Brief Report: Low Rates of Herpesvirus Detection in Blood of Individuals with Autism Spectrum Disorder and Controls / T. L. SWEETEN in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.410-414 Titre : Brief Report: Low Rates of Herpesvirus Detection in Blood of Individuals with Autism Spectrum Disorder and Controls Type de document : Texte imprimé et/ou numérique Auteurs : T. L. SWEETEN, Auteur ; Lisa A. CROEN, Auteur ; G. C. WINDHAM, Auteur ; J. D. ODELL, Auteur ; E. G. STUBBS, Auteur ; A. R. TORRES, Auteur Article en page(s) : p.410-414 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorder  Hhv-6  Herpesvirus Index. décimale : PER Périodiques Résumé : Previous research indicates that infection, especially from viruses in the family Herpesviridae, may play a role in the etiology of some cases of autism spectrum disorder (ASD). Using a case-control design and the polymerase chain reaction with site-specific primers, we screened newborn and childhood blood samples for the presence of eight human herpesviruses. Herpesvirus DNA was detected in 4 of 225 ASD individuals and 2 of 235 controls, with the most frequently detected virus being HHV-6B. Although this study does not detect a significant ASD-Herpesviridae association, it is limited by the use of site-specific primers. We suggest that new techniques using bioinformatics to search next-generation sequencing databases will be more revealing of possible ASD-virus associations. En ligne : http://dx.doi.org/10.1007/s10803-018-3691-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377 [article] Brief Report: Low Rates of Herpesvirus Detection in Blood of Individuals with Autism Spectrum Disorder and Controls [Texte imprimé et/ou numérique] / T. L. SWEETEN, Auteur ; Lisa A. CROEN, Auteur ; G. C. WINDHAM, Auteur ; J. D. ODELL, Auteur ; E. G. STUBBS, Auteur ; A. R. TORRES, Auteur . - p.410-414. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.410-414 Mots-clés : Autism  Autism spectrum disorder  Hhv-6  Herpesvirus Index. décimale : PER Périodiques Résumé : Previous research indicates that infection, especially from viruses in the family Herpesviridae, may play a role in the etiology of some cases of autism spectrum disorder (ASD). Using a case-control design and the polymerase chain reaction with site-specific primers, we screened newborn and childhood blood samples for the presence of eight human herpesviruses. Herpesvirus DNA was detected in 4 of 225 ASD individuals and 2 of 235 controls, with the most frequently detected virus being HHV-6B. Although this study does not detect a significant ASD-Herpesviridae association, it is limited by the use of site-specific primers. We suggest that new techniques using bioinformatics to search next-generation sequencing databases will be more revealing of possible ASD-virus associations. En ligne : http://dx.doi.org/10.1007/s10803-018-3691-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377

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