Anomalies immuno-inflammatoires et troubles du spectre autistique (TSA) / Marion LEBOYER in Bulletin Scientifique de l'arapi (Le), 40 (Hiver 2017)

Public ISBD [article]  inBulletin Scientifique de l'arapi (Le) > 40 (Hiver 2017) . - p.41-43 Titre : Anomalies immuno-inflammatoires et troubles du spectre autistique (TSA) Type de document : texte imprimé Auteurs : Marion LEBOYER, Auteur ; Ryad TAMOUZA, Auteur ; Laure TABOUY, Auteur Année de publication : 2017 Article en page(s) : p.41-43 Langues : Français (fre) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=373 [article] Anomalies immuno-inflammatoires et troubles du spectre autistique (TSA) [texte imprimé] / Marion LEBOYER, Auteur ; Ryad TAMOUZA, Auteur ; Laure TABOUY, Auteur . - 2017 . - p.41-43. Langues : Français (fre) in Bulletin Scientifique de l'arapi (Le) > 40 (Hiver 2017) . - p.41-43 Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=373

HLA Polymorphism in Regressive and Non-Regressive Autism: A Preliminary Study / Ryad TAMOUZA in Autism Research, 13-2 (February 2020)  

Public ISBD [article]  inAutism Research > 13-2 (February 2020) . - p.182-186 Titre : HLA Polymorphism in Regressive and Non-Regressive Autism: A Preliminary Study Type de document : texte imprimé Auteurs : Ryad TAMOUZA, Auteur ; Elisabeth FERNELL, Auteur ; Mats Anders ERIKSSON, Auteur ; Britt-Marie ANDERLID, Auteur ; Celine MANIER, Auteur ; Christina Mary MARIASELVAM, Auteur ; Wahid BOUKOUACI, Auteur ; Marion LEBOYER, Auteur ; Christopher GILLBERG, Auteur Article en page(s) : p.182-186 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  autoimmunity  haplotypes  human leucocyte antigens  inflammation  regression Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) comprises heterogeneous neurodevelopmental conditions with symptom onset usually during infancy. However, about 10%-30% of affected cases experience a loss of language and social skills around 18-30 months, so-called regressive autism. In this subset with regression, immune dysfunctions including inflammation and autoimmunity have been proposed to be at risk factors. Given the implication of the human histocompatibility antigens (HLA) system in various aspects of immune responses, including autoimmunity, and in ASD, we investigate here the distribution of the HLA Class I and Class II haplotypes in 131 children with ASD meeting DSM-IV TR criteria, with and without regression. We found that 62 of the 98 non-regressive ASD patients carry the HLA-DPA1*01-DPB1*04 sub-haplotype as compared to 14 of the 33 patients with regression (63% vs. 43% respectively, Pc = 0.02), suggesting that this HLA haplotype may exert a protective effect against regression. Similarly, the HLA-DPA1*01-DPB1*04 has also been found to be more represented in healthy controls as compared to patients affected with common nonpsychiatric autoimmune disorders. Overall our findings suggest a possible involvement of HLA polymorphism in the context of regressive ASD. Autism Res 2020, 13: 182-186. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Immune dysfunctions including inflammatory and autoimmune processes have been reported in autism, particularly in regressive forms. In this study, we analyzed the distribution of HLA haplotypes among children with autism spectrum disorder (ASD), with and without regression from Sweden and observed that HLA-DPA1*01-DPB1*04 sub-haplotype was less represented in patients with regressive autism as compared with those without regression. Such possible protective effect, also observed in other common autoimmune disorders, may constitute a link between HLA-mediated immune processes and regressive ASD. En ligne : http://dx.doi.org/10.1002/aur.2217 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420 [article] HLA Polymorphism in Regressive and Non-Regressive Autism: A Preliminary Study [texte imprimé] / Ryad TAMOUZA, Auteur ; Elisabeth FERNELL, Auteur ; Mats Anders ERIKSSON, Auteur ; Britt-Marie ANDERLID, Auteur ; Celine MANIER, Auteur ; Christina Mary MARIASELVAM, Auteur ; Wahid BOUKOUACI, Auteur ; Marion LEBOYER, Auteur ; Christopher GILLBERG, Auteur . - p.182-186. Langues : Anglais (eng) in Autism Research > 13-2 (February 2020) . - p.182-186 Mots-clés : autism spectrum disorders  autoimmunity  haplotypes  human leucocyte antigens  inflammation  regression Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) comprises heterogeneous neurodevelopmental conditions with symptom onset usually during infancy. However, about 10%-30% of affected cases experience a loss of language and social skills around 18-30 months, so-called regressive autism. In this subset with regression, immune dysfunctions including inflammation and autoimmunity have been proposed to be at risk factors. Given the implication of the human histocompatibility antigens (HLA) system in various aspects of immune responses, including autoimmunity, and in ASD, we investigate here the distribution of the HLA Class I and Class II haplotypes in 131 children with ASD meeting DSM-IV TR criteria, with and without regression. We found that 62 of the 98 non-regressive ASD patients carry the HLA-DPA1*01-DPB1*04 sub-haplotype as compared to 14 of the 33 patients with regression (63% vs. 43% respectively, Pc = 0.02), suggesting that this HLA haplotype may exert a protective effect against regression. Similarly, the HLA-DPA1*01-DPB1*04 has also been found to be more represented in healthy controls as compared to patients affected with common nonpsychiatric autoimmune disorders. Overall our findings suggest a possible involvement of HLA polymorphism in the context of regressive ASD. Autism Res 2020, 13: 182-186. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Immune dysfunctions including inflammatory and autoimmune processes have been reported in autism, particularly in regressive forms. In this study, we analyzed the distribution of HLA haplotypes among children with autism spectrum disorder (ASD), with and without regression from Sweden and observed that HLA-DPA1*01-DPB1*04 sub-haplotype was less represented in patients with regressive autism as compared with those without regression. Such possible protective effect, also observed in other common autoimmune disorders, may constitute a link between HLA-mediated immune processes and regressive ASD. En ligne : http://dx.doi.org/10.1002/aur.2217 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420

Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events? / Meriem BENNABI in Molecular Autism, 10 (2019)  

Public ISBD [article]  inMolecular Autism > 10 (2019) . - 22p. Titre : Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events? Type de document : texte imprimé Auteurs : Meriem BENNABI, Auteur ; Nadine TARANTINO, Auteur ; Alexandru GAMAN, Auteur ; Isabelle SCHEID, Auteur ; Rajagopal KRISHNAMOORTHY, Auteur ; P. DEBRE, Auteur ; Arthur BOULEAU, Auteur ; Mireille CARALP, Auteur ; Sonia GUEGUEN, Auteur ; Myriam Ly LE-MOAL, Auteur ; Manuel P. BOUVARD, Auteur ; Anouck AMESTOY, Auteur ; Richard DELORME, Auteur ; Marion LEBOYER, Auteur ; Ryad TAMOUZA, Auteur ; Vincent VIEILLARD, Auteur Article en page(s) : 22p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  High-functioning autism  Natural killer cells  Pathogens Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASD) are characterized by abnormal neurodevelopment, genetic, and environmental risk factors, as well as immune dysfunctions. Several lines of evidence suggest alterations in innate immune responses in children with ASD. To address this question in adults with high-functioning ASD (hf-ASD), we sought to investigate the role of natural killer (NK) cells in the persistence of ASD. Methods: NK cells from 35 adults with hf-ASD were compared to that of 35 healthy controls (HC), selected for the absence of any immune dysfunctions, at different time-points, and over a 2-year follow-up period for four patients. The phenotype and polyfunctional capacities of NK cells were explored according to infectious stigma and clinical parameters (IQ, social, and communication scores). Results: As compared to HC, NK cells from patients with hf-ASD showed a high level of cell activation (p < 0.0001), spontaneous degranulation (p < 0.0001), and interferon-gamma production (p = 0.0004), whereas they were exhausted after in vitro stimulations (p = 0.0006). These data yielded a specific HLA-DR(+)KIR2DL1(+)NKG2C(+) NK-cell signature. Significant overexpression of NKG2C in hf-ASD patients (p = 0.0005), indicative of viral infections, was inversely correlated with the NKp46 receptor level (r = - 0.67; p < 0.0001), regardless of the IgG status of tested pathogens. Multivariate linear regression analysis also revealed that expression of the late-activating HLA-DR marker was both associated with structural language (r = 0.48; p = 0.007) and social awareness (r = 0.60; p = 0.0007) scores in adult patients with hf-ASD, while KIR2DL1 expression correlated with IQ scores (p = 0.0083). Conclusions: This study demonstrates that adults with hf-ASD have specific NK-cell profile. Presence of NKG2C overexpression together with high-level activation of NK cells suggest an association with underlying pathogens, a hypothesis warranting further exploration in future studies. En ligne : http://dx.doi.org/10.1186/s13229-019-0269-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events? [texte imprimé] / Meriem BENNABI, Auteur ; Nadine TARANTINO, Auteur ; Alexandru GAMAN, Auteur ; Isabelle SCHEID, Auteur ; Rajagopal KRISHNAMOORTHY, Auteur ; P. DEBRE, Auteur ; Arthur BOULEAU, Auteur ; Mireille CARALP, Auteur ; Sonia GUEGUEN, Auteur ; Myriam Ly LE-MOAL, Auteur ; Manuel P. BOUVARD, Auteur ; Anouck AMESTOY, Auteur ; Richard DELORME, Auteur ; Marion LEBOYER, Auteur ; Ryad TAMOUZA, Auteur ; Vincent VIEILLARD, Auteur . - 22p. Langues : Anglais (eng) in Molecular Autism > 10 (2019) . - 22p. Mots-clés : Autism spectrum disorders  High-functioning autism  Natural killer cells  Pathogens Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASD) are characterized by abnormal neurodevelopment, genetic, and environmental risk factors, as well as immune dysfunctions. Several lines of evidence suggest alterations in innate immune responses in children with ASD. To address this question in adults with high-functioning ASD (hf-ASD), we sought to investigate the role of natural killer (NK) cells in the persistence of ASD. Methods: NK cells from 35 adults with hf-ASD were compared to that of 35 healthy controls (HC), selected for the absence of any immune dysfunctions, at different time-points, and over a 2-year follow-up period for four patients. The phenotype and polyfunctional capacities of NK cells were explored according to infectious stigma and clinical parameters (IQ, social, and communication scores). Results: As compared to HC, NK cells from patients with hf-ASD showed a high level of cell activation (p < 0.0001), spontaneous degranulation (p < 0.0001), and interferon-gamma production (p = 0.0004), whereas they were exhausted after in vitro stimulations (p = 0.0006). These data yielded a specific HLA-DR(+)KIR2DL1(+)NKG2C(+) NK-cell signature. Significant overexpression of NKG2C in hf-ASD patients (p = 0.0005), indicative of viral infections, was inversely correlated with the NKp46 receptor level (r = - 0.67; p < 0.0001), regardless of the IgG status of tested pathogens. Multivariate linear regression analysis also revealed that expression of the late-activating HLA-DR marker was both associated with structural language (r = 0.48; p = 0.007) and social awareness (r = 0.60; p = 0.0007) scores in adult patients with hf-ASD, while KIR2DL1 expression correlated with IQ scores (p = 0.0083). Conclusions: This study demonstrates that adults with hf-ASD have specific NK-cell profile. Presence of NKG2C overexpression together with high-level activation of NK cells suggest an association with underlying pathogens, a hypothesis warranting further exploration in future studies. En ligne : http://dx.doi.org/10.1186/s13229-019-0269-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

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