Regional cerebellar structural deficits distinguish psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder: a cross-sectional morphometric analysis / Biqiu TANG in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.766-776 Titre : Regional cerebellar structural deficits distinguish psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder: a cross-sectional morphometric analysis Type de document : texte imprimé Auteurs : Biqiu TANG, Auteur ; L. Rodrigo PATINO, Auteur ; Wenjing ZHANG, Auteur ; Su LUI, Auteur ; Melissa P. DELBELLO, Auteur ; Robert K. MCNAMARA, Auteur Article en page(s) : p.766-776 Langues : Anglais (eng) Mots-clés : Bipolar disorder  attention-deficit/hyperactivity disorder  familial risk  adolescence  cerebellum Index. décimale : PER Périodiques Résumé : Background Although attention-deficit/hyperactivity disorder (ADHD) with familial risk for bipolar I disorder (BD) may represent a more severe illness conferring greater risk for developing BD, associated neurostructural substrates remain poorly understood. This study examined cerebellum structural alterations, which prior studies suggested may be associated with BD risk. Methods We enrolled 151 youth (ages 10?18?years) in three groups: psychostimulant-free ADHD youth with a biological parent or sibling with BD (high-risk, n?=?52, mean age 13.8?±?2.6?years), psychostimulant-free ADHD youth without any first- or second-degree relative with mood or psychotic disorders (low-risk, n?=?50, mean age 14.1?±?2.5?years), and healthy controls (HC, n?=?49, mean age 14.6?±?2.4?years). ADHD youth were stimulant-naïve or had no psychostimulant exposure within 3?months prior to enrollment. Region-of-interest (ROI) analyses were conducted on the whole cerebellum and 28 lobules to quantify cerebellar volumes using the SUIT toolbox, and voxel-based morphometry (VBM) analyses were also performed. Exploratory analyses evaluated associations between regional cerebellar volumes and symptom measures. Results Significant group differences in volume were observed for the whole cerebellum, bilateral lobules VIIIa, right VIIb, and left X. Post hoc comparisons showed that the high-risk group exhibited volume deficits in the whole cerebellum, bilateral lobules VIIIa, and right VIIb, compared with HC and low-risk groups, whereas both high-risk and low-risk groups exhibited left X volume deficits compared to HC. Similar results were obtained using VBM. Among all ADHD youth, significant inverse correlations were observed between significant ROI volumes and Child Behavior Checklist (CBCL) total score and several subscales, including the dysregulation profile. Conclusions Psychostimulant-free ADHD youth with BD familial risk exhibit whole and regional cerebellar volume deficits compared with those without such risk and healthy youth. Inverse associations between regional cerebellar volumes and CBCL total and subscale scores among ADHD youth suggest clinical relevance and may represent a potential BD risk biomarker. En ligne : https://doi.org/10.1111/jcpp.70072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Regional cerebellar structural deficits distinguish psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder: a cross-sectional morphometric analysis [texte imprimé] / Biqiu TANG, Auteur ; L. Rodrigo PATINO, Auteur ; Wenjing ZHANG, Auteur ; Su LUI, Auteur ; Melissa P. DELBELLO, Auteur ; Robert K. MCNAMARA, Auteur . - p.766-776. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.766-776 Mots-clés : Bipolar disorder  attention-deficit/hyperactivity disorder  familial risk  adolescence  cerebellum Index. décimale : PER Périodiques Résumé : Background Although attention-deficit/hyperactivity disorder (ADHD) with familial risk for bipolar I disorder (BD) may represent a more severe illness conferring greater risk for developing BD, associated neurostructural substrates remain poorly understood. This study examined cerebellum structural alterations, which prior studies suggested may be associated with BD risk. Methods We enrolled 151 youth (ages 10?18?years) in three groups: psychostimulant-free ADHD youth with a biological parent or sibling with BD (high-risk, n?=?52, mean age 13.8?±?2.6?years), psychostimulant-free ADHD youth without any first- or second-degree relative with mood or psychotic disorders (low-risk, n?=?50, mean age 14.1?±?2.5?years), and healthy controls (HC, n?=?49, mean age 14.6?±?2.4?years). ADHD youth were stimulant-naïve or had no psychostimulant exposure within 3?months prior to enrollment. Region-of-interest (ROI) analyses were conducted on the whole cerebellum and 28 lobules to quantify cerebellar volumes using the SUIT toolbox, and voxel-based morphometry (VBM) analyses were also performed. Exploratory analyses evaluated associations between regional cerebellar volumes and symptom measures. Results Significant group differences in volume were observed for the whole cerebellum, bilateral lobules VIIIa, right VIIb, and left X. Post hoc comparisons showed that the high-risk group exhibited volume deficits in the whole cerebellum, bilateral lobules VIIIa, and right VIIb, compared with HC and low-risk groups, whereas both high-risk and low-risk groups exhibited left X volume deficits compared to HC. Similar results were obtained using VBM. Among all ADHD youth, significant inverse correlations were observed between significant ROI volumes and Child Behavior Checklist (CBCL) total score and several subscales, including the dysregulation profile. Conclusions Psychostimulant-free ADHD youth with BD familial risk exhibit whole and regional cerebellar volume deficits compared with those without such risk and healthy youth. Inverse associations between regional cerebellar volumes and CBCL total and subscale scores among ADHD youth suggest clinical relevance and may represent a potential BD risk biomarker. En ligne : https://doi.org/10.1111/jcpp.70072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Static and dynamic postural control deficits in aging fragile X mental retardation 1 (FMR1) gene premutation carriers / Ziqi WANG in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 2 p. Titre : Static and dynamic postural control deficits in aging fragile X mental retardation 1 (FMR1) gene premutation carriers Type de document : texte imprimé Auteurs : Ziqi WANG, Auteur ; Pravin KHEMANI, Auteur ; Lauren M. SCHMITT, Auteur ; Su LUI, Auteur ; Matthew W. MOSCONI, Auteur Article en page(s) : 2 p. Langues : Anglais (eng) Mots-clés : Cerebellum  FMR1gene premutation allele  Fragile X mental retardation 1 (FMR1) gene  Fragile X-associated tremor/ataxia syndrome (FXTAS)  Postural control Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with premutation alleles of the fragile X mental retardation 1 (FMR1) gene are at risk of developing fragile X-associated tremor/ataxia syndrome (FXTAS) during aging. Characterization of motor issues associated with aging in FMR1 premutation carriers is needed to determine neurodegenerative processes and establish new biobehavioral indicators to help identify individuals at greatest risk of developing FXTAS. METHODS: We examined postural stability in 18 premutation carriers ages 46-77 years and 14 age-matched healthy controls. Participants completed a test of static stance and two tests of dynamic postural sway on a force platform to quantify postural variability and complexity. CGG repeat length was measured for each premutation carrier, and MRI and neurological evaluations were conducted to identify carriers who currently met criteria for FXTAS. Of the 18 premutation carriers, seven met criteria for definite/probable FXTAS (FXTAS+), seven showed no MRI or neurological signs of FXTAS (FXTAS-), and four were inconclusive due to insufficient data. RESULTS: Compared to controls, premutation carriers showed increased center of pressure (COP) variability in the mediolateral (COPML) direction during static stance and reduced COP variability in the anterior-posterior (COPAP) direction during dynamic AP sway. They also showed reductions in COPML complexity during each postural condition. FXTAS+ individuals showed reduced COPAP variability compared to FXTAS- carriers and healthy controls during dynamic AP sway. Across all carriers, increased sway variability during static stance and decreased sway variability in target directions during dynamic sways were associated with greater CGG repeat length and more severe neurologically rated posture and gait abnormalities. CONCLUSION: Our findings indicate that aging FMR1 premutation carriers show static and dynamic postural control deficits relative to healthy controls implicating degenerative processes of spinocerebellar and cerebellar-brainstem circuits that may be independent of or precede the onset of FXTAS. Our finding that FXTAS+ and FXTAS- premutation carriers differed on their level of intentional AP sway suggests that neural mechanisms of dynamic postural control may be differentially impacted in patients with FXTAS, and its measurement may be useful for rapidly and precisely identifying disease presence and onset. En ligne : http://dx.doi.org/10.1186/s11689-018-9261-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Static and dynamic postural control deficits in aging fragile X mental retardation 1 (FMR1) gene premutation carriers [texte imprimé] / Ziqi WANG, Auteur ; Pravin KHEMANI, Auteur ; Lauren M. SCHMITT, Auteur ; Su LUI, Auteur ; Matthew W. MOSCONI, Auteur . - 2 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 2 p. Mots-clés : Cerebellum  FMR1gene premutation allele  Fragile X mental retardation 1 (FMR1) gene  Fragile X-associated tremor/ataxia syndrome (FXTAS)  Postural control Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with premutation alleles of the fragile X mental retardation 1 (FMR1) gene are at risk of developing fragile X-associated tremor/ataxia syndrome (FXTAS) during aging. Characterization of motor issues associated with aging in FMR1 premutation carriers is needed to determine neurodegenerative processes and establish new biobehavioral indicators to help identify individuals at greatest risk of developing FXTAS. METHODS: We examined postural stability in 18 premutation carriers ages 46-77 years and 14 age-matched healthy controls. Participants completed a test of static stance and two tests of dynamic postural sway on a force platform to quantify postural variability and complexity. CGG repeat length was measured for each premutation carrier, and MRI and neurological evaluations were conducted to identify carriers who currently met criteria for FXTAS. Of the 18 premutation carriers, seven met criteria for definite/probable FXTAS (FXTAS+), seven showed no MRI or neurological signs of FXTAS (FXTAS-), and four were inconclusive due to insufficient data. RESULTS: Compared to controls, premutation carriers showed increased center of pressure (COP) variability in the mediolateral (COPML) direction during static stance and reduced COP variability in the anterior-posterior (COPAP) direction during dynamic AP sway. They also showed reductions in COPML complexity during each postural condition. FXTAS+ individuals showed reduced COPAP variability compared to FXTAS- carriers and healthy controls during dynamic AP sway. Across all carriers, increased sway variability during static stance and decreased sway variability in target directions during dynamic sways were associated with greater CGG repeat length and more severe neurologically rated posture and gait abnormalities. CONCLUSION: Our findings indicate that aging FMR1 premutation carriers show static and dynamic postural control deficits relative to healthy controls implicating degenerative processes of spinocerebellar and cerebellar-brainstem circuits that may be independent of or precede the onset of FXTAS. Our finding that FXTAS+ and FXTAS- premutation carriers differed on their level of intentional AP sway suggests that neural mechanisms of dynamic postural control may be differentially impacted in patients with FXTAS, and its measurement may be useful for rapidly and precisely identifying disease presence and onset. En ligne : http://dx.doi.org/10.1186/s11689-018-9261-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

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