Adverse family life events during pregnancy and ADHD symptoms in five-year-old offspring / M. A. ROSENQVIST in Journal of Child Psychology and Psychiatry, 60-6 (June 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-6 (June 2019) . - p.665-675 Titre : Adverse family life events during pregnancy and ADHD symptoms in five-year-old offspring Type de document : Texte imprimé et/ou numérique Auteurs : M. A. ROSENQVIST, Auteur ; A. SJOLANDER, Auteur ; E. YSTROM, Auteur ; H. LARSSON, Auteur ; T. REICHBORN-KJENNERUD, Auteur Article en page(s) : p.665-675 Langues : Anglais (eng) Mots-clés : Adhd  MoBa  adverse life events  antenatal stress  delayed effects  prenatal exposures  the Norwegian Mother and Child Cohort Study Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to maternal adverse life events has been associated with offspring ADHD, but the role of familial confounding is unclear. We aimed to clarify if adverse life events during pregnancy are related to ADHD symptoms in offspring, taking shared familial factors into account. METHOD: Data were collected on 34,751 children (including 6,427 siblings) participating in the population-based Norwegian Mother and Child Cohort Study. During pregnancy, mothers reported whether they had experienced specific life events. We assessed ADHD symptoms in five-year-old children with the Conners' Parent Rating Scale-Revised: short form. We modeled the associations between life events and mean ADHD scores with ordinary linear regression in the full cohort, and with fixed-effect linear regression in sibling comparisons to adjust for familial confounding. RESULTS: Children exposed to adverse life events had higher ADHD scores at age 5, with the strongest effect observed for financial problems (mean differences 0.10 [95% CI: 0.09, 0.11] in adjusted model), and the weakest for having lost someone close (0.02 [95% CI 0.01, 0.04] in adjusted model). Comparing exposure-discordant siblings resulted in attenuated estimates that were no longer statistically significant (e.g. mean difference for financial problems -0.03 [95% CI -0.07, 0.02]). ADHD scores increased if the mother had experienced the event as painful or difficult, and with the number of events, whereas sibling-comparison analyses resulted in estimates attenuated toward the null. CONCLUSIONS: These results suggest that the association between adverse life events during pregnancy and offspring ADHD symptoms is largely explained by familial factors. En ligne : http://dx.doi.org/10.1111/jcpp.12990 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Adverse family life events during pregnancy and ADHD symptoms in five-year-old offspring [Texte imprimé et/ou numérique] / M. A. ROSENQVIST, Auteur ; A. SJOLANDER, Auteur ; E. YSTROM, Auteur ; H. LARSSON, Auteur ; T. REICHBORN-KJENNERUD, Auteur . - p.665-675. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-6 (June 2019) . - p.665-675 Mots-clés : Adhd  MoBa  adverse life events  antenatal stress  delayed effects  prenatal exposures  the Norwegian Mother and Child Cohort Study Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to maternal adverse life events has been associated with offspring ADHD, but the role of familial confounding is unclear. We aimed to clarify if adverse life events during pregnancy are related to ADHD symptoms in offspring, taking shared familial factors into account. METHOD: Data were collected on 34,751 children (including 6,427 siblings) participating in the population-based Norwegian Mother and Child Cohort Study. During pregnancy, mothers reported whether they had experienced specific life events. We assessed ADHD symptoms in five-year-old children with the Conners' Parent Rating Scale-Revised: short form. We modeled the associations between life events and mean ADHD scores with ordinary linear regression in the full cohort, and with fixed-effect linear regression in sibling comparisons to adjust for familial confounding. RESULTS: Children exposed to adverse life events had higher ADHD scores at age 5, with the strongest effect observed for financial problems (mean differences 0.10 [95% CI: 0.09, 0.11] in adjusted model), and the weakest for having lost someone close (0.02 [95% CI 0.01, 0.04] in adjusted model). Comparing exposure-discordant siblings resulted in attenuated estimates that were no longer statistically significant (e.g. mean difference for financial problems -0.03 [95% CI -0.07, 0.02]). ADHD scores increased if the mother had experienced the event as painful or difficult, and with the number of events, whereas sibling-comparison analyses resulted in estimates attenuated toward the null. CONCLUSIONS: These results suggest that the association between adverse life events during pregnancy and offspring ADHD symptoms is largely explained by familial factors. En ligne : http://dx.doi.org/10.1111/jcpp.12990 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Development of ADHD symptoms in preschool children: Genetic and environmental contributions / E. M. EILERTSEN in Development and Psychopathology, 31-4 (October 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-4 (October 2019) . - p.1299-1305 Titre : Development of ADHD symptoms in preschool children: Genetic and environmental contributions Type de document : Texte imprimé et/ou numérique Auteurs : E. M. EILERTSEN, Auteur ; L. C. GJERDE, Auteur ; Kenneth S. KENDLER, Auteur ; E. ROYSAMB, Auteur ; S. H. AGGEN, Auteur ; K. GUSTAVSON, Auteur ; T. REICHBORN-KJENNERUD, Auteur ; E. YSTROM, Auteur Article en page(s) : p.1299-1305 Langues : Anglais (eng) Mots-clés : Norwegian Mother and Child Cohort Study (MoBa)  attention-deficit/hyperactivity disorder symptoms  heritability  longitudinal  twin study Index. décimale : PER Périodiques Résumé : We examined genetic and environmental contributions to the development of symptoms of attention-deficit/hyperactivity disorder (ADHD) in preschool children. ADHD symptoms in siblings at 1.5, 3, and 5 years of age were investigated in a population-based sample from the prospective Norwegian Mother and Child Cohort Study. The longitudinal contributions of additive genetic, shared, twin-specific, and unique environmental influences were estimated using biometric structural equation models. Heritability of ADHD symptoms ranged from 54% to 70%. There was evidence of partially new genetic influences at successive ages, with genetic correlations ranging from .58 to .89. Contributions from shared environmental factors and twin-specific factors were minor. The importance of unique environmental effects appeared to increase across ages, and was mostly specific to a given age. There was no evidence suggesting that this pattern differs across males and females. Symptoms of ADHD are highly heritability in young children from as early as 1.5 years of age. Longitudinal stability of ADHD symptoms is mainly attributable to genetic influences, but there is also some evidence for age-specific genetic influences. These findings contribute to our understanding of development of ADHD early in life, and can guide future molecular genetics studies. En ligne : http://dx.doi.org/10.1017/s0954579418000731 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Development of ADHD symptoms in preschool children: Genetic and environmental contributions [Texte imprimé et/ou numérique] / E. M. EILERTSEN, Auteur ; L. C. GJERDE, Auteur ; Kenneth S. KENDLER, Auteur ; E. ROYSAMB, Auteur ; S. H. AGGEN, Auteur ; K. GUSTAVSON, Auteur ; T. REICHBORN-KJENNERUD, Auteur ; E. YSTROM, Auteur . - p.1299-1305. Langues : Anglais (eng) in Development and Psychopathology > 31-4 (October 2019) . - p.1299-1305 Mots-clés : Norwegian Mother and Child Cohort Study (MoBa)  attention-deficit/hyperactivity disorder symptoms  heritability  longitudinal  twin study Index. décimale : PER Périodiques Résumé : We examined genetic and environmental contributions to the development of symptoms of attention-deficit/hyperactivity disorder (ADHD) in preschool children. ADHD symptoms in siblings at 1.5, 3, and 5 years of age were investigated in a population-based sample from the prospective Norwegian Mother and Child Cohort Study. The longitudinal contributions of additive genetic, shared, twin-specific, and unique environmental influences were estimated using biometric structural equation models. Heritability of ADHD symptoms ranged from 54% to 70%. There was evidence of partially new genetic influences at successive ages, with genetic correlations ranging from .58 to .89. Contributions from shared environmental factors and twin-specific factors were minor. The importance of unique environmental effects appeared to increase across ages, and was mostly specific to a given age. There was no evidence suggesting that this pattern differs across males and females. Symptoms of ADHD are highly heritability in young children from as early as 1.5 years of age. Longitudinal stability of ADHD symptoms is mainly attributable to genetic influences, but there is also some evidence for age-specific genetic influences. These findings contribute to our understanding of development of ADHD early in life, and can guide future molecular genetics studies. En ligne : http://dx.doi.org/10.1017/s0954579418000731 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

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