Brief Report: Pilot Study of a Novel Interactive Digital Treatment to Improve Cognitive Control in Children with Autism Spectrum Disorder and Co-occurring ADHD Symptoms / B. E. YERYS in Journal of Autism and Developmental Disorders, 49-4 (April 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1727-1737 Titre : Brief Report: Pilot Study of a Novel Interactive Digital Treatment to Improve Cognitive Control in Children with Autism Spectrum Disorder and Co-occurring ADHD Symptoms Type de document : Texte imprimé et/ou numérique Auteurs : B. E. YERYS, Auteur ; Jennifer R. BERTOLLO, Auteur ; L. KENWORTHY, Auteur ; G. DAWSON, Auteur ; E. J. MARCO, Auteur ; Robert T. SCHULTZ, Auteur ; L. SIKICH, Auteur Article en page(s) : p.1727-1737 Langues : Anglais (eng) Mots-clés : Attention deficit/hyperactivity disorder  Comorbidity  Executive function  Go/No-Go  Inhibition  Neurodevelopmental disorder Index. décimale : PER Périodiques Résumé : The presence of attention deficit/hyperactivity disorder (ADHD) symptoms in children with autism spectrum disorder (ASD) is associated with worse cognitive control. Children with ASD and ADHD often respond poorly to medications, thus we need alternative treatments. We examined the feasibility, acceptability, and preliminary efficacy of Project Evo-a digital treatment. Nineteen children with ASD and co-occurring ADHD symptoms completed this app-based treatment that targets multi-tasking through gameplay versus a comparison educational treatment. Children had a high engagement with both treatments, and parents and children reported high acceptability. Within-group analyses suggest the multi-tasking but not the educational treatment may improve cognitive control. This multi-tasking treatment is feasible, acceptable, and possibly efficacious for cognitive control impairments in children with ASD and ADHD. En ligne : https://dx.doi.org/10.1007/s10803-018-3856-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 [article] Brief Report: Pilot Study of a Novel Interactive Digital Treatment to Improve Cognitive Control in Children with Autism Spectrum Disorder and Co-occurring ADHD Symptoms [Texte imprimé et/ou numérique] / B. E. YERYS, Auteur ; Jennifer R. BERTOLLO, Auteur ; L. KENWORTHY, Auteur ; G. DAWSON, Auteur ; E. J. MARCO, Auteur ; Robert T. SCHULTZ, Auteur ; L. SIKICH, Auteur . - p.1727-1737. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1727-1737 Mots-clés : Attention deficit/hyperactivity disorder  Comorbidity  Executive function  Go/No-Go  Inhibition  Neurodevelopmental disorder Index. décimale : PER Périodiques Résumé : The presence of attention deficit/hyperactivity disorder (ADHD) symptoms in children with autism spectrum disorder (ASD) is associated with worse cognitive control. Children with ASD and ADHD often respond poorly to medications, thus we need alternative treatments. We examined the feasibility, acceptability, and preliminary efficacy of Project Evo-a digital treatment. Nineteen children with ASD and co-occurring ADHD symptoms completed this app-based treatment that targets multi-tasking through gameplay versus a comparison educational treatment. Children had a high engagement with both treatments, and parents and children reported high acceptability. Within-group analyses suggest the multi-tasking but not the educational treatment may improve cognitive control. This multi-tasking treatment is feasible, acceptable, and possibly efficacious for cognitive control impairments in children with ASD and ADHD. En ligne : https://dx.doi.org/10.1007/s10803-018-3856-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388

Sensory over-responsivity: parent report, direct assessment measures, and neural architecture / Teresa TAVASSOLI in Molecular Autism, 10 (2019)  

Public ISBD [article]  inMolecular Autism > 10 (2019) . - 4 p. Titre : Sensory over-responsivity: parent report, direct assessment measures, and neural architecture Type de document : Texte imprimé et/ou numérique Auteurs : Teresa TAVASSOLI, Auteur ; Annie BRANDES-AITKEN, Auteur ; R. CHU, Auteur ; L. PORTER, Auteur ; S. SCHOEN, Auteur ; L. J. MILLER, Auteur ; M. R. GERDES, Auteur ; J. OWEN, Auteur ; P. MUKHERJEE, Auteur ; E. J. MARCO, Auteur Article en page(s) : 4 p. Langues : Anglais (eng) Mots-clés : *Assessment  *Diffusion Tensor Imaging  *Neurodevelopmental disorder  *Sensory over-responsivity  *Sensory processing disorder  *autism  of California, San Francisco (10-01940). Written consent was collected from  parents of the participants.All recruited participants/parents have given consent  for publication during the recruitment process.The authors declare that they have  no competing interests.Springer Nature remains neutral with regard to  jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Sensory processing difficulties are common across neurodevelopmental disorders. Thus, reliable measures are needed to understand the biological underpinnings of these differences. This study aimed to define a scoring methodology specific to auditory (AOR) and tactile (TOR) over-responsivity. Second, in a pilot cohort using MRI Diffusion Tensor Imaging, we performed a proof of concept study of whether children with AOR showed measurable differences in their white matter integrity. Methods: This study included children with AOR and TOR from a mixed neurodevelopmental disorder cohort including autism and sensory processing dysfunction (n = 176) as well as neurotypical children (n = 128). We established cohorts based on sensory over-responsivity using parent report (Short Sensory Profile (SSP)) and direct assessment (Sensory Processing-Three Dimensions: Assessment (SP-3D:A)) measures. With a subset of the children (n = 39), group comparisons, based on AOR phenotype, were conducted comparing the white matter fractional anisotropy in 23 regions of interest. Results: Using direct assessment, 31% of the children with neurodevelopmental disorders had AOR and 27% had TOR. The inter-test agreement between SSP and SP-3D:A for AOR was 65% and TOR was 50%. Children with AOR had three white matter tracts showing decreased fractional anisotropy relative to children without AOR. Conclusions: This study identified cut-off scores for AOR and TOR using the SSP parent report and SP-3D:A observation. A combination of questionnaire and direct observation measures should be used in clinical and research settings. The SSP parent report and SP-3D:A direct observation ratings overlapped moderately for sensory related behaviors. Based on these preliminary structural neuroimaging results, we suggest a putative neural network may contribute to AOR. En ligne : https://dx.doi.org/10.1186/s13229-019-0255-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 [article] Sensory over-responsivity: parent report, direct assessment measures, and neural architecture [Texte imprimé et/ou numérique] / Teresa TAVASSOLI, Auteur ; Annie BRANDES-AITKEN, Auteur ; R. CHU, Auteur ; L. PORTER, Auteur ; S. SCHOEN, Auteur ; L. J. MILLER, Auteur ; M. R. GERDES, Auteur ; J. OWEN, Auteur ; P. MUKHERJEE, Auteur ; E. J. MARCO, Auteur . - 4 p. Langues : Anglais (eng) in Molecular Autism > 10 (2019) . - 4 p. Mots-clés : *Assessment  *Diffusion Tensor Imaging  *Neurodevelopmental disorder  *Sensory over-responsivity  *Sensory processing disorder  *autism  of California, San Francisco (10-01940). Written consent was collected from  parents of the participants.All recruited participants/parents have given consent  for publication during the recruitment process.The authors declare that they have  no competing interests.Springer Nature remains neutral with regard to  jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Sensory processing difficulties are common across neurodevelopmental disorders. Thus, reliable measures are needed to understand the biological underpinnings of these differences. This study aimed to define a scoring methodology specific to auditory (AOR) and tactile (TOR) over-responsivity. Second, in a pilot cohort using MRI Diffusion Tensor Imaging, we performed a proof of concept study of whether children with AOR showed measurable differences in their white matter integrity. Methods: This study included children with AOR and TOR from a mixed neurodevelopmental disorder cohort including autism and sensory processing dysfunction (n = 176) as well as neurotypical children (n = 128). We established cohorts based on sensory over-responsivity using parent report (Short Sensory Profile (SSP)) and direct assessment (Sensory Processing-Three Dimensions: Assessment (SP-3D:A)) measures. With a subset of the children (n = 39), group comparisons, based on AOR phenotype, were conducted comparing the white matter fractional anisotropy in 23 regions of interest. Results: Using direct assessment, 31% of the children with neurodevelopmental disorders had AOR and 27% had TOR. The inter-test agreement between SSP and SP-3D:A for AOR was 65% and TOR was 50%. Children with AOR had three white matter tracts showing decreased fractional anisotropy relative to children without AOR. Conclusions: This study identified cut-off scores for AOR and TOR using the SSP parent report and SP-3D:A observation. A combination of questionnaire and direct observation measures should be used in clinical and research settings. The SSP parent report and SP-3D:A direct observation ratings overlapped moderately for sensory related behaviors. Based on these preliminary structural neuroimaging results, we suggest a putative neural network may contribute to AOR. En ligne : https://dx.doi.org/10.1186/s13229-019-0255-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389

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