[article]
| Titre : |
Aberrant oscillatory activity in neurofibromatosis type 1: an EEG study of resting state and working memory |
| Type de document : |
texte imprimé |
| Auteurs : |
Samantha J. BOOTH, Auteur ; Shruti GARG, Auteur ; Laura J.E. BROWN, Auteur ; Jonathan GREEN, Auteur ; Gorana POBRIC, Auteur ; Jason R. TAYLOR, Auteur |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Adolescent Female Humans Cognition Cognitive Dysfunction/etiology Electroencephalography Memory, Short-Term Neurofibromatosis 1/complications Male Electroencephalography (EEG) Neurofibromatosis type 1 (NF1) Oscillations Oscillatory power Phase coherence Working memory |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Neurofibromatosis type 1 (NF1) is a genetic neurodevelopmental disorder commonly associated with impaired cognitive function. Despite the well-explored functional roles of neural oscillations in neurotypical populations, only a limited number of studies have investigated oscillatory activity in the NF1 population. METHODS: We compared oscillatory spectral power and theta phase coherence in a paediatric sample with NF1 (N = 16; mean age: 13.03Â years; female: n = 7) to an age/sex-matched typically developing control group (N = 16; mean age: 13.34Â years; female: n = 7) using electroencephalography measured during rest and during working memory task performance. RESULTS: Relative to typically developing children, the NF1 group displayed higher resting state slow wave power and a lower peak alpha frequency. Moreover, higher theta power and frontoparietal theta phase coherence were observed in the NF1 group during working memory task performance, but these differences disappeared when controlling for baseline (resting state) activity. CONCLUSIONS: Overall, results suggest that NF1 is characterised by aberrant resting state oscillatory activity that may contribute towards the cognitive impairments experienced in this population. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03310996 (first posted: October 16, 2017). |
| En ligne : |
https://dx.doi.org/10.1186/s11689-023-09492-y |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 |
in Journal of Neurodevelopmental Disorders > 15 (2023)
|  |
Aberrant oscillatory activity in neurofibromatosis type 1: an EEG study of resting state and working memory in Journal of Neurodevelopmental Disorders, 15 (2023)
