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ASD concordance of twins across DSM-IV-TR and DSM-5 diagnostic criteria / Elizabeth P. MCKERNAN in Research in Autism Spectrum Disorders, 41-42 (September 2017)
[article]
Titre : ASD concordance of twins across DSM-IV-TR and DSM-5 diagnostic criteria Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth P. MCKERNAN, Auteur ; Natalie RUSSO, Auteur ; Courtney BURNETTE, Auteur ; Wendy R. KATES, Auteur Article en page(s) : p.51-56 Langues : Anglais (eng) Mots-clés : Concordance Monozygotic twins DSM-5 Index. décimale : PER Périodiques Résumé : Previous research has supported a high degree of concordance for ASD among monozygotic twins, but no studies have examined concordance rates using DSM-5 diagnostic criteria for ASD. This pilot study examines monozygotic concordance for ASD from the perspective of both DSM-IV-TR and DSM-5 diagnostic criteria. Method Items of the Autism Diagnostic Interview–Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS) were matched to diagnostic criteria (Huerta et al., 2012). Diagnoses were assigned to 14 pairs of monozygotic twins, among whom at least one twin had an autism diagnosis, using DSM-IV-TR and DSM-5 criteria. McNemar tests were performed to determine whether there was a significant difference in sample pairwise concordance rates between the two diagnostic systems. Results Using strict criteria, which required items endorsed from both the ADI-R and the ADOS, eight of the fourteen twin pairs were concordant using DSM-IV-TR criteria compared to five pairs using DSM-5 criteria, yielding pairwise concordance rates of 57.14% and 35.71%, respectively. The use of either the ADI-R or the ADOS (relaxed criteria) resulted in pairwise concordance rates of 85.71% for DSM-IV-TR criteria and 78.57% for DSM-5 criteria. Pairwise concordance rates were not different across DSM-IV-TR and DSM-5 diagnostic criteria using these two methods, but were significantly greater with the use of relaxed as compared to strict criteria for DSM-5. Conclusions In this pilot study, monozygotic pairwise concordance rates were higher for DSM-5 when using information from either the ADI-R or the ADOS, as opposed to both measures. En ligne : https://doi.org/10.1016/j.rasd.2017.08.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=321
in Research in Autism Spectrum Disorders > 41-42 (September 2017) . - p.51-56[article] ASD concordance of twins across DSM-IV-TR and DSM-5 diagnostic criteria [Texte imprimé et/ou numérique] / Elizabeth P. MCKERNAN, Auteur ; Natalie RUSSO, Auteur ; Courtney BURNETTE, Auteur ; Wendy R. KATES, Auteur . - p.51-56.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 41-42 (September 2017) . - p.51-56
Mots-clés : Concordance Monozygotic twins DSM-5 Index. décimale : PER Périodiques Résumé : Previous research has supported a high degree of concordance for ASD among monozygotic twins, but no studies have examined concordance rates using DSM-5 diagnostic criteria for ASD. This pilot study examines monozygotic concordance for ASD from the perspective of both DSM-IV-TR and DSM-5 diagnostic criteria. Method Items of the Autism Diagnostic Interview–Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS) were matched to diagnostic criteria (Huerta et al., 2012). Diagnoses were assigned to 14 pairs of monozygotic twins, among whom at least one twin had an autism diagnosis, using DSM-IV-TR and DSM-5 criteria. McNemar tests were performed to determine whether there was a significant difference in sample pairwise concordance rates between the two diagnostic systems. Results Using strict criteria, which required items endorsed from both the ADI-R and the ADOS, eight of the fourteen twin pairs were concordant using DSM-IV-TR criteria compared to five pairs using DSM-5 criteria, yielding pairwise concordance rates of 57.14% and 35.71%, respectively. The use of either the ADI-R or the ADOS (relaxed criteria) resulted in pairwise concordance rates of 85.71% for DSM-IV-TR criteria and 78.57% for DSM-5 criteria. Pairwise concordance rates were not different across DSM-IV-TR and DSM-5 diagnostic criteria using these two methods, but were significantly greater with the use of relaxed as compared to strict criteria for DSM-5. Conclusions In this pilot study, monozygotic pairwise concordance rates were higher for DSM-5 when using information from either the ADI-R or the ADOS, as opposed to both measures. En ligne : https://doi.org/10.1016/j.rasd.2017.08.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=321 Multimodal brain imaging in autism spectrum disorder and the promise of twin research / Katell MEVEL in Autism, 19-5 (July 2015)
[article]
Titre : Multimodal brain imaging in autism spectrum disorder and the promise of twin research Type de document : Texte imprimé et/ou numérique Auteurs : Katell MEVEL, Auteur ; Peter FRANSSON, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.527-541 Langues : Anglais (eng) Mots-clés : autism connectome diffusion tensor imaging monozygotic twins neurodevelopmental disorders resting-state functional magnetic resonance imaging review Index. décimale : PER Périodiques Résumé : Current evidence suggests the phenotype of autism spectrum disorder to be driven by a complex interaction of genetic and environmental factors impacting onto brain maturation, synaptic function, and cortical networks. However, findings are heterogeneous, and the exact neurobiological pathways of autism spectrum disorder still remain poorly understood. The co-twin control or twin-difference design is a potentially powerful tool to disentangle causal genetic and environmental contributions on neurodevelopment in autism spectrum disorder. To this end, monozygotic twins discordant for this condition provide unique means for the maximum control of potentially confounding factors. Unfortunately, only few studies of a rather narrow scope, and limited sample size, have been conducted. In an attempt to highlight the great potential of combining the brain connectome approach with monozygotic twin design, we first give an overview of the existing neurobiological evidence for autism spectrum disorder and its cognitive correlates. Then, a special focus is made onto the brain imaging findings reported within populations of monozygotic twins phenotypically discordant for autism spectrum disorder. Finally, we introduce the brain connectome model and describe an ongoing project using this approach among the largest cohort of monozygotic twins discordant for autism spectrum disorder ever recruited. En ligne : http://dx.doi.org/10.1177/1362361314535510 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261
in Autism > 19-5 (July 2015) . - p.527-541[article] Multimodal brain imaging in autism spectrum disorder and the promise of twin research [Texte imprimé et/ou numérique] / Katell MEVEL, Auteur ; Peter FRANSSON, Auteur ; Sven BÖLTE, Auteur . - p.527-541.
Langues : Anglais (eng)
in Autism > 19-5 (July 2015) . - p.527-541
Mots-clés : autism connectome diffusion tensor imaging monozygotic twins neurodevelopmental disorders resting-state functional magnetic resonance imaging review Index. décimale : PER Périodiques Résumé : Current evidence suggests the phenotype of autism spectrum disorder to be driven by a complex interaction of genetic and environmental factors impacting onto brain maturation, synaptic function, and cortical networks. However, findings are heterogeneous, and the exact neurobiological pathways of autism spectrum disorder still remain poorly understood. The co-twin control or twin-difference design is a potentially powerful tool to disentangle causal genetic and environmental contributions on neurodevelopment in autism spectrum disorder. To this end, monozygotic twins discordant for this condition provide unique means for the maximum control of potentially confounding factors. Unfortunately, only few studies of a rather narrow scope, and limited sample size, have been conducted. In an attempt to highlight the great potential of combining the brain connectome approach with monozygotic twin design, we first give an overview of the existing neurobiological evidence for autism spectrum disorder and its cognitive correlates. Then, a special focus is made onto the brain imaging findings reported within populations of monozygotic twins phenotypically discordant for autism spectrum disorder. Finally, we introduce the brain connectome model and describe an ongoing project using this approach among the largest cohort of monozygotic twins discordant for autism spectrum disorder ever recruited. En ligne : http://dx.doi.org/10.1177/1362361314535510 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261