4 recherche sur le mot-clé 'consanguinity'

Consanguinity in India and Its Association With Autism Spectrum Disorder / Madhu P. MAMIDALA in Autism Research, 8-2 (April 2015)  

Public ISBD [article]  inAutism Research > 8-2 (April 2015) . - p.224-228 Titre : Consanguinity in India and Its Association With Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Madhu P. MAMIDALA, Auteur ; Mahesh Kumar KALIKIRI, Auteur ; P.T.V. PRAVEEN KUMAR, Auteur ; N. RAJESH, Auteur ; OmSai R. VALLAMKONDA, Auteur ; Vidya RAJESH, Auteur Article en page(s) : p.224-228 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  consanguinity  risk factors  genetic association  India Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) has both genetic and environmental factors in its etiology. The risk for many disorders is increased by consanguinity, but it is not known whether it increases the risk for ASD. Our study from large population in India concludes that consanguinity increases the risk for ASD with an odds ratio of 3.22. En ligne : http://dx.doi.org/10.1002/aur.1431 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Consanguinity in India and Its Association With Autism Spectrum Disorder [texte imprimé] / Madhu P. MAMIDALA, Auteur ; Mahesh Kumar KALIKIRI, Auteur ; P.T.V. PRAVEEN KUMAR, Auteur ; N. RAJESH, Auteur ; OmSai R. VALLAMKONDA, Auteur ; Vidya RAJESH, Auteur . - p.224-228. Langues : Anglais (eng) in Autism Research > 8-2 (April 2015) . - p.224-228 Mots-clés : Autism Spectrum Disorder  consanguinity  risk factors  genetic association  India Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) has both genetic and environmental factors in its etiology. The risk for many disorders is increased by consanguinity, but it is not known whether it increases the risk for ASD. Our study from large population in India concludes that consanguinity increases the risk for ASD with an odds ratio of 3.22. En ligne : http://dx.doi.org/10.1002/aur.1431 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Association of Autism with Maternal Infections, Perinatal and Other Risk Factors: A Case-Control Study / Dikran Richard GUISSO in Journal of Autism and Developmental Disorders, 48-6 (June 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-6 (June 2018) . - p.2010-2021 Titre : Association of Autism with Maternal Infections, Perinatal and Other Risk Factors: A Case-Control Study Type de document : texte imprimé Auteurs : Dikran Richard GUISSO, Auteur ; Fadi S. SAADEH, Auteur ; Dahlia SAAB, Auteur ; Joud EL DEEK, Auteur ; Sarah CHAMSEDDINE, Auteur ; H.A. EL HASSAN, Auteur ; Ghidaa MAJARI, Auteur ; Rose-Mary BOUSTANY, Auteur Article en page(s) : p.2010-2021 Langues : Anglais (eng) Mots-clés : Autism  Consanguinity  Maternal infections  Perinatal factors  Risk factors Index. décimale : PER Périodiques Résumé : This case-control study explores the association between pregnancy/birth complications and other factors with Autism Spectrum Disorder (ASD) in Lebanese subjects aged 2-18 years. Researchers interviewed 136 ASD cases from the American University of Beirut Medical Center Special Kids Clinic, and 178 controls selected by systematic digit dialing in the Greater-Beirut area. Male gender (Adjusted Odds Ratio [95% CI]: 3.9 [2.2-7.0]); postpartum feeding difficulties (2.5 [1.2-5.4]); maternal infections/complications during pregnancy (2.9 [1.5-5.5], 2.1 [1.1-3.9]); consanguinity (2.5 [1.0-6.0]); family history of psychiatric disorders (2.2 [1.1-4.4]) were risk factors for ASD. Being born first/second (0.52 [0.28-0.95]) and maternal psychological support during pregnancy (0.49 [0.27-0.89]) were negatively associated with ASD. Identifying ASD correlates is crucial for instigating timely screening and subsequent early intervention. En ligne : http://dx.doi.org/10.1007/s10803-017-3449-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=361 [article] Association of Autism with Maternal Infections, Perinatal and Other Risk Factors: A Case-Control Study [texte imprimé] / Dikran Richard GUISSO, Auteur ; Fadi S. SAADEH, Auteur ; Dahlia SAAB, Auteur ; Joud EL DEEK, Auteur ; Sarah CHAMSEDDINE, Auteur ; H.A. EL HASSAN, Auteur ; Ghidaa MAJARI, Auteur ; Rose-Mary BOUSTANY, Auteur . - p.2010-2021. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-6 (June 2018) . - p.2010-2021 Mots-clés : Autism  Consanguinity  Maternal infections  Perinatal factors  Risk factors Index. décimale : PER Périodiques Résumé : This case-control study explores the association between pregnancy/birth complications and other factors with Autism Spectrum Disorder (ASD) in Lebanese subjects aged 2-18 years. Researchers interviewed 136 ASD cases from the American University of Beirut Medical Center Special Kids Clinic, and 178 controls selected by systematic digit dialing in the Greater-Beirut area. Male gender (Adjusted Odds Ratio [95% CI]: 3.9 [2.2-7.0]); postpartum feeding difficulties (2.5 [1.2-5.4]); maternal infections/complications during pregnancy (2.9 [1.5-5.5], 2.1 [1.1-3.9]); consanguinity (2.5 [1.0-6.0]); family history of psychiatric disorders (2.2 [1.1-4.4]) were risk factors for ASD. Being born first/second (0.52 [0.28-0.95]) and maternal psychological support during pregnancy (0.49 [0.27-0.89]) were negatively associated with ASD. Identifying ASD correlates is crucial for instigating timely screening and subsequent early intervention. En ligne : http://dx.doi.org/10.1007/s10803-017-3449-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=361

Prevalence and correlates of autism spectrum disorder in Qatar: a national study / Fouad ALSHABAN in Journal of Child Psychology and Psychiatry, 60-12 (December 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-12 (December 2019) . - p.1254-1268 Titre : Prevalence and correlates of autism spectrum disorder in Qatar: a national study Type de document : texte imprimé Auteurs : Fouad ALSHABAN, Auteur ; Mohammed ALDOSARI, Auteur ; Hawraa AL-SHAMMARI, Auteur ; Saba EL-HAG, Auteur ; Iman GHAZAL, Auteur ; Mohamed TOLEFAT, Auteur ; Mogahed ALI, Auteur ; Madeeha KAMAL, Auteur ; Nazim ABDEL AATI, Auteur ; Mahmoud ABEIDAH, Auteur ; Ahmad Hassan SAAD, Auteur ; Lobna DEKAIR, Auteur ; Mohanad AL KHASAWNEH, Auteur ; Katrina RAMSAY, Auteur ; Eric FOMBONNE, Auteur Article en page(s) : p.1254-1268 Langues : Anglais (eng) Mots-clés : Arabic  autism spectrum disorders  child  consanguinity  epidemiology  prevalence  regression  school age  screening Index. décimale : PER Périodiques Résumé : BACKGROUND: Few epidemiological data on autism spectrum disorders (ASD) exist for Arabic countries. We conducted the first survey of ASD in Qatar, a population with high consanguinity level. METHODS: This cross-sectional survey was conducted from 2015 to 2018 in Qatar school-age children (N = 176,960) from national and immigrant families. Children diagnosed with ASD were identified through medical centers and special needs schools. Records were abstracted and supplemented by parental interviews. Additionally, children attending 93 schools were screened; ASD case status was confirmed in random samples of screen-positive and screen-negative children. Prevalence was estimated after taking into account different sampling fractions and participation rates at each survey phase. RESULTS: One thousand three hundred and ninety-three children already diagnosed with ASD were identified. Among 9,074 school survey participants, 760 screen-negative children and 163 screen-positive children were evaluated; 17 were confirmed to have ASD including five children newly diagnosed. Prevalence was 1.14% (95% CI: 0.89-1.46) among 6- to 11-year-olds. ASD was reported in full siblings/extended relatives in 5.9% (95% CI: 0.042-0.080)/11.8% (95% CI: 0.095-0.146) families. First-degree consanguinity in Qatari cases (45%) was comparable to known population levels. Among 844 ASD cases (mean age: 7.2 years; 81% male), most children experienced language delay (words: 75.1%; phrase speech: 91.4%), and 19.4% reported developmental regression. At the time of the survey, persisting deficits in expressive language (19.4%) and peer interactions (14.0%) were reported in conjunction with behavioral problems (ADHD: 30.2%; anxiety: 11.0%). In multivariate logistic regression, ASD severity was associated with parental consanguinity, gestational diabetes, delay in walking, and developmental regression. CONCLUSIONS: ASD prevalence in Qatar is consistent with recent international studies. The methods employed in this study should help designing comparable surveys in the region. We estimated that 187,000 youths under age 20 have ASD in Gulf countries. This figure should assist in planning health and educational services for a young, fast-growing population. En ligne : http://dx.doi.org/10.1111/jcpp.13066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412 [article] Prevalence and correlates of autism spectrum disorder in Qatar: a national study [texte imprimé] / Fouad ALSHABAN, Auteur ; Mohammed ALDOSARI, Auteur ; Hawraa AL-SHAMMARI, Auteur ; Saba EL-HAG, Auteur ; Iman GHAZAL, Auteur ; Mohamed TOLEFAT, Auteur ; Mogahed ALI, Auteur ; Madeeha KAMAL, Auteur ; Nazim ABDEL AATI, Auteur ; Mahmoud ABEIDAH, Auteur ; Ahmad Hassan SAAD, Auteur ; Lobna DEKAIR, Auteur ; Mohanad AL KHASAWNEH, Auteur ; Katrina RAMSAY, Auteur ; Eric FOMBONNE, Auteur . - p.1254-1268. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-12 (December 2019) . - p.1254-1268 Mots-clés : Arabic  autism spectrum disorders  child  consanguinity  epidemiology  prevalence  regression  school age  screening Index. décimale : PER Périodiques Résumé : BACKGROUND: Few epidemiological data on autism spectrum disorders (ASD) exist for Arabic countries. We conducted the first survey of ASD in Qatar, a population with high consanguinity level. METHODS: This cross-sectional survey was conducted from 2015 to 2018 in Qatar school-age children (N = 176,960) from national and immigrant families. Children diagnosed with ASD were identified through medical centers and special needs schools. Records were abstracted and supplemented by parental interviews. Additionally, children attending 93 schools were screened; ASD case status was confirmed in random samples of screen-positive and screen-negative children. Prevalence was estimated after taking into account different sampling fractions and participation rates at each survey phase. RESULTS: One thousand three hundred and ninety-three children already diagnosed with ASD were identified. Among 9,074 school survey participants, 760 screen-negative children and 163 screen-positive children were evaluated; 17 were confirmed to have ASD including five children newly diagnosed. Prevalence was 1.14% (95% CI: 0.89-1.46) among 6- to 11-year-olds. ASD was reported in full siblings/extended relatives in 5.9% (95% CI: 0.042-0.080)/11.8% (95% CI: 0.095-0.146) families. First-degree consanguinity in Qatari cases (45%) was comparable to known population levels. Among 844 ASD cases (mean age: 7.2 years; 81% male), most children experienced language delay (words: 75.1%; phrase speech: 91.4%), and 19.4% reported developmental regression. At the time of the survey, persisting deficits in expressive language (19.4%) and peer interactions (14.0%) were reported in conjunction with behavioral problems (ADHD: 30.2%; anxiety: 11.0%). In multivariate logistic regression, ASD severity was associated with parental consanguinity, gestational diabetes, delay in walking, and developmental regression. CONCLUSIONS: ASD prevalence in Qatar is consistent with recent international studies. The methods employed in this study should help designing comparable surveys in the region. We estimated that 187,000 youths under age 20 have ASD in Gulf countries. This figure should assist in planning health and educational services for a young, fast-growing population. En ligne : http://dx.doi.org/10.1111/jcpp.13066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412

Diagnostic Yield of Chromosomal Microarray Analysis in a Cohort of Patients with Autism Spectrum Disorders from a Highly Consanguineous Population / Watfa AL-MAMARI in Journal of Autism and Developmental Disorders, 45-8 (August 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-8 (August 2015) . - p.2323-2328 Titre : Diagnostic Yield of Chromosomal Microarray Analysis in a Cohort of Patients with Autism Spectrum Disorders from a Highly Consanguineous Population Type de document : texte imprimé Auteurs : Watfa AL-MAMARI, Auteur ; Abeer AL-SAEGH, Auteur ; Adila AL-KINDY, Auteur ; Zandre BRUWER, Auteur ; Fathiya AL-MURSHEDI, Auteur ; Khalid AL-THIHLI, Auteur Année de publication : 2015 Article en page(s) : p.2323-2328 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorders  Chromosomal microarray  Array-CGH  Diagnostic yield  Consanguinity Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorders are a complicated group of disorders characterized with heterogeneous genetic etiologies. The genetic investigations for this group of disorders have expanded considerably over the past decade. In our study we designed a tired approach and studied the diagnostic yield of chromosomal microarray analysis on patients referred to the Genetic and Developmental Medicine clinic in Sultan Qaboos University in Oman for autism spectrum disorders in a highly consanguineous population. Copy number variants were seen in 27 % of our studied cohort of patients and it was strongly associated with dysmorphic features and congenital anomalies. En ligne : http://dx.doi.org/10.1007/s10803-015-2394-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 [article] Diagnostic Yield of Chromosomal Microarray Analysis in a Cohort of Patients with Autism Spectrum Disorders from a Highly Consanguineous Population [texte imprimé] / Watfa AL-MAMARI, Auteur ; Abeer AL-SAEGH, Auteur ; Adila AL-KINDY, Auteur ; Zandre BRUWER, Auteur ; Fathiya AL-MURSHEDI, Auteur ; Khalid AL-THIHLI, Auteur . - 2015 . - p.2323-2328. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-8 (August 2015) . - p.2323-2328 Mots-clés : Autism  Autism spectrum disorders  Chromosomal microarray  Array-CGH  Diagnostic yield  Consanguinity Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorders are a complicated group of disorders characterized with heterogeneous genetic etiologies. The genetic investigations for this group of disorders have expanded considerably over the past decade. In our study we designed a tired approach and studied the diagnostic yield of chromosomal microarray analysis on patients referred to the Genetic and Developmental Medicine clinic in Sultan Qaboos University in Oman for autism spectrum disorders in a highly consanguineous population. Copy number variants were seen in 27 % of our studied cohort of patients and it was strongly associated with dysmorphic features and congenital anomalies. En ligne : http://dx.doi.org/10.1007/s10803-015-2394-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263