Autism spectrum disorder in Qatar: Profiles and correlates of a large clinical sample / Fouad ALSHABAN in Autism & Developmental Language Impairments, 2 (January-December 2017)  

Public ISBD [article]  inAutism & Developmental Language Impairments > 2 (January-December 2017) Titre : Autism spectrum disorder in Qatar: Profiles and correlates of a large clinical sample Type de document : Texte imprimé et/ou numérique Auteurs : Fouad ALSHABAN, Auteur ; Mohammed ALDOSARI, Auteur ; Zakaria EL SAYED, Auteur ; Mohammed TOLEFAT, Auteur ; Saba EL HAG, Auteur ; Hawra AL SHAMMARI, Auteur ; Iman GHAZAL, Auteur ; Eric FOMBONNE, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is an increasingly prevalent disorder. Although around 15% of cases are caused by specific genetic causes, most cases involve a complex and variable combination of genetic risk and environmental factors that are not yet identified. There is a paucity of studies on ASD in Qatar, mostly in the form of case reports and genetic causes. The current study was designed to describe the clinical characteristics of ASD and its correlates in Qatar. Individuals with ASD were recruited from the Shafallah Center for Children with Special Needs which is the largest special needs center in Qatar. Within the sample of 171 individuals with ASD, 47% were ethnic Qataris, while 53% were nonethnic Qataris (Arabs and other nationalities). The analysis included the following factors: nationality, age, gender, socioeconomic status, consanguinity, prenatal/postnatal complications, and comorbidities. Eighty percent of the identified cases were males, with a 4:1 male to female ratio. Additionally, 83% of the families had one proband, 9.9% with 2 probands, and 7.1% with more than two. Comorbid conditions included: intellectual disabilities (ID) in 83% and epilepsy in 18.8%. 76.6% of subjects were nonverbal. There were 3 (1.8%) children with Rett?s syndrome, 3 (1.8%) with Fragile X, and 1 (0.6%) with tuberous sclerosis. There are currently no publications that clarify the mean age of diagnosis in Qatar, however, the present study showed that more than half of the diagnosed cases were among the ages of 7?14 years (56%). The effect of consanguinity as a risk factor was not found to be significant. En ligne : https://doi.org/10.1177/2396941517699215 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Autism spectrum disorder in Qatar: Profiles and correlates of a large clinical sample [Texte imprimé et/ou numérique] / Fouad ALSHABAN, Auteur ; Mohammed ALDOSARI, Auteur ; Zakaria EL SAYED, Auteur ; Mohammed TOLEFAT, Auteur ; Saba EL HAG, Auteur ; Hawra AL SHAMMARI, Auteur ; Iman GHAZAL, Auteur ; Eric FOMBONNE, Auteur. Langues : Anglais (eng) in Autism & Developmental Language Impairments > 2 (January-December 2017) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is an increasingly prevalent disorder. Although around 15% of cases are caused by specific genetic causes, most cases involve a complex and variable combination of genetic risk and environmental factors that are not yet identified. There is a paucity of studies on ASD in Qatar, mostly in the form of case reports and genetic causes. The current study was designed to describe the clinical characteristics of ASD and its correlates in Qatar. Individuals with ASD were recruited from the Shafallah Center for Children with Special Needs which is the largest special needs center in Qatar. Within the sample of 171 individuals with ASD, 47% were ethnic Qataris, while 53% were nonethnic Qataris (Arabs and other nationalities). The analysis included the following factors: nationality, age, gender, socioeconomic status, consanguinity, prenatal/postnatal complications, and comorbidities. Eighty percent of the identified cases were males, with a 4:1 male to female ratio. Additionally, 83% of the families had one proband, 9.9% with 2 probands, and 7.1% with more than two. Comorbid conditions included: intellectual disabilities (ID) in 83% and epilepsy in 18.8%. 76.6% of subjects were nonverbal. There were 3 (1.8%) children with Rett?s syndrome, 3 (1.8%) with Fragile X, and 1 (0.6%) with tuberous sclerosis. There are currently no publications that clarify the mean age of diagnosis in Qatar, however, the present study showed that more than half of the diagnosed cases were among the ages of 7?14 years (56%). The effect of consanguinity as a risk factor was not found to be significant. En ligne : https://doi.org/10.1177/2396941517699215 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

Prevalence and correlates of autism spectrum disorder in Qatar: a national study / Fouad ALSHABAN in Journal of Child Psychology and Psychiatry, 60-12 (December 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-12 (December 2019) . - p.1254-1268 Titre : Prevalence and correlates of autism spectrum disorder in Qatar: a national study Type de document : Texte imprimé et/ou numérique Auteurs : Fouad ALSHABAN, Auteur ; Mohammed ALDOSARI, Auteur ; H. AL-SHAMMARI, Auteur ; S. EL-HAG, Auteur ; I. GHAZAL, Auteur ; M. TOLEFAT, Auteur ; M. ALI, Auteur ; M. KAMAL, Auteur ; N. ABDEL AATI, Auteur ; M. ABEIDAH, Auteur ; A. H. SAAD, Auteur ; L. DEKAIR, Auteur ; M. AL KHASAWNEH, Auteur ; K. RAMSAY, Auteur ; E. FOMBONNE, Auteur Article en page(s) : p.1254-1268 Langues : Anglais (eng) Mots-clés : Arabic  autism spectrum disorders  child  consanguinity  epidemiology  prevalence  regression  school age  screening Index. décimale : PER Périodiques Résumé : BACKGROUND: Few epidemiological data on autism spectrum disorders (ASD) exist for Arabic countries. We conducted the first survey of ASD in Qatar, a population with high consanguinity level. METHODS: This cross-sectional survey was conducted from 2015 to 2018 in Qatar school-age children (N = 176,960) from national and immigrant families. Children diagnosed with ASD were identified through medical centers and special needs schools. Records were abstracted and supplemented by parental interviews. Additionally, children attending 93 schools were screened; ASD case status was confirmed in random samples of screen-positive and screen-negative children. Prevalence was estimated after taking into account different sampling fractions and participation rates at each survey phase. RESULTS: One thousand three hundred and ninety-three children already diagnosed with ASD were identified. Among 9,074 school survey participants, 760 screen-negative children and 163 screen-positive children were evaluated; 17 were confirmed to have ASD including five children newly diagnosed. Prevalence was 1.14% (95% CI: 0.89-1.46) among 6- to 11-year-olds. ASD was reported in full siblings/extended relatives in 5.9% (95% CI: 0.042-0.080)/11.8% (95% CI: 0.095-0.146) families. First-degree consanguinity in Qatari cases (45%) was comparable to known population levels. Among 844 ASD cases (mean age: 7.2 years; 81% male), most children experienced language delay (words: 75.1%; phrase speech: 91.4%), and 19.4% reported developmental regression. At the time of the survey, persisting deficits in expressive language (19.4%) and peer interactions (14.0%) were reported in conjunction with behavioral problems (ADHD: 30.2%; anxiety: 11.0%). In multivariate logistic regression, ASD severity was associated with parental consanguinity, gestational diabetes, delay in walking, and developmental regression. CONCLUSIONS: ASD prevalence in Qatar is consistent with recent international studies. The methods employed in this study should help designing comparable surveys in the region. We estimated that 187,000 youths under age 20 have ASD in Gulf countries. This figure should assist in planning health and educational services for a young, fast-growing population. En ligne : http://dx.doi.org/10.1111/jcpp.13066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412 [article] Prevalence and correlates of autism spectrum disorder in Qatar: a national study [Texte imprimé et/ou numérique] / Fouad ALSHABAN, Auteur ; Mohammed ALDOSARI, Auteur ; H. AL-SHAMMARI, Auteur ; S. EL-HAG, Auteur ; I. GHAZAL, Auteur ; M. TOLEFAT, Auteur ; M. ALI, Auteur ; M. KAMAL, Auteur ; N. ABDEL AATI, Auteur ; M. ABEIDAH, Auteur ; A. H. SAAD, Auteur ; L. DEKAIR, Auteur ; M. AL KHASAWNEH, Auteur ; K. RAMSAY, Auteur ; E. FOMBONNE, Auteur . - p.1254-1268. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-12 (December 2019) . - p.1254-1268 Mots-clés : Arabic  autism spectrum disorders  child  consanguinity  epidemiology  prevalence  regression  school age  screening Index. décimale : PER Périodiques Résumé : BACKGROUND: Few epidemiological data on autism spectrum disorders (ASD) exist for Arabic countries. We conducted the first survey of ASD in Qatar, a population with high consanguinity level. METHODS: This cross-sectional survey was conducted from 2015 to 2018 in Qatar school-age children (N = 176,960) from national and immigrant families. Children diagnosed with ASD were identified through medical centers and special needs schools. Records were abstracted and supplemented by parental interviews. Additionally, children attending 93 schools were screened; ASD case status was confirmed in random samples of screen-positive and screen-negative children. Prevalence was estimated after taking into account different sampling fractions and participation rates at each survey phase. RESULTS: One thousand three hundred and ninety-three children already diagnosed with ASD were identified. Among 9,074 school survey participants, 760 screen-negative children and 163 screen-positive children were evaluated; 17 were confirmed to have ASD including five children newly diagnosed. Prevalence was 1.14% (95% CI: 0.89-1.46) among 6- to 11-year-olds. ASD was reported in full siblings/extended relatives in 5.9% (95% CI: 0.042-0.080)/11.8% (95% CI: 0.095-0.146) families. First-degree consanguinity in Qatari cases (45%) was comparable to known population levels. Among 844 ASD cases (mean age: 7.2 years; 81% male), most children experienced language delay (words: 75.1%; phrase speech: 91.4%), and 19.4% reported developmental regression. At the time of the survey, persisting deficits in expressive language (19.4%) and peer interactions (14.0%) were reported in conjunction with behavioral problems (ADHD: 30.2%; anxiety: 11.0%). In multivariate logistic regression, ASD severity was associated with parental consanguinity, gestational diabetes, delay in walking, and developmental regression. CONCLUSIONS: ASD prevalence in Qatar is consistent with recent international studies. The methods employed in this study should help designing comparable surveys in the region. We estimated that 187,000 youths under age 20 have ASD in Gulf countries. This figure should assist in planning health and educational services for a young, fast-growing population. En ligne : http://dx.doi.org/10.1111/jcpp.13066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412

Validation of the Arabic version of the Social Communication Questionnaire / Mohammed ALDOSARI in Autism, 23-7 (October 2019)  

Public ISBD [article]  inAutism > 23-7 (October 2019) . - p.1655-1662 Titre : Validation of the Arabic version of the Social Communication Questionnaire Type de document : Texte imprimé et/ou numérique Auteurs : Mohammed ALDOSARI, Auteur ; E. FOMBONNE, Auteur ; Hesham M. ALDHALAAN, Auteur ; M. OUDA, Auteur ; S. ELHAG, Auteur ; H. ALSHAMMARI, Auteur ; I. GHAZAL, Auteur ; A. ALSALEH, Auteur ; T. ALQADOUMI, Auteur ; R. THOMSON, Auteur ; M. AL KHASAWNEH, Auteur ; M. TOLEFAT, Auteur ; Fouad ALSHABAN, Auteur Article en page(s) : p.1655-1662 Langues : Anglais (eng) Mots-clés : Arabic  Social Communication Questionnaire  autism spectrum disorder  cutoff values  early intervention  epidemiology  screening  validity Index. décimale : PER Périodiques Résumé : Validated screening and diagnostic tools for autism spectrum disorder for use in Arabic-speaking individuals are scarce. This study validated the Arabic version of the Social Communication Questionnaire. The total study sample included 206 children with autism spectrum disorder and 206 typically developing children (73.8% male; mean age: 8.5 (standard deviation = 2.6) years). The mean Social Communication Questionnaire total score was significantly higher in autism spectrum disorder children than in typically developing children (p < 0.0001). Scores on the three Social Communication Questionnaire subscales also differed significantly between the groups (p < 0.001). Of the 39 items, 37 were endorsed significantly more often in the autism spectrum disorder group. The total Social Communication Questionnaire score did not vary by age or gender. Internal consistency was excellent (alpha = 0.92). In the receiver operating characteristic analysis, the area under the curve for the total score showed excellent discrimination between autism spectrum disorder and typically developing children (area under the curve = 0.95; 95% confidence interval: 0.93-0.97). The areas under the curve for the scale subscores were 0.923 (95% confidence interval: 0.898-0.949) for the social interaction score, 0.872 (95% confidence interval: 0.838-0.905) for the communication score, and 0.856 (95% confidence interval: 0.819-0.893) for the repetitive behaviors score. The findings support the use of the Arabic Social Communication Questionnaire to successfully differentiate children with clinically diagnosed autism spectrum disorder using the established cutoff value for the English version. En ligne : http://dx.doi.org/10.1177/1362361318816065 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Validation of the Arabic version of the Social Communication Questionnaire [Texte imprimé et/ou numérique] / Mohammed ALDOSARI, Auteur ; E. FOMBONNE, Auteur ; Hesham M. ALDHALAAN, Auteur ; M. OUDA, Auteur ; S. ELHAG, Auteur ; H. ALSHAMMARI, Auteur ; I. GHAZAL, Auteur ; A. ALSALEH, Auteur ; T. ALQADOUMI, Auteur ; R. THOMSON, Auteur ; M. AL KHASAWNEH, Auteur ; M. TOLEFAT, Auteur ; Fouad ALSHABAN, Auteur . - p.1655-1662. Langues : Anglais (eng) in Autism > 23-7 (October 2019) . - p.1655-1662 Mots-clés : Arabic  Social Communication Questionnaire  autism spectrum disorder  cutoff values  early intervention  epidemiology  screening  validity Index. décimale : PER Périodiques Résumé : Validated screening and diagnostic tools for autism spectrum disorder for use in Arabic-speaking individuals are scarce. This study validated the Arabic version of the Social Communication Questionnaire. The total study sample included 206 children with autism spectrum disorder and 206 typically developing children (73.8% male; mean age: 8.5 (standard deviation = 2.6) years). The mean Social Communication Questionnaire total score was significantly higher in autism spectrum disorder children than in typically developing children (p < 0.0001). Scores on the three Social Communication Questionnaire subscales also differed significantly between the groups (p < 0.001). Of the 39 items, 37 were endorsed significantly more often in the autism spectrum disorder group. The total Social Communication Questionnaire score did not vary by age or gender. Internal consistency was excellent (alpha = 0.92). In the receiver operating characteristic analysis, the area under the curve for the total score showed excellent discrimination between autism spectrum disorder and typically developing children (area under the curve = 0.95; 95% confidence interval: 0.93-0.97). The areas under the curve for the scale subscores were 0.923 (95% confidence interval: 0.898-0.949) for the social interaction score, 0.872 (95% confidence interval: 0.838-0.905) for the communication score, and 0.856 (95% confidence interval: 0.819-0.893) for the repetitive behaviors score. The findings support the use of the Arabic Social Communication Questionnaire to successfully differentiate children with clinically diagnosed autism spectrum disorder using the established cutoff value for the English version. En ligne : http://dx.doi.org/10.1177/1362361318816065 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

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