[article]
| Titre : |
Social communication in fragile X syndrome: pilot examination of the Brief Observation of Social Communication Change (BOSCC) |
| Type de document : |
texte imprimé |
| Auteurs : |
Rebecca SHAFFER, Auteur ; Angela John THURMAN, Auteur ; Lucienne RONCO, Auteur ; Diego CADAVID, Auteur ; Shane RAINES, Auteur ; So Hyun KIM, Auteur |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism Spectrum Disorder/diagnosis Child Child, Preschool Communication Fragile X Syndrome/diagnosis Humans Male Reproducibility of Results Social Communication Disorder/diagnosis Boscc Fragile X syndrome Outcome measure Repetitive behaviors Social communication Diego Cadavid and Lucienne Ronco were employees of Fulcrum Therapeutics at the time of the study and they own stock in Fulcrum Therapeutics. Shane Raines was a paid consultant to Fulcrum Therapeutics. The other authors have no conflicts to report. |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Social communication is a key area of difficulty in fragile X syndrome (FXS) and there are not yet adequate outcome measurement tools. Appropriate outcome measures for FXS have been identified as a key area of research interest in order to evaluate future therapeutic trials. The Brief Observation of Social Communication Change-Minimally Verbal (BOSCC-MV), an outcome measure with strong psychometrics developed for autism spectrum disorder, has promise as an outcome measure to assess social communication change with FXS participants. METHODS: We examined the BOSCC-MV via central coders in this multi-site-trial to assess its appropriateness for FXS. Eighteen minimally verbal males ages 3-12 years were enrolled and assessed on two consecutive days and 7 participants completed a third visit 6 months later. We examined test-retest reliability, inter-rater reliability, and both convergent and divergent validity with standard clinical measures including the Autism Diagnostic and Observation Schedule-2, Vineland 3, Social Responsiveness Scale, and the Aberrant Behavior Checklist. RESULTS: The BOSCC-MV in FXS demonstrated strong inter-rater and test-retest reliability, comparable to previous trials in idiopathic ASD. Strong convergent validity was found with Autism Diagnostic Observation Schedule-2 and Vineland-3. Divergent validity was demonstrated between BOSCC-MV and unrelated measures. CONCLUSIONS: The BOSCC-MV shows promise as a FXS social communication outcome measure, warranting further large-scale evaluation. |
| En ligne : |
https://dx.doi.org/10.1186/s11689-021-09411-z |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 |
in Journal of Neurodevelopmental Disorders > 14 (2022)
[article] Social communication in fragile X syndrome: pilot examination of the Brief Observation of Social Communication Change (BOSCC) [texte imprimé] / Rebecca SHAFFER, Auteur ; Angela John THURMAN, Auteur ; Lucienne RONCO, Auteur ; Diego CADAVID, Auteur ; Shane RAINES, Auteur ; So Hyun KIM, Auteur. Langues : Anglais ( eng) in Journal of Neurodevelopmental Disorders > 14 (2022)
| Mots-clés : |
Autism Spectrum Disorder/diagnosis Child Child, Preschool Communication Fragile X Syndrome/diagnosis Humans Male Reproducibility of Results Social Communication Disorder/diagnosis Boscc Fragile X syndrome Outcome measure Repetitive behaviors Social communication Diego Cadavid and Lucienne Ronco were employees of Fulcrum Therapeutics at the time of the study and they own stock in Fulcrum Therapeutics. Shane Raines was a paid consultant to Fulcrum Therapeutics. The other authors have no conflicts to report. |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Social communication is a key area of difficulty in fragile X syndrome (FXS) and there are not yet adequate outcome measurement tools. Appropriate outcome measures for FXS have been identified as a key area of research interest in order to evaluate future therapeutic trials. The Brief Observation of Social Communication Change-Minimally Verbal (BOSCC-MV), an outcome measure with strong psychometrics developed for autism spectrum disorder, has promise as an outcome measure to assess social communication change with FXS participants. METHODS: We examined the BOSCC-MV via central coders in this multi-site-trial to assess its appropriateness for FXS. Eighteen minimally verbal males ages 3-12 years were enrolled and assessed on two consecutive days and 7 participants completed a third visit 6 months later. We examined test-retest reliability, inter-rater reliability, and both convergent and divergent validity with standard clinical measures including the Autism Diagnostic and Observation Schedule-2, Vineland 3, Social Responsiveness Scale, and the Aberrant Behavior Checklist. RESULTS: The BOSCC-MV in FXS demonstrated strong inter-rater and test-retest reliability, comparable to previous trials in idiopathic ASD. Strong convergent validity was found with Autism Diagnostic Observation Schedule-2 and Vineland-3. Divergent validity was demonstrated between BOSCC-MV and unrelated measures. CONCLUSIONS: The BOSCC-MV shows promise as a FXS social communication outcome measure, warranting further large-scale evaluation. |
| En ligne : |
https://dx.doi.org/10.1186/s11689-021-09411-z |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 |
|  |
Social communication in fragile X syndrome: pilot examination of the Brief Observation of Social Communication Change (BOSCC) in Journal of Neurodevelopmental Disorders, 14 (2022)
