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Consanguinity in India and Its Association With Autism Spectrum Disorder / Madhu P. MAMIDALA in Autism Research, 8-2 (April 2015)
[article]
Titre : Consanguinity in India and Its Association With Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Madhu P. MAMIDALA, Auteur ; Mahesh Kumar KALIKIRI, Auteur ; P. T. V. PRAVEEN KUMAR, Auteur ; N. RAJESH, Auteur ; OmSai R. VALLAMKONDA, Auteur ; Vidya RAJESH, Auteur Article en page(s) : p.224-228 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder consanguinity risk factors genetic association India Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) has both genetic and environmental factors in its etiology. The risk for many disorders is increased by consanguinity, but it is not known whether it increases the risk for ASD. Our study from large population in India concludes that consanguinity increases the risk for ASD with an odds ratio of 3.22. En ligne : http://dx.doi.org/10.1002/aur.1431 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256
in Autism Research > 8-2 (April 2015) . - p.224-228[article] Consanguinity in India and Its Association With Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Madhu P. MAMIDALA, Auteur ; Mahesh Kumar KALIKIRI, Auteur ; P. T. V. PRAVEEN KUMAR, Auteur ; N. RAJESH, Auteur ; OmSai R. VALLAMKONDA, Auteur ; Vidya RAJESH, Auteur . - p.224-228.
Langues : Anglais (eng)
in Autism Research > 8-2 (April 2015) . - p.224-228
Mots-clés : Autism Spectrum Disorder consanguinity risk factors genetic association India Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) has both genetic and environmental factors in its etiology. The risk for many disorders is increased by consanguinity, but it is not known whether it increases the risk for ASD. Our study from large population in India concludes that consanguinity increases the risk for ASD with an odds ratio of 3.22. En ligne : http://dx.doi.org/10.1002/aur.1431 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 Association of Autism with Maternal Infections, Perinatal and Other Risk Factors: A Case-Control Study / D. R. GUISSO in Journal of Autism and Developmental Disorders, 48-6 (June 2018)
[article]
Titre : Association of Autism with Maternal Infections, Perinatal and Other Risk Factors: A Case-Control Study Type de document : Texte imprimé et/ou numérique Auteurs : D. R. GUISSO, Auteur ; F. S. SAADEH, Auteur ; D. SAAB, Auteur ; J. EL DEEK, Auteur ; S. CHAMSEDDINE, Auteur ; H. A. EL HASSAN, Auteur ; G. MAJARI, Auteur ; Rose-Mary BOUSTANY, Auteur Article en page(s) : p.2010-2021 Langues : Anglais (eng) Mots-clés : Autism Consanguinity Maternal infections Perinatal factors Risk factors Index. décimale : PER Périodiques Résumé : This case-control study explores the association between pregnancy/birth complications and other factors with Autism Spectrum Disorder (ASD) in Lebanese subjects aged 2-18 years. Researchers interviewed 136 ASD cases from the American University of Beirut Medical Center Special Kids Clinic, and 178 controls selected by systematic digit dialing in the Greater-Beirut area. Male gender (Adjusted Odds Ratio [95% CI]: 3.9 [2.2-7.0]); postpartum feeding difficulties (2.5 [1.2-5.4]); maternal infections/complications during pregnancy (2.9 [1.5-5.5], 2.1 [1.1-3.9]); consanguinity (2.5 [1.0-6.0]); family history of psychiatric disorders (2.2 [1.1-4.4]) were risk factors for ASD. Being born first/second (0.52 [0.28-0.95]) and maternal psychological support during pregnancy (0.49 [0.27-0.89]) were negatively associated with ASD. Identifying ASD correlates is crucial for instigating timely screening and subsequent early intervention. En ligne : http://dx.doi.org/10.1007/s10803-017-3449-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=361
in Journal of Autism and Developmental Disorders > 48-6 (June 2018) . - p.2010-2021[article] Association of Autism with Maternal Infections, Perinatal and Other Risk Factors: A Case-Control Study [Texte imprimé et/ou numérique] / D. R. GUISSO, Auteur ; F. S. SAADEH, Auteur ; D. SAAB, Auteur ; J. EL DEEK, Auteur ; S. CHAMSEDDINE, Auteur ; H. A. EL HASSAN, Auteur ; G. MAJARI, Auteur ; Rose-Mary BOUSTANY, Auteur . - p.2010-2021.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-6 (June 2018) . - p.2010-2021
Mots-clés : Autism Consanguinity Maternal infections Perinatal factors Risk factors Index. décimale : PER Périodiques Résumé : This case-control study explores the association between pregnancy/birth complications and other factors with Autism Spectrum Disorder (ASD) in Lebanese subjects aged 2-18 years. Researchers interviewed 136 ASD cases from the American University of Beirut Medical Center Special Kids Clinic, and 178 controls selected by systematic digit dialing in the Greater-Beirut area. Male gender (Adjusted Odds Ratio [95% CI]: 3.9 [2.2-7.0]); postpartum feeding difficulties (2.5 [1.2-5.4]); maternal infections/complications during pregnancy (2.9 [1.5-5.5], 2.1 [1.1-3.9]); consanguinity (2.5 [1.0-6.0]); family history of psychiatric disorders (2.2 [1.1-4.4]) were risk factors for ASD. Being born first/second (0.52 [0.28-0.95]) and maternal psychological support during pregnancy (0.49 [0.27-0.89]) were negatively associated with ASD. Identifying ASD correlates is crucial for instigating timely screening and subsequent early intervention. En ligne : http://dx.doi.org/10.1007/s10803-017-3449-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=361 Prevalence and correlates of autism spectrum disorder in Qatar: a national study / Fouad ALSHABAN in Journal of Child Psychology and Psychiatry, 60-12 (December 2019)
[article]
Titre : Prevalence and correlates of autism spectrum disorder in Qatar: a national study Type de document : Texte imprimé et/ou numérique Auteurs : Fouad ALSHABAN, Auteur ; Mohammed ALDOSARI, Auteur ; H. AL-SHAMMARI, Auteur ; S. EL-HAG, Auteur ; I. GHAZAL, Auteur ; M. TOLEFAT, Auteur ; M. ALI, Auteur ; M. KAMAL, Auteur ; N. ABDEL AATI, Auteur ; M. ABEIDAH, Auteur ; A. H. SAAD, Auteur ; L. DEKAIR, Auteur ; M. AL KHASAWNEH, Auteur ; K. RAMSAY, Auteur ; E. FOMBONNE, Auteur Article en page(s) : p.1254-1268 Langues : Anglais (eng) Mots-clés : Arabic autism spectrum disorders child consanguinity epidemiology prevalence regression school age screening Index. décimale : PER Périodiques Résumé : BACKGROUND: Few epidemiological data on autism spectrum disorders (ASD) exist for Arabic countries. We conducted the first survey of ASD in Qatar, a population with high consanguinity level. METHODS: This cross-sectional survey was conducted from 2015 to 2018 in Qatar school-age children (N = 176,960) from national and immigrant families. Children diagnosed with ASD were identified through medical centers and special needs schools. Records were abstracted and supplemented by parental interviews. Additionally, children attending 93 schools were screened; ASD case status was confirmed in random samples of screen-positive and screen-negative children. Prevalence was estimated after taking into account different sampling fractions and participation rates at each survey phase. RESULTS: One thousand three hundred and ninety-three children already diagnosed with ASD were identified. Among 9,074 school survey participants, 760 screen-negative children and 163 screen-positive children were evaluated; 17 were confirmed to have ASD including five children newly diagnosed. Prevalence was 1.14% (95% CI: 0.89-1.46) among 6- to 11-year-olds. ASD was reported in full siblings/extended relatives in 5.9% (95% CI: 0.042-0.080)/11.8% (95% CI: 0.095-0.146) families. First-degree consanguinity in Qatari cases (45%) was comparable to known population levels. Among 844 ASD cases (mean age: 7.2 years; 81% male), most children experienced language delay (words: 75.1%; phrase speech: 91.4%), and 19.4% reported developmental regression. At the time of the survey, persisting deficits in expressive language (19.4%) and peer interactions (14.0%) were reported in conjunction with behavioral problems (ADHD: 30.2%; anxiety: 11.0%). In multivariate logistic regression, ASD severity was associated with parental consanguinity, gestational diabetes, delay in walking, and developmental regression. CONCLUSIONS: ASD prevalence in Qatar is consistent with recent international studies. The methods employed in this study should help designing comparable surveys in the region. We estimated that 187,000 youths under age 20 have ASD in Gulf countries. This figure should assist in planning health and educational services for a young, fast-growing population. En ligne : http://dx.doi.org/10.1111/jcpp.13066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412
in Journal of Child Psychology and Psychiatry > 60-12 (December 2019) . - p.1254-1268[article] Prevalence and correlates of autism spectrum disorder in Qatar: a national study [Texte imprimé et/ou numérique] / Fouad ALSHABAN, Auteur ; Mohammed ALDOSARI, Auteur ; H. AL-SHAMMARI, Auteur ; S. EL-HAG, Auteur ; I. GHAZAL, Auteur ; M. TOLEFAT, Auteur ; M. ALI, Auteur ; M. KAMAL, Auteur ; N. ABDEL AATI, Auteur ; M. ABEIDAH, Auteur ; A. H. SAAD, Auteur ; L. DEKAIR, Auteur ; M. AL KHASAWNEH, Auteur ; K. RAMSAY, Auteur ; E. FOMBONNE, Auteur . - p.1254-1268.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-12 (December 2019) . - p.1254-1268
Mots-clés : Arabic autism spectrum disorders child consanguinity epidemiology prevalence regression school age screening Index. décimale : PER Périodiques Résumé : BACKGROUND: Few epidemiological data on autism spectrum disorders (ASD) exist for Arabic countries. We conducted the first survey of ASD in Qatar, a population with high consanguinity level. METHODS: This cross-sectional survey was conducted from 2015 to 2018 in Qatar school-age children (N = 176,960) from national and immigrant families. Children diagnosed with ASD were identified through medical centers and special needs schools. Records were abstracted and supplemented by parental interviews. Additionally, children attending 93 schools were screened; ASD case status was confirmed in random samples of screen-positive and screen-negative children. Prevalence was estimated after taking into account different sampling fractions and participation rates at each survey phase. RESULTS: One thousand three hundred and ninety-three children already diagnosed with ASD were identified. Among 9,074 school survey participants, 760 screen-negative children and 163 screen-positive children were evaluated; 17 were confirmed to have ASD including five children newly diagnosed. Prevalence was 1.14% (95% CI: 0.89-1.46) among 6- to 11-year-olds. ASD was reported in full siblings/extended relatives in 5.9% (95% CI: 0.042-0.080)/11.8% (95% CI: 0.095-0.146) families. First-degree consanguinity in Qatari cases (45%) was comparable to known population levels. Among 844 ASD cases (mean age: 7.2 years; 81% male), most children experienced language delay (words: 75.1%; phrase speech: 91.4%), and 19.4% reported developmental regression. At the time of the survey, persisting deficits in expressive language (19.4%) and peer interactions (14.0%) were reported in conjunction with behavioral problems (ADHD: 30.2%; anxiety: 11.0%). In multivariate logistic regression, ASD severity was associated with parental consanguinity, gestational diabetes, delay in walking, and developmental regression. CONCLUSIONS: ASD prevalence in Qatar is consistent with recent international studies. The methods employed in this study should help designing comparable surveys in the region. We estimated that 187,000 youths under age 20 have ASD in Gulf countries. This figure should assist in planning health and educational services for a young, fast-growing population. En ligne : http://dx.doi.org/10.1111/jcpp.13066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412 Diagnostic Yield of Chromosomal Microarray Analysis in a Cohort of Patients with Autism Spectrum Disorders from a Highly Consanguineous Population / Watfa AL-MAMARI in Journal of Autism and Developmental Disorders, 45-8 (August 2015)
[article]
Titre : Diagnostic Yield of Chromosomal Microarray Analysis in a Cohort of Patients with Autism Spectrum Disorders from a Highly Consanguineous Population Type de document : Texte imprimé et/ou numérique Auteurs : Watfa AL-MAMARI, Auteur ; Abeer AL-SAEGH, Auteur ; Adila AL-KINDY, Auteur ; Zandre BRUWER, Auteur ; Fathiya AL-MURSHEDI, Auteur ; Khalid AL-THIHLI, Auteur Année de publication : 2015 Article en page(s) : p.2323-2328 Langues : Anglais (eng) Mots-clés : Autism Autism spectrum disorders Chromosomal microarray Array-CGH Diagnostic yield Consanguinity Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorders are a complicated group of disorders characterized with heterogeneous genetic etiologies. The genetic investigations for this group of disorders have expanded considerably over the past decade. In our study we designed a tired approach and studied the diagnostic yield of chromosomal microarray analysis on patients referred to the Genetic and Developmental Medicine clinic in Sultan Qaboos University in Oman for autism spectrum disorders in a highly consanguineous population. Copy number variants were seen in 27 % of our studied cohort of patients and it was strongly associated with dysmorphic features and congenital anomalies. En ligne : http://dx.doi.org/10.1007/s10803-015-2394-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263
in Journal of Autism and Developmental Disorders > 45-8 (August 2015) . - p.2323-2328[article] Diagnostic Yield of Chromosomal Microarray Analysis in a Cohort of Patients with Autism Spectrum Disorders from a Highly Consanguineous Population [Texte imprimé et/ou numérique] / Watfa AL-MAMARI, Auteur ; Abeer AL-SAEGH, Auteur ; Adila AL-KINDY, Auteur ; Zandre BRUWER, Auteur ; Fathiya AL-MURSHEDI, Auteur ; Khalid AL-THIHLI, Auteur . - 2015 . - p.2323-2328.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-8 (August 2015) . - p.2323-2328
Mots-clés : Autism Autism spectrum disorders Chromosomal microarray Array-CGH Diagnostic yield Consanguinity Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorders are a complicated group of disorders characterized with heterogeneous genetic etiologies. The genetic investigations for this group of disorders have expanded considerably over the past decade. In our study we designed a tired approach and studied the diagnostic yield of chromosomal microarray analysis on patients referred to the Genetic and Developmental Medicine clinic in Sultan Qaboos University in Oman for autism spectrum disorders in a highly consanguineous population. Copy number variants were seen in 27 % of our studied cohort of patients and it was strongly associated with dysmorphic features and congenital anomalies. En ligne : http://dx.doi.org/10.1007/s10803-015-2394-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263