, Auteur ; Natalie RUSSO, Auteur ; Courtney BURNETTE, Auteur ; Wendy R. KATES, Auteur . - p.51-56. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 41-42 (September 2017) . - p.51-56 Mots-clés : Concordance  Monozygotic twins  DSM-5 Index. décimale : PER Périodiques Résumé : Previous research has supported a high degree of concordance for ASD among monozygotic twins, but no studies have examined concordance rates using DSM-5 diagnostic criteria for ASD. This pilot study examines monozygotic concordance for ASD from the perspective of both DSM-IV-TR and DSM-5 diagnostic criteria. Method Items of the Autism Diagnostic Interview–Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS) were matched to diagnostic criteria (Huerta et al., 2012). Diagnoses were assigned to 14 pairs of monozygotic twins, among whom at least one twin had an autism diagnosis, using DSM-IV-TR and DSM-5 criteria. McNemar tests were performed to determine whether there was a significant difference in sample pairwise concordance rates between the two diagnostic systems. Results Using strict criteria, which required items endorsed from both the ADI-R and the ADOS, eight of the fourteen twin pairs were concordant using DSM-IV-TR criteria compared to five pairs using DSM-5 criteria, yielding pairwise concordance rates of 57.14% and 35.71%, respectively. The use of either the ADI-R or the ADOS (relaxed criteria) resulted in pairwise concordance rates of 85.71% for DSM-IV-TR criteria and 78.57% for DSM-5 criteria. Pairwise concordance rates were not different across DSM-IV-TR and DSM-5 diagnostic criteria using these two methods, but were significantly greater with the use of relaxed as compared to strict criteria for DSM-5. Conclusions In this pilot study, monozygotic pairwise concordance rates were higher for DSM-5 when using information from either the ADI-R or the ADOS, as opposed to both measures. En ligne : https://doi.org/10.1016/j.rasd.2017.08.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=321

ECHO Autism STAT: Accelerating Early Access to Autism Diagnosis / M. O. MAZUREK in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.127-137 Titre : ECHO Autism STAT: Accelerating Early Access to Autism Diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : M. O. MAZUREK, Auteur ; A. CURRAN, Auteur ; Courtney BURNETTE, Auteur ; K. SOHL, Auteur Article en page(s) : p.127-137 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorder  Health care access  Primary care provider  Screening Index. décimale : PER Périodiques Résumé : Although early diagnosis of autism is critical for promoting access to early intervention, many children experience significant diagnostic delays. Shortages of healthcare providers, limited capacity at autism centers, and geographic and socioeconomic challenges contribute to these delays. The current pilot study examined the feasibility of a new model for training community-based primary care providers (PCPs) in underserved areas in screening and diagnosis of young children at highest risk for autism. By combining hands-on training in standardized techniques with ongoing virtual mentorship and practice, the program emphasized both timely diagnosis and appropriate referral for more comprehensive assessment when necessary. Results indicated improvements in PCP practice and self-efficacy, and feasibility of the model for enhancing local access to care. En ligne : http://dx.doi.org/10.1007/s10803-018-3696-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 [article] ECHO Autism STAT: Accelerating Early Access to Autism Diagnosis [Texte imprimé et/ou numérique] / M. O. MAZUREK, Auteur ; A. CURRAN, Auteur ; Courtney BURNETTE, Auteur ; K. SOHL, Auteur . - p.127-137. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.127-137 Mots-clés : Autism  Autism spectrum disorder  Health care access  Primary care provider  Screening Index. décimale : PER Périodiques Résumé : Although early diagnosis of autism is critical for promoting access to early intervention, many children experience significant diagnostic delays. Shortages of healthcare providers, limited capacity at autism centers, and geographic and socioeconomic challenges contribute to these delays. The current pilot study examined the feasibility of a new model for training community-based primary care providers (PCPs) in underserved areas in screening and diagnosis of young children at highest risk for autism. By combining hands-on training in standardized techniques with ongoing virtual mentorship and practice, the program emphasized both timely diagnosis and appropriate referral for more comprehensive assessment when necessary. Results indicated improvements in PCP practice and self-efficacy, and feasibility of the model for enhancing local access to care. En ligne : http://dx.doi.org/10.1007/s10803-018-3696-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376

Erratum to: Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes / Beth A. MALOW in Journal of Autism and Developmental Disorders, 42-8 (August 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-8 (August 2012) . - p.1738 Titre : Erratum to: Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes Type de document : Texte imprimé et/ou numérique Auteurs : Beth A. MALOW, Auteur ; Karen W. ADKINS, Auteur ; Susan G. MCGREW, Auteur ; Lily WANG, Auteur ; Suzanne E. GOLDMAN, Auteur ; Diane FAWKES, Auteur ; Courtney BURNETTE, Auteur Année de publication : 2012 Article en page(s) : p.1738 Langues : Anglais (eng) Mots-clés : Melatonin  Insomnia  Actigraphy  Clinical trial  Children’s sleep habits questionnaire  Child behavior checklist  Autism diagnostic observation schedule Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-012-1507-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Erratum to: Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes [Texte imprimé et/ou numérique] / Beth A. MALOW, Auteur ; Karen W. ADKINS, Auteur ; Susan G. MCGREW, Auteur ; Lily WANG, Auteur ; Suzanne E. GOLDMAN, Auteur ; Diane FAWKES, Auteur ; Courtney BURNETTE, Auteur . - 2012 . - p.1738. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-8 (August 2012) . - p.1738 Mots-clés : Melatonin  Insomnia  Actigraphy  Clinical trial  Children’s sleep habits questionnaire  Child behavior checklist  Autism diagnostic observation schedule Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-012-1507-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

Gyrification patterns in monozygotic twin pairs varying in discordance for autism / Wendy R. KATES in Autism Research, 2-5 (October 2009)  

Public ISBD [article]  inAutism Research > 2-5 (October 2009) . - p.267-278 Titre : Gyrification patterns in monozygotic twin pairs varying in discordance for autism Type de document : Texte imprimé et/ou numérique Auteurs : Wendy R. KATES, Auteur ; Courtney BURNETTE, Auteur ; Ichiro IKUTA, Auteur Année de publication : 2009 Article en page(s) : p.267-278 Langues : Anglais (eng) Mots-clés : Autism twins cortical-gyrification MRI brain Index. décimale : PER Périodiques Résumé : In order to disentangle genetic and environmental contributions to cortical anomalies in children with autism, we investigated cortical folding patterns in a cohort of 14 monozygotic (MZ) twin pairs who displayed a range of phenotypic discordance for autism, and 14 typically developing community controls. Cortical folding was assessed with the gyrification index, which was calculated on high resolution anatomic MR images. We found that the cortical folding patterns across most lobar regions of the cerebral cortex was highly discordant within MZ twin pairs. In addition, children with autism and their co-twins exhibited increased cortical folding in the right parietal lobe, relative to age- and gender-matched typical developing children. Increased folding in the right parietal lobe was associated with more symptoms of autism for co-twins. Finally, the robust association between cortical folding and IQ observed in typical children was not observed in either children with autism or their co-twins. These findings, which contribute to our understanding of the limits of genetic liability in autism, suggest that anomalies in the structural integrity of the cortex in this PDD may disrupt the association between cortical folding and intelligence that has been reported in typical individuals, and may account, in part, for the deficits in visual spatial attention and in social cognition that have been reported in children with autism. En ligne : http://dx.doi.org/10.1002/aur.98 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938 [article] Gyrification patterns in monozygotic twin pairs varying in discordance for autism [Texte imprimé et/ou numérique] / Wendy R. KATES, Auteur ; Courtney BURNETTE, Auteur ; Ichiro IKUTA, Auteur . - 2009 . - p.267-278. Langues : Anglais (eng) in Autism Research > 2-5 (October 2009) . - p.267-278 Mots-clés : Autism twins cortical-gyrification MRI brain Index. décimale : PER Périodiques Résumé : In order to disentangle genetic and environmental contributions to cortical anomalies in children with autism, we investigated cortical folding patterns in a cohort of 14 monozygotic (MZ) twin pairs who displayed a range of phenotypic discordance for autism, and 14 typically developing community controls. Cortical folding was assessed with the gyrification index, which was calculated on high resolution anatomic MR images. We found that the cortical folding patterns across most lobar regions of the cerebral cortex was highly discordant within MZ twin pairs. In addition, children with autism and their co-twins exhibited increased cortical folding in the right parietal lobe, relative to age- and gender-matched typical developing children. Increased folding in the right parietal lobe was associated with more symptoms of autism for co-twins. Finally, the robust association between cortical folding and IQ observed in typical children was not observed in either children with autism or their co-twins. These findings, which contribute to our understanding of the limits of genetic liability in autism, suggest that anomalies in the structural integrity of the cortex in this PDD may disrupt the association between cortical folding and intelligence that has been reported in typical individuals, and may account, in part, for the deficits in visual spatial attention and in social cognition that have been reported in children with autism. En ligne : http://dx.doi.org/10.1002/aur.98 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938

Joint Attention and Neurodevelopmental Models of Autism / Peter C. MUNDY

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Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes / Beth A. MALOW in Journal of Autism and Developmental Disorders, 42-8 (August 2012)  

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The rubber hand illusion in children with autism spectrum disorders: delayed influence of combined tactile and visual input on proprioception / Carissa J. CASCIO in Autism, 16-4 (July 2012)  

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