Cortical volume alterations in the limbic network in adolescents with high reactive aggression / Johannah BASHFORD-LARGO in Development and Psychopathology, 37-2 (May 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-2 (May 2025) . - p.918-926 Titre : Cortical volume alterations in the limbic network in adolescents with high reactive aggression Type de document : Texte imprimé et/ou numérique Auteurs : Johannah BASHFORD-LARGO, Auteur ; R. James R. BLAIR, Auteur ; Karina S. BLAIR, Auteur ; Matthew DOBBERTIN, Auteur ; Jaimie ELOWSKY, Auteur ; Ahria DOMINGUEZ, Auteur ; Melissa HATCH, Auteur ; Sahil BAJAJ, Auteur Article en page(s) : p.918-926 Langues : Anglais (eng) Mots-clés : MRI  adolescence  aggression  limbic  network  reactive Index. décimale : PER Périodiques Résumé : Previous studies show aggression-related structural alterations in frontal and limbic brain regions. Most studies have focused on overall aggression, instead of its subtypes, and on specific regions instead of networks. This study aims to identify both brain networks and regions that are associated with reactive and proactive subtypes of aggression. Structural MRI data were collected from 340 adolescents (125 F/215 M) with a mean age of 16.29 (SD = 1.20). Aggression symptomology was indexed via the Reactive Proactive Aggression Questionnaire (RPQ). Freesurfer was used to estimate Cortical Volume (CV) from seven networks and regions within specific networks associated with aggression. Two multivariate analyses of covariance (MANCOVAs) were conducted on groups for low versus higher reactive and proactive RPQ scores. Our reactive aggression MANCOVA showed a main effect in CV [F(14,321) = 1.935, p = 0.022,?p2 = 0.078] across all the 7-Networks. Unpacking this main effect revealed significant volumetric differences in the right Limbic Network (LN) (p = 0.029) and the Temporal Pole (p = 0.011), where adolescents in the higher reactive aggression group showed higher cortical volumes. Such findings are consistent with region/voxel-specific analyses that have associated atypical structure within the LN and reactive aggression. Moreover, the temporal pole is highly interconnected with regions important in the regulation and initiation of reactive aggression. En ligne : https://dx.doi.org/10.1017/S0954579424000750 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552 [article] Cortical volume alterations in the limbic network in adolescents with high reactive aggression [Texte imprimé et/ou numérique] / Johannah BASHFORD-LARGO, Auteur ; R. James R. BLAIR, Auteur ; Karina S. BLAIR, Auteur ; Matthew DOBBERTIN, Auteur ; Jaimie ELOWSKY, Auteur ; Ahria DOMINGUEZ, Auteur ; Melissa HATCH, Auteur ; Sahil BAJAJ, Auteur . - p.918-926. Langues : Anglais (eng) in Development and Psychopathology > 37-2 (May 2025) . - p.918-926 Mots-clés : MRI  adolescence  aggression  limbic  network  reactive Index. décimale : PER Périodiques Résumé : Previous studies show aggression-related structural alterations in frontal and limbic brain regions. Most studies have focused on overall aggression, instead of its subtypes, and on specific regions instead of networks. This study aims to identify both brain networks and regions that are associated with reactive and proactive subtypes of aggression. Structural MRI data were collected from 340 adolescents (125 F/215 M) with a mean age of 16.29 (SD = 1.20). Aggression symptomology was indexed via the Reactive Proactive Aggression Questionnaire (RPQ). Freesurfer was used to estimate Cortical Volume (CV) from seven networks and regions within specific networks associated with aggression. Two multivariate analyses of covariance (MANCOVAs) were conducted on groups for low versus higher reactive and proactive RPQ scores. Our reactive aggression MANCOVA showed a main effect in CV [F(14,321) = 1.935, p = 0.022,?p2 = 0.078] across all the 7-Networks. Unpacking this main effect revealed significant volumetric differences in the right Limbic Network (LN) (p = 0.029) and the Temporal Pole (p = 0.011), where adolescents in the higher reactive aggression group showed higher cortical volumes. Such findings are consistent with region/voxel-specific analyses that have associated atypical structure within the LN and reactive aggression. Moreover, the temporal pole is highly interconnected with regions important in the regulation and initiation of reactive aggression. En ligne : https://dx.doi.org/10.1017/S0954579424000750 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552

Face emotion labeling deficits in children with bipolar disorder and severe mood dysregulation / Brendan A. RICH in Development and Psychopathology, 20-2 (Spring 2008)  

Public ISBD [article]  inDevelopment and Psychopathology > 20-2 (Spring 2008) . - p.529-546 Titre : Face emotion labeling deficits in children with bipolar disorder and severe mood dysregulation Type de document : Texte imprimé et/ou numérique Auteurs : Brendan A. RICH, Auteur ; Ellen LEIBENLUFT, Auteur ; Mary E. GRIMLEY, Auteur ; Mariana SCHMAJUK, Auteur ; Karina S. BLAIR, Auteur ; James R. BLAIR, Auteur Année de publication : 2008 Article en page(s) : p.529-546 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Children with narrow phenotype bipolar disorder (NP-BD; i.e., history of at least one hypomanic or manic episode with euphoric mood) are deficient when labeling face emotions. It is unknown if this deficit is specific to particular emotions, or if it extends to children with severe mood dysregulation (SMD; i.e., chronic irritability and hyperarousal without episodes of mania). Thirty-nine NP-BD, 31 SMD, and 36 control subjects completed the emotional expression multimorph task, which presents gradations of facial emotions from 100% neutrality to 100% emotional expression (happiness, surprise, fear, sadness, anger, and disgust). Groups were compared in terms of intensity of emotion required before identification occurred and accuracy. Both NP-BD and SMD youth required significantly more morphs than controls to label correctly disgusted, surprised, fearful, and happy faces. Impaired face labeling correlated with deficient social reciprocity skills in NP-BD youth and dysfunctional family relationships in SMD youth. Compared to controls, patients with NP-BD or SMD require significantly more intense facial emotion before they are able to label the emotion correctly. These deficits are associated with psychosocial impairments. Understanding the neural circuitry associated with face-labeling deficits has the potential to clarify the pathophysiology of these disorders. En ligne : http://dx.doi.org/10.1017/s0954579408000266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412 [article] Face emotion labeling deficits in children with bipolar disorder and severe mood dysregulation [Texte imprimé et/ou numérique] / Brendan A. RICH, Auteur ; Ellen LEIBENLUFT, Auteur ; Mary E. GRIMLEY, Auteur ; Mariana SCHMAJUK, Auteur ; Karina S. BLAIR, Auteur ; James R. BLAIR, Auteur . - 2008 . - p.529-546. Langues : Anglais (eng) in Development and Psychopathology > 20-2 (Spring 2008) . - p.529-546 Index. décimale : PER Périodiques Résumé : Children with narrow phenotype bipolar disorder (NP-BD; i.e., history of at least one hypomanic or manic episode with euphoric mood) are deficient when labeling face emotions. It is unknown if this deficit is specific to particular emotions, or if it extends to children with severe mood dysregulation (SMD; i.e., chronic irritability and hyperarousal without episodes of mania). Thirty-nine NP-BD, 31 SMD, and 36 control subjects completed the emotional expression multimorph task, which presents gradations of facial emotions from 100% neutrality to 100% emotional expression (happiness, surprise, fear, sadness, anger, and disgust). Groups were compared in terms of intensity of emotion required before identification occurred and accuracy. Both NP-BD and SMD youth required significantly more morphs than controls to label correctly disgusted, surprised, fearful, and happy faces. Impaired face labeling correlated with deficient social reciprocity skills in NP-BD youth and dysfunctional family relationships in SMD youth. Compared to controls, patients with NP-BD or SMD require significantly more intense facial emotion before they are able to label the emotion correctly. These deficits are associated with psychosocial impairments. Understanding the neural circuitry associated with face-labeling deficits has the potential to clarify the pathophysiology of these disorders. En ligne : http://dx.doi.org/10.1017/s0954579408000266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412

Reduced activity within the dorsal endogenous orienting of attention network to fearful expressions in youth with disruptive behavior disorders and psychopathic traits / Stuart F. WHITE in Development and Psychopathology, 24-3 (August 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-3 (August 2012) . - p.1105-16. Titre : Reduced activity within the dorsal endogenous orienting of attention network to fearful expressions in youth with disruptive behavior disorders and psychopathic traits Type de document : Texte imprimé et/ou numérique Auteurs : Stuart F. WHITE, Auteur ; Craig WILLIAMS W., Auteur ; Sarah J., BRISLIN, Auteur ; Stephen SINCLAIR, Auteur ; Karina S. BLAIR, Auteur ; Katherine A. FOWLER, Auteur ; Daniel Samuel PINE, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur Année de publication : 2012 Article en page(s) : p.1105-16. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Using behavioral and blood oxygen level dependent (BOLD) response indices through functional magnetic resonance imaging (fMRI), the current study investigated whether youths with disruptive behavior disorders (conduct disorder and oppositional defiant disorder) plus psychopathic traits (DBD + PT) show aberrant sensitivity to eye gaze information generally and/or whether they show particular insensitivity to eye gaze information in the context of fearful expressions. The participants were 36 children and adolescents (ages 10–17 years); 17 had DBD + PT and 19 were healthy comparison subjects. Participants performed a spatial attention paradigm where spatial attention was cued by eye gaze in faces displaying fearful, angry, or neutral affect. Eye gaze sensitivity was indexed both behaviorally and as BOLD response. There were no group differences in behavioral response: both groups showed significantly faster responses if the target was in the congruent spatial direction indicated by eye gaze. Neither group showed a Congruence × Emotion interaction; neither group showed an advantage from the displayer's emotional expression behaviorally. However, the BOLD response revealed a significant Group × Congruence × Emotion interaction. The comparison youth showed increased activity within the dorsal endogenous orienting network (superior parietal lobule and inferior parietal sulcus) for fearful congruent relative to incongruent trials relative to the youth with DBD + PT. The results are discussed with reference to current models of DBD + PT and possible treatment innovations. En ligne : http://dx.doi.org/10.1017/S0954579412000569 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Reduced activity within the dorsal endogenous orienting of attention network to fearful expressions in youth with disruptive behavior disorders and psychopathic traits [Texte imprimé et/ou numérique] / Stuart F. WHITE, Auteur ; Craig WILLIAMS W., Auteur ; Sarah J., BRISLIN, Auteur ; Stephen SINCLAIR, Auteur ; Karina S. BLAIR, Auteur ; Katherine A. FOWLER, Auteur ; Daniel Samuel PINE, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur . - 2012 . - p.1105-16. Langues : Anglais (eng) in Development and Psychopathology > 24-3 (August 2012) . - p.1105-16. Index. décimale : PER Périodiques Résumé : Using behavioral and blood oxygen level dependent (BOLD) response indices through functional magnetic resonance imaging (fMRI), the current study investigated whether youths with disruptive behavior disorders (conduct disorder and oppositional defiant disorder) plus psychopathic traits (DBD + PT) show aberrant sensitivity to eye gaze information generally and/or whether they show particular insensitivity to eye gaze information in the context of fearful expressions. The participants were 36 children and adolescents (ages 10–17 years); 17 had DBD + PT and 19 were healthy comparison subjects. Participants performed a spatial attention paradigm where spatial attention was cued by eye gaze in faces displaying fearful, angry, or neutral affect. Eye gaze sensitivity was indexed both behaviorally and as BOLD response. There were no group differences in behavioral response: both groups showed significantly faster responses if the target was in the congruent spatial direction indicated by eye gaze. Neither group showed a Congruence × Emotion interaction; neither group showed an advantage from the displayer's emotional expression behaviorally. However, the BOLD response revealed a significant Group × Congruence × Emotion interaction. The comparison youth showed increased activity within the dorsal endogenous orienting network (superior parietal lobule and inferior parietal sulcus) for fearful congruent relative to incongruent trials relative to the youth with DBD + PT. The results are discussed with reference to current models of DBD + PT and possible treatment innovations. En ligne : http://dx.doi.org/10.1017/S0954579412000569 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

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