Children's sleep, impulsivity, and anger: shared genetic etiology and implications for developmental psychopathology / Samantha A. MIADICH in Journal of Child Psychology and Psychiatry, 61-10 (October 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-10 (October 2020) . - p.1070-1079 Titre : Children's sleep, impulsivity, and anger: shared genetic etiology and implications for developmental psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Samantha A. MIADICH, Auteur ; Amanda M. SHREWSBURY, Auteur ; Leah D. DOANE, Auteur ; Mary C. DAVIS, Auteur ; Sierra CLIFFORD, Auteur ; Kathryn LEMERY-CHALFANT, Auteur Article en page(s) : p.1070-1079 Langues : Anglais (eng) Mots-clés : Sleep  anger  impulsivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Prior research has established links between poor sleep and problems in emotion regulation. Impulsivity and anger/frustration are core features of child psychopathology. Further, sleep problems are commonly associated with psychopathology. This study examined shared and unique genetic and environmental influences on sleep, impulsivity, and anger/frustration in the middle childhood period with potential ramifications for psychopathology. METHODS: Families (29.9% monozygotic, 38.6% same-sex dizygotic, 31.5% opposite-sex dizygotic) from a longitudinal twin study participated (N = 613 twins). Twins (M(age)  = 8.37, SD = 0.66; 49% female; 58% non-Latinx European American, 30% Latinx) wore actigraph watches for seven days to assess sleep. Primary caregivers (95.3% mothers) completed standardized questionnaires to assess twins' temperament (impulsivity, anger/frustration). RESULTS: Univariate ACE twin structural equation models indicated strong genetic influences (76%) on impulsivity, whereas the largest proportion of variance in anger/frustration was attributed to the shared environment (56%). Bivariate model fitting indicated that sleep-impulsivity and sleep-anger/frustration associations in children are genetic; thus, a mutual underlying genetic factor likely contributes to the commonality in these associations. CONCLUSIONS: Given evidence that sleep problems, impulsivity, and anger/frustration are mechanisms associated with psychopathology, our findings suggest a genetic commonality and the need to focus on shared and unique risk factors when understanding etiology. Early intervention and prevention efforts should target both sleep problems and high levels of impulsivity and anger/frustration in children, which may have implications for later psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13328 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Children's sleep, impulsivity, and anger: shared genetic etiology and implications for developmental psychopathology [Texte imprimé et/ou numérique] / Samantha A. MIADICH, Auteur ; Amanda M. SHREWSBURY, Auteur ; Leah D. DOANE, Auteur ; Mary C. DAVIS, Auteur ; Sierra CLIFFORD, Auteur ; Kathryn LEMERY-CHALFANT, Auteur . - p.1070-1079. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-10 (October 2020) . - p.1070-1079 Mots-clés : Sleep  anger  impulsivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Prior research has established links between poor sleep and problems in emotion regulation. Impulsivity and anger/frustration are core features of child psychopathology. Further, sleep problems are commonly associated with psychopathology. This study examined shared and unique genetic and environmental influences on sleep, impulsivity, and anger/frustration in the middle childhood period with potential ramifications for psychopathology. METHODS: Families (29.9% monozygotic, 38.6% same-sex dizygotic, 31.5% opposite-sex dizygotic) from a longitudinal twin study participated (N = 613 twins). Twins (M(age)  = 8.37, SD = 0.66; 49% female; 58% non-Latinx European American, 30% Latinx) wore actigraph watches for seven days to assess sleep. Primary caregivers (95.3% mothers) completed standardized questionnaires to assess twins' temperament (impulsivity, anger/frustration). RESULTS: Univariate ACE twin structural equation models indicated strong genetic influences (76%) on impulsivity, whereas the largest proportion of variance in anger/frustration was attributed to the shared environment (56%). Bivariate model fitting indicated that sleep-impulsivity and sleep-anger/frustration associations in children are genetic; thus, a mutual underlying genetic factor likely contributes to the commonality in these associations. CONCLUSIONS: Given evidence that sleep problems, impulsivity, and anger/frustration are mechanisms associated with psychopathology, our findings suggest a genetic commonality and the need to focus on shared and unique risk factors when understanding etiology. Early intervention and prevention efforts should target both sleep problems and high levels of impulsivity and anger/frustration in children, which may have implications for later psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13328 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

Genetic moderation of the effects of the Family Check-Up intervention on children's internalizing symptoms: A longitudinal study with a racially/ethnically diverse sample / Kathryn LEMERY-CHALFANT in Development and Psychopathology, 30-5 (December 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-5 (December 2018) . - p.1729-1747 Titre : Genetic moderation of the effects of the Family Check-Up intervention on children's internalizing symptoms: A longitudinal study with a racially/ethnically diverse sample Type de document : Texte imprimé et/ou numérique Auteurs : Kathryn LEMERY-CHALFANT, Auteur ; Sierra CLIFFORD, Auteur ; Thomas J. DISHION, Auteur ; Daniel S. SHAW, Auteur ; Melvin N. WILSON, Auteur Article en page(s) : p.1729-1747 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Development involves synergistic interplay among genotypes and the physical and cultural environments, and integrating genetics into experimental designs that manipulate the environment can improve understanding of developmental psychopathology and intervention efficacy. Consistent with differential susceptibility theory, individuals can vary in their sensitivity to environmental conditions including intervention for reasons including their genotype. As a consequence, understanding genetic influences on intervention response is critical. Empirically, we tested an interaction between a genetic index representing sensitivity to the environment and the Family Check-Up intervention. Participants were drawn from the Early Steps Multisite randomized prevention trial that included a low-income and racially/ethnically diverse sample of children and their families followed longitudinally (n = 515). As hypothesized, polygenic sensitivity to the environment moderated the effects of the intervention on 10-year-old children's symptoms of internalizing psychopathology, such that children who were genetically sensitive and were randomly assigned to the intervention had fewer symptoms of child psychopathology than genetically sensitive children assigned to the control condition. A significant difference in internalizing symptoms assessed with a clinical interview emerged between the intervention and control groups for those 0.493 SD above the mean on polygenic sensitivity, or 25% of the sample. Similar to personalized medicine, it is time to understand individual and sociocultural differences in treatment response and individualize psychosocial interventions to reduce the burden of child psychopathology and maximize well-being for children growing up in a wide range of physical environments and cultures. En ligne : http://dx.doi.org/10.1017/S095457941800127X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Genetic moderation of the effects of the Family Check-Up intervention on children's internalizing symptoms: A longitudinal study with a racially/ethnically diverse sample [Texte imprimé et/ou numérique] / Kathryn LEMERY-CHALFANT, Auteur ; Sierra CLIFFORD, Auteur ; Thomas J. DISHION, Auteur ; Daniel S. SHAW, Auteur ; Melvin N. WILSON, Auteur . - p.1729-1747. Langues : Anglais (eng) in Development and Psychopathology > 30-5 (December 2018) . - p.1729-1747 Index. décimale : PER Périodiques Résumé : Development involves synergistic interplay among genotypes and the physical and cultural environments, and integrating genetics into experimental designs that manipulate the environment can improve understanding of developmental psychopathology and intervention efficacy. Consistent with differential susceptibility theory, individuals can vary in their sensitivity to environmental conditions including intervention for reasons including their genotype. As a consequence, understanding genetic influences on intervention response is critical. Empirically, we tested an interaction between a genetic index representing sensitivity to the environment and the Family Check-Up intervention. Participants were drawn from the Early Steps Multisite randomized prevention trial that included a low-income and racially/ethnically diverse sample of children and their families followed longitudinally (n = 515). As hypothesized, polygenic sensitivity to the environment moderated the effects of the intervention on 10-year-old children's symptoms of internalizing psychopathology, such that children who were genetically sensitive and were randomly assigned to the intervention had fewer symptoms of child psychopathology than genetically sensitive children assigned to the control condition. A significant difference in internalizing symptoms assessed with a clinical interview emerged between the intervention and control groups for those 0.493 SD above the mean on polygenic sensitivity, or 25% of the sample. Similar to personalized medicine, it is time to understand individual and sociocultural differences in treatment response and individualize psychosocial interventions to reduce the burden of child psychopathology and maximize well-being for children growing up in a wide range of physical environments and cultures. En ligne : http://dx.doi.org/10.1017/S095457941800127X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Genotype?environment correlation by intervention effects underlying middle childhood peer rejection and associations with adolescent marijuana use / Kit K. ELAM in Development and Psychopathology, 34-1 (February 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-1 (February 2022) . - p.171-182 Titre : Genotype?environment correlation by intervention effects underlying middle childhood peer rejection and associations with adolescent marijuana use Type de document : Texte imprimé et/ou numérique Auteurs : Kit K. ELAM, Auteur ; Sierra CLIFFORD, Auteur ; Ariana RUOF, Auteur ; Daniel S. SHAW, Auteur ; Melvin N. WILSON, Auteur ; Kathryn LEMERY-CHALFANT, Auteur Article en page(s) : p.171-182 Langues : Anglais (eng) Mots-clés : gene?environment correlation  marijuana use  middle childhood  peer rejection  time-varying effect modeling Index. décimale : PER Périodiques Résumé : Aggressive behavior in middle childhood can contribute to peer rejection, subsequently increasing risk for substance use in adolescence. However, the quality of peer relationships a child experiences can be associated with his or her genetic predisposition, a genotype?environment correlation (rGE). In addition, recent evidence indicates that psychosocial preventive interventions can buffer genetic predispositions for negative behavior. The current study examined associations between polygenic risk for aggression, aggressive behavior, and peer rejection from 8.5 to 10.5 years, and the subsequent influence of peer rejection on marijuana use in adolescence (n = 515; 256 control, 259 intervention). Associations were examined separately in control and intervention groups for children of families who participated in a randomized controlled trial of the family-based preventive intervention, the Family Check-Up . Using time-varying effect modeling (TVEM), polygenic risk for aggression was associated with peer rejection from approximately age 8.50 to 9.50 in the control group but no associations were present in the intervention group. Subsequent analyses showed peer rejection mediated the association between polygenic risk for aggression and adolescent marijuana use in the control group. The role of rGEs in middle childhood peer processes and implications for preventive intervention programs for adolescent substance use are discussed. En ligne : http://dx.doi.org/10.1017/s0954579420001066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Genotype?environment correlation by intervention effects underlying middle childhood peer rejection and associations with adolescent marijuana use [Texte imprimé et/ou numérique] / Kit K. ELAM, Auteur ; Sierra CLIFFORD, Auteur ; Ariana RUOF, Auteur ; Daniel S. SHAW, Auteur ; Melvin N. WILSON, Auteur ; Kathryn LEMERY-CHALFANT, Auteur . - p.171-182. Langues : Anglais (eng) in Development and Psychopathology > 34-1 (February 2022) . - p.171-182 Mots-clés : gene?environment correlation  marijuana use  middle childhood  peer rejection  time-varying effect modeling Index. décimale : PER Périodiques Résumé : Aggressive behavior in middle childhood can contribute to peer rejection, subsequently increasing risk for substance use in adolescence. However, the quality of peer relationships a child experiences can be associated with his or her genetic predisposition, a genotype?environment correlation (rGE). In addition, recent evidence indicates that psychosocial preventive interventions can buffer genetic predispositions for negative behavior. The current study examined associations between polygenic risk for aggression, aggressive behavior, and peer rejection from 8.5 to 10.5 years, and the subsequent influence of peer rejection on marijuana use in adolescence (n = 515; 256 control, 259 intervention). Associations were examined separately in control and intervention groups for children of families who participated in a randomized controlled trial of the family-based preventive intervention, the Family Check-Up . Using time-varying effect modeling (TVEM), polygenic risk for aggression was associated with peer rejection from approximately age 8.50 to 9.50 in the control group but no associations were present in the intervention group. Subsequent analyses showed peer rejection mediated the association between polygenic risk for aggression and adolescent marijuana use in the control group. The role of rGEs in middle childhood peer processes and implications for preventive intervention programs for adolescent substance use are discussed. En ligne : http://dx.doi.org/10.1017/s0954579420001066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

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